Fiche traitement
Norepinephrine
Yale University • Accident vasculaire cérébral, Maladie coronarienne
Suivi actif
Phase 1
Résumé
Norepinephrine est développé par Yale University. Le traitement est actuellement en Phase 1. Il est associé à Accident vasculaire cérébral, Maladie coronarienne. Son objectif thérapeutique principal est Ralentissement de la progression. Le statut actuel est : suivi actif.
À vérifier
Ralentissement de la progression
Phase 1
Yale University
United States
The goal of this multicenter, open-label, randomized clinical trial is to learn whether norepinephrine or dopamine is more effective and safer as the first-line vasoactive drug for treating cardiogenic shock in adults. Cardiogenic shock is a life-threatening condition in which the heart cannot pump enough blood to supply the body. The main questions this study aims to answer are:
Does norepinephrine reduce the risk of death or worsening cardiogenic shock compared with dopamine?
Does norepinephrine lead to fewer complications such as arrhythmias, the need for mechanical circulatory support, or cardiac arrest?
Researchers will compare norepinephrine and dopamine to see which drug better stabilizes blood pressure, improves tissue perfusion, and prevents progression of shock during the early phase of treatment.
Participants will:
Be randomly assigned to receive either norepinephrine or dopamine as the first vasoactive drug
Receive treatment and monitoring based on current clinical guidelines for cardiogenic shock
Undergo regular assessments of blood pressure, laboratory values, heart rhythm, and organ function during hospitalization
Be followed for outcomes at 1 month, 6 months, and 1 year after enrollment
This study aims to provide evidence that will help determine which initial vasoactive drug offers better outcomes for patients with cardiogenic shock and guide future treatment recommendations.
2026-10-09
Début phase actuelle
Non disponible dans les sources synchronisées
Timeline clinique
Phase 1
Début phase actuelle
Non disponible dans les sources synchronisées
Préclinique
Phase 1
Phase 2
Phase 3
Approuvé
Objectif scientifique de l’étude
classification automatique vérifiable
Ralentissement de la progression
Confiance automatique : 66%
Ce pourcentage n’est pas une probabilité de succès clinique.
Il mesure uniquement la force de la classification automatique de l’objectif scientifique. Le calcul part de 45 points, ajoute 7 points par unité de poids du mot-clé le plus fortement détecté, puis est plafonné à 95 %. Exemple : un score maximal de 2 donne 45 + (2 × 7) = 59 %.
Indices détectés : progression → Ralentissement de la progression
Ce score est heuristique et doit être vérifié dans le protocole ou une publication.
Description affichée depuis l’essai compatible NCT07562932, afin d’éviter le mélange entre plusieurs indications d’une même molécule.
Aucune incohérence majeure détectée entre la maladie, l’objectif et la description.
Transparence et qualité de la fiche
données vérifiablesClassificationCohérente automatiquement
Confiance de la fiche100 %
Source principaleSource officielle ou publication indexée
Dernière vérification2026-10-09
Anomalies détectées0
Validation humaineValidation humaine non effectuée
Donnée issue d’une source
Donnée normalisée automatiquement
Interprétation algorithmique
Classification scientifique multi-axes
ne pas confondre statut et résultatÉtat de l’étudeRecrutement en cours
Disponibilité des résultatsRésultats à vérifier
InterprétationImpossible à déterminer
Niveau de preuveNon évaluable
Un essai terminé n’est pas nécessairement positif. Un essai arrêté n’est classé comme échec scientifique que lorsqu’un résultat ou une raison explicite le confirme.
Indicateurs factuels
sans score subjectifPhase enregistréePhase 1
Études associées1
Publications associées21
Statut consolidéSuivi actif
Aucune chance de succès, note d’innovation, potentiel thérapeutique ou probabilité de commercialisation n’est calculé tant qu’un modèle validé et des données suffisantes ne sont pas disponibles.
Historique factuel de la molécule
25 événement(s) daté(s)Cette liste reprend uniquement les dates trouvées dans les registres et publications liés. Elle ne constitue pas une prévision.
| Date | Événement | Source |
|---|---|---|
| 2026-06-16 | Début de l’étudeNCT07562932 | Registre d’essai clinique |
| 2026-07-08 | Publicationα-Adrenergic receptor modulates 5-HT-mediated behavioral effects of MDMA and psilocybin in mice. | Molecular psychiatry |
| 2026-07-08 | PublicationEvaluation of [18F]MFPBG: a novel automatically radiolabeled probe for NET PET imaging. | EJNMMI research |
| 2026-07-18 | PublicationTwo Cases of Malaria-Associated Acute Respiratory Distress Syndrome and Severe Pulmonary Complications From Plasmodium falciparum in Tanzania. | The American journal of case reports |
| 2026-07-18 | Publication36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016. | Critical care (London, England) |
| 2026-08-08 | PublicationA Vagal-Renal-Splenic Reflex Suppresses Renal Sympathetic Nerve Activity and Preserves Kidney Function After Ischemic Injury. | Journal of the American Society of Nephrology : JASN |
| 2026-08-08 | PublicationEffects of antidepressant administration on physical performance and perceived exertion in athletes: systematic review and meta-analysis. | International journal of clinical pharmacy |
| 2026-08-13 | PublicationA pharmacometric framework for norepinephrine transporter occupancy and dose equivalence across psychotropic medications. | Journal of psychopharmacology (Oxford, England) |
| 2026-08-13 | PublicationLocked in Lucid Rhythms: A Case of Rhythmic Movement Disorder in Rapid Eye Movement (REM) Sleep. | Cureus |
| 2026-08-13 | PublicationAntidepressant medications have differential effects on REM sleep without atonia quantified by chin and upper extremity EMG. | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine |
| 2026-08-13 | PublicationAudiovisual Distraction During Mitral Transcatheter Edge-to-Edge Repair: A Sedation-Sparing Randomized Trial. | JACC. Advances |
| 2026-08-13 | PublicationComparing Electrical and Ultrasound Transcutaneous Auricular Vagus Nerve Stimulation on Associative Memory. | Neuromodulation : journal of the International Neuromodulation Society |
| 2026-08-16 | PublicationNeuroimmune circuits in respiratory pathophysiology: decoding molecular crosstalk for precision therapeutic targeting. | Annals of medicine |
| 2026-08-16 | PublicationA Passiflora incarnata extract exerts multi-target effects on selected sleep-related receptors. | Journal of ethnopharmacology |
| 2026-08-16 | PublicationIntervals for Oscillometric Arterial Pressure Monitoring during Noncardiac Surgery: The "2.5-Minute versus 5-Minute" Randomized Clinical Trial. | Anesthesiology |
| 2026-08-16 | PublicationThe onset of hypertension in metabolic syndrome is independent of renal sympathetic innervation. | Life science alliance |
| 2026-08-16 | PublicationRisk Factors for Adverse Drug Reactions of Augmented Mean Arterial Pressure Management After Spinal Cord Injury. | The Journal of surgical research |
| 2026-08-16 | PublicationEfficacy and safety of adjunctive orexin receptor antagonist therapy in major depressive disorder: A systematic review and meta-analysis of randomized controlled trials. | Journal of affective disorders |
| 2026-09-14 | PublicationNew pharmacologic agents for insomnia and hypersomnia. | Current opinion in pulmonary medicine |
| 2026-09-20 | PublicationThe role of the LC-NE system in attention: From cells, to systems, to sensory-motor control. | Neuroscience and biobehavioral reviews |
| 2026-09-20 | PublicationPharmacological treatment of cardiogenic shock. | Current opinion in critical care |
| 2026-10-09 | Dernière mise à jour des donnéesNorepinephrine | Biomedical Watch |
| 2026-10-18 | Création de l’enregistrementNCT07562932 | Registre d’essai clinique |
| 2026-10-18 | PublicationAmeliorative effects of half-dose saffron and chamomile combination on Psycho-endocrinological changes in a diabetic murine model. | PloS one |
| 2032-05-31 | Fin de l’étude prévue / enregistréeNCT07562932 | Registre d’essai clinique |
Début phase actuelle
Non disponible dans les sources synchronisées
Essais cliniques liés
1 essai(s)
Début phase actuelle
Non disponible dans les sources synchronisées
| NCT | Titre | Phase | Statut administratif | Pays | Sponsor |
|---|---|---|---|---|---|
| NCT07562932 | ACTION-CS — Assessing Catecholamine Treatment Initiation Options: Norepinephrine vs Dopamine for Cardiogenic Shock | Non applicable | RECRUITING | South Korea | Chonnam National University Hospital |
Publications liées
21 publication(s)Publications liées
21 publication(s)| Titre | PMID | DOI | Journal | Date |
|---|---|---|---|---|
| Ameliorative effects of half-dose saffron and chamomile combination on Psycho-endocrinological changes in a diabetic murine model. Voir source | 36302045 | 10.1371/journal.pone.0276236 | PloS one | |
| The role of the LC-NE system in attention: From cells, to systems, to sensory-motor control. Voir source | 40412462 | 10.1016/j.neubiorev.2025.106233 | Neuroscience and biobehavioral reviews | |
| Pharmacological treatment of cardiogenic shock. Voir source | 42273963 | 10.1097/MCC.0000000000001393 | Current opinion in critical care | |
| New pharmacologic agents for insomnia and hypersomnia. Voir source | 32890017 | 10.1097/MCP.0000000000000722 | Current opinion in pulmonary medicine | |
| Neuroimmune circuits in respiratory pathophysiology: decoding molecular crosstalk for precision therapeutic targeting. Voir source | 41601146 | 10.1080/07853890.2026.2620337 | Annals of medicine | |
| A Passiflora incarnata extract exerts multi-target effects on selected sleep-related receptors. Voir source | 42462921 | 10.1016/j.jep.2026.122198 | Journal of ethnopharmacology | |
| Intervals for Oscillometric Arterial Pressure Monitoring during Noncardiac Surgery: The "2.5-Minute versus 5-Minute" Randomized Clinical Trial. Voir source | 42102346 | 10.1097/ALN.0000000000006140 | Anesthesiology | |
| The onset of hypertension in metabolic syndrome is independent of renal sympathetic innervation. Voir source | 42448569 | 10.26508/lsa.202503568 | Life science alliance | |
| Risk Factors for Adverse Drug Reactions of Augmented Mean Arterial Pressure Management After Spinal Cord Injury. Voir source | 42341613 | 10.1016/j.jss.2026.05.045 | The Journal of surgical research | |
| Efficacy and safety of adjunctive orexin receptor antagonist therapy in major depressive disorder: A systematic review and meta-analysis of randomized controlled trials. Voir source | 42309189 | 10.1016/j.jad.2026.122139 | Journal of affective disorders | |
| A pharmacometric framework for norepinephrine transporter occupancy and dose equivalence across psychotropic medications. Voir source | 42549822 | 10.1177/02698811261470450 | Journal of psychopharmacology (Oxford, England) | |
| Locked in Lucid Rhythms: A Case of Rhythmic Movement Disorder in Rapid Eye Movement (REM) Sleep. Voir source | 42416935 | 10.7759/cureus.110405 | Cureus | |
| Antidepressant medications have differential effects on REM sleep without atonia quantified by chin and upper extremity EMG. Voir source | 42426312 | 10.1007/s44470-026-00127-2 | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine | |
| Audiovisual Distraction During Mitral Transcatheter Edge-to-Edge Repair: A Sedation-Sparing Randomized Trial. Voir source | 42167101 | 10.1016/j.jacadv.2026.102835 | JACC. Advances | |
| Comparing Electrical and Ultrasound Transcutaneous Auricular Vagus Nerve Stimulation on Associative Memory. Voir source | 42565762 | 10.1016/j.neurom.2026.07.001 | Neuromodulation : journal of the International Neuromodulation Society | |
| A Vagal-Renal-Splenic Reflex Suppresses Renal Sympathetic Nerve Activity and Preserves Kidney Function After Ischemic Injury. Voir source | 42555213 | 10.1681/ASN.0000001196 | Journal of the American Society of Nephrology : JASN | |
| Effects of antidepressant administration on physical performance and perceived exertion in athletes: systematic review and meta-analysis. Voir source | 42560424 | 10.1007/s11096-026-02206-z | International journal of clinical pharmacy | |
| Two Cases of Malaria-Associated Acute Respiratory Distress Syndrome and Severe Pulmonary Complications From Plasmodium falciparum in Tanzania. Voir source | 42464474 | 10.12659/AJCR.951737 | The American journal of case reports | |
| 36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016. Voir source | 27885969 | 10.1186/s13054-016-1208-6 | Critical care (London, England) | |
| α-Adrenergic receptor modulates 5-HT-mediated behavioral effects of MDMA and psilocybin in mice. Voir source | 42414551 | 10.1038/s41380-026-03713-1 | Molecular psychiatry | |
| Evaluation of [18F]MFPBG: a novel automatically radiolabeled probe for NET PET imaging. Voir source | 42414788 | 10.1186/s13550-026-01482-0 | EJNMMI research |
Sources officielles
liens de rechercheDernière mise à jour des données : 2026-10-09
Ces sources sont proposées pour vérification. Les informations de la fiche doivent être confirmées dans les registres officiels ou les publications originales.