Fiche traitement
Botulinum toxin
Oxford University Hospitals NHS Trust • SEP
Suivi actif
Phase 4
Résumé
Botulinum toxin est développé par Oxford University Hospitals NHS Trust. Le traitement est actuellement en Phase 4. Il est associé à SEP. Son objectif thérapeutique principal est Traitement symptomatique. Le statut actuel est : suivi actif.
À vérifier
Traitement symptomatique
Phase 4
Oxford University Hospitals NHS Trust
United Kingdom
Botulinum toxin (BT) injections are a painful treatment frequently used to treat spasticity following central neurological damage (stroke, multiple sclerosis, spinal cord injury, head trauma). Tolerance of injections varies from patient to patient. For most patients, the pain experienced during the injection is a major source of stress.
Numerous clinical trials have demonstrated the role of music therapy in pain management. Music therapy uses a "U" shaped technique, allowing the patient to relax in different phases. This system has demonstrated beneficial effects on pain and anxiety in various fields, such as chronic and acute pain, Alzheimer's disease, fibromyalgia and neurological pain. Given the painful nature of spasticity and anxiety treatment, we aim to use a musical intervention to help patients cope better with injections.
The primary objective of the study is to investigate the effect of exposure to a musical intervention session during botulinum toxin injections, on injection-induced stress (heart rate variability).
Secondary objectives:
To study the effect of exposure to a musical intervention session during botulinum toxin injections, during the visit to injections #1, in terms of:
* Injection-induced stress for HRV parameters other than LF/HF
* Injection-induced pain
* Injection anxiety
* Patient satisfaction
* Effect of musical intervention on the medical procedure performed (botulinum toxin injections) expressed by the doctor at the end of the session.
To study the effect of exposure to a musical intervention session, during injections visit n°2, in order to evaluate the effect of repeated exposure to a musical intervention session, in terms of :
* Injection-induced stress for HRV parameters other than LF/HF
* Injection-induced pain
* Injection anxiety
* Patient satisfaction
* Effect of musical intervention on the medical procedure performed (botulinum toxin injections) expressed by the physician at the end of the session.
The hypothesis of this research is that a responsive musical intervention can, in adults, reduce the stress induced by botulinum toxin injections.
Patients will be selected from the cohort of patients regularly treated for botulinum toxin injections in the Physical and Rehabilitation Medicine (PRM) department at Clermont-Ferrand University Hospital. Botulinum toxin injections will take place in the PRM department. Each patient will participate in the study for a maximum of 4 months.
This study will be carried out in patients receiving regular botulinum toxin injections to treat spasticity. The first injection will be given with (IM-IM) or without musical intervention (CT-IM), depending on the randomization group, followed by the next injection with musical intervention. Patients will be able to choose the style of music (Jazz, Classical, Electronic, R\&B, Ambient, Rock, etc.) that appeals to them in order to benefit from a minimum 20-minute session of musical intervention (duration varying according to the number of injections to be performed).
2026-11-02
Début phase actuelle
Non disponible dans les sources synchronisées
Timeline clinique
Phase 4
Début phase actuelle
Non disponible dans les sources synchronisées
Préclinique
Phase 1
Phase 2
Phase 3
Approuvé
Objectif scientifique de l’étude
classification automatique vérifiable
Traitement symptomatique
Confiance automatique : 95%
Ce pourcentage n’est pas une probabilité de succès clinique.
Il mesure uniquement la force de la classification automatique de l’objectif scientifique. Le calcul part de 45 points, ajoute 7 points par unité de poids du mot-clé le plus fortement détecté, puis est plafonné à 95 %. Exemple : un score maximal de 2 donne 45 + (2 × 7) = 59 %.
Indices détectés : spasticity → Traitement symptomatique, symptom → Traitement symptomatique, pain → Traitement symptomatique
Ce score est heuristique et doit être vérifié dans le protocole ou une publication.
Description affichée depuis l’essai compatible NCT06920524, afin d’éviter le mélange entre plusieurs indications d’une même molécule.
Aucune incohérence majeure détectée entre la maladie, l’objectif et la description.
Transparence et qualité de la fiche
données vérifiablesClassificationCohérente automatiquement
Confiance de la fiche100 %
Source principaleSource officielle ou publication indexée
Dernière vérification2026-11-02
Anomalies détectées0
Validation humaineValidation humaine non effectuée
Donnée issue d’une source
Donnée normalisée automatiquement
Interprétation algorithmique
Classification scientifique multi-axes
ne pas confondre statut et résultatÉtat de l’étudeRecrutement en cours
Disponibilité des résultatsRésultats à vérifier
InterprétationImpossible à déterminer
Niveau de preuveNon évaluable
Un essai terminé n’est pas nécessairement positif. Un essai arrêté n’est classé comme échec scientifique que lorsqu’un résultat ou une raison explicite le confirme.
Indicateurs factuels
sans score subjectifPhase enregistréePhase 4
Études associées25
Publications associées47
Statut consolidéSuivi actif
Aucune chance de succès, note d’innovation, potentiel thérapeutique ou probabilité de commercialisation n’est calculé tant qu’un modèle validé et des données suffisantes ne sont pas disponibles.
Historique factuel de la molécule
129 événement(s) daté(s)Cette liste reprend uniquement les dates trouvées dans les registres et publications liés. Elle ne constitue pas une prévision.
| Date | Événement | Source |
|---|---|---|
| 2003-02-01 | Début de l’étudeNCT00258609 | Registre d’essai clinique |
| 2003-02-01 | Début de l’étudeNCT00301665 | Registre d’essai clinique |
| 2004-06-01 | Fin de l’étude prévue / enregistréeNCT00258609 | Registre d’essai clinique |
| 2005-03-01 | Fin de l’étude prévue / enregistréeNCT00301665 | Registre d’essai clinique |
| 2008-01-01 | Début de l’étudeNCT00660192 | Registre d’essai clinique |
| 2010-02-22 | Début de l’étudeNCT00909883 | Registre d’essai clinique |
| 2010-04-01 | Début de l’étudeNCT02293083 | Registre d’essai clinique |
| 2011-05-01 | Fin de l’étude prévue / enregistréeNCT02293083 | Registre d’essai clinique |
| 2014-02-12 | Fin de l’étude prévue / enregistréeNCT00909883 | Registre d’essai clinique |
| 2014-07-01 | Début de l’étudeNCT02280083 | Registre d’essai clinique |
| 2015-07-01 | Fin de l’étude prévue / enregistréeNCT00660192 | Registre d’essai clinique |
| 2016-09-01 | Fin de l’étude prévue / enregistréeNCT02280083 | Registre d’essai clinique |
| 2018-09-13 | Début de l’étudeNCT04544280 | Registre d’essai clinique |
| 2018-09-21 | Début de l’étudeNCT03521076 | Registre d’essai clinique |
| 2019-10-01 | Début de l’étudeNCT04069897 | Registre d’essai clinique |
| 2021-12-31 | Fin de l’étude prévue / enregistréeNCT04544280 | Registre d’essai clinique |
| 2023-05-17 | Fin de l’étude prévue / enregistréeNCT03521076 | Registre d’essai clinique |
| 2023-09-01 | Début de l’étudeNCT06243874 | Registre d’essai clinique |
| 2023-09-29 | Début de l’étudeNCT06047457 | Registre d’essai clinique |
| 2023-10-12 | Début de l’étudeNCT06047444 | Registre d’essai clinique |
| 2023-11-14 | Début de l’étudeNCT05720065 | Registre d’essai clinique |
| 2024-01-01 | Fin de l’étude prévue / enregistréeNCT06243874 | Registre d’essai clinique |
| 2024-02-01 | Début de l’étudeNCT07875868 | Registre d’essai clinique |
| 2024-10-10 | Début de l’étudeNCT07758322 | Registre d’essai clinique |
| 2025-01-01 | Fin de l’étude prévue / enregistréeNCT07875868 | Registre d’essai clinique |
| 2025-04-25 | Début de l’étudeNCT06920524 | Registre d’essai clinique |
| 2025-12-02 | Début de l’étudeNCT07303582 | Registre d’essai clinique |
| 2026-01-05 | Début de l’étudeNCT07286435 | Registre d’essai clinique |
| 2026-03-03 | Début de l’étudeNCT07571889 | Registre d’essai clinique |
| 2026-03-06 | Début de l’étudeNCT07501429 | Registre d’essai clinique |
| 2026-04-01 | Début de l’étudeNCT07535723 | Registre d’essai clinique |
| 2026-06-13 | Fin de l’étude prévue / enregistréeNCT04069897 | Registre d’essai clinique |
| 2026-07-08 | PublicationOne-day rejuvenation: a preliminary case series of a multimodal protocol combining Q-switched 1064 nm laser, botulinum toxin, and laser-assisted delivery of PDRN and retinoids. | Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology |
| 2026-07-08 | PublicationLong-term neuromuscular alterations during botulinum toxin treatment for chronic migraine. | Clinical neurophysiology practice |
| 2026-07-08 | PublicationGeographic Variation in Botulinum Toxin Type A Longevity: A Pilot Comparative Study Between Saint Petersburg and Ashgabat. | Cureus |
| 2026-07-10 | Création de l’enregistrementNCT02280083 | Registre d’essai clinique |
| 2026-07-10 | PublicationThe Efficacy of Laser and Botox Therapies for Post-Thyroidectomy Scar Management: A Comprehensive Systematic Review and Meta-Analysis. | Aesthetic plastic surgery |
| 2026-07-10 | PublicationAssociation of AbobotulinumtoxinA and Skinbooster for Periorbital Wrinkles: A Randomized, Controlled, Double-Blind, Split-Face Study. | Aesthetic plastic surgery |
| 2026-07-12 | Création de l’enregistrementNCT02293083 | Registre d’essai clinique |
| 2026-07-12 | PublicationAnalyzing the Effect of Extracorporeal Shockwave Therapy after Botulinum Toxin Injection on Calf Muscle Spasticity Improvement in Patients with Multiple Sclerosis - A Randomized Clinical Trial. | Advanced biomedical research |
| 2026-07-12 | PublicationCellular Remodeling of Skeletal Muscle Following Botulinum Toxin A Injection: A Single-Nucleus RNA Sequencing Study. | Aesthetic plastic surgery |
| 2026-07-13 | Dernière mise à jour du registreNCT02293083 | Registre d’essai clinique |
| 2026-07-13 | Dernière mise à jour du registreNCT02280083 | Registre d’essai clinique |
| 2026-07-14 | PublicationTherapeutic progress in rosacea: targeting the neuro-vascular-immune triad. | Frontiers in immunology |
| 2026-07-14 | PublicationAdvanced on Minimally Invasive Techniques in Facial Rejuvenation: A Comprehensive Review. | World journal of plastic surgery |
| 2026-07-18 | PublicationBotulinum Toxin Type A for the Treatment of Focal Spasticity in Children With Cerebral Palsy in Thailand: A Cost-Utility and Budget Impact Analysis. | Value in health regional issues |
| 2026-07-18 | PublicationComparing the real-world effectiveness of botulinum toxin type A injections across distinct poststroke muscle hyper-resistance patterns. | Frontiers in neurology |
| 2026-07-23 | Création de l’enregistrementNCT00258609 | Registre d’essai clinique |
| 2026-07-23 | Création de l’enregistrementNCT00301665 | Registre d’essai clinique |
| 2026-07-23 | Création de l’enregistrementNCT06047457 | Registre d’essai clinique |
| 2026-07-23 | Création de l’enregistrementNCT06047444 | Registre d’essai clinique |
| 2026-07-23 | PublicationBotulinum Neurotoxin for Postoperative Facial Nerve Paralysis: A Technical Note. | Neurology India |
| 2026-07-23 | PublicationA retrospective study of intravesical botulin toxin type A in children with refractory detrusor overactivity. | Scientific reports |
| 2026-07-24 | Création de l’enregistrementNCT07535723 | Registre d’essai clinique |
| 2026-07-29 | Création de l’enregistrementNCT06920524 | Registre d’essai clinique |
| 2026-08-05 | Création de l’enregistrementNCT04544280 | Registre d’essai clinique |
| 2026-08-08 | PublicationThree men in a boat: The comparison of the combination therapy of botulinum toxin and greater occipital nerve block with bupivacaine, with botulinum toxin monotherapy in the management of chronic migraine. | Clinical neurology and neurosurgery |
| 2026-08-08 | PublicationCorrugator Supercilii Muscle and Its Relationship with Neurovascular Structures of the Frontal Region: A Cadaveric Study. | Aesthetic plastic surgery |
| 2026-08-08 | PublicationComparison of the Effectiveness of Greater Occipital Nerve Block and Botulinum Toxin Type A in Chronic Migraine: An Exploratory Pilot Study From a Tertiary Care Centre in a Resource-Limited Setting. | Cureus |
| 2026-08-08 | PublicationTwelve-months prospective real-world assessment of effectiveness and safety of eptinezumab in migraine patients difficult-to-treat and naïve to CGRP monoclonal antibodies: results of the French FHU INOVPAIN registry. | The journal of headache and pain |
| 2026-08-08 | PublicationBotulinum toxin in peripheral facial paralysis: systematic review and rehabilitation perspectives. | European journal of physical and rehabilitation medicine |
| 2026-08-08 | PublicationRepeated botulinum toxin injections for neurogenic thoracic outlet syndrome: A case report. | Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology |
| 2026-08-08 | Publication[Treatment persistence and adherence with botulinum toxin type A and anti-calcitonin gene-related peptide monoclonal antibodies in migraine. (A retrospective cohort study from a specialized headache center)]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova |
| 2026-08-08 | PublicationDiagnostic value of shear wave elastography in assessing the effectiveness of preoperative botulinum toxin type A therapy in patients with postoperative ventral hernias W3. | Hernia : the journal of hernias and abdominal wall surgery |
| 2026-08-13 | Création de l’enregistrementNCT07571889 | Registre d’essai clinique |
| 2026-08-13 | Création de l’enregistrementNCT07758322 | Registre d’essai clinique |
| 2026-08-13 | Création de l’enregistrementNCT00660192 | Registre d’essai clinique |
| 2026-08-13 | Création de l’enregistrementNCT07691164 | Registre d’essai clinique |
| 2026-08-13 | Création de l’enregistrementNCT04069897 | Registre d’essai clinique |
| 2026-08-13 | Dernière mise à jour du registreNCT07535723 | Registre d’essai clinique |
| 2026-08-13 | PublicationRadial extracorporeal shock wave therapy improves upper limb function in chronic stroke patients: a randomized sham-controlled trial. | Clinics (Sao Paulo, Brazil) |
| 2026-08-13 | PublicationCentral and Peripheral Sensitization in Temporomandibular Disorders: Proposed Mechanisms of Botulinum Toxin Therapy. | Toxins |
| 2026-08-13 | PublicationSafety and efficacy of recombinant botulinum toxin type A (Eveotox®) in patients with post-stroke upper limb spasticity: Results from a Phase Ib/II clinical trial. | Toxicon : official journal of the International Society on Toxinology |
| 2026-08-13 | PublicationHealth-Related Quality of Life Following Botulinum Toxin for Retrograde Cricopharyngeus Dysfunction. | The Laryngoscope |
| 2026-08-13 | PublicationEMG-guided Onabotulinum Toxin A for provoked vestibulodynia: addressing methodological concerns while confirming clinical benefit (Reply to Letter-to-the-Editor). | American journal of obstetrics and gynecology |
| 2026-08-13 | PublicationShort-term quantitative ultrasonographic assessment of masseter muscle changes following botulinum toxin injection in patients with bruxism: A prospective pilot study. | Cranio : the journal of craniomandibular practice |
| 2026-08-13 | PublicationThe STIIM UP Protocol: Exploratory Evaluation of the Potential of Combined Calcium Hydroxyapatite, Hyaluronic Acid, and Botulinum Toxin A in Neck Rejuvenation. | Journal of clinical medicine |
| 2026-08-13 | PublicationMusical intervention to reduce stress during botulinum toxin injection for spasticity: Protocol for a randomized controlled trial (MUSIBOT). | PloS one |
| 2026-08-16 | Création de l’enregistrementNCT05720065 | Registre d’essai clinique |
| 2026-08-16 | Création de l’enregistrementNCT06243874 | Registre d’essai clinique |
| 2026-08-16 | PublicationBotulinum toxin effects on biochemical biomarkers related to inflammation-associated head and neck chronic conditions: a systematic review of clinical research. | Journal of neural transmission (Vienna, Austria : 1996) |
| 2026-08-16 | PublicationEffect of Preoperative Botulinum Toxin on the Outcome of Large Midline Hernia Repair. | ANZ journal of surgery |
| 2026-08-16 | PublicationA Systematic Review on Administration of Botulinum Toxin in the Management of Male Sexual Dysfunctions. | Andrology |
| 2026-08-16 | PublicationPerceived comfort with migraine treatments and control of migraine symptoms: Results from the Headache Assessment via Digital Platform in United States study. | Headache |
| 2026-08-16 | PublicationBotulinum Toxin Type A in Spasticity and Cervical Dystonia: Practical Clinical Recommendations from a Mexican Multidisciplinary Panel of Specialist Injectors. | Toxins |
| 2026-08-16 | PublicationMigraine-advanced preventative treatments: the British Association for the Study of Headache Clinical Practice Recommendations and Consensus Guidance. | Journal of neurology, neurosurgery, and psychiatry |
| 2026-08-16 | PublicationEnhanced Efficacy of Post-Procedural Skin Care: A Double-Blind, Randomized, Vehicle-Controlled, Split-Face Clinical Study Assessing a Novel Neuropeptide Serum Following Botulinum Toxin Injection. | Clinical, cosmetic and investigational dermatology |
| 2026-08-16 | PublicationThe Botox Paradox: How Rising Drug Costs and Reimbursement Failures Threaten Access to Botulinum Toxin Therapy in Neurology. | Cureus |
| 2026-08-16 | PublicationA new treatment for focal dystonias: incobotulinumtoxinA (Xeomin®), a botulinum neurotoxin type A free from complexing proteins. | Neuropsychiatric disease and treatment |
| 2026-08-16 | PublicationChronic migraine prophylaxis: Comparative study between ultrasound-guided greater occipital nerve block and medical treatment. | Clinical neurology and neurosurgery |
| 2026-08-16 | PublicationManagement of refractory chronic migraine using ultrasound-guided pulsed radiofrequency of greater occipital nerve: Two case reports. | Medicine |
| 2026-08-16 | PublicationCACNA1C -Related Channelopathy Presenting With Adult-Onset Combined Dystonia-Parkinsonism: A Novel Neurological Presentation. | American journal of medical genetics. Part A |
| 2026-08-16 | PublicationEfficacy and durability of therapies for neurogenic lower urinary tract dysfunction: A network meta-analysis of Botulinum Toxin a, instillations, and neuromodulation. | Toxicon : official journal of the International Society on Toxinology |
| 2026-08-16 | PublicationComparative efficacy of intralesional therapies for keloid scars: a network meta-analysis. | Annals of medicine |
| 2026-08-16 | PublicationCatamenial loss of botulinum toxin efficacy successfully managed with tamoxifen: A case report. | JAAD case reports |
| 2026-08-16 | PublicationEarly local antitoxin intervention attenuates botulinum neurotoxin-induced neuromuscular dysfunction. | Toxicon : official journal of the International Society on Toxinology |
| 2026-08-16 | PublicationLocal therapeutic strategies for neurocutaneous dysesthesia: from capsaicin to cannabinoids. | The Journal of dermatological treatment |
| 2026-08-16 | PublicationRecent Developments in the Drug Treatment of Parkinson's Disease. | Drugs |
| 2026-08-26 | Création de l’enregistrementNCT07780136 | Registre d’essai clinique |
| 2026-09-03 | Création de l’enregistrementNCT07286435 | Registre d’essai clinique |
| 2026-09-11 | Dernière mise à jour du registreNCT06047457 | Registre d’essai clinique |
| 2026-09-11 | Dernière mise à jour du registreNCT06047444 | Registre d’essai clinique |
| 2026-09-27 | Création de l’enregistrementNCT03521076 | Registre d’essai clinique |
| 2026-09-27 | Création de l’enregistrementNCT07837570 | Registre d’essai clinique |
| 2026-09-27 | Dernière mise à jour du registreNCT07780136 | Registre d’essai clinique |
| 2026-10-01 | Début de l’étudeNCT07837570 | Registre d’essai clinique |
| 2026-10-01 | Début de l’étudeNCT07780136 | Registre d’essai clinique |
| 2026-10-01 | Début de l’étudeNCT07691164 | Registre d’essai clinique |
| 2026-10-08 | Fin de l’étude prévue / enregistréeNCT07758322 | Registre d’essai clinique |
| 2026-10-11 | Début de l’étudeNCT07867379 | Registre d’essai clinique |
| 2026-10-11 | Création de l’enregistrementNCT07867379 | Registre d’essai clinique |
| 2026-10-18 | Création de l’enregistrementNCT07875868 | Registre d’essai clinique |
| 2026-10-25 | Création de l’enregistrementNCT07501429 | Registre d’essai clinique |
| 2026-11-02 | Dernière mise à jour des donnéesBotulinum toxin | Biomedical Watch |
| 2026-11-08 | Création de l’enregistrementNCT07303582 | Registre d’essai clinique |
| 2026-11-09 | Création de l’enregistrementNCT00909883 | Registre d’essai clinique |
| 2026-11-12 | Fin de l’étude prévue / enregistréeNCT06047444 | Registre d’essai clinique |
| 2026-11-16 | Fin de l’étude prévue / enregistréeNCT06047457 | Registre d’essai clinique |
| 2026-12-01 | Fin de l’étude prévue / enregistréeNCT07780136 | Registre d’essai clinique |
| 2026-12-01 | Fin de l’étude prévue / enregistréeNCT07535723 | Registre d’essai clinique |
| 2026-12-24 | Fin de l’étude prévue / enregistréeNCT07867379 | Registre d’essai clinique |
| 2027-01-01 | Fin de l’étude prévue / enregistréeNCT07571889 | Registre d’essai clinique |
| 2027-08-31 | Fin de l’étude prévue / enregistréeNCT05720065 | Registre d’essai clinique |
| 2027-10-30 | Fin de l’étude prévue / enregistréeNCT06920524 | Registre d’essai clinique |
| 2027-12-01 | Fin de l’étude prévue / enregistréeNCT07837570 | Registre d’essai clinique |
| 2027-12-01 | Fin de l’étude prévue / enregistréeNCT07286435 | Registre d’essai clinique |
| 2028-04-01 | Fin de l’étude prévue / enregistréeNCT07303582 | Registre d’essai clinique |
| 2028-12-01 | Fin de l’étude prévue / enregistréeNCT07501429 | Registre d’essai clinique |
| 2029-09-30 | Fin de l’étude prévue / enregistréeNCT07691164 | Registre d’essai clinique |
Début phase actuelle
Non disponible dans les sources synchronisées
Essais cliniques liés
25 essai(s)
Début phase actuelle
Non disponible dans les sources synchronisées
| NCT | Titre | Phase | Statut administratif | Pays | Sponsor |
|---|---|---|---|---|---|
| NCT00909883 | RBHP 2008 — Foot Dystonia Treatment by Botulinum Toxin Injections in Parkinson Disease : Efficiency of Injections Made in Extrinsic Muscle (Flexor Digitorum Longus Muscle) Compared to Intrinsic Muscle (Flexor Digitorum Brevis or Quadratus Plantae Muscles) | Phase 3 | COMPLETED | France | University Hospital, Clermont-Ferrand |
| NCT07303582 | ICE — Individualised Cryoneurolysis to Treat Pain in the Context of Spasticity in the Upper and Lower Extremities | Phase 4 | RECRUITING | United Kingdom | Oxford University Hospitals NHS Trust |
| NCT07501429 | Shockwave for Elbow and Wrist Spasticity in People With Spinal Cord Injury | Phase 1 | RECRUITING | United States | Kessler Foundation |
| NCT07875868 | Radial Extracorporeal Shock Wave Therapy as an Adjunct to Botulinum Toxin Type A for Post-Stroke Lower Limb Spasticity (SOLUTION) | Phase 1 | COMPLETED | Spain | Parc de Salut Mar |
| NCT07867379 | Botulinum Toxin Type A Versus Triamcinolone for Facial Myalgia | Phase 4 | NOT_YET_RECRUITING | Saudi Arabia | Riyadh Elm University |
| NCT03521076 | Randomized Controlled Trial of Virtual Reality | Non applicable | COMPLETED | United States | Gillette Children's Specialty Healthcare |
| NCT07837570 | Comparison of the Effectiveness of Greater Occipital Nerve and Supratrochlear Nerve Pulsed Radiofrequency Versus Botulinum Toxin Type A Injection in Chronic Migraine | Phase 4 | NOT_YET_RECRUITING | Non communiqué | Assiut University |
| NCT07286435 | The Effect of Whole-Body Vibration Therapy Following Botulinum Toxin A Injection on Spasticity and Balance in Stroke Patients | Non applicable | RECRUITING | Turkey (Türkiye) | Uludag University |
| NCT07780136 | Effectiveness of Greater Occipital Nerve and Supratrochlear Nerve Pulsed Radiofrequency Versus Botulinum Toxin Type A Injection in Chronic Migraine | Phase 4 | NOT_YET_RECRUITING | Non communiqué | Assiut University |
| NCT05720065 | Peripheral TMD Pain Mechanisms and the Effect by Botulinum Toxin A | Phase 2 | RECRUITING | Sweden | Karolinska Institutet |
| NCT06243874 | Comparison of Occipital Nerve and Sphenopalatine Ganglion Blockade | Non applicable | COMPLETED | Turkey (Türkiye) | Ankara University |
| NCT07571889 | Topical Intranasal Anesthetic Block for Reducing the Pain of Botulinum Toxin Injections for Chronic Migraine | Non applicable | RECRUITING | United States | Association of Migraine Disorders |
| NCT07758322 | Efficacy of Focused Shock Wave Therapy Before and After Botulinum Toxin Injection in Patients With Post-Stroke Spastic Equinus/Equinovarus Foot: A Randomized Clinical Trial | Non applicable | ACTIVE_NOT_RECRUITING | Spain | María Belén Martínez Luna |
| NCT00660192 | Investigation of Efficacy and Safety of Botulinum Toxin A (Botox-Allergan Inc) in Migraine Headaches | Phase 2 | COMPLETED | United States | Yale University |
| NCT07691164 | CEREB — Evolution of the Cognitive Profile and Quality of Life of Adult Patients Suffering From Severe Migraines Under Preventive Treatment | Non applicable | NOT_YET_RECRUITING | France | University Hospital, Strasbourg, France |
| NCT04069897 | MiBlock — Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Migraine | Phase 3 | COMPLETED | Norway | St. Olavs Hospital |
| NCT04544280 | Effect of Repeated Injections of Higher Doses of Botulinum Toxin on Lower Limb of Spastic Hemiplegic Patients on Gait. | NA | COMPLETED | Belgium | Cliniques universitaires Saint-Luc- Université Catholique de Louvain |
| NCT06920524 | Interest of a Musical Intervention on Stress Induced During Botulinum Toxin Injections in Spasticity (MUSIBOT) | NA | RECRUITING | France | University Hospital, Clermont-Ferrand |
| NCT07535723 | Botulinum Toxin and/or Greater Occipital Nerve Block for Patients With Chronic Migraine | Non applicable | NOT_YET_RECRUITING | Egypt | Beni-Suef University |
| NCT00258609 | Dysport® In Migraine Without Aura Prophylaxis : DIMWAP Study | Phase 3 | COMPLETED | Thailand | Department of Medical Services Ministry of Public Health of Thailand |
| NCT00301665 | Efficacy and Safety Study of Dysport® Used for Migraine Prophylaxis | Phase 2 | COMPLETED | Czechia, Poland, Slovakia | Ipsen |
| NCT06047457 | E-BEOND — A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Episodic Migraine in Adults | Phase 3 | ACTIVE_NOT_RECRUITING | United States, Canada, Czechia, France, Georgia, Germany, Poland, Spain | Ipsen |
| NCT06047444 | C-BEOND — A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Chronic Migraine in Adults | Phase 3 | ACTIVE_NOT_RECRUITING | United States, Canada, Czechia, Georgia, Germany, Italy, Poland, Spain, United Kingdom | Ipsen |
| NCT02293083 | Hyaluronidase for Trigger Point Injection in Myofascial Pain Syndrome | NA | COMPLETED | Non communiqué | Samsung Medical Center |
| NCT02280083 | A Study to Evaluate the Botulinum Toxin Type A for Injection(HengLi®) in Subjects With Post-stroke Upper Limb Spasticity | Phase 3 | COMPLETED | Non communiqué | Lanzhou Institute of Biological Products Co., Ltd |
Publications liées
47 publication(s)Publications liées
47 publication(s)| Titre | PMID | DOI | Journal | Date |
|---|---|---|---|---|
| Botulinum toxin effects on biochemical biomarkers related to inflammation-associated head and neck chronic conditions: a systematic review of clinical research. Voir source | 40035830 | 10.1007/s00702-024-02869-w | Journal of neural transmission (Vienna, Austria : 1996) | |
| Effect of Preoperative Botulinum Toxin on the Outcome of Large Midline Hernia Repair. Voir source | 42596800 | 10.1111/ans.70902 | ANZ journal of surgery | |
| A Systematic Review on Administration of Botulinum Toxin in the Management of Male Sexual Dysfunctions. Voir source | 41185533 | 10.1111/andr.70142 | Andrology | |
| Perceived comfort with migraine treatments and control of migraine symptoms: Results from the Headache Assessment via Digital Platform in United States study. Voir source | 42517716 | 10.1111/head.70165 | Headache | |
| Botulinum Toxin Type A in Spasticity and Cervical Dystonia: Practical Clinical Recommendations from a Mexican Multidisciplinary Panel of Specialist Injectors. Voir source | 42506707 | 10.3390/toxins18070287 | Toxins | |
| Migraine-advanced preventative treatments: the British Association for the Study of Headache Clinical Practice Recommendations and Consensus Guidance. Voir source | 42469019 | 10.1136/jnnp-2026-339062 | Journal of neurology, neurosurgery, and psychiatry | |
| Enhanced Efficacy of Post-Procedural Skin Care: A Double-Blind, Randomized, Vehicle-Controlled, Split-Face Clinical Study Assessing a Novel Neuropeptide Serum Following Botulinum Toxin Injection. Voir source | 42299447 | 10.2147/CCID.S581831 | Clinical, cosmetic and investigational dermatology | |
| The Botox Paradox: How Rising Drug Costs and Reimbursement Failures Threaten Access to Botulinum Toxin Therapy in Neurology. Voir source | 42500787 | 10.7759/cureus.111414 | Cureus | |
| A new treatment for focal dystonias: incobotulinumtoxinA (Xeomin®), a botulinum neurotoxin type A free from complexing proteins. Voir source | 22275842 | 10.2147/NDT.S16085 | Neuropsychiatric disease and treatment | |
| Chronic migraine prophylaxis: Comparative study between ultrasound-guided greater occipital nerve block and medical treatment. Voir source | 41875819 | 10.1016/j.clineuro.2026.109405 | Clinical neurology and neurosurgery | |
| Management of refractory chronic migraine using ultrasound-guided pulsed radiofrequency of greater occipital nerve: Two case reports. Voir source | 30407333 | 10.1097/MD.0000000000013127 | Medicine | |
| CACNA1C -Related Channelopathy Presenting With Adult-Onset Combined Dystonia-Parkinsonism: A Novel Neurological Presentation. Voir source | 41978253 | 10.1002/ajmg.a.70168 | American journal of medical genetics. Part A | |
| Efficacy and durability of therapies for neurogenic lower urinary tract dysfunction: A network meta-analysis of Botulinum Toxin a, instillations, and neuromodulation. Voir source | 42203154 | 10.1016/j.toxicon.2026.109165 | Toxicon : official journal of the International Society on Toxinology | |
| Comparative efficacy of intralesional therapies for keloid scars: a network meta-analysis. Voir source | 41860092 | 10.1080/07853890.2026.2619295 | Annals of medicine | |
| Catamenial loss of botulinum toxin efficacy successfully managed with tamoxifen: A case report. Voir source | 42571515 | 10.1016/j.jdcr.2026.06.048 | JAAD case reports | |
| Early local antitoxin intervention attenuates botulinum neurotoxin-induced neuromuscular dysfunction. Voir source | 42315011 | 10.1016/j.toxicon.2026.109198 | Toxicon : official journal of the International Society on Toxinology | |
| Local therapeutic strategies for neurocutaneous dysesthesia: from capsaicin to cannabinoids. Voir source | 41884965 | 10.1080/09546634.2026.2646556 | The Journal of dermatological treatment | |
| Recent Developments in the Drug Treatment of Parkinson's Disease. Voir source | 42162439 | 10.1007/s40265-026-02327-9 | Drugs | |
| Radial extracorporeal shock wave therapy improves upper limb function in chronic stroke patients: a randomized sham-controlled trial. Voir source | 42424664 | 10.1016/j.clinsp.2026.101034 | Clinics (Sao Paulo, Brazil) | |
| Central and Peripheral Sensitization in Temporomandibular Disorders: Proposed Mechanisms of Botulinum Toxin Therapy. Voir source | 41591174 | 10.3390/toxins18010028 | Toxins | |
| Safety and efficacy of recombinant botulinum toxin type A (Eveotox®) in patients with post-stroke upper limb spasticity: Results from a Phase Ib/II clinical trial. Voir source | 42492662 | 10.1016/j.toxicon.2026.109225 | Toxicon : official journal of the International Society on Toxinology | |
| Health-Related Quality of Life Following Botulinum Toxin for Retrograde Cricopharyngeus Dysfunction. Voir source | 42572920 | 10.1002/lary.70807 | The Laryngoscope | |
| EMG-guided Onabotulinum Toxin A for provoked vestibulodynia: addressing methodological concerns while confirming clinical benefit (Reply to Letter-to-the-Editor). Voir source | 42575277 | 10.1016/j.ajog.2026.08.005 | American journal of obstetrics and gynecology | |
| Short-term quantitative ultrasonographic assessment of masseter muscle changes following botulinum toxin injection in patients with bruxism: A prospective pilot study. Voir source | 42579291 | 10.1080/08869634.2026.2715421 | Cranio : the journal of craniomandibular practice | |
| The STIIM UP Protocol: Exploratory Evaluation of the Potential of Combined Calcium Hydroxyapatite, Hyaluronic Acid, and Botulinum Toxin A in Neck Rejuvenation. Voir source | 42590155 | 10.3390/jcm15156052 | Journal of clinical medicine | |
| Musical intervention to reduce stress during botulinum toxin injection for spasticity: Protocol for a randomized controlled trial (MUSIBOT). Voir source | 41289288 | 10.1371/journal.pone.0327259 | PloS one | |
| Three men in a boat: The comparison of the combination therapy of botulinum toxin and greater occipital nerve block with bupivacaine, with botulinum toxin monotherapy in the management of chronic migraine. Voir source | 36731164 | 10.1016/j.clineuro.2023.107609 | Clinical neurology and neurosurgery | |
| Corrugator Supercilii Muscle and Its Relationship with Neurovascular Structures of the Frontal Region: A Cadaveric Study. Voir source | 42192010 | 10.1007/s00266-026-05933-w | Aesthetic plastic surgery | |
| Comparison of the Effectiveness of Greater Occipital Nerve Block and Botulinum Toxin Type A in Chronic Migraine: An Exploratory Pilot Study From a Tertiary Care Centre in a Resource-Limited Setting. Voir source | 42005143 | 10.7759/cureus.105513 | Cureus | |
| Twelve-months prospective real-world assessment of effectiveness and safety of eptinezumab in migraine patients difficult-to-treat and naïve to CGRP monoclonal antibodies: results of the French FHU INOVPAIN registry. Voir source | 42533319 | 10.1186/s10194-026-02428-6 | The journal of headache and pain | |
| Botulinum toxin in peripheral facial paralysis: systematic review and rehabilitation perspectives. Voir source | 42517166 | 10.23736/S1973-9087.26.09406-2 | European journal of physical and rehabilitation medicine | |
| Repeated botulinum toxin injections for neurogenic thoracic outlet syndrome: A case report. Voir source | 42550976 | 10.5606/agri.2026.43 | Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology | |
| [Treatment persistence and adherence with botulinum toxin type A and anti-calcitonin gene-related peptide monoclonal antibodies in migraine. (A retrospective cohort study from a specialized headache center)]. Voir source | 42565401 | 10.17116/jnevro202612607169 | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | |
| Diagnostic value of shear wave elastography in assessing the effectiveness of preoperative botulinum toxin type A therapy in patients with postoperative ventral hernias W3. Voir source | 42566101 | 10.1007/s10029-026-03812-6 | Hernia : the journal of hernias and abdominal wall surgery | |
| Botulinum Neurotoxin for Postoperative Facial Nerve Paralysis: A Technical Note. Voir source | 42478402 | 10.4103/neurol-india.Neurol-India-D-26-00277 | Neurology India | |
| A retrospective study of intravesical botulin toxin type A in children with refractory detrusor overactivity. Voir source | 42481558 | 10.1038/s41598-026-61910-y | Scientific reports | |
| Botulinum Toxin Type A for the Treatment of Focal Spasticity in Children With Cerebral Palsy in Thailand: A Cost-Utility and Budget Impact Analysis. Voir source | 42461205 | 10.1016/j.vhri.2026.101673 | Value in health regional issues | |
| Comparing the real-world effectiveness of botulinum toxin type A injections across distinct poststroke muscle hyper-resistance patterns. Voir source | 42465548 | 10.3389/fneur.2026.1836266 | Frontiers in neurology | |
| Therapeutic progress in rosacea: targeting the neuro-vascular-immune triad. Voir source | 42440475 | 10.3389/fimmu.2026.1876564 | Frontiers in immunology | |
| Advanced on Minimally Invasive Techniques in Facial Rejuvenation: A Comprehensive Review. Voir source | 42441192 | 10.61882/wjps.15.1.3 | World journal of plastic surgery | |
| Analyzing the Effect of Extracorporeal Shockwave Therapy after Botulinum Toxin Injection on Calf Muscle Spasticity Improvement in Patients with Multiple Sclerosis - A Randomized Clinical Trial. Voir source | 42427431 | 10.4103/abr.abr_671_24 | Advanced biomedical research | |
| Cellular Remodeling of Skeletal Muscle Following Botulinum Toxin A Injection: A Single-Nucleus RNA Sequencing Study. Voir source | 42432377 | 10.1007/s00266-026-05996-9 | Aesthetic plastic surgery | |
| The Efficacy of Laser and Botox Therapies for Post-Thyroidectomy Scar Management: A Comprehensive Systematic Review and Meta-Analysis. Voir source | 42420659 | 10.1007/s00266-026-05981-2 | Aesthetic plastic surgery | |
| Association of AbobotulinumtoxinA and Skinbooster for Periorbital Wrinkles: A Randomized, Controlled, Double-Blind, Split-Face Study. Voir source | 42420660 | 10.1007/s00266-026-06059-9 | Aesthetic plastic surgery | |
| One-day rejuvenation: a preliminary case series of a multimodal protocol combining Q-switched 1064 nm laser, botulinum toxin, and laser-assisted delivery of PDRN and retinoids. Voir source | 42418230 | 10.1080/14764172.2026.2698113 | Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology | |
| Long-term neuromuscular alterations during botulinum toxin treatment for chronic migraine. Voir source | 42394961 | 10.1016/j.cnp.2026.06.010 | Clinical neurophysiology practice | |
| Geographic Variation in Botulinum Toxin Type A Longevity: A Pilot Comparative Study Between Saint Petersburg and Ashgabat. Voir source | 42403809 | 10.7759/cureus.110279 | Cureus |
Sources officielles
liens de rechercheDernière mise à jour des données : 2026-11-02
Ces sources sont proposées pour vérification. Les informations de la fiche doivent être confirmées dans les registres officiels ou les publications originales.