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Toutes les maladies
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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| active tDCS NCT02315781 · tDCS in Parkinson's Disease With Depression | Maladie de Parkinson | À vérifier | NA | TERMINATED | Parkinson's disease (PD) is a progressive neurological disease that has ef… À vérifier | ClinicalTrials.gov 2026-07-12 19:40:00 | Détail |
| CJH1 (CLR4001) NCT01684475 · A STUDY TO EVALUATE THE EFFICACY OF CJH1 (CLR4001) IN PARKINSON'S DISEASE | Maladie de Parkinson | Traitement symptomatique | Phase 1 | UNKNOWN | The purpose of this study is to assess the ability of CJH1 to increase the… À vérifier | ClinicalTrials.gov 2026-07-12 19:40:00 | Détail |
| Exploratory Open Label Study for Development of a Method To Detect De… NCT05482867 · NCT05482867 | Maladie d’Alzheimer | À vérifier | À vérifier | COMPLETED | This is a proof-of-concept study designed to confirm that human phagocytic… À vérifier | ClinicalTrials.gov 2026-07-12 19:40:00 | Détail |
| Metabolic Cofactor Supplementation NCT04044131 · Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's D… | Maladie de Parkinson | Remyélinisation · Remyélinisation indirecte / réparation | Phase 2 | COMPLETED | This double-blind, randomized, placebo-controlled, investigator-initiated,… À vérifier | ClinicalTrials.gov 2026-07-12 19:40:00 | Détail |
| Non Invasive Neuromodulation for Patients With Motor Control Disorders NCT04017481 · NCT04017481 | Maladie de Parkinson | À vérifier | NA | COMPLETED | Movement disorders are neurological syndromes leading to excessive movemen… À vérifier | ClinicalTrials.gov 2026-07-12 19:40:00 | Détail |
| Pathways Mediating Impaired Postural Control in Parkinson's Disease NCT06464029 · NCT06464029 | Maladie de Parkinson | Ralentissement de la progression | À vérifier | RECRUITING | The purpose of this project is to use transcranial magnetic stimulation (T… À vérifier | ClinicalTrials.gov 2026-07-12 19:40:00 | Détail |
| Perindopril NCT02085265 · Telmisartan vs. Perindopril in Mild-Moderate Alzheimer's Disease Patients | Maladie d’Alzheimer | À vérifier | Phase 2 | TERMINATED | To conduct a proof of concept study in patients with mild to moderate Alzh… À vérifier | ClinicalTrials.gov 2026-07-12 19:40:00 | Détail |
| SHARE(D) Stage II: Alzheimer's Risk Disclosure Protocol Piloting NCT04309500 · NCT04309500 | Maladie d’Alzheimer | À vérifier | NA | COMPLETED | The goal of this study is to test efficacy and safety of person-centered,… À vérifier | ClinicalTrials.gov 2026-07-12 19:40:00 | Détail |
| The MapHabit system (MHS) NCT05422339 · Efficacy of Gamification in Enhancing User Engagement | Maladie d’Alzheimer | À vérifier | NA | COMPLETED | As part of Phase II of the NIH SBIR grant, the study will conduct a random… À vérifier | ClinicalTrials.gov 2026-07-12 19:40:00 | Détail |
| GNbAC1 NCT03574428 · Single Ascending Doses Study With GNbAC1 in Healthy Male Volunteers | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The monoclonal antibody GNbAC1 targets the envelope protein (Env) of the h… À vérifier | ClinicalTrials.gov 2026-07-12 19:39:59 | Détail |
| Temelimab 18 mg/kg NCT04480307 · ProTEct-MS — Clinical Trial Assessing Temelimab Following Rituximab Treatment in… | Sclérose en plaques | À vérifier | Phase 2 | COMPLETED | This Phase II study is a monocenter, long-term extension study of study GN… À vérifier | ClinicalTrials.gov 2026-07-12 19:39:59 | Détail |
| gold nanocrystals NCT03993171 · REPAIR-MS — 31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neurona… | Sclérose en plaques | Remyélinisation · Remyélinisation indirecte / réparation · Neuroprotection | Phase 2 | COMPLETED | REPAIR-MS is a single-center open label, sequential group, investigator an… À vérifier | ClinicalTrials.gov 2026-07-12 19:39:56 | Détail |
| A Reeducation Program to Effort to Improve the Walking of Multiple Sc… NCT02874677 · NCT02874677 | Sclérose en plaques | Ralentissement de la progression · Traitement symptomatique | NA | TERMINATED | Multiple sclerosis (MS) is a disease affecting the white matter of the cen… À vérifier | ClinicalTrials.gov 2026-07-12 19:39:55 | Détail |
| GLPG1690 NCT03798366 · A Clinical Study to Test How Effective and Safe GLPG1690 is for Participants Wit… | Sclérose en plaques | Ralentissement de la progression | Phase 2 | COMPLETED | The main purpose of the study is to see if GLPG1690 helps (together with t… À vérifier | ClinicalTrials.gov 2026-07-12 19:39:55 | Détail |
| Immunoglobulin Deficiency a Treatable Cause of Fatigue in Patients Wi… NCT05357781 · NCT05357781 | Sclérose en plaques | Traitement symptomatique | À vérifier | RECRUITING | The investigators hypothesize that hypogammaglobulinemia (defined as IgG s… À vérifier | ClinicalTrials.gov 2026-07-12 19:39:55 | Détail |
| Platelet transfusion NCT02601131 · Post-transfusion Platelet Count | Sclérose en plaques | À vérifier | À vérifier | COMPLETED | The purpose of this study is to identify how the platelet count, complemen… À vérifier | ClinicalTrials.gov 2026-07-12 19:39:55 | Détail |
| Sham Transcranial direct current stimulation NCT02538094 · tDCS and Cognition in Adults With Multiple Sclerosis or Encephalitis | Sclérose en plaques | À vérifier | NA | COMPLETED | This research is being done to determine whether transcranial direct curre… À vérifier | ClinicalTrials.gov 2026-07-12 19:39:55 | Détail |
| Abatacept Injection [Orencia] and Proleukin (aldesleukin) NCT06307301 · Study in ALS With Abatacept & IL-2 | Sclérose latérale amyotrophique | Ralentissement de la progression | Phase 1 | COMPLETED | Description non affichée : incohérence de maladie détectée. Consultez l’es… À vérifier | ClinicalTrials.gov 2026-07-10 00:13:42 | Détail |
| Circulating Biomarker for Amyotrophic Lateral Sclerosis (ALS) NCT03088839 · NCT03088839 | Sclérose latérale amyotrophique | Ralentissement de la progression | À vérifier | UNKNOWN | Description non affichée : incohérence de maladie détectée. Consultez l’es… À vérifier | ClinicalTrials.gov 2026-07-10 00:13:42 | Détail |
| Human Allogeneic Induced Pluripotent Stem Cells (iPSCs) -Derived Moto… NCT07118319 · The Safety, Tolerability and Preliminary Efficacy of Derived Motor Neuron Progen… | Sclérose latérale amyotrophique | Thérapie cellulaire | Phase 1 | RECRUITING | Description non affichée : incohérence de maladie détectée. Consultez l’es… À vérifier | ClinicalTrials.gov 2026-07-10 00:13:42 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Effects of testosterone-augmented multimodal exercise intervention in… Whole-body Electrical Muscle Stimulation Exercise · PMID 41988780 | Myasthénie | À vérifier | Publication | PubMed | Voir la publication source Spinal cord injury (SCI) leads to profound muscle atrophy, aerobic deconditioning, and metabolic dysfunction. Exercise-… | The Journal of clinical endocrinology and metabolism 2026-09-20 04:37:05 | Source |
| Feasibility and acceptability of whole-body electromyostimulation in… Whole-body Electrical Muscle Stimulation Exercise · PMID 42464389 | Myasthénie | À vérifier | Publication | PubMed | Voir la publication source Evidence on the effectiveness of electromyostimulation (EMS) has been reported in pulmonary rehabilitation, but the ben… | Pilot and feasibility studies 2026-09-20 04:37:05 | Source |
| Vestibular contributions adapt to the balance strategies adopted duri… Whole-body Electrical Muscle Stimulation Exercise · PMID 42616645 | Myasthénie | À vérifier | Publication | PubMed | Voir la publication source Vestibular contributions during walking are not uniform, but vary with gait phase, muscle group, and balance demands. M… | Journal of neurophysiology 2026-09-20 04:37:05 | Source |
| Clinical efficacy of abdominal moxibustion at the Zhongji (CV3) in co… Yangyin Roujin Decoction · PMID 42015783 | Myopathies | Neuroprotection · Traitement symptomatique | Publication | PubMed | Voir la publication source To investigate the clinical effect of abdominal moxibustion at the Zhongji (CV3) combined with Yiqi Tonglin Yangyin dec… | Journal of traditional Chinese medicine = Chung i tsa… 2026-09-20 04:37:03 | Source |
| Yiqi Huoxue Yangyin Decoction Ameliorates Diabetic Nephropathy by Tar… Yangyin Roujin Decoction · PMID 42713045 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source This study aimed to investigate the protective effects and underlying mechanisms of Yiqi Huoxue Yangyin Decoction (YHY)… | Diabetes, metabolic syndrome and obesity : targets and… 2026-09-20 04:37:03 | Source |
| Yiqi Huoxue Yangyin Decoction attenuates diabetic nephropathy in mice… Yangyin Roujin Decoction · PMID 42016924 | Myopathies | Thérapie génique | Publication | PubMed | Voir la publication source Diabetic nephropathy (DN) is a major complication of diabetes with limited therapeutic options. Yiqi Huoxue Yangyin Dec… | Frontiers in pharmacology 2026-09-20 04:37:03 | Source |
| Barcoded oligonucleotide system (BOLT) for targeted organ delivery. Immunotherapy · PMID 42733790 | Cancer | À vérifier | Publication | PubMed | Voir la publication source The therapeutic potential of oligonucleotides (oligos) is limited by insufficient delivery to extrahepatic tissues. In… | Bioactive materials 2026-09-20 04:36:56 | Source |
| Dual metabolic checkpoint blockade a 3D-Printed metalloplatform remod… Immunotherapy · PMID 42724565 | Cancer | Immunomodulation | Publication | PubMed | Voir la publication source The immunosuppressive tumor microenvironment limits the efficacy of therapies that target metabolism. Here we show a st… | Bioactive materials 2026-09-20 04:36:56 | Source |
| Oligosaccharide adjuvant-deferred antigen endocytosis promotes cross-… Immunotherapy · PMID 42751513 | Cancer | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Antigen cross-presentation by dendritic cells (DCs) is essential for inducing cytotoxic immune responses, which are cru… | Bioactive materials 2026-09-20 04:36:56 | Source |
| Feasibility and safety of early discharge after robot-assisted uro-on… Digital care pathway for hypertension · PMID 42671715 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Early discharge after robot-assisted uro-oncologic surgery remains limited by concerns regarding patient safety and the… | Journal of robotic surgery 2026-09-20 04:36:49 | Source |
| HomeSafe: Postpartum Hypertensive Care Enabled by Electronic Health R… Digital care pathway for hypertension · PMID 41707683 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source The objective is to present stepwise refinements to , an Epic-tethered, population-health-coordinated postpartum pathwa… | American journal of perinatology 2026-09-20 04:36:49 | Source |
| Nutraceutical and functional food: efficacy against metabolic disorde… Digital care pathway for hypertension · PMID 42603698 | Hypertension artérielle | Neuroprotection · Immunomodulation | Publication | PubMed | Voir la publication source The growing global emphasis on health consciousness has significantly increased demand for traditional and complementar… | Journal of advanced research 2026-09-20 04:36:49 | Source |
| Community-engaged design of a virtual diabetes prevention program int… Asynchronous communication with nurse · PMID 42288862 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source The Diabetes Prevention Program (DPP) is an evidence-based approach to prevent Type 2 Diabetes (T2D), the leading cause… | BMC health services research 2026-09-20 04:36:48 | Source |
| Evolving Lung Cancer Navigator Practice Through Targeted Professional… Asynchronous communication with nurse · PMID 42463006 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Lung cancer remains the leading cause of cancer deaths worldwide, and it has persistent disparities in detection, treat… | Chest 2026-09-20 04:36:48 | Source |
| Mass casualty training for prehospital and emergency providers in Kig… Asynchronous communication with nurse · PMID 42751142 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source A mass casualty incident (MCI) occurs when the number of patients exceeds available healthcare resources, placing signi… | African journal of emergency medicine : Revue africain… 2026-09-20 04:36:48 | Source |
| Innovating a Teach-Back Model for Community Health Workers Led Health… Health Literacy Project · PMID 40194526 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source From 2021 to 2023, the City of Albuquerque, the University of New Mexico (UNM) Office for Community Health, the UNM Hos… | Health literacy research and practice 2026-09-20 04:36:34 | Source |
| Carotid intima-media thickness may be an early biomarker for cardiova… Impact of Ketogenic Diets on Cardiovascular Health in Adults With Epilepsy · PMID 41026111 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source To assess early signs of atherosclerosis following long-term treatment with the ketogenic diet therapy due to concerns… | Epilepsia open 2026-09-20 04:36:33 | Source |
| Impact of low-carbohydrate diet on health status: an umbrella review. Impact of Ketogenic Diets on Cardiovascular Health in Adults With Epilepsy · PMID 39385794 | Cancer | À vérifier | Publication | PubMed | Voir la publication source The prevalence of diet-related non-communicable diseases has increased. A low-carbohydrate diet (LCDs) is one of the mo… | Frontiers in nutrition 2026-09-20 04:36:33 | Source |
| The effect of anti-seizure medications on lipid values in adults with… Impact of Ketogenic Diets on Cardiovascular Health in Adults With Epilepsy · PMID 37244221 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source Certain anti-seizure medications (ASMs) adversely impact lipid values. Here, we explored the impact of ASMs on lipid va… | Epilepsy & behavior : E&B 2026-09-20 04:36:33 | Source |
| Possible role of locus coeruleus neuronal loss in age-related memory… The Role of the Locus Coeruleus in Age-related Distractibility · PMID 37694113 | Maladie d’Alzheimer | Immunomodulation | Publication | PubMed | Voir la publication source Aging is associated with a decline in cognitive abilities, including memory and attention. It is generally accepted tha… | Frontiers in neuroscience 2026-09-20 04:36:30 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||