Fiche traitement
Radiofrequency Ablation
Johns Hopkins University • Cancer, Parkinson
Suivi actif
Non applicable
Résumé
Radiofrequency Ablation est développé par Johns Hopkins University. Le traitement est actuellement en Non applicable. Il est associé à Cancer, Parkinson. Son objectif thérapeutique principal est À vérifier. Le statut actuel est : suivi actif.
À vérifier
À vérifier
Non applicable
Johns Hopkins University
United States
Traditionally, surgery has been the standard recommendation for treating papillary thyroid cancer. The risk of surgery including permanent hoarseness, permanent hypocalcemia, a mid-cervical scar, and the potential for permanent hypothyroidism may be unacceptable for some patients, especially with low risk papillary thyroid carcinoma. The recent American Thyroid Association guidelines have proposed the option of active surveillance with low risk papillary thyroid cancer less than 210 mm. However, most patients find observation anxiety provoking knowing of having cancer. Radiofrequency ablation (RFA) of small low risk papillary thyroid cancer is a promising therapeutic modality for these patients that reduces the risks associated with surgery and the anxiety of taking a watchful approach. However, this technique has not been validated in the North American population.
The investigators aim to describe the investigators' initial experience with RFA of low risk papillary thyroid microcarcinoma (PTMC) compared to active surveillance (AS) done by Head and Neck Endocrine surgeons at Johns Hopkins Medical Institute.
Primary objective:
* To evaluate the safety, efficacy and oncological outcomes of the procedure.
Secondary objective:
* To determine the patient functional outcomes in comparison to the observational control.
2025-01-28
Début phase actuelle
Non disponible dans les sources synchronisées
Timeline clinique
Non applicable
Début phase actuelle
Non disponible dans les sources synchronisées
Préclinique
Phase 1
Phase 2
Phase 3
Approuvé
Objectif scientifique de l’étude
classification automatique vérifiable
À vérifier
Confiance automatique : 0%
Ce pourcentage n’est pas une probabilité de succès clinique.
Il mesure uniquement la force de la classification automatique de l’objectif scientifique. Le calcul part de 45 points, ajoute 7 points par unité de poids du mot-clé le plus fortement détecté, puis est plafonné à 95 %. Exemple : un score maximal de 2 donne 45 + (2 × 7) = 59 %.
Ce score est heuristique et doit être vérifié dans le protocole ou une publication.
Description affichée depuis l’essai compatible NCT05132205, afin d’éviter le mélange entre plusieurs indications d’une même molécule.
Contrôle de cohérence : 85/100
L’objectif est absent ou classé « Autre » et doit être recalculé à partir du protocole.
Transparence et qualité de la fiche
données vérifiablesClassificationÀ vérifier
Confiance de la fiche85 %
Source principaleSource officielle ou publication indexée
Dernière vérification2025-01-28
Anomalies détectées1
Validation humaineValidation humaine non effectuée
Donnée issue d’une source
Donnée normalisée automatiquement
Interprétation algorithmique
Classification scientifique multi-axes
ne pas confondre statut et résultatÉtat de l’étudeTerminée
Disponibilité des résultatsRésultats à vérifier
InterprétationImpossible à déterminer
Niveau de preuveNon évaluable
Un essai terminé n’est pas nécessairement positif. Un essai arrêté n’est classé comme échec scientifique que lorsqu’un résultat ou une raison explicite le confirme.
Indicateurs factuels
sans score subjectifPhase enregistréeNon applicable
Études associées3
Publications associées17
Statut consolidéSuivi actif
Aucune chance de succès, note d’innovation, potentiel thérapeutique ou probabilité de commercialisation n’est calculé tant qu’un modèle validé et des données suffisantes ne sont pas disponibles.
Historique factuel de la molécule
27 événement(s) daté(s)Cette liste reprend uniquement les dates trouvées dans les registres et publications liés. Elle ne constitue pas une prévision.
| Date | Événement | Source |
|---|---|---|
| 2021-12-17 | Début de l’étudeNCT05132205 | Registre d’essai clinique |
| 2022-10-04 | Début de l’étudeNCT05580224 | Registre d’essai clinique |
| 2024-01-29 | Début de l’étudeNCT06553625 | Registre d’essai clinique |
| 2024-08-30 | Fin de l’étude prévue / enregistréeNCT05580224 | Registre d’essai clinique |
| 2024-11-19 | Fin de l’étude prévue / enregistréeNCT05132205 | Registre d’essai clinique |
| 2025-01-28 | Dernière mise à jour des donnéesRadiofrequency Ablation | Biomedical Watch |
| 2026-08-08 | PublicationEvidence-Based Patient Selection in Headache Surgery: Impact of Preoperative Radiofrequency Ablation on Surgical Outcomes. | Plastic and reconstructive surgery |
| 2026-08-08 | PublicationRight amygdala ablation reduces maladaptive negative interpretation bias and symptoms in a patient with post-traumatic stress disorder. | Nature communications |
| 2026-08-13 | PublicationPathophysiology, diagnosis, and management of discogenic low back pain: a phenotype-driven precision framework for surgical and interventional decision-making. | Frontiers in surgery |
| 2026-08-13 | PublicationBacterial Outer Membrane Vesicle-Based Versatile In Situ Nanovaccine Enhancer Synergized With Radiofrequency Ablation Against Hepatocellular Carcinoma. | Advanced healthcare materials |
| 2026-08-16 | Création de l’enregistrementNCT06553625 | Registre d’essai clinique |
| 2026-08-16 | PublicationManagement of a Hypoglossal Nerve, Upper Airway Stimulator in the Pain Patient: Safety Considerations. | Pain practice : the official journal of World Institute of Pain |
| 2026-08-16 | PublicationManagement of Recurrent Laryngeal Nerve Injury During Radiofrequency Ablation of Thyroid Nodules. | AACE clinical case reports |
| 2026-08-16 | PublicationL5-S1 basivertebral nerve ablation for chronic vertebrogenic low back pain following lumbar fusion: a case report. | Journal of spine surgery (Hong Kong) |
| 2026-08-16 | PublicationEndoscopic ultrasound-guided radiofrequency ablation of pancreatic insulinoma. | Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery |
| 2026-08-16 | PublicationEndoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA): Are We Getting Evidence-Based Results? A Systematic Review According to the Levels of Evidence. | Medicina (Kaunas, Lithuania) |
| 2026-08-16 | PublicationEndoscopic Ultrasound-Guided Radiofrequency Ablation for Pancreatic Metastases: Safety and Clinical Outcomes in a Single-Center Case Series. | Journal of clinical medicine |
| 2026-08-16 | PublicationAnalysis of Lesion Shrinkage and Factors Influencing Shrinkage Following Radiofrequency Ablation of Breast Nodules: An Observational Study. | Journal of investigative surgery : the official journal of the Academy of Surgical Research |
| 2026-08-16 | PublicationComparative efficacy and thyroid function effects of non-surgical treatments for benign thyroid nodules: a Bayesian network meta-analysis. | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group |
| 2026-08-16 | PublicationCryoablation versus radiofrequency ablation for hepatocellular carcinoma: a systematic review and meta-analysis. | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group |
| 2026-08-16 | PublicationRecent Development of Endo-hepatology. | DEN open |
| 2026-09-03 | PublicationIrreversible electroporation versus radiofrequency ablation for malignant hepatic tumor: A prospective single-center double-arm trial. | Journal of interventional medicine |
| 2026-09-27 | Création de l’enregistrementNCT05580224 | Registre d’essai clinique |
| 2026-11-08 | Création de l’enregistrementNCT05132205 | Registre d’essai clinique |
| 2026-11-08 | PublicationClinical evaluation of a novel multipoint radiofrequency ablation device to treat chronic rhinitis. | Laryngoscope investigative otolaryngology |
| 2026-11-08 | PublicationImpedance-Controlled Multipoint Radiofrequency Ablation for Chronic Rhinitis: A Randomized Controlled Trial. | International forum of allergy & rhinology |
| 2035-12-01 | Fin de l’étude prévue / enregistréeNCT06553625 | Registre d’essai clinique |
Début phase actuelle
Non disponible dans les sources synchronisées
Essais cliniques liés
3 essai(s)
Début phase actuelle
Non disponible dans les sources synchronisées
| NCT | Titre | Phase | Statut administratif | Pays | Sponsor |
|---|---|---|---|---|---|
| NCT05132205 | Radiofrequency Ablation of Papillary Thyroid Microcarcinoma | Non applicable | COMPLETED | United States | Johns Hopkins University |
| NCT05580224 | Anatomical Radiofrequency Ablation for Small Hepatocellular Carcinoma | Non applicable | UNKNOWN | South Korea | Seoul National University Hospital |
| NCT06553625 | Radiofrequency (RF) Ablation Prospective Outcomes Study for Central Nervous System - RAPID for CNS | À vérifier | RECRUITING | Germany, United Kingdom | Boston Scientific Corporation |
Publications liées
17 publication(s)Publications liées
17 publication(s)| Titre | PMID | DOI | Journal | Date |
|---|---|---|---|---|
| Clinical evaluation of a novel multipoint radiofrequency ablation device to treat chronic rhinitis. Voir source | 37090860 | 10.1002/lio2.1040 | Laryngoscope investigative otolaryngology | |
| Impedance-Controlled Multipoint Radiofrequency Ablation for Chronic Rhinitis: A Randomized Controlled Trial. Voir source | 41508908 | 10.1002/alr.70101 | International forum of allergy & rhinology | |
| Irreversible electroporation versus radiofrequency ablation for malignant hepatic tumor: A prospective single-center double-arm trial. Voir source | 35936662 | 10.1016/j.jimed.2022.03.010 | Journal of interventional medicine | |
| Management of a Hypoglossal Nerve, Upper Airway Stimulator in the Pain Patient: Safety Considerations. Voir source | 41794549 | 10.1111/papr.70141 | Pain practice : the official journal of World Institute of Pain | |
| Management of Recurrent Laryngeal Nerve Injury During Radiofrequency Ablation of Thyroid Nodules. Voir source | 35415225 | 10.1016/j.aace.2022.02.004 | AACE clinical case reports | |
| L5-S1 basivertebral nerve ablation for chronic vertebrogenic low back pain following lumbar fusion: a case report. Voir source | 42582823 | 10.21037/jss-2026-0097 | Journal of spine surgery (Hong Kong) | |
| Endoscopic ultrasound-guided radiofrequency ablation of pancreatic insulinoma. Voir source | 42417742 | 10.1590/0102-67202025000052e1921 | Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery | |
| Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA): Are We Getting Evidence-Based Results? A Systematic Review According to the Levels of Evidence. Voir source | 42512924 | 10.3390/medicina62071382 | Medicina (Kaunas, Lithuania) | |
| Endoscopic Ultrasound-Guided Radiofrequency Ablation for Pancreatic Metastases: Safety and Clinical Outcomes in a Single-Center Case Series. Voir source | 42589874 | 10.3390/jcm15155773 | Journal of clinical medicine | |
| Analysis of Lesion Shrinkage and Factors Influencing Shrinkage Following Radiofrequency Ablation of Breast Nodules: An Observational Study. Voir source | 42454750 | 10.1080/08941939.2026.2696115 | Journal of investigative surgery : the official journal of the Academy of Surgical Research | |
| Comparative efficacy and thyroid function effects of non-surgical treatments for benign thyroid nodules: a Bayesian network meta-analysis. Voir source | 42581826 | 10.1080/02656736.2026.2713764 | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group | |
| Cryoablation versus radiofrequency ablation for hepatocellular carcinoma: a systematic review and meta-analysis. Voir source | 42595456 | 10.1080/02656736.2026.2713200 | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group | |
| Recent Development of Endo-hepatology. Voir source | 42602295 | 10.1002/deo2.70404 | DEN open | |
| Pathophysiology, diagnosis, and management of discogenic low back pain: a phenotype-driven precision framework for surgical and interventional decision-making. Voir source | 42266214 | 10.3389/fsurg.2026.1787353 | Frontiers in surgery | |
| Bacterial Outer Membrane Vesicle-Based Versatile In Situ Nanovaccine Enhancer Synergized With Radiofrequency Ablation Against Hepatocellular Carcinoma. Voir source | 42590861 | 10.1002/adhm.71589 | Advanced healthcare materials | |
| Evidence-Based Patient Selection in Headache Surgery: Impact of Preoperative Radiofrequency Ablation on Surgical Outcomes. Voir source | 36728939 | 10.1097/PRS.0000000000010044 | Plastic and reconstructive surgery | |
| Right amygdala ablation reduces maladaptive negative interpretation bias and symptoms in a patient with post-traumatic stress disorder. Voir source | 42331801 | 10.1038/s41467-026-74099-5 | Nature communications |
Sources officielles
liens de rechercheDernière mise à jour des données : 2025-01-28
Ces sources sont proposées pour vérification. Les informations de la fiche doivent être confirmées dans les registres officiels ou les publications originales.