Fiche traitement
Aspirin
Pejman Ghanouni • Cancer
Suivi actif
Non applicable
Résumé
Aspirin est développé par Pejman Ghanouni. Le traitement est actuellement en Non applicable. Il est associé à Cancer. Son objectif thérapeutique principal est Immunomodulation. Le statut actuel est : suivi actif.
À vérifier
Immunomodulation
Non applicable
Pejman Ghanouni
United States
Background:
Less toxic and more effective treatments are needed for cancers caused by viruses. These cancers include Hodgkin and non-Hodgkin lymphoma, hepatocellular carcinoma, head and neck cancer, nasopharyngeal carcinoma, gastric cancer, anal cancer, cervical cancer, vaginal cancer, vulvar cancer, penile cancer, Merkel cell carcinoma, Kaposi sarcoma, and leiomyosarcoma. Researchers want to see if a combination of drugs can help.
Objective:
To find a safe dose of pomalidomide plus nivolumab in people with cancers caused by viruses.
Eligibility:
Adults ages 18 or older who have cancers caused by Epstein Barr virus (EBV), human herpes virus 8/Kaposi sarcoma herpesvirus (HHV8/KSHV), human papilloma virus (HPV), hepatitis B or C virus (HBV/HCV), and Merkel cell polyomavirus (MCPyV) that have not responded to previous treatments or have relapsed, or in adults who do not want to have surgery because of disfigurement or other risks. Adults who have HIV with any CD4 T cell count are eligible.
Design:
Participants will be screened with blood and urine tests, scans, and heart tests. They will have a physical exam. Their ability to perform normal daily activities will be assessed. They may have a tumor biopsy.
Treatment will be given in 28-day cycles. Participants will take pomalidomide as a tablet by mouth for 21 days of each cycle, for up to 24 cycles. They will get nivolumab by intravenous infusion once each cycle. They will take an aspirin each day until 30 days after their last dose of the study drugs.
Participants will keep a pill diary. They will bring it to their study visit at the end of each cycle. At these visits, some screening tests will be repeated. Participants with Kaposi sarcoma will have pictures taken of their lesions.
Participants will give blood and saliva samples for research. They may have optional anal and/or cervical swabs. They may have optional biopsies.
Participants will have a follow-up visit 30 days after they stop taking the study drugs, then every month for 100 days. Some screening tests will be repeated. Then they may by contacted by phone every 3 months for 9 months, and then every 6 months thereafter.
2018-04-28
Début phase actuelle
Non disponible dans les sources synchronisées
Timeline clinique
Non applicable
Début phase actuelle
Non disponible dans les sources synchronisées
Préclinique
Phase 1
Phase 2
Phase 3
Approuvé
Objectif scientifique de l’étude
classification automatique vérifiable
Immunomodulation
Confiance automatique : 66%
Ce pourcentage n’est pas une probabilité de succès clinique.
Il mesure uniquement la force de la classification automatique de l’objectif scientifique. Le calcul part de 45 points, ajoute 7 points par unité de poids du mot-clé le plus fortement détecté, puis est plafonné à 95 %. Exemple : un score maximal de 2 donne 45 + (2 × 7) = 59 %.
Indices détectés : t cell → Immunomodulation
Ce score est heuristique et doit être vérifié dans le protocole ou une publication.
Description affichée depuis l’essai compatible NCT04902443, afin d’éviter le mélange entre plusieurs indications d’une même molécule.
Contrôle de cohérence : 85/100
L’objectif est absent ou classé « Autre » et doit être recalculé à partir du protocole.
Transparence et qualité de la fiche
données vérifiablesClassificationÀ vérifier
Confiance de la fiche85 %
Source principaleSource officielle ou publication indexée
Dernière vérification2018-04-28
Anomalies détectées1
Validation humaineValidation humaine non effectuée
Donnée issue d’une source
Donnée normalisée automatiquement
Interprétation algorithmique
Classification scientifique multi-axes
ne pas confondre statut et résultatÉtat de l’étudeRecrutement en cours
Disponibilité des résultatsRésultats à vérifier
InterprétationImpossible à déterminer
Niveau de preuveNon évaluable
Un essai terminé n’est pas nécessairement positif. Un essai arrêté n’est classé comme échec scientifique que lorsqu’un résultat ou une raison explicite le confirme.
Indicateurs factuels
sans score subjectifPhase enregistréeNon applicable
Études associées4
Publications associées29
Statut consolidéSuivi actif
Aucune chance de succès, note d’innovation, potentiel thérapeutique ou probabilité de commercialisation n’est calculé tant qu’un modèle validé et des données suffisantes ne sont pas disponibles.
Historique factuel de la molécule
42 événement(s) daté(s)Cette liste reprend uniquement les dates trouvées dans les registres et publications liés. Elle ne constitue pas une prévision.
| Date | Événement | Source |
|---|---|---|
| 2010-11-01 | Début de l’étudeNCT01257893 | Registre d’essai clinique |
| 2012-08-01 | Fin de l’étude prévue / enregistréeNCT01257893 | Registre d’essai clinique |
| 2018-04-28 | Dernière mise à jour des donnéesAspirin | Biomedical Watch |
| 2020-09-22 | Début de l’étudeNCT05891808 | Registre d’essai clinique |
| 2021-12-10 | Début de l’étudeNCT04902443 | Registre d’essai clinique |
| 2024-01-01 | Fin de l’étude prévue / enregistréeNCT05891808 | Registre d’essai clinique |
| 2026-07-14 | PublicationPilot feasibility study of intraprocedural transcranial Doppler monitoring to assess Heal coating thrombogenicity in flow diversion. | Frontiers in neurology |
| 2026-07-14 | PublicationEffect of Low-Dose Rivaroxaban Plus Aspirin on 18F-FDG PET/CT-Detectable Carotid Plaque Inflammation: A Randomised Trial. | European heart journal. Cardiovascular Imaging |
| 2026-07-23 | PublicationDrug repurposing as a promising therapeutic strategy against renal cell carcinoma. | Cancer chemotherapy and pharmacology |
| 2026-07-23 | PublicationLow-Dose Rivaroxaban to Prevent Left Ventricular Thrombosis After Anterior Myocardial Infarction: The APERITIF Randomized Clinical Trial. | JAMA cardiology |
| 2026-07-23 | PublicationAntithrombotic Drug Eruptions in Dermatology Practice: Selection Bias, Clinical Phenotypes, and Diagnostic Approaches. | Cureus |
| 2026-07-24 | Création de l’enregistrementNCT01257893 | Registre d’essai clinique |
| 2026-08-08 | PublicationNon-O blood groups as independent predictors of chronic subdural hematoma recurrence in antithrombotic-naive patients: risk mitigation by prior aspirin use and new perspectives for stratification. | Journal of neurosurgery |
| 2026-08-08 | PublicationAspirin for Venous Thromboembolism Prevention in Orthopaedic Surgery with Focus on Trauma and Arthroplasty: A Structured Evidence-Based Review of Randomised Trials, Guidelines, and Contemporary Practice Considerations. | Journal of clinical medicine |
| 2026-08-08 | PublicationAssociation Between Low-Dose Aspirin Use and Early Renal Injury Biomarkers in Patients with Type 2 Diabetes Mellitus: A Retrospective Matched Cohort Study. | Diabetes, metabolic syndrome and obesity : targets and therapy |
| 2026-08-08 | PublicationHarnessing Repurposed Drugs to Enhance Temozolomide Efficacy in Glioblastoma. | Cancer reports (Hoboken, N.J.) |
| 2026-08-13 | Création de l’enregistrementNCT07762703 | Registre d’essai clinique |
| 2026-08-13 | PublicationSmell and the sinuses. | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology |
| 2026-08-16 | Création de l’enregistrementNCT05891808 | Registre d’essai clinique |
| 2026-08-16 | PublicationNonsteroidal Anti-Inflammatory Drugs (NSAIDs) Use Is Associated With an Increased Risk of Femoral Osteonecrosis in Migraine Patients: A Retrospective, TriNetX Database-Based Study. | Cureus |
| 2026-08-16 | PublicationDifferent duration of dual antiplatelet therapy after endovascular treatment for unruptured intracranial aneurysms. | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia |
| 2026-08-16 | PublicationImpact of dual antiplatelet therapy duration after percutaneous coronary intervention on outcomes in acute coronary syndrome patients with and without chronic kidney disease: a nationwide cohort study. | Renal failure |
| 2026-08-16 | Publication"Two for One", Novel Dual Left Anterior Descending Artery (LAD) Variant: Type XIII. | Cureus |
| 2026-08-16 | PublicationThe influence of body size on the pharmacodynamic and pharmacokinetic response to clopidogrel and prasugrel: a retrospective analysis of the FEATHER study. | Thrombosis research |
| 2026-08-16 | PublicationRisk Stratification for Rebleeding in Obscure Gastrointestinal Bleeding After Comprehensive Gastrointestinal Evaluation. | DEN open |
| 2026-08-16 | PublicationShared genetics of IgA nephropathy and cardiometabolic diseases revealed by integrative genomic analysis. | Renal failure |
| 2026-08-16 | PublicationHigh-throughput signal detection of hepatotoxic drug-drug interactions in hospitalized elderly patients: an NLP-driven pharmacovigilance study. | Annals of medicine |
| 2026-08-16 | PublicationWIN-MTB-2024017 - WIN International Molecular Tumor Board: A 48-year-old female with multiple primary cancers. | Oncotarget |
| 2026-08-16 | PublicationPharmacogenetic Drug Administration and Community Health: A Cross-Sectional Telecommunication-Based Study. | Archives of medical research |
| 2026-08-16 | PublicationCurrent Evidence on Medical Therapy for Sporadic Vestibular Schwannoma: A Systematic Review and Meta-analysis. | Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology |
| 2026-08-16 | PublicationBlack Elderberry Exposure in Apparent Idiopathic Mild Acute Pancreatitis: A Case Report. | Cureus |
| 2026-08-16 | PublicationExtensive bilateral pulmonary embolism revealing iron deficiency-masked JAK2-positive polycythemia vera: A case report. | Radiology case reports |
| 2026-08-16 | PublicationQuality of Diabetes Care Among Older Adults in Germany-Results of the Study on Health of Older People 2022/2023 Compared With Previous National Health Surveys. | Diabetes, obesity & metabolism |
| 2026-08-16 | PublicationAspirin protects trophoblast function against hypoxia-induced oxidative stress through activation of NRF2 signaling in preeclampsia. | Reproductive biology |
| 2026-08-16 | PublicationPrognostic implications of single antiplatelet therapy in individuals developing diabetic foot disease with concurrent peripheral arterial disease. | Annals of medicine |
| 2026-08-16 | PublicationPolyphenol-rich Dactyloctenium aegyptium extract protects against aspirin or ethanol-induced gastric ulcers via antioxidant, anti-inflammatory, and anti-apoptotic pathways. | Tissue & cell |
| 2026-08-16 | PublicationPericonceptional nonsteroidal anti-inflammatory drug use, folic acid intake, and the risk of spina bifida. | Birth defects research |
| 2026-09-01 | Début de l’étudeNCT07762703 | Registre d’essai clinique |
| 2026-09-01 | PublicationPregnancy and COVID-19: pharmacologic considerations. | Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology |
| 2026-09-14 | Création de l’enregistrementNCT04902443 | Registre d’essai clinique |
| 2027-12-01 | Fin de l’étude prévue / enregistréeNCT04902443 | Registre d’essai clinique |
| 2030-09-01 | Fin de l’étude prévue / enregistréeNCT07762703 | Registre d’essai clinique |
Début phase actuelle
Non disponible dans les sources synchronisées
Essais cliniques liés
4 essai(s)
Début phase actuelle
Non disponible dans les sources synchronisées
| NCT | Titre | Phase | Statut administratif | Pays | Sponsor |
|---|---|---|---|---|---|
| NCT04902443 | Pomalidomide and Nivolumab in People With Virus-Associated Malignancies With or Without HIV | Phase 1 | RECRUITING | United States | National Cancer Institute (NCI) |
| NCT05891808 | miR-155 Expression in Episodic and Chronic Migraine | À vérifier | UNKNOWN | Italy | IRCCS National Neurological Institute "C. Mondino" Foundation |
| NCT07762703 | Combination Immunotherapy Treatment for Locally Advanced Unresectable or Metastatic, PD-L1 Negative (CPS<10), gBRCA Negative, Triple Negative Breast Cancer Including BreakVax ImmunoTreatment (Designed and Manufactured Per Patient), Chemotherapy and Anti PD-1 Therapy | Phase 1 | NOT_YET_RECRUITING | United States | BreakBio Corp |
| NCT01257893 | ARWM — Aspirin Resistance in Women With Migraine | NA | WITHDRAWN | United States | Swedish Medical Center |
Publications liées
29 publication(s)Publications liées
29 publication(s)| Titre | PMID | DOI | Journal | Date |
|---|---|---|---|---|
| Pregnancy and COVID-19: pharmacologic considerations. Voir source | 32959455 | 10.1002/uog.23116 | Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology | |
| Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Use Is Associated With an Increased Risk of Femoral Osteonecrosis in Migraine Patients: A Retrospective, TriNetX Database-Based Study. Voir source | 41293358 | 10.7759/cureus.95391 | Cureus | |
| Different duration of dual antiplatelet therapy after endovascular treatment for unruptured intracranial aneurysms. Voir source | 42241917 | 10.1016/j.jocn.2026.112124 | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia | |
| Impact of dual antiplatelet therapy duration after percutaneous coronary intervention on outcomes in acute coronary syndrome patients with and without chronic kidney disease: a nationwide cohort study. Voir source | 42443728 | 10.1080/0886022X.2026.2697379 | Renal failure | |
| "Two for One", Novel Dual Left Anterior Descending Artery (LAD) Variant: Type XIII. Voir source | 34055556 | 10.7759/cureus.14717 | Cureus | |
| The influence of body size on the pharmacodynamic and pharmacokinetic response to clopidogrel and prasugrel: a retrospective analysis of the FEATHER study. Voir source | 25022828 | 10.1016/j.thromres.2014.05.019 | Thrombosis research | |
| Risk Stratification for Rebleeding in Obscure Gastrointestinal Bleeding After Comprehensive Gastrointestinal Evaluation. Voir source | 42440754 | 10.1002/deo2.70378 | DEN open | |
| Shared genetics of IgA nephropathy and cardiometabolic diseases revealed by integrative genomic analysis. Voir source | 42535737 | 10.1080/0886022X.2026.2706884 | Renal failure | |
| High-throughput signal detection of hepatotoxic drug-drug interactions in hospitalized elderly patients: an NLP-driven pharmacovigilance study. Voir source | 42311091 | 10.1080/07853890.2026.2682581 | Annals of medicine | |
| WIN-MTB-2024017 - WIN International Molecular Tumor Board: A 48-year-old female with multiple primary cancers. Voir source | 42478852 | 10.18632/oncotarget.28899 | Oncotarget | |
| Pharmacogenetic Drug Administration and Community Health: A Cross-Sectional Telecommunication-Based Study. Voir source | 40997434 | 10.1016/j.arcmed.2025.103307 | Archives of medical research | |
| Current Evidence on Medical Therapy for Sporadic Vestibular Schwannoma: A Systematic Review and Meta-analysis. Voir source | 41952108 | 10.1097/MAO.0000000000004904 | Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology | |
| Black Elderberry Exposure in Apparent Idiopathic Mild Acute Pancreatitis: A Case Report. Voir source | 42572604 | 10.7759/cureus.112391 | Cureus | |
| Extensive bilateral pulmonary embolism revealing iron deficiency-masked JAK2-positive polycythemia vera: A case report. Voir source | 42381746 | 10.1016/j.radcr.2026.06.035 | Radiology case reports | |
| Quality of Diabetes Care Among Older Adults in Germany-Results of the Study on Health of Older People 2022/2023 Compared With Previous National Health Surveys. Voir source | 42581634 | 10.1111/dom.71184 | Diabetes, obesity & metabolism | |
| Aspirin protects trophoblast function against hypoxia-induced oxidative stress through activation of NRF2 signaling in preeclampsia. Voir source | 42241790 | 10.1016/j.repbio.2026.101239 | Reproductive biology | |
| Prognostic implications of single antiplatelet therapy in individuals developing diabetic foot disease with concurrent peripheral arterial disease. Voir source | 41981998 | 10.1080/07853890.2026.2653300 | Annals of medicine | |
| Polyphenol-rich Dactyloctenium aegyptium extract protects against aspirin or ethanol-induced gastric ulcers via antioxidant, anti-inflammatory, and anti-apoptotic pathways. Voir source | 42594500 | 10.1016/j.tice.2026.103859 | Tissue & cell | |
| Periconceptional nonsteroidal anti-inflammatory drug use, folic acid intake, and the risk of spina bifida. Voir source | 34346174 | 10.1002/bdr2.1944 | Birth defects research | |
| Smell and the sinuses. Voir source | 42219147 | 10.1016/j.anai.2026.05.036 | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology | |
| Non-O blood groups as independent predictors of chronic subdural hematoma recurrence in antithrombotic-naive patients: risk mitigation by prior aspirin use and new perspectives for stratification. Voir source | 42566780 | 10.3171/2026.2.JNS252663 | Journal of neurosurgery | |
| Aspirin for Venous Thromboembolism Prevention in Orthopaedic Surgery with Focus on Trauma and Arthroplasty: A Structured Evidence-Based Review of Randomised Trials, Guidelines, and Contemporary Practice Considerations. Voir source | 42355718 | 10.3390/jcm15124550 | Journal of clinical medicine | |
| Association Between Low-Dose Aspirin Use and Early Renal Injury Biomarkers in Patients with Type 2 Diabetes Mellitus: A Retrospective Matched Cohort Study. Voir source | 42436762 | 10.2147/DMSO.S624979 | Diabetes, metabolic syndrome and obesity : targets and therapy | |
| Harnessing Repurposed Drugs to Enhance Temozolomide Efficacy in Glioblastoma. Voir source | 42557676 | 10.1002/cnr2.70643 | Cancer reports (Hoboken, N.J.) | |
| Drug repurposing as a promising therapeutic strategy against renal cell carcinoma. Voir source | 42479152 | 10.1007/s00280-026-04923-8 | Cancer chemotherapy and pharmacology | |
| Low-Dose Rivaroxaban to Prevent Left Ventricular Thrombosis After Anterior Myocardial Infarction: The APERITIF Randomized Clinical Trial. Voir source | 41739450 | 10.1001/jamacardio.2026.0026 | JAMA cardiology | |
| Antithrombotic Drug Eruptions in Dermatology Practice: Selection Bias, Clinical Phenotypes, and Diagnostic Approaches. Voir source | 42465709 | 10.7759/cureus.112751 | Cureus | |
| Pilot feasibility study of intraprocedural transcranial Doppler monitoring to assess Heal coating thrombogenicity in flow diversion. Voir source | 42422222 | 10.3389/fneur.2026.1831348 | Frontiers in neurology | |
| Effect of Low-Dose Rivaroxaban Plus Aspirin on 18F-FDG PET/CT-Detectable Carotid Plaque Inflammation: A Randomised Trial. Voir source | 42439277 | 10.1093/ehjci/jeag176 | European heart journal. Cardiovascular Imaging |
Sources officielles
liens de rechercheDernière mise à jour des données : 2018-04-28
Ces sources sont proposées pour vérification. Les informations de la fiche doivent être confirmées dans les registres officiels ou les publications originales.