Fiche traitement
Lidocaine
Fundación Santa Fe de Bogota • Cancer
Suivi actif
À vérifier
Résumé
Lidocaine est développé par Fundación Santa Fe de Bogota. Le traitement est actuellement en À vérifier. Il est associé à Cancer. Son objectif thérapeutique principal est Traitement symptomatique. Le statut actuel est : suivi actif.
À vérifier
Traitement symptomatique
À vérifier
Fundación Santa Fe de Bogota
Non renseigné
Malignant bowel obstruction is a frequent complication of advanced cancer, particularly of abdominal and pelvic origin, and most affected patients experience pain. Opioids are the mainstay of analgesic treatment, but some patients have pain that does not respond adequately or cannot tolerate further opioid dose increases. Lidocaine infusions are sometimes used as an adjuvant pain treatment in this setting, but specific evidence is limited to case reports and small series.
This retrospective cohort study will review the medical records of adults with cancer and malignant bowel obstruction who received lidocaine infusions for pain as part of routine palliative care at Hospital Universitario Fundación Santa Fe de Bogotá (Bogotá, Colombia) between 2015 and 2025. The study will describe patient characteristics and lidocaine regimens, and will evaluate changes in pain intensity and opioid requirements before and after the start of the infusion, the proportion of patients with a clinically meaningful pain reduction, adverse events, treatment discontinuation due to toxicity, and hospital outcomes. The investigators will not assign or modify any treatment.
2026-09-28
Début phase actuelle
Non disponible dans les sources synchronisées
Timeline clinique
À vérifier
Début phase actuelle
Non disponible dans les sources synchronisées
Préclinique
Phase 1
Phase 2
Phase 3
Approuvé
Objectif scientifique de l’étude
classification automatique vérifiable
Traitement symptomatique
Confiance automatique : 87%
Ce pourcentage n’est pas une probabilité de succès clinique.
Il mesure uniquement la force de la classification automatique de l’objectif scientifique. Le calcul part de 45 points, ajoute 7 points par unité de poids du mot-clé le plus fortement détecté, puis est plafonné à 95 %. Exemple : un score maximal de 2 donne 45 + (2 × 7) = 59 %.
Indices détectés : symptom → Traitement symptomatique, pain → Traitement symptomatique
Ce score est heuristique et doit être vérifié dans le protocole ou une publication.
Description affichée depuis l’essai compatible NCT07856251, afin d’éviter le mélange entre plusieurs indications d’une même molécule.
Aucune incohérence majeure détectée entre la maladie, l’objectif et la description.
Transparence et qualité de la fiche
données vérifiablesClassificationCohérente automatiquement
Confiance de la fiche100 %
Source principaleSource officielle ou publication indexée
Dernière vérification2026-09-28
Anomalies détectées0
Validation humaineValidation humaine non effectuée
Donnée issue d’une source
Donnée normalisée automatiquement
Interprétation algorithmique
Classification scientifique multi-axes
ne pas confondre statut et résultatÉtat de l’étudeRecrutement en cours
Disponibilité des résultatsRésultats à vérifier
InterprétationImpossible à déterminer
Niveau de preuveNon évaluable
Un essai terminé n’est pas nécessairement positif. Un essai arrêté n’est classé comme échec scientifique que lorsqu’un résultat ou une raison explicite le confirme.
Indicateurs factuels
sans score subjectifPhase enregistréeÀ vérifier
Études associées1
Publications associées33
Statut consolidéSuivi actif
Aucune chance de succès, note d’innovation, potentiel thérapeutique ou probabilité de commercialisation n’est calculé tant qu’un modèle validé et des données suffisantes ne sont pas disponibles.
Historique factuel de la molécule
37 événement(s) daté(s)Cette liste reprend uniquement les dates trouvées dans les registres et publications liés. Elle ne constitue pas une prévision.
| Date | Événement | Source |
|---|---|---|
| 2026-07-10 | Publication[Efficacy of electroacupuncture nerve stimulation therapy for interstitial cystitis/bladder pain syndrome]. | Zhongguo zhen jiu = Chinese acupuncture & moxibustion |
| 2026-07-12 | PublicationEvaluation of Two Treatment Options in Myofascial Pain Transcutaneous Electrical Nerve Stimulation versus Trigger Point Injection. | Annals of African medicine |
| 2026-07-14 | PublicationCommon genetic variants of the cardiac sodium channel alter patient response to class 1b antiarrhythmics. | Journal of precision medicine (Amsterdam, Netherlands) |
| 2026-07-14 | PublicationManagement of Pain and Pruritus in Pediatric Recessive Dystrophic Epidermolysis Bullosa. | Clinical case reports |
| 2026-07-14 | PublicationKetamine-induced cystitis: Lessons from a case of recreational use. | Journal of the American Pharmacists Association : JAPhA |
| 2026-08-08 | PublicationImpact of Menthol Concentration on Ketoprofen Permeation and Photostability in Compounded Topical Preparations in a Pentravan Base. | ACS omega |
| 2026-08-08 | PublicationCompound Chamomile and Lidocaine Hydrochloride Gel in Oral Diseases: A Review of Current Evidence and Potential Applications. | Drug design, development and therapy |
| 2026-08-08 | PublicationCombined Occipital Nerve and Sphenopalatine Ganglion Neuromodulation for Refractory Craniofacial Pain with Trigeminal Autonomic Features: A 12-Year Follow-Up (Case Report). | Local and regional anesthesia |
| 2026-08-08 | PublicationGreater occipital nerve blockade for the preventive treatment of chronic migraine: A randomized double-blind placebo-controlled study. | Cephalalgia : an international journal of headache |
| 2026-08-08 | PublicationEfficacy of Greater Occipital Nerve Blockade in Craniofacial Neuralgia and Facial Pain Syndromes: A Retrospective Chart Review with Prospectively Collected Follow-Up Data. | Journal of clinical medicine |
| 2026-08-08 | Publication2025 guideline update to acute treatment of migraine for adults in the emergency department: The American Headache Society evidence assessment of parenteral pharmacotherapies. | Headache |
| 2026-08-08 | PublicationEfficacy and tolerability of combination treatment of topiramate and greater occipital nerve block versus topiramate monotherapy for the preventive treatment of chronic migraine: A randomized controlled trial. | Cephalalgia : an international journal of headache |
| 2026-08-08 | PublicationComparison of the Effectiveness of Greater Occipital Nerve Block and Botulinum Toxin Type A in Chronic Migraine: An Exploratory Pilot Study From a Tertiary Care Centre in a Resource-Limited Setting. | Cureus |
| 2026-08-13 | PublicationEffect of Instrument-Assisted Soft Tissue Mobilization Combined With Lidocaine Phonophoresis on Tension-Type Headache: A Randomized Clinical Trial. | Journal of manipulative and physiological therapeutics |
| 2026-08-13 | PublicationLocal anesthetics and antibiotics display synergistic and antagonistic drug interactions against pathogens causing septic arthritis in horses. | American journal of veterinary research |
| 2026-08-13 | PublicationSolvent-Driven Enrichment and Multiplex Analysis of Local Anesthetics by Thin-Layer Chromatography Coupled with Surface-Enhanced Raman Spectroscopy. | Molecules (Basel, Switzerland) |
| 2026-08-16 | PublicationA Randomized Controlled Trial of Instillation Protocols Prior to Intradetrusor OnabotulinumtoxinA. | International urogynecology journal |
| 2026-08-16 | PublicationEvaluation of continuous intravenous lidocaine on brain relaxation, intraoperative opioid consumption, and surgeon's satisfaction in adult patients undergoing craniotomy tumor surgery: A randomized controlled trial. | Medicine |
| 2026-08-16 | PublicationCould an intraoperative lidocaine intravenous infusion enhance patient recovery after functional endoscopic sinus surgery? | Minerva anestesiologica |
| 2026-08-16 | PublicationEarly Postoperative Analgesic Evaluation of Intravenous Lidocaine Infusion or a Combination of Intraperitoneal and Incisional Lidocaine Splash in Female Dogs Undergoing Ovariohysterectomy. | Veterinary sciences |
| 2026-08-16 | PublicationAn evaluation of peripheral nerve damage that may develop following intraneural bupivacaine, dexmedetomidine, and lidocaine injections: multifaceted analysis in an experimental model. | BMC anesthesiology |
| 2026-08-16 | PublicationComparison of a TrachoSpray Device and Manual Lidocaine Spray on Hemodynamic Stability and Postoperative Sore Throat in Patients Undergoing Double-Lumen Tube Intubation: A Randomized Controlled Trial. | Journal of investigative surgery : the official journal of the Academy of Surgical Research |
| 2026-08-16 | PublicationAdvances in ERAS to Reduce the Incidence of Chronic Post-Surgical Pain and Persistent Postoperative Opioid Use: A Narrative Review. | Journal of investigative surgery : the official journal of the Academy of Surgical Research |
| 2026-08-16 | PublicationLidocaine Spray Versus Viscous Lidocaine Solution Plus Lidocaine Spray in Patients Undergoing Non-Sedated Esophagogastroduodenoscopy: A Randomized Controlled Trial. | DEN open |
| 2026-08-16 | PublicationEffects of a Lidocaine-Loaded Alginate/CMC/PEO Electrospun Nanofiber Film on Postoperative Pain and Peritoneal Adhesion in a Rat Model. | Medicina (Kaunas, Lithuania) |
| 2026-08-16 | PublicationAn eco-friendly triple quadrupole mass spectrometry approach for the simultaneous screening of N-nitroso-desethyl lidocaine and N-nitroso lidocaine EP impurity E in lidocaine drug substance and injectable solutions. | European journal of mass spectrometry (Chichester, England) |
| 2026-08-16 | PublicationUltrasound-guided stellate ganglion block for refractory sympathetically mediated arrhythmia following acute myocardial infarction: a tutorial and examples. | Frontiers in cardiovascular medicine |
| 2026-08-16 | PublicationUltrasound-guided 5-in-1 trigger point injection for treating tension-type headache: A case report. | Medicine |
| 2026-08-16 | PublicationVoltage-gated sodium channels in the nervous system: Molecular physiology to therapeutic interventions. | Neural regeneration research |
| 2026-08-16 | PublicationLidocaine spray vs mepivacaine local infiltration for suturing 1st/2nd grade perineal lacerations: a randomised controlled non-inferiority trial. | BMC pregnancy and childbirth |
| 2026-08-16 | PublicationTopical delivery of Lidocaine using spicules for local anesthesia. | Drug delivery and translational research |
| 2026-08-16 | PublicationComparison between Perineural and Intravenous Dexamethasone on Duration of Analgesia in Supraclavicular Brachial Plexus Block - An Observational Study. | Annals of African medicine |
| 2026-08-16 | PublicationLocal therapeutic strategies for neurocutaneous dysesthesia: from capsaicin to cannabinoids. | The Journal of dermatological treatment |
| 2026-09-28 | Dernière mise à jour des donnéesLidocaine | Biomedical Watch |
| 2026-10-04 | Création de l’enregistrementNCT07856251 | Registre d’essai clinique |
| 2026-11-01 | Début de l’étudeNCT07856251 | Registre d’essai clinique |
| 2027-02-01 | Fin de l’étude prévue / enregistréeNCT07856251 | Registre d’essai clinique |
Début phase actuelle
Non disponible dans les sources synchronisées
Essais cliniques liés
1 essai(s)
Début phase actuelle
Non disponible dans les sources synchronisées
| NCT | Titre | Phase | Statut administratif | Pays | Sponsor |
|---|---|---|---|---|---|
| NCT07856251 | Lidocaine Infusions for Pain in Patients With Malignant Bowel Obstruction | À vérifier | NOT_YET_RECRUITING | Non communiqué | Fundación Santa Fe de Bogota |
Publications liées
33 publication(s)Publications liées
33 publication(s)| Titre | PMID | DOI | Journal | Date |
|---|---|---|---|---|
| A Randomized Controlled Trial of Instillation Protocols Prior to Intradetrusor OnabotulinumtoxinA. Voir source | 40025238 | 10.1007/s00192-025-06080-7 | International urogynecology journal | |
| Evaluation of continuous intravenous lidocaine on brain relaxation, intraoperative opioid consumption, and surgeon's satisfaction in adult patients undergoing craniotomy tumor surgery: A randomized controlled trial. Voir source | 36086723 | 10.1097/MD.0000000000030227 | Medicine | |
| Could an intraoperative lidocaine intravenous infusion enhance patient recovery after functional endoscopic sinus surgery? Voir source | 36367408 | 10.23736/S0375-9393.22.16907-5 | Minerva anestesiologica | |
| Early Postoperative Analgesic Evaluation of Intravenous Lidocaine Infusion or a Combination of Intraperitoneal and Incisional Lidocaine Splash in Female Dogs Undergoing Ovariohysterectomy. Voir source | 41472096 | 10.3390/vetsci12121116 | Veterinary sciences | |
| An evaluation of peripheral nerve damage that may develop following intraneural bupivacaine, dexmedetomidine, and lidocaine injections: multifaceted analysis in an experimental model. Voir source | 42251255 | 10.1186/s12871-026-03992-9 | BMC anesthesiology | |
| Comparison of a TrachoSpray Device and Manual Lidocaine Spray on Hemodynamic Stability and Postoperative Sore Throat in Patients Undergoing Double-Lumen Tube Intubation: A Randomized Controlled Trial. Voir source | 41797600 | 10.1080/08941939.2025.2586017 | Journal of investigative surgery : the official journal of the Academy of Surgical Research | |
| Advances in ERAS to Reduce the Incidence of Chronic Post-Surgical Pain and Persistent Postoperative Opioid Use: A Narrative Review. Voir source | 42138101 | 10.1080/08941939.2026.2664932 | Journal of investigative surgery : the official journal of the Academy of Surgical Research | |
| Lidocaine Spray Versus Viscous Lidocaine Solution Plus Lidocaine Spray in Patients Undergoing Non-Sedated Esophagogastroduodenoscopy: A Randomized Controlled Trial. Voir source | 42559051 | 10.1002/deo2.70393 | DEN open | |
| Effects of a Lidocaine-Loaded Alginate/CMC/PEO Electrospun Nanofiber Film on Postoperative Pain and Peritoneal Adhesion in a Rat Model. Voir source | 42075660 | 10.3390/medicina62040789 | Medicina (Kaunas, Lithuania) | |
| An eco-friendly triple quadrupole mass spectrometry approach for the simultaneous screening of N-nitroso-desethyl lidocaine and N-nitroso lidocaine EP impurity E in lidocaine drug substance and injectable solutions. Voir source | 42187176 | 10.1177/14690667261453520 | European journal of mass spectrometry (Chichester, England) | |
| Ultrasound-guided stellate ganglion block for refractory sympathetically mediated arrhythmia following acute myocardial infarction: a tutorial and examples. Voir source | 42403899 | 10.3389/fcvm.2026.1846647 | Frontiers in cardiovascular medicine | |
| Ultrasound-guided 5-in-1 trigger point injection for treating tension-type headache: A case report. Voir source | 35945722 | 10.1097/MD.0000000000029987 | Medicine | |
| Voltage-gated sodium channels in the nervous system: Molecular physiology to therapeutic interventions. Voir source | 40808385 | 10.4103/NRR.NRR-D-25-00260 | Neural regeneration research | |
| Lidocaine spray vs mepivacaine local infiltration for suturing 1st/2nd grade perineal lacerations: a randomised controlled non-inferiority trial. Voir source | 38914976 | 10.1186/s12884-024-06640-7 | BMC pregnancy and childbirth | |
| Topical delivery of Lidocaine using spicules for local anesthesia. Voir source | 41402578 | 10.1007/s13346-025-02030-4 | Drug delivery and translational research | |
| Comparison between Perineural and Intravenous Dexamethasone on Duration of Analgesia in Supraclavicular Brachial Plexus Block - An Observational Study. Voir source | 41574836 | 10.4103/aam.aam_288_25 | Annals of African medicine | |
| Local therapeutic strategies for neurocutaneous dysesthesia: from capsaicin to cannabinoids. Voir source | 41884965 | 10.1080/09546634.2026.2646556 | The Journal of dermatological treatment | |
| Effect of Instrument-Assisted Soft Tissue Mobilization Combined With Lidocaine Phonophoresis on Tension-Type Headache: A Randomized Clinical Trial. Voir source | 41206797 | 10.1016/j.jmpt.2025.09.010 | Journal of manipulative and physiological therapeutics | |
| Local anesthetics and antibiotics display synergistic and antagonistic drug interactions against pathogens causing septic arthritis in horses. Voir source | 39970538 | 10.2460/ajvr.24.08.0214 | American journal of veterinary research | |
| Solvent-Driven Enrichment and Multiplex Analysis of Local Anesthetics by Thin-Layer Chromatography Coupled with Surface-Enhanced Raman Spectroscopy. Voir source | 40286164 | 10.3390/molecules30071585 | Molecules (Basel, Switzerland) | |
| Impact of Menthol Concentration on Ketoprofen Permeation and Photostability in Compounded Topical Preparations in a Pentravan Base. Voir source | 42518428 | 10.1021/acsomega.5c13180 | ACS omega | |
| Compound Chamomile and Lidocaine Hydrochloride Gel in Oral Diseases: A Review of Current Evidence and Potential Applications. Voir source | 42558651 | 10.2147/DDDT.S626126 | Drug design, development and therapy | |
| Combined Occipital Nerve and Sphenopalatine Ganglion Neuromodulation for Refractory Craniofacial Pain with Trigeminal Autonomic Features: A 12-Year Follow-Up (Case Report). Voir source | 42100751 | 10.2147/LRA.S595517 | Local and regional anesthesia | |
| Greater occipital nerve blockade for the preventive treatment of chronic migraine: A randomized double-blind placebo-controlled study. Voir source | 36739512 | 10.1177/03331024221143541 | Cephalalgia : an international journal of headache | |
| Efficacy of Greater Occipital Nerve Blockade in Craniofacial Neuralgia and Facial Pain Syndromes: A Retrospective Chart Review with Prospectively Collected Follow-Up Data. Voir source | 40725724 | 10.3390/jcm14145034 | Journal of clinical medicine | |
| 2025 guideline update to acute treatment of migraine for adults in the emergency department: The American Headache Society evidence assessment of parenteral pharmacotherapies. Voir source | 41321235 | 10.1111/head.70016 | Headache | |
| Efficacy and tolerability of combination treatment of topiramate and greater occipital nerve block versus topiramate monotherapy for the preventive treatment of chronic migraine: A randomized controlled trial. Voir source | 35259978 | 10.1177/03331024221082077 | Cephalalgia : an international journal of headache | |
| Comparison of the Effectiveness of Greater Occipital Nerve Block and Botulinum Toxin Type A in Chronic Migraine: An Exploratory Pilot Study From a Tertiary Care Centre in a Resource-Limited Setting. Voir source | 42005143 | 10.7759/cureus.105513 | Cureus | |
| Common genetic variants of the cardiac sodium channel alter patient response to class 1b antiarrhythmics. Voir source | 42422555 | 10.1016/j.premed.2026.100034 | Journal of precision medicine (Amsterdam, Netherlands) | |
| Management of Pain and Pruritus in Pediatric Recessive Dystrophic Epidermolysis Bullosa. Voir source | 42437100 | 10.1002/ccr3.73135 | Clinical case reports | |
| Ketamine-induced cystitis: Lessons from a case of recreational use. Voir source | 42431377 | 10.1016/j.japh.2026.103486 | Journal of the American Pharmacists Association : JAPhA | |
| Evaluation of Two Treatment Options in Myofascial Pain Transcutaneous Electrical Nerve Stimulation versus Trigger Point Injection. Voir source | 42411416 | 10.4103/aam.aam_369_26 | Annals of African medicine | |
| [Efficacy of electroacupuncture nerve stimulation therapy for interstitial cystitis/bladder pain syndrome]. Voir source | 31099215 | 10.13703/j.0255-2930.2019.05.003 | Zhongguo zhen jiu = Chinese acupuncture & moxibustion |
Sources officielles
liens de rechercheDernière mise à jour des données : 2026-09-28
Ces sources sont proposées pour vérification. Les informations de la fiche doivent être confirmées dans les registres officiels ou les publications originales.