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Périmètre
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10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 68Ga-NNS309 NCT07261631 · Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid Tumors | Cancer | À vérifier | Phase 1 | RECRUITING | The purpose of this study is to evaluate the safety, tolerability, dosimet… À vérifier | ClinicalTrials.gov 2026-10-11 04:36:52 | Détail |
| Biospecimen Collection NCT04269902 · Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia… | Cancer | À vérifier | Phase 3 | RECRUITING | This phase III trial compares standard of care hormone therapy plus riboci… À vérifier | ClinicalTrials.gov 2026-10-11 04:36:52 | Détail |
| Ponatinib NCT03934372 · Safety and Efficacy of Ponatinib for Treatment of Pediatric Recurrent or Refract… | Cancer | À vérifier | Phase 1/2 | RECRUITING | The purpose of this study is to evaluate the safety, tolerability, pharmac… À vérifier | ClinicalTrials.gov 2026-10-11 04:36:52 | Détail |
| azacytidine NCT06694454 · Neoadjuvant Inhaled Azacytidine With Platinum-Based Chemotherapy and Durvalumab… | Cancer | À vérifier | Phase 1/2 | SUSPENDED | Background: Lung cancer is the leading cause of cancer-related death world… À vérifier | ClinicalTrials.gov 2026-10-11 04:36:51 | Détail |
| Calderasib NCT07554339 · A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small… | Cancer | Ralentissement de la progression | Phase 3 | RECRUITING | This is a study evaluating the efficacy and safety of calderasib with pemb… À vérifier | ClinicalTrials.gov 2026-10-11 04:36:51 | Détail |
| Glycerol Tributyrate NCT06792500 · A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochon… | Migraine | Remyélinisation · Remyélinisation indirecte / réparation · Traitement symptomat… | Phase 1/2 | NOT_YET_RECRUITING | This is a parallel arm non-randomized dose-escalation, open-label basket e… À vérifier | ClinicalTrials.gov 2026-10-11 04:36:37 | Détail |
| intranasal zavegepant NCT07861412 · A Prospective Interventional Study of Intranasal Zavegepant for the Acute Treatm… | Migraine | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Primary Objective: To evaluate the effectiveness of zavegepant in real-wor… À vérifier | ClinicalTrials.gov 2026-10-11 04:36:37 | Détail |
| Low-Intensity Focused Ultrasound Stimulation NCT07857109 · Low-Intensity Focused Ultrasound Targeting the Dorsolateral Prefrontal Cortex fo… | Migraine | Ralentissement de la progression | Non applicable | NOT_YET_RECRUITING | Chronic migraine is a disabling neurological disorder characterized by fre… À vérifier | ClinicalTrials.gov 2026-10-11 04:36:37 | Détail |
| Oral metoclopramide and ibuprofen NCT05983354 · Oral Medications for the Management of Acute Migraine Headache in the Emergency… | Migraine | Traitement symptomatique | Non applicable | WITHDRAWN | The goal of this pilot randomized control trial is to assess the feasibili… À vérifier | ClinicalTrials.gov 2026-10-11 04:36:37 | Détail |
| Lidocaine 2% and Methylprednisolone 80 mg NCT07568496 · GONB_MOH — Greater Occipital Nerve Block for Migraine With Medication Overuse He… | Migraine | Ralentissement de la progression · Traitement symptomatique | Non applicable | RECRUITING | Migraine is among the leading causes of disability worldwide. Inappropriat… À vérifier | ClinicalTrials.gov 2026-10-11 04:36:36 | Détail |
| MTrPs Injection NCT07347028 · Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of… | Migraine | Traitement symptomatique · Thérapie génique | Non applicable | RECRUITING | Chronic musculoskeletal pain (CMP) is a common disease in China, with a hi… À vérifier | ClinicalTrials.gov 2026-10-11 04:36:36 | Détail |
| Prasugrel 5mg NCT07629635 · COMFORT-PFO — Migraine Headaches Elimination With Patent Foramen Ovale-Directed… | Migraine | À vérifier | Phase 3 | RECRUITING | Migraine is a common and often disabling condition, but its exact causes a… À vérifier | ClinicalTrials.gov 2026-10-11 04:36:36 | Détail |
| 1 Hypercapnic challenge while participant is awake NCT07249034 · BRAVE — Impact of Epilepsy on the Brainstem Adenosine Pathway and Its Relation W… | Épilepsie | Thérapie génique | Non applicable | RECRUITING | Despite the continuous development of new antiseizure medications over the… À vérifier | ClinicalTrials.gov 2026-10-11 04:36:33 | Détail |
| Byteflies Remote patient monitoring solution (with reduced EEG) NCT07225231 · TETRIS — Clinical Utility of Reduced EEG Home Monitoring in Fenfluramine Titrati… | Épilepsie | À vérifier | Non applicable | ENROLLING_BY_INVITATION | The goal of this real world data study is to evaluate the clinical utility… À vérifier | ClinicalTrials.gov 2026-10-11 04:36:33 | Détail |
| High Intensity Focused Ultrasound NCT03417297 · A Pilot Study: Focused Ultrasound Thalamotomy for the Prevention of Secondary Ge… | Épilepsie | Traitement symptomatique | Non applicable | ACTIVE_NOT_RECRUITING | This study is to confirm the safety and technical of MRI guided High Inten… À vérifier | ClinicalTrials.gov 2026-10-11 04:36:33 | Détail |
| MRI NCT02107989 · Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establis… | Épilepsie | Remyélinisation · Thérapie génique | À vérifier | RECRUITING | The cognitive disorders of adult forms of myotonic dystrophies type 1 are… À vérifier | ClinicalTrials.gov 2026-10-11 04:36:33 | Détail |
| Personalized Adaptive Deep Brain Stimulation Therapy NCT07568860 · ADAPT LGS — Sleep-Driven Adaptive Neuromodulation in Lennox-Gastaut Syndrome | Épilepsie | À vérifier | Non applicable | NOT_YET_RECRUITING | The goal of this clinical trial is to explore a new type of personalized b… À vérifier | ClinicalTrials.gov 2026-10-11 04:36:33 | Détail |
| Cannabidiol Oral Solution NCT05803434 · CBD_RE — Cannabidiol in Children and Young Adults With Rare Disease-associated S… | Épilepsie | Thérapie génique | Phase 2 | ACTIVE_NOT_RECRUITING | This is a Phase 3b/Phase 4 study. The purpose of this study is to learn mo… À vérifier | ClinicalTrials.gov 2026-10-11 04:36:32 | Détail |
| Cenobamate (tablet) for 12 to < 18 year olds NCT07594158 · A Study to Evaluate the Safety, Efficacy, and PK of ONO-2017 in Japanese Patient… | Épilepsie | À vérifier | Phase 3 | RECRUITING | Primary objective: To evaluate the safety and tolerability of cenobamate i… À vérifier | ClinicalTrials.gov 2026-10-11 04:36:32 | Détail |
| Clemizole HCl NCT05066217 · An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Sy… | Épilepsie | À vérifier | Phase 3 | RECRUITING | This is a multicenter, Phase 3, randomized, double-blind, placebo-controll… À vérifier | ClinicalTrials.gov 2026-10-11 04:36:32 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Effects of continuous vs. intermittent transcutaneous electrical stim… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 41866984 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source To compare the effects of two transcutaneous electrical stimulation (TES) patterns applied to the auricular branches of… | Cranio : the journal of craniomandibular practice 2026-11-08 04:38:07 | Source |
| Optimizing Percutaneous Tibial Nerve Stimulation Intensity for Overac… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42554545 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source Overactive bladder (OAB) is a significant global health issue. The standard percutaneous tibial nerve stimulation (PTNS… | Neuromodulation : journal of the International Neuromo… 2026-11-08 04:38:07 | Source |
| Transcutaneous auricular vagus nerve stimulation improves dysautonomi… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42802247 | Maladie rénale chronique | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Autonomic nervous system dysfunction is highly prevalent in hypermobile Ehlers-Danlos syndrome (hEDS) and contributes s… | Neurological sciences : official journal of the Italia… 2026-11-08 04:38:07 | Source |
| Factors associated with high-flow therapy failure in COVID-19-related… Non-Invasive Positive Pressure Ventilation · PMID 42888091 | Maladie rénale chronique | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source The optimal selection of non-invasive respiratory support for patients with COVID-19-related acute hypoxemic respirator… | Enfermedades infecciosas y microbiologia clinica (Engl… 2026-11-08 04:38:06 | Source |
| High-Flow Nasal Cannula in Adult Acute Care: Physiological Mechanisms… Non-Invasive Positive Pressure Ventilation · PMID 42942512 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source High-flow nasal cannula (HFNC) oxygen therapy is widely used in emergency, intensive care, perioperative, and procedura… | Medicina (Kaunas, Lithuania) 2026-11-08 04:38:06 | Source |
| Impact of respiratory support on time to achieve full oral feeding in… Non-Invasive Positive Pressure Ventilation · PMID 42871336 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source Very low birth weight infants often require respiratory support, which may delay full oral feeding. The independent rol… | Frontiers in pediatrics 2026-11-08 04:38:06 | Source |
| A comparative analysis of 3MAX aspiration versus 3 mm Trevo Retriever… Thromboaspiration catheter · PMID 31243066 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Although aspiration and stent retriever thrombectomy perform similarly in proximal occlusions, no comparative series ar… | Journal of neurointerventional surgery 2026-11-08 04:38:02 | Source |
| Percutaneous Pulmonary Thrombectomy Beyond Acute Pulmonary Embolism:… Thromboaspiration catheter · PMID 38385241 | Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Subacute massive pulmonary embolism is an uncommon manifestation of severe pulmonary embolism associated with poor prog… | Journal of endovascular therapy : an official journal… 2026-11-08 04:38:02 | Source |
| Simplified classification of cavernous internal carotid artery tortuo… Thromboaspiration catheter · PMID 35475775 | Hypertension artérielle · Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Thromboaspiration catheters are increasingly used for the endovascular treatment of large vessel stroke (LVS), while to… | Neurological research 2026-11-08 04:38:02 | Source |
| Multifocal continuous theta burst stimulation in idiopathic generaliz… Continuous Theta Burst Stimulation (cTBS) · PMID 42731195 | Accident vasculaire cérébral | Traitement symptomatique | Publication | PubMed | Voir la publication source Idiopathic generalized epilepsy (IGE) is a disorder of the cortico-subcortical networks. Continuous theta burst stimula… | Clinical neurophysiology : official journal of the Int… 2026-11-08 04:38:00 | Source |
| Optimizing brain functional-structural architecture with cTBS to redu… Continuous Theta Burst Stimulation (cTBS) · PMID 42457860 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Alcohol use disorder (AUD) is characterized by high relapse rates, necessitating novel interventions. Continuous theta-… | Molecular psychiatry 2026-11-08 04:38:00 | Source |
| Digital Outreach to Improve Statin Refills in Patients With Low Stati… Cordio System · PMID 42667613 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Statin nonadherence is a leading, addressable driver of preventable cardiovascular events. Although health systems rout… | JAMA 2026-11-08 04:37:54 | Source |
| Endovascular ablation of the right greater splanchnic nerve for the m… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42257781 | Insuffisance cardiaque | Traitement symptomatique | Publication | PubMed | Voir la publication source Heart failure with preserved ejection fraction (HFpEF) remains difficult to manage because conventional therapies often… | The Egyptian heart journal : (EHJ) : official bulletin… 2026-11-08 04:37:54 | Source |
| Incidence, medical therapy, and outcomes in heart failure with improv… Cordio System · PMID 42702264 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source To assess the incidence of heart failure with improved ejection fraction (HFimpEF) across guideline definitions (ACC/AH… | American heart journal 2026-11-08 04:37:54 | Source |
| Relationship Between the Azygos Vein and the Greater Splanchnic Nerve… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42249803 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Although ablation of the greater splanchnic nerve is now being used to treat some patients with heart failure, the anat… | Clinical anatomy (New York, N.Y.) 2026-11-08 04:37:54 | Source |
| Validation of the PREVENT-HF Risk Prediction Equation in US Veterans. Cordio System · PMID 42969140 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Circulation 2026-11-08 04:37:54 | Source |
| Changes in right ventricular-pulmonary artery coupling after transcat… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42822601 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Right ventricular-pulmonary artery (RV-PA) coupling is an established marker of prognosis in mitral regurgitation (MR),… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Intraprocedural evaluation of residual mitral and tricuspid regurgita… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42982241 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Transcatheter edge-to-edge repair (TEER) has emerged as an established therapeutic option for selected patients with se… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Tricuspid transcatheter edge-to-edge repair versus transcatheter tric… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42989943 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Recent clinical studies of tricuspid transcatheter edge-to-edge repair (T-TEER) and transcatheter tricuspid valve repla… | Current opinion in cardiology 2026-11-08 04:37:47 | Source |
| Automated Production of Gene-Edited CAR-T Cells for People Living wit… RAPA-501 Autologous T stem cells · PMID 42847201 | Cancer | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source Adoptive transfer of gene-modified autologous T cells, for example, expressing chimeric antigen receptors (CARs), is a… | Human gene therapy 2026-11-08 04:37:39 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||