Fiche traitement
Adenosine
Prof Muzaffar Ali Zahidi • Maladie coronarienne
Suivi actif
Non applicable
Résumé
Adenosine est développé par Prof Muzaffar Ali Zahidi. Le traitement est actuellement en Non applicable. Il est associé à Maladie coronarienne. Son objectif thérapeutique principal est À vérifier. Le statut actuel est : suivi actif.
À vérifier
À vérifier
Non applicable
Prof Muzaffar Ali Zahidi
Pakistan
The REFLOW AMI Trial aims to determine whether prophylactic high-dose intracoronary adenosine reduces slow-flow or no-reflow (SNR) in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI).
Slow-flow or no-reflow occurs when blood flow to the heart muscle remains reduced despite treatment of the blocked coronary artery. This complication can lead to greater heart muscle damage and worse clinical outcomes.
The study will evaluate a protocol involving 200 micrograms of intracoronary adenosine administered before each balloon or stent inflation during PPCI. Researchers will compare outcomes with standard PPCI care without prophylactic adenosine.
The main questions the study aims to answer are:
* Does prophylactic intracoronary adenosine reduce the incidence of slow-flow or no-reflow after PPCI?
* Does the protocol improve post-PCI coronary blood flow, assessed by TIMI flow grade and myocardial blush grade?
* What are the rates of major adverse cardiovascular events (MACE) during hospitalization and at 30 days?
* Does the protocol affect left ventricular ejection fraction (LVEF) at discharge and at 30 days?
* Does the protocol improve functional capacity at 30 days, assessed by the six-minute walk test?
* Is the prophylactic adenosine protocol safe?
Participants will undergo PPCI according to their assigned study group and will be assessed for angiographic outcomes, safety events, and clinical outcomes during hospitalization and follow-up, including at 30 days.
2026-10-23
Début phase actuelle
Non disponible dans les sources synchronisées
Timeline clinique
Non applicable
Début phase actuelle
Non disponible dans les sources synchronisées
Préclinique
Phase 1
Phase 2
Phase 3
Approuvé
Objectif scientifique de l’étude
classification automatique vérifiable
À vérifier
Confiance automatique : 0%
Ce pourcentage n’est pas une probabilité de succès clinique.
Il mesure uniquement la force de la classification automatique de l’objectif scientifique. Le calcul part de 45 points, ajoute 7 points par unité de poids du mot-clé le plus fortement détecté, puis est plafonné à 95 %. Exemple : un score maximal de 2 donne 45 + (2 × 7) = 59 %.
Ce score est heuristique et doit être vérifié dans le protocole ou une publication.
Description affichée depuis l’essai compatible NCT07898696, afin d’éviter le mélange entre plusieurs indications d’une même molécule.
Contrôle de cohérence : 85/100
L’objectif est absent ou classé « Autre » et doit être recalculé à partir du protocole.
Transparence et qualité de la fiche
données vérifiablesClassificationÀ vérifier
Confiance de la fiche85 %
Source principaleSource officielle ou publication indexée
Dernière vérification2026-10-23
Anomalies détectées1
Validation humaineValidation humaine non effectuée
Donnée issue d’une source
Donnée normalisée automatiquement
Interprétation algorithmique
Classification scientifique multi-axes
ne pas confondre statut et résultatÉtat de l’étudeRecrutement en cours
Disponibilité des résultatsRésultats à vérifier
InterprétationImpossible à déterminer
Niveau de preuveNon évaluable
Un essai terminé n’est pas nécessairement positif. Un essai arrêté n’est classé comme échec scientifique que lorsqu’un résultat ou une raison explicite le confirme.
Indicateurs factuels
sans score subjectifPhase enregistréeNon applicable
Études associées1
Publications associées25
Statut consolidéSuivi actif
Aucune chance de succès, note d’innovation, potentiel thérapeutique ou probabilité de commercialisation n’est calculé tant qu’un modèle validé et des données suffisantes ne sont pas disponibles.
Historique factuel de la molécule
29 événement(s) daté(s)Cette liste reprend uniquement les dates trouvées dans les registres et publications liés. Elle ne constitue pas une prévision.
| Date | Événement | Source |
|---|---|---|
| 2026-07-10 | PublicationCannabinoid and adenosine A receptor crosstalk regulates postnatal and adult hippocampal neurogenesis. | British journal of pharmacology |
| 2026-07-10 | PublicationElectronic structure-activity relationships of adenine-based istradefylline derivatives investigated by DFT, topological analysis, and exploratory neuronal excitability modeling. | Scientific reports |
| 2026-07-12 | PublicationIdentification of FOXK1 and SEMA7A as key genes associated with mA-related programmed cell death in diabetic retinopathy. | Hereditas |
| 2026-07-12 | PublicationIntermittent olaparib with neoadjuvant platinum-based chemotherapy in BRCA-mutated un-resectable ovarian cancer: the NUVOLA trial. | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society |
| 2026-07-12 | PublicationEffects of Bifidobacterium animalis ssp. lactis IU100 and resistant starch type III on texture and flavor of fermented milk during storage. | Journal of dairy science |
| 2026-07-14 | PublicationAdenosine-A Regulator of Human Testicular Peritubular Cells. | Andrology |
| 2026-07-14 | Publication[Effect of eye acupuncture on mitophagy in neurons of ischemic cortical brain tissue in rats with cerebral ischemia reperfusion injury based on AMPK/ULK1/FUNDC1 signaling axis]. | Zhongguo zhen jiu = Chinese acupuncture & moxibustion |
| 2026-07-18 | Publication36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016. | Critical care (London, England) |
| 2026-07-22 | PublicationA varying presentation of refractory supra ventricular tachycardia in a newborn: A rare and unusual case report. | Journal of family medicine and primary care |
| 2026-08-08 | PublicationThe Anti-Parkinsonian A2A Receptor Antagonist Istradefylline (KW-6002) Attenuates Behavioral Abnormalities, Neuroinflammation, and Neurodegeneration in Cerebral Ischemia: An Adenosinergic Signaling Link Between Stroke and Parkinson's Disease. | International journal of molecular sciences |
| 2026-08-08 | PublicationAdenosine A Receptors Control the Mis-Localization of Aquaporin-4 in Rats Subject to Repeated Restraint Stress. | Journal of neurochemistry |
| 2026-08-08 | PublicationVitamin B deficiency and sarcopenia: an integrated narrative review of metabolic, inflammatory, endoplasmic reticulum stress, and myokine signaling pathways. | Journal of Yeungnam medical science |
| 2026-08-13 | PublicationTargeting PRMT5 inhibitor-induced adaptation in pancreatic cancer with the RBM39 degrader indisulam. | Cancer research communications |
| 2026-08-13 | PublicationThe discovery of potent and selective N-modified adenosine derivatives as effective chemotherapeutic agents to overcome p53-dependent drug resistance in cancer and HPIV-3/AdV5 respiratory tract infections. | Bioorganic chemistry |
| 2026-08-14 | Début de l’étudeNCT07898696 | Registre d’essai clinique |
| 2026-08-16 | PublicationDesign and rationale of TROCADERO: A TRial Of Caffeine to Alleviate DyspnEa Related to ticagrelOr. | American heart journal |
| 2026-08-16 | PublicationDe novo nitric oxide synthesis drives tactile hypersensitivity induced by ATP-sensitive potassium channel opening in mice: relevance to migraine and other headache disorders. | Pain |
| 2026-08-16 | PublicationA Passiflora incarnata extract exerts multi-target effects on selected sleep-related receptors. | Journal of ethnopharmacology |
| 2026-08-16 | PublicationN6-methyladenosine modification of mRNAs in retinal ischemia-reperfusion in mice. | Epigenetics |
| 2026-08-16 | PublicationStatement of Retraction: Ibuprofen promotes p75 neurotrophin receptor expression through modifying promoter methylation and N6-methyladenosine-RNA-methylation in human gastric cancer cells. | Bioengineered |
| 2026-08-16 | PublicationEvaluation of safety and effectiveness of NAD in different clinical conditions: a systematic review. | American journal of physiology. Endocrinology and metabolism |
| 2026-08-16 | PublicationStudy of istradefylline in patients with Parkinson's disease on levodopa with motor fluctuations. | Movement disorders : official journal of the Movement Disorder Society |
| 2026-08-16 | PublicationGlycohypoxia: a hypothesis linking chronic hyperglycemia to functional hypoxia and diabetic complications in type 2 diabetes. | Medical gas research |
| 2026-08-16 | PublicationAdenosine A receptor activation in the nucleus accumbens decreases motivation for wheel running in male mice. | Psychopharmacology |
| 2026-08-16 | PublicationCNM-Au8 in Amyotrophic Lateral Sclerosis: The HEALEY ALS Platform Trial. | JAMA |
| 2026-10-23 | Dernière mise à jour des donnéesAdenosine | Biomedical Watch |
| 2026-10-25 | PublicationContractile and relaxant responses of the canine isolated spinal artery to vasoactive substances. | British journal of pharmacology |
| 2026-11-01 | Création de l’enregistrementNCT07898696 | Registre d’essai clinique |
| 2027-08-14 | Fin de l’étude prévue / enregistréeNCT07898696 | Registre d’essai clinique |
Début phase actuelle
Non disponible dans les sources synchronisées
Essais cliniques liés
1 essai(s)
Début phase actuelle
Non disponible dans les sources synchronisées
| NCT | Titre | Phase | Statut administratif | Pays | Sponsor |
|---|---|---|---|---|---|
| NCT07898696 | Reducing Slow/No-Reflow With Prophylactic High-Dose Intracoronary Adenosine Protocol in ST-Elevation Myocardial Infarction The REFLOW AMI Trial | Non applicable | RECRUITING | Pakistan | Prof Muzaffar Ali Zahidi |
Publications liées
25 publication(s)Publications liées
25 publication(s)| Titre | PMID | DOI | Journal | Date |
|---|---|---|---|---|
| Contractile and relaxant responses of the canine isolated spinal artery to vasoactive substances. Voir source | 1980836 | 10.1111/j.1476-5381.1990.tb12113.x | British journal of pharmacology | |
| Design and rationale of TROCADERO: A TRial Of Caffeine to Alleviate DyspnEa Related to ticagrelOr. Voir source | 26385029 | 10.1016/j.ahj.2015.06.014 | American heart journal | |
| De novo nitric oxide synthesis drives tactile hypersensitivity induced by ATP-sensitive potassium channel opening in mice: relevance to migraine and other headache disorders. Voir source | 42048631 | 10.1097/j.pain.0000000000003955 | Pain | |
| A Passiflora incarnata extract exerts multi-target effects on selected sleep-related receptors. Voir source | 42462921 | 10.1016/j.jep.2026.122198 | Journal of ethnopharmacology | |
| N6-methyladenosine modification of mRNAs in retinal ischemia-reperfusion in mice. Voir source | 42437753 | 10.1080/15592294.2026.2700836 | Epigenetics | |
| Statement of Retraction: Ibuprofen promotes p75 neurotrophin receptor expression through modifying promoter methylation and N6-methyladenosine-RNA-methylation in human gastric cancer cells. Voir source | 42165207 | 10.1080/21655979.2026.2667578 | Bioengineered | |
| Evaluation of safety and effectiveness of NAD in different clinical conditions: a systematic review. Voir source | 37971292 | 10.1152/ajpendo.00242.2023 | American journal of physiology. Endocrinology and metabolism | |
| Study of istradefylline in patients with Parkinson's disease on levodopa with motor fluctuations. Voir source | 18831530 | 10.1002/mds.22095 | Movement disorders : official journal of the Movement Disorder Society | |
| Glycohypoxia: a hypothesis linking chronic hyperglycemia to functional hypoxia and diabetic complications in type 2 diabetes. Voir source | 41830794 | 10.4103/mgr.MEDGASRES-D-25-00137 | Medical gas research | |
| Adenosine A receptor activation in the nucleus accumbens decreases motivation for wheel running in male mice. Voir source | 41085662 | 10.1007/s00213-025-06919-3 | Psychopharmacology | |
| CNM-Au8 in Amyotrophic Lateral Sclerosis: The HEALEY ALS Platform Trial. Voir source | 40067821 | 10.1001/jama.2024.27643 | JAMA | |
| Targeting PRMT5 inhibitor-induced adaptation in pancreatic cancer with the RBM39 degrader indisulam. Voir source | 42585676 | 10.1158/2767-9764.CRC-25-0670 | Cancer research communications | |
| The discovery of potent and selective N-modified adenosine derivatives as effective chemotherapeutic agents to overcome p53-dependent drug resistance in cancer and HPIV-3/AdV5 respiratory tract infections. Voir source | 42570380 | 10.1016/j.bioorg.2026.110335 | Bioorganic chemistry | |
| The Anti-Parkinsonian A2A Receptor Antagonist Istradefylline (KW-6002) Attenuates Behavioral Abnormalities, Neuroinflammation, and Neurodegeneration in Cerebral Ischemia: An Adenosinergic Signaling Link Between Stroke and Parkinson's Disease. Voir source | 40565142 | 10.3390/ijms26125680 | International journal of molecular sciences | |
| Adenosine A Receptors Control the Mis-Localization of Aquaporin-4 in Rats Subject to Repeated Restraint Stress. Voir source | 42043306 | 10.1111/jnc.70450 | Journal of neurochemistry | |
| Vitamin B deficiency and sarcopenia: an integrated narrative review of metabolic, inflammatory, endoplasmic reticulum stress, and myokine signaling pathways. Voir source | 42544408 | 10.12701/jyms.2026.43.51 | Journal of Yeungnam medical science | |
| A varying presentation of refractory supra ventricular tachycardia in a newborn: A rare and unusual case report. Voir source | 42483369 | 10.4103/jfmpc.jfmpc_948_23 | Journal of family medicine and primary care | |
| 36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016. Voir source | 27885969 | 10.1186/s13054-016-1208-6 | Critical care (London, England) | |
| Adenosine-A Regulator of Human Testicular Peritubular Cells. Voir source | 42444403 | 10.1111/andr.70304 | Andrology | |
| [Effect of eye acupuncture on mitophagy in neurons of ischemic cortical brain tissue in rats with cerebral ischemia reperfusion injury based on AMPK/ULK1/FUNDC1 signaling axis]. Voir source | 42443081 | 10.13703/j.0255-2930.20250322-k0002 | Zhongguo zhen jiu = Chinese acupuncture & moxibustion | |
| Identification of FOXK1 and SEMA7A as key genes associated with mA-related programmed cell death in diabetic retinopathy. Voir source | 42432759 | 10.1186/s41065-026-00710-w | Hereditas | |
| Intermittent olaparib with neoadjuvant platinum-based chemotherapy in BRCA-mutated un-resectable ovarian cancer: the NUVOLA trial. Voir source | 42435644 | 10.1016/j.ijgc.2026.104816 | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society | |
| Effects of Bifidobacterium animalis ssp. lactis IU100 and resistant starch type III on texture and flavor of fermented milk during storage. Voir source | 42379360 | 10.3168/jds.2026-28437 | Journal of dairy science | |
| Cannabinoid and adenosine A receptor crosstalk regulates postnatal and adult hippocampal neurogenesis. Voir source | 42324982 | 10.1111/bph.70466 | British journal of pharmacology | |
| Electronic structure-activity relationships of adenine-based istradefylline derivatives investigated by DFT, topological analysis, and exploratory neuronal excitability modeling. Voir source | 42350597 | 10.1038/s41598-026-60070-3 | Scientific reports |
Sources officielles
liens de rechercheDernière mise à jour des données : 2026-10-23
Ces sources sont proposées pour vérification. Les informations de la fiche doivent être confirmées dans les registres officiels ou les publications originales.