Fiche traitement
Epinephrine
China National Center for Cardiovascular Diseases • Insuffisance cardiaque, Maladie coronarienne
Suivi actif
Non applicable
Résumé
Epinephrine est développé par China National Center for Cardiovascular Diseases. Le traitement est actuellement en Non applicable. Il est associé à Insuffisance cardiaque, Maladie coronarienne. Son objectif thérapeutique principal est À vérifier. Le statut actuel est : suivi actif.
À vérifier
À vérifier
Non applicable
China National Center for Cardiovascular Diseases
China
The observational study titled "Observational Assessment of Support with Impella Best Practices in Acute Myocardial Infarction Complicated by Cardiogenic Shock (OASIS-AMICS)" aims to evaluate the safety outcomes of patients with acute myocardial infarction complicated by cardiogenic shock (AMICS) who receive Impella CP during percutaneous coronary intervention (PCI) and who are managed with Impella best practices while receiving guideline-directed standard of care. This prospective, multicenter study will enroll up to 350 hemodynamically unstable patients with cardiogenic shock of less than 12 hours duration and acute myocardial infarction (AMI) of less than 24 hours duration. Cardiogenic shock will be confirmed by tissue hypoperfusion (lactate ≥ 2.5mmol/L and/or SvO2 \<55% with a normal PaO2) and systolic blood pressure \<100 mmHg and/or need for vasopressor therapy (dopamine/norepinepherine or epinephrine). Patients will be assessed for various safety endpoints, including a composite safety endpoint involving major bleeding, acute limb ischemia, and acute kidney injury. Secondary endpoints will evaluate all-cause mortality, major adverse cardiovascular and cerebrovascular events (MACCE), and hospitalizations through 1-year post-Impella implant. All patients presenting with AMICS at study sites will be screened for inclusion in the study after hospital discharge (or after death, if prior to hospital discharge). IRB approved consent waiver will be used to collect data from electronic health records from; Impella placement to discharge and post-discharge at 30 days post-Impella implant, 6 months post-Impella implant, and 1 year post-Impella implant.
2026-10-28
Début phase actuelle
Non disponible dans les sources synchronisées
Timeline clinique
Non applicable
Début phase actuelle
Non disponible dans les sources synchronisées
Préclinique
Phase 1
Phase 2
Phase 3
Approuvé
Objectif scientifique de l’étude
classification automatique vérifiable
À vérifier
Confiance automatique : 0%
Ce pourcentage n’est pas une probabilité de succès clinique.
Il mesure uniquement la force de la classification automatique de l’objectif scientifique. Le calcul part de 45 points, ajoute 7 points par unité de poids du mot-clé le plus fortement détecté, puis est plafonné à 95 %. Exemple : un score maximal de 2 donne 45 + (2 × 7) = 59 %.
Ce score est heuristique et doit être vérifié dans le protocole ou une publication.
Description affichée depuis l’essai compatible NCT06964685, afin d’éviter le mélange entre plusieurs indications d’une même molécule.
Contrôle de cohérence : 85/100
L’objectif est absent ou classé « Autre » et doit être recalculé à partir du protocole.
Transparence et qualité de la fiche
données vérifiablesClassificationÀ vérifier
Confiance de la fiche85 %
Source principaleSource officielle ou publication indexée
Dernière vérification2026-10-28
Anomalies détectées1
Validation humaineValidation humaine non effectuée
Donnée issue d’une source
Donnée normalisée automatiquement
Interprétation algorithmique
Classification scientifique multi-axes
ne pas confondre statut et résultatÉtat de l’étudeRecrutement en cours
Disponibilité des résultatsRésultats à vérifier
InterprétationImpossible à déterminer
Niveau de preuveNon évaluable
Un essai terminé n’est pas nécessairement positif. Un essai arrêté n’est classé comme échec scientifique que lorsqu’un résultat ou une raison explicite le confirme.
Indicateurs factuels
sans score subjectifPhase enregistréeNon applicable
Études associées4
Publications associées30
Statut consolidéSuivi actif
Aucune chance de succès, note d’innovation, potentiel thérapeutique ou probabilité de commercialisation n’est calculé tant qu’un modèle validé et des données suffisantes ne sont pas disponibles.
Historique factuel de la molécule
43 événement(s) daté(s)Cette liste reprend uniquement les dates trouvées dans les registres et publications liés. Elle ne constitue pas une prévision.
| Date | Événement | Source |
|---|---|---|
| 2020-03-12 | Début de l’étudeNCT04144257 | Registre d’essai clinique |
| 2021-04-13 | Fin de l’étude prévue / enregistréeNCT04144257 | Registre d’essai clinique |
| 2025-07-10 | Début de l’étudeNCT06964685 | Registre d’essai clinique |
| 2026-06-16 | Début de l’étudeNCT07562932 | Registre d’essai clinique |
| 2026-07-08 | Publicationα-Adrenergic receptor modulates 5-HT-mediated behavioral effects of MDMA and psilocybin in mice. | Molecular psychiatry |
| 2026-07-08 | PublicationEvaluation of [18F]MFPBG: a novel automatically radiolabeled probe for NET PET imaging. | EJNMMI research |
| 2026-07-18 | PublicationTwo Cases of Malaria-Associated Acute Respiratory Distress Syndrome and Severe Pulmonary Complications From Plasmodium falciparum in Tanzania. | The American journal of case reports |
| 2026-07-18 | Publication36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016. | Critical care (London, England) |
| 2026-08-08 | PublicationA Vagal-Renal-Splenic Reflex Suppresses Renal Sympathetic Nerve Activity and Preserves Kidney Function After Ischemic Injury. | Journal of the American Society of Nephrology : JASN |
| 2026-08-08 | PublicationNovel neonatal hypoxic-ischemic model demonstrates glial activation and memory deficits without neuronal loss. | Pediatric research |
| 2026-08-08 | PublicationEffects of antidepressant administration on physical performance and perceived exertion in athletes: systematic review and meta-analysis. | International journal of clinical pharmacy |
| 2026-08-13 | PublicationThe effect of tranexamic acid and epinephrine on visual clarity during arthroscopic shoulder surgery: A meta-analysis of RCTs. | Orthopaedics & traumatology, surgery & research : OTSR |
| 2026-08-13 | PublicationA pharmacometric framework for norepinephrine transporter occupancy and dose equivalence across psychotropic medications. | Journal of psychopharmacology (Oxford, England) |
| 2026-08-13 | PublicationLocked in Lucid Rhythms: A Case of Rhythmic Movement Disorder in Rapid Eye Movement (REM) Sleep. | Cureus |
| 2026-08-13 | PublicationAntidepressant medications have differential effects on REM sleep without atonia quantified by chin and upper extremity EMG. | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine |
| 2026-08-13 | PublicationAudiovisual Distraction During Mitral Transcatheter Edge-to-Edge Repair: A Sedation-Sparing Randomized Trial. | JACC. Advances |
| 2026-08-13 | PublicationComparing Electrical and Ultrasound Transcutaneous Auricular Vagus Nerve Stimulation on Associative Memory. | Neuromodulation : journal of the International Neuromodulation Society |
| 2026-08-13 | PublicationA Case Report of Venezuelan Suntiger Tarantula (Psalmopoeus Irminia) Envenomation and Review of Tarantula Exposures. | The Journal of emergency medicine |
| 2026-08-13 | Publication[Treatment of mast cell-mediated angioedema]. | Dermatologie (Heidelberg, Germany) |
| 2026-08-16 | PublicationQuadratus Lumborum Block During Minimally Invasive Colorectal Surgery: A Tool for Enhanced Recovery. | Diseases of the colon and rectum |
| 2026-08-16 | PublicationNeuroimmune circuits in respiratory pathophysiology: decoding molecular crosstalk for precision therapeutic targeting. | Annals of medicine |
| 2026-08-16 | PublicationA Passiflora incarnata extract exerts multi-target effects on selected sleep-related receptors. | Journal of ethnopharmacology |
| 2026-08-16 | PublicationSustained Clinical Improvement in Birch Pollen Allergy After Two Pre-Seasonal Short Courses of Allergen-Specific Immunotherapy: A Long-Term Open-Label Extension Study. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology |
| 2026-08-16 | PublicationIntervals for Oscillometric Arterial Pressure Monitoring during Noncardiac Surgery: The "2.5-Minute versus 5-Minute" Randomized Clinical Trial. | Anesthesiology |
| 2026-08-16 | PublicationThe onset of hypertension in metabolic syndrome is independent of renal sympathetic innervation. | Life science alliance |
| 2026-08-16 | PublicationRisk Factors for Adverse Drug Reactions of Augmented Mean Arterial Pressure Management After Spinal Cord Injury. | The Journal of surgical research |
| 2026-08-16 | PublicationEfficacy and safety of adjunctive orexin receptor antagonist therapy in major depressive disorder: A systematic review and meta-analysis of randomized controlled trials. | Journal of affective disorders |
| 2026-08-19 | Début de l’étudeNCT07667829 | Registre d’essai clinique |
| 2026-09-11 | PublicationAdjunct Medications for Single-Injection Pediatric Regional Blocks: Implications for Peripheral Nerve Blocks. | Current pain and headache reports |
| 2026-09-14 | PublicationNew pharmacologic agents for insomnia and hypersomnia. | Current opinion in pulmonary medicine |
| 2026-09-20 | PublicationThe role of the LC-NE system in attention: From cells, to systems, to sensory-motor control. | Neuroscience and biobehavioral reviews |
| 2026-09-20 | PublicationPharmacological treatment of cardiogenic shock. | Current opinion in critical care |
| 2026-10-18 | Création de l’enregistrementNCT07562932 | Registre d’essai clinique |
| 2026-10-18 | Création de l’enregistrementNCT04144257 | Registre d’essai clinique |
| 2026-10-18 | PublicationAmeliorative effects of half-dose saffron and chamomile combination on Psycho-endocrinological changes in a diabetic murine model. | PloS one |
| 2026-10-25 | PublicationInfluence of perivascular adipose tissue on rat aortic smooth muscle responsiveness. | Clinical and experimental hypertension. Part A, Theory and practice |
| 2026-10-28 | Dernière mise à jour des donnéesEpinephrine | Biomedical Watch |
| 2026-11-01 | Création de l’enregistrementNCT06964685 | Registre d’essai clinique |
| 2026-11-01 | Création de l’enregistrementNCT07667829 | Registre d’essai clinique |
| 2026-11-01 | PublicationA Survey Comparing Cardiac Operating Room Setup and Anesthetic Management Among Academic US Adult Cardiothoracic Anesthesiology Programs. | Journal of cardiothoracic and vascular anesthesia |
| 2028-10-30 | Fin de l’étude prévue / enregistréeNCT06964685 | Registre d’essai clinique |
| 2029-01-31 | Fin de l’étude prévue / enregistréeNCT07667829 | Registre d’essai clinique |
| 2032-05-31 | Fin de l’étude prévue / enregistréeNCT07562932 | Registre d’essai clinique |
Début phase actuelle
Non disponible dans les sources synchronisées
Essais cliniques liés
4 essai(s)
Début phase actuelle
Non disponible dans les sources synchronisées
| NCT | Titre | Phase | Statut administratif | Pays | Sponsor |
|---|---|---|---|---|---|
| NCT06964685 | OASIS-AMICS — Assessment of Support With Impella® Best Practices in Acute Myocardial Infarction Complicated by Cardiogenic Shock | À vérifier | RECRUITING | United States | Abiomed Inc. |
| NCT07667829 | Vasopressor Agents in Pulmonary Hypertension Crisis | Non applicable | RECRUITING | China | China National Center for Cardiovascular Diseases |
| NCT07562932 | ACTION-CS — Assessing Catecholamine Treatment Initiation Options: Norepinephrine vs Dopamine for Cardiogenic Shock | Non applicable | RECRUITING | South Korea | Chonnam National University Hospital |
| NCT04144257 | Role of Microglial Activation and Norepinephrine Transporter Abnormalities in Pathogenesis of MS-related Fatigue | Phase 1/2 | COMPLETED | United States | Brigham and Women's Hospital |
Publications liées
30 publication(s)Publications liées
30 publication(s)| Titre | PMID | DOI | Journal | Date |
|---|---|---|---|---|
| A Survey Comparing Cardiac Operating Room Setup and Anesthetic Management Among Academic US Adult Cardiothoracic Anesthesiology Programs. Voir source | 42562730 | 10.1053/j.jvca.2026.07.012 | Journal of cardiothoracic and vascular anesthesia | |
| Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness. Voir source | 2065467 | 10.3109/10641969109042063 | Clinical and experimental hypertension. Part A, Theory and practice | |
| Ameliorative effects of half-dose saffron and chamomile combination on Psycho-endocrinological changes in a diabetic murine model. Voir source | 36302045 | 10.1371/journal.pone.0276236 | PloS one | |
| The role of the LC-NE system in attention: From cells, to systems, to sensory-motor control. Voir source | 40412462 | 10.1016/j.neubiorev.2025.106233 | Neuroscience and biobehavioral reviews | |
| Pharmacological treatment of cardiogenic shock. Voir source | 42273963 | 10.1097/MCC.0000000000001393 | Current opinion in critical care | |
| New pharmacologic agents for insomnia and hypersomnia. Voir source | 32890017 | 10.1097/MCP.0000000000000722 | Current opinion in pulmonary medicine | |
| Adjunct Medications for Single-Injection Pediatric Regional Blocks: Implications for Peripheral Nerve Blocks. Voir source | 42667510 | 10.1007/s11916-026-01528-x | Current pain and headache reports | |
| Quadratus Lumborum Block During Minimally Invasive Colorectal Surgery: A Tool for Enhanced Recovery. Voir source | 42228437 | 10.1097/DCR.0000000000004308 | Diseases of the colon and rectum | |
| Neuroimmune circuits in respiratory pathophysiology: decoding molecular crosstalk for precision therapeutic targeting. Voir source | 41601146 | 10.1080/07853890.2026.2620337 | Annals of medicine | |
| A Passiflora incarnata extract exerts multi-target effects on selected sleep-related receptors. Voir source | 42462921 | 10.1016/j.jep.2026.122198 | Journal of ethnopharmacology | |
| Sustained Clinical Improvement in Birch Pollen Allergy After Two Pre-Seasonal Short Courses of Allergen-Specific Immunotherapy: A Long-Term Open-Label Extension Study. Voir source | 42057631 | 10.1111/cea.70323 | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology | |
| Intervals for Oscillometric Arterial Pressure Monitoring during Noncardiac Surgery: The "2.5-Minute versus 5-Minute" Randomized Clinical Trial. Voir source | 42102346 | 10.1097/ALN.0000000000006140 | Anesthesiology | |
| The onset of hypertension in metabolic syndrome is independent of renal sympathetic innervation. Voir source | 42448569 | 10.26508/lsa.202503568 | Life science alliance | |
| Risk Factors for Adverse Drug Reactions of Augmented Mean Arterial Pressure Management After Spinal Cord Injury. Voir source | 42341613 | 10.1016/j.jss.2026.05.045 | The Journal of surgical research | |
| Efficacy and safety of adjunctive orexin receptor antagonist therapy in major depressive disorder: A systematic review and meta-analysis of randomized controlled trials. Voir source | 42309189 | 10.1016/j.jad.2026.122139 | Journal of affective disorders | |
| The effect of tranexamic acid and epinephrine on visual clarity during arthroscopic shoulder surgery: A meta-analysis of RCTs. Voir source | 38395349 | 10.1016/j.otsr.2024.103844 | Orthopaedics & traumatology, surgery & research : OTSR | |
| A pharmacometric framework for norepinephrine transporter occupancy and dose equivalence across psychotropic medications. Voir source | 42549822 | 10.1177/02698811261470450 | Journal of psychopharmacology (Oxford, England) | |
| Locked in Lucid Rhythms: A Case of Rhythmic Movement Disorder in Rapid Eye Movement (REM) Sleep. Voir source | 42416935 | 10.7759/cureus.110405 | Cureus | |
| Antidepressant medications have differential effects on REM sleep without atonia quantified by chin and upper extremity EMG. Voir source | 42426312 | 10.1007/s44470-026-00127-2 | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine | |
| Audiovisual Distraction During Mitral Transcatheter Edge-to-Edge Repair: A Sedation-Sparing Randomized Trial. Voir source | 42167101 | 10.1016/j.jacadv.2026.102835 | JACC. Advances | |
| Comparing Electrical and Ultrasound Transcutaneous Auricular Vagus Nerve Stimulation on Associative Memory. Voir source | 42565762 | 10.1016/j.neurom.2026.07.001 | Neuromodulation : journal of the International Neuromodulation Society | |
| A Case Report of Venezuelan Suntiger Tarantula (Psalmopoeus Irminia) Envenomation and Review of Tarantula Exposures. Voir source | 37635034 | 10.1016/j.jemermed.2023.05.022 | The Journal of emergency medicine | |
| [Treatment of mast cell-mediated angioedema]. Voir source | 42489912 | 10.1007/s00105-026-05753-8 | Dermatologie (Heidelberg, Germany) | |
| A Vagal-Renal-Splenic Reflex Suppresses Renal Sympathetic Nerve Activity and Preserves Kidney Function After Ischemic Injury. Voir source | 42555213 | 10.1681/ASN.0000001196 | Journal of the American Society of Nephrology : JASN | |
| Novel neonatal hypoxic-ischemic model demonstrates glial activation and memory deficits without neuronal loss. Voir source | 42547840 | 10.1038/s41390-026-05281-0 | Pediatric research | |
| Effects of antidepressant administration on physical performance and perceived exertion in athletes: systematic review and meta-analysis. Voir source | 42560424 | 10.1007/s11096-026-02206-z | International journal of clinical pharmacy | |
| Two Cases of Malaria-Associated Acute Respiratory Distress Syndrome and Severe Pulmonary Complications From Plasmodium falciparum in Tanzania. Voir source | 42464474 | 10.12659/AJCR.951737 | The American journal of case reports | |
| 36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016. Voir source | 27885969 | 10.1186/s13054-016-1208-6 | Critical care (London, England) | |
| α-Adrenergic receptor modulates 5-HT-mediated behavioral effects of MDMA and psilocybin in mice. Voir source | 42414551 | 10.1038/s41380-026-03713-1 | Molecular psychiatry | |
| Evaluation of [18F]MFPBG: a novel automatically radiolabeled probe for NET PET imaging. Voir source | 42414788 | 10.1186/s13550-026-01482-0 | EJNMMI research |
Sources officielles
liens de rechercheDernière mise à jour des données : 2026-10-28
Ces sources sont proposées pour vérification. Les informations de la fiche doivent être confirmées dans les registres officiels ou les publications originales.