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Toutes les maladies
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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| SC291 NCT05878184 · Study Evaluating SC291 in Subjects With r/r B-cell Malignancies (ARDENT) | Sclérose en plaques | À vérifier | Phase 1 | ACTIVE_NOT_RECRUITING | SC291-101 is a Phase 1 study to evaluate SC291 safety and tolerability, an… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:14 | Détail |
| TCRαβ+/CD19+ depleted Hematopoietic stem cell (HSC) graft NCT04806347 · Alpha/Beta T-cell Depleted Blood-forming Stem Cell Transplant From Related or Un… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This study is being done to see if the investigators can take peripheral b… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:14 | Détail |
| Autologous CD4+T cells stimulated and expanded ex vivo by a MOG pepti… NCT02427776 · SCLEROLYM — A Trial for Evaluating Both Safety and Preliminary Efficacy of a Sin… | Sclérose en plaques | Immunomodulation | Phase 1/2 | TERMINATED | The purpose of this study is to assess the safety and the preliminary effi… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:12 | Détail |
| Autologous Mesenchymal Stem Cells NCT01895439 · Safety and Efficacy Study of Autologus Bone Marrow Mesenchymal Stem Cells in Mul… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | COMPLETED | 1. Expanding and priming Bone Marrow (BM)- Mesenchymal Stem Cells (MSCs) t… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:11 | Détail |
| Clemastine Fumarate Combined With Engineered Sound NCT07304024 · CAPD-LOOT — A Treatment for a Form of Age-Related Central Auditory Processing Di… | Sclérose en plaques | Remyélinisation | Phase 1/2 | RECRUITING | The goal of this clinical trial is to determine the efficacy of Clemastine… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:11 | Détail |
| Ifenprodil NCT06330077 · MODIF-MS — Ifenprodil as a ReMyelinating repurpOsed Drug in Multiple Sclerosis | Sclérose en plaques | Remyélinisation · Remyélinisation indirecte / réparation · Ralentissement de la… | Phase 2 | NOT_YET_RECRUITING | Multiple sclerosis (MS) is the most frequently acquired demyelinating dise… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:11 | Détail |
| Metformin Hydrochloride 850 mg Oral Tablet NCT05893225 · Metformin Add-on Clinical Study in Multiple Sclerosis to Evaluate Brain Remyelin… | Sclérose en plaques | Remyélinisation · Ralentissement de la progression | Phase 2 | ACTIVE_NOT_RECRUITING | This clinical trial aims to demonstrate that metformin can prevent clinica… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:11 | Détail |
| Phenytoin NCT01451593 · Neuroprotection With Phenytoin in Optic Neuritis | Sclérose en plaques | Neuroprotection · Immunomodulation | Phase 2 | COMPLETED | Optic neuritis is caused by inflammation of the optic nerve and causes los… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:11 | Détail |
| CYB704 NCT06847724 · Comparative PK, PD, Efficacy, and Safety Assessment of the Proposed Ocrelizumab… | Sclérose en plaques | Thérapie génique | Phase 3 | ACTIVE_NOT_RECRUITING | The goal of this clinical trial is to learn if drug CYB704, a proposed bio… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:06 | Détail |
| Ocrelizumab NCT03562975 · Upper Extremity Function in Multiple Sclerosis Patients With Advanced Disability… | Sclérose en plaques | Ralentissement de la progression | À vérifier | COMPLETED | A study to evaluate the efficacy and safety of fenebrutinib on disability… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:06 | Détail |
| BIIB017 (peginterferon beta-1a) NCT03958877 · A Study to Evaluate the Safety, Tolerability, and Efficacy of BIIB017 (Peginterf… | Sclérose en plaques | À vérifier | Phase 3 | ACTIVE_NOT_RECRUITING | This study will evaluate the safety, tolerability, and descriptive efficac… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:05 | Détail |
| Cannabidiol Oil NCT07840924 · The CanISleepinMS Study: Effect of Cannabidiol (CBD) on Sleep Quality in Patient… | Sclérose en plaques | À vérifier | Phase 2 | COMPLETED | Evaluating the effect of 300 mg purified cannabidiol (CBD) on sleep qualit… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:05 | Détail |
| Intrathecal MSC-NP injection NCT03822858 · Expanded Access to Intrathecal Administration of Autologous Mesenchymal Stem Cel… | Sclérose en plaques | Thérapie cellulaire | À vérifier | NO_LONGER_AVAILABLE | To give expanded access to intrathecal autologous MSC-NP treatment to pati… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:05 | Détail |
| Keeogo NCT05835622 · EXHOMESEP — Clinical Investigation of the Quality of Life Benefit of Using a Hom… | Sclérose en plaques | À vérifier | Non applicable | COMPLETED | The goal of this clinical investigation is to evaluate the effectiveness o… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:05 | Détail |
| LY3541860 NCT06220669 · A Study of LY3541860 in Adult Participants With Relapsing Multiple Sclerosis | Sclérose en plaques | À vérifier | Phase 2 | TERMINATED | The main purpose of this study is to evaluate the safety and efficacy of L… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:05 | Détail |
| SUN-627 NCT07840326 · A Phase 2a Study of SUN-627 in Participants With Non-Active Secondary Progressiv… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | The goal of this Phase 2 clinical trial is to investigate the safety and t… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:05 | Détail |
| TMS NCT07842302 · NIBS_MSf — Fighting Fatigue in Multiple Sclerosis: TMS vs. tDCS Efficacy. | Sclérose en plaques | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Multiple Sclerosis (MS) is a chronic neurological disease impacting 2.8 mi… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:05 | Détail |
| Ocrelizumab NCT03599245 · This is an Extension Study of the Roche P-trials to Investigate Safety and Effec… | Sclérose en plaques | Ralentissement de la progression | Phase 3 | COMPLETED | A study to evaluate the efficacy and safety of fenebrutinib on disability… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:04 | Détail |
| Lymphodepleting Chemotherapy Étude non communiquée | Lupus | Immunomodulation · Thérapie cellulaire | Phase 1 | Actif | This study is evaluating the safety and potential benefits of CD19 chimeri… À vérifier | ClinicalTrials.gov 2026-09-27 | Détail |
| KPG-818 high dose in phase 1b Étude non communiquée | Lupus | À vérifier | Phase 1/2 | Terminé | The clinical trial is titled "A Phase 1b/2a Multicenter Study to Assess th… À vérifier | ClinicalTrials.gov 2026-09-26 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Effects of continuous vs. intermittent transcutaneous electrical stim… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 41866984 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source To compare the effects of two transcutaneous electrical stimulation (TES) patterns applied to the auricular branches of… | Cranio : the journal of craniomandibular practice 2026-11-08 04:38:07 | Source |
| Optimizing Percutaneous Tibial Nerve Stimulation Intensity for Overac… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42554545 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source Overactive bladder (OAB) is a significant global health issue. The standard percutaneous tibial nerve stimulation (PTNS… | Neuromodulation : journal of the International Neuromo… 2026-11-08 04:38:07 | Source |
| Transcutaneous auricular vagus nerve stimulation improves dysautonomi… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42802247 | Maladie rénale chronique | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Autonomic nervous system dysfunction is highly prevalent in hypermobile Ehlers-Danlos syndrome (hEDS) and contributes s… | Neurological sciences : official journal of the Italia… 2026-11-08 04:38:07 | Source |
| Factors associated with high-flow therapy failure in COVID-19-related… Non-Invasive Positive Pressure Ventilation · PMID 42888091 | Maladie rénale chronique | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source The optimal selection of non-invasive respiratory support for patients with COVID-19-related acute hypoxemic respirator… | Enfermedades infecciosas y microbiologia clinica (Engl… 2026-11-08 04:38:06 | Source |
| High-Flow Nasal Cannula in Adult Acute Care: Physiological Mechanisms… Non-Invasive Positive Pressure Ventilation · PMID 42942512 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source High-flow nasal cannula (HFNC) oxygen therapy is widely used in emergency, intensive care, perioperative, and procedura… | Medicina (Kaunas, Lithuania) 2026-11-08 04:38:06 | Source |
| Impact of respiratory support on time to achieve full oral feeding in… Non-Invasive Positive Pressure Ventilation · PMID 42871336 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source Very low birth weight infants often require respiratory support, which may delay full oral feeding. The independent rol… | Frontiers in pediatrics 2026-11-08 04:38:06 | Source |
| A comparative analysis of 3MAX aspiration versus 3 mm Trevo Retriever… Thromboaspiration catheter · PMID 31243066 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Although aspiration and stent retriever thrombectomy perform similarly in proximal occlusions, no comparative series ar… | Journal of neurointerventional surgery 2026-11-08 04:38:02 | Source |
| Percutaneous Pulmonary Thrombectomy Beyond Acute Pulmonary Embolism:… Thromboaspiration catheter · PMID 38385241 | Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Subacute massive pulmonary embolism is an uncommon manifestation of severe pulmonary embolism associated with poor prog… | Journal of endovascular therapy : an official journal… 2026-11-08 04:38:02 | Source |
| Simplified classification of cavernous internal carotid artery tortuo… Thromboaspiration catheter · PMID 35475775 | Hypertension artérielle · Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Thromboaspiration catheters are increasingly used for the endovascular treatment of large vessel stroke (LVS), while to… | Neurological research 2026-11-08 04:38:02 | Source |
| Multifocal continuous theta burst stimulation in idiopathic generaliz… Continuous Theta Burst Stimulation (cTBS) · PMID 42731195 | Accident vasculaire cérébral | Traitement symptomatique | Publication | PubMed | Voir la publication source Idiopathic generalized epilepsy (IGE) is a disorder of the cortico-subcortical networks. Continuous theta burst stimula… | Clinical neurophysiology : official journal of the Int… 2026-11-08 04:38:00 | Source |
| Optimizing brain functional-structural architecture with cTBS to redu… Continuous Theta Burst Stimulation (cTBS) · PMID 42457860 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Alcohol use disorder (AUD) is characterized by high relapse rates, necessitating novel interventions. Continuous theta-… | Molecular psychiatry 2026-11-08 04:38:00 | Source |
| Digital Outreach to Improve Statin Refills in Patients With Low Stati… Cordio System · PMID 42667613 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Statin nonadherence is a leading, addressable driver of preventable cardiovascular events. Although health systems rout… | JAMA 2026-11-08 04:37:54 | Source |
| Endovascular ablation of the right greater splanchnic nerve for the m… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42257781 | Insuffisance cardiaque | Traitement symptomatique | Publication | PubMed | Voir la publication source Heart failure with preserved ejection fraction (HFpEF) remains difficult to manage because conventional therapies often… | The Egyptian heart journal : (EHJ) : official bulletin… 2026-11-08 04:37:54 | Source |
| Incidence, medical therapy, and outcomes in heart failure with improv… Cordio System · PMID 42702264 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source To assess the incidence of heart failure with improved ejection fraction (HFimpEF) across guideline definitions (ACC/AH… | American heart journal 2026-11-08 04:37:54 | Source |
| Relationship Between the Azygos Vein and the Greater Splanchnic Nerve… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42249803 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Although ablation of the greater splanchnic nerve is now being used to treat some patients with heart failure, the anat… | Clinical anatomy (New York, N.Y.) 2026-11-08 04:37:54 | Source |
| Validation of the PREVENT-HF Risk Prediction Equation in US Veterans. Cordio System · PMID 42969140 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Circulation 2026-11-08 04:37:54 | Source |
| Changes in right ventricular-pulmonary artery coupling after transcat… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42822601 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Right ventricular-pulmonary artery (RV-PA) coupling is an established marker of prognosis in mitral regurgitation (MR),… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Intraprocedural evaluation of residual mitral and tricuspid regurgita… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42982241 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Transcatheter edge-to-edge repair (TEER) has emerged as an established therapeutic option for selected patients with se… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Tricuspid transcatheter edge-to-edge repair versus transcatheter tric… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42989943 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Recent clinical studies of tricuspid transcatheter edge-to-edge repair (T-TEER) and transcatheter tricuspid valve repla… | Current opinion in cardiology 2026-11-08 04:37:47 | Source |
| Automated Production of Gene-Edited CAR-T Cells for People Living wit… RAPA-501 Autologous T stem cells · PMID 42847201 | Cancer | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source Adoptive transfer of gene-modified autologous T cells, for example, expressing chimeric antigen receptors (CARs), is a… | Human gene therapy 2026-11-08 04:37:39 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||