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Toutes les maladies
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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Parkinson Progression Marker Initiative Online (PPMI Online) NCT05065060 · NCT05065060 | Maladie de Parkinson | Ralentissement de la progression | À vérifier | RECRUITING | Parkinson Progression Marker Initiative Online (PPMI Online) is an observa… À vérifier | ClinicalTrials.gov 2026-09-14 12:36:20 | Détail |
| [18F] AV-133 PET Imaging NCT07809438 · A Comparative Performance Study Between High and Standard Resolution Positron Em… | Maladie de Parkinson | Ralentissement de la progression | Phase 2 | RECRUITING | This study is a single-center, longitudinal study and will be conducted at… À vérifier | ClinicalTrials.gov 2026-09-14 12:36:20 | Détail |
| Active taVNS NCT07017257 · taVNS-PPCS — Transcutaneous Auricular Vagus Nerve Stimulation for Persistent Pos… | Sclérose en plaques | Traitement symptomatique | Non applicable | RECRUITING | The aim of this clinical trial is to determine if trans-auricular vagus ne… À vérifier | ClinicalTrials.gov 2026-09-14 12:36:13 | Détail |
| Active Transauricular Vagus Nerve Stimulation NCT07007884 · Effect of Transauricular Vagal Stimulation on Cardiac Function After Spinal Cord… | Sclérose en plaques | À vérifier | Non applicable | RECRUITING | The aim of this study is to investigate the effect of transauricular vagal… À vérifier | ClinicalTrials.gov 2026-09-14 12:36:13 | Détail |
| GammaCore/electroCore non-invasive VNS device NCT02992899 · Closed Loop Vagal Nerve Stimulation for Patients With Posttraumatic Stress Disor… | Sclérose en plaques | Immunomodulation | Phase 3 | COMPLETED | The tasks of the project are to map the potency and kinetics of the neurol… À vérifier | ClinicalTrials.gov 2026-09-14 12:36:13 | Détail |
| Parasym device NCT02548754 · TREAT-AF — Transcutaneous Electrical Vagus Nerve Stimulation to Suppress Atrial… | Sclérose en plaques | Immunomodulation | Non applicable | COMPLETED | Atrial fibrillation (AF) is the most common cardiac arrhythmia. In previou… À vérifier | ClinicalTrials.gov 2026-09-14 12:36:13 | Détail |
| t-VNS verum NCT01176721 · 02VNS2009 — Transcutaneous Non-invasive Vagus Nerve Stimulation (t-VNS) in the T… | Sclérose en plaques | Traitement symptomatique | Phase 2 | COMPLETED | Randomized, controlled, double-blind, two-armed clinical investigation to… À vérifier | ClinicalTrials.gov 2026-09-14 12:36:13 | Détail |
| Transcutaneous Auricular Vagus Nerve Stimulator NCT07271147 · Effects of taVNS Combined With Dexmedetomidine on POVN | Sclérose en plaques | À vérifier | Non applicable | RECRUITING | To explore the effects and possible mechanisms of dexmedetomidine combined… À vérifier | ClinicalTrials.gov 2026-09-14 12:36:13 | Détail |
| Vagus nerve stimulation NCT07310381 · Vagus Nerve Stimulation (VNS) Electroencephalogram (EEG) Protocol Supplement | Sclérose en plaques | À vérifier | Non applicable | NOT_YET_RECRUITING | Vagus nerve stimulation is thought to reduce sympathetic nerve outflow and… À vérifier | ClinicalTrials.gov 2026-09-14 12:36:13 | Détail |
| ABLE Exoskeleton with Functional Electrical Stimulation (ABLE FES) NCT07550699 · Clinical Investigation to Validate the Safety and Performance of Integrating Fun… | Sclérose en plaques | À vérifier | Non applicable | COMPLETED | The primary objective of this study is to validate the safety and clinical… À vérifier | ClinicalTrials.gov 2026-09-14 12:36:04 | Détail |
| BALANCE-MS — Monitoring Intensity During Balance Training in Persons… NCT07805850 · NCT07805850 | Sclérose en plaques | À vérifier | Non applicable | RECRUITING | Balance training is recommended to improve gait stability and mobility. Ho… À vérifier | ClinicalTrials.gov 2026-09-14 12:36:04 | Détail |
| Cladribine (MAVENCLAD®) NCT04695080 · ChariotMS - Cladribine to Halt Deterioration in People With Advanced Multiple Sc… | Sclérose en plaques | Ralentissement de la progression · Immunomodulation | Phase 2/3 | ACTIVE_NOT_RECRUITING | MS is a chronic inflammatory and degenerative disease of the central nervo… À vérifier | ClinicalTrials.gov 2026-09-14 12:36:04 | Détail |
| EMS_Rehab — Early Symptoms in Multiple Sclerosis: an Investigation Us… NCT07805733 · NCT07805733 | Sclérose en plaques | Ralentissement de la progression · Traitement symptomatique · Thérapie génique | Non applicable | NOT_YET_RECRUITING | Background Many people with Multiple Sclerosis (MS) experience a hidden ye… À vérifier | ClinicalTrials.gov 2026-09-14 12:36:04 | Détail |
| Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Scl… NCT00001248 · NCT00001248 | Sclérose en plaques | Neuroprotection | À vérifier | RECRUITING | Studies performed under 89-N-0045 are designed to examine the natural hist… À vérifier | ClinicalTrials.gov 2026-09-14 12:36:04 | Détail |
| OCR SC NCT07609719 · OSSIA — A Study of Ocrelizumab Administered Subcutaneously in Participants With… | Sclérose en plaques | Immunomodulation | Phase 4 | RECRUITING | The purpose of this study is to assess the imaging biomarkers, patient out… À vérifier | ClinicalTrials.gov 2026-09-14 12:36:04 | Détail |
| Online Program for Fatigue NCT06441617 · CAFE-MS — Confirmatory Trial for Alleviating Fatigue in Multiple Sclerosis | Sclérose en plaques | Traitement symptomatique | Non applicable | ENROLLING_BY_INVITATION | CAFE-MS will assess the effectiveness of two online programs for fatigue i… À vérifier | ClinicalTrials.gov 2026-09-14 12:36:04 | Détail |
| rapcabtagene autoleucel (YTB323) NCT06675864 · Open-label, Multi-center, Phase I/II Study to Assess Safety, Disease Progression… | Sclérose en plaques | Ralentissement de la progression | Phase 1/2 | ACTIVE_NOT_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-14 12:36:04 | Détail |
| SIZOMUS Safety of Ixazomib Targeting Plasma Cells in Multiple Scleros… NCT03783416 · NCT03783416 | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | The study seeks to investigate safety and efficacy of ixazomib (NINLARO),… À vérifier | ClinicalTrials.gov 2026-09-14 12:36:04 | Détail |
| sSIT-MS — Short Sprint Interval Training in People With Multiple Scle… NCT07804264 · NCT07804264 | Sclérose en plaques | Traitement symptomatique · Thérapie génique | Non applicable | RECRUITING | The goal of this clinical trial is to learn whether a short sprint interva… À vérifier | ClinicalTrials.gov 2026-09-14 12:36:04 | Détail |
| [18F]fluorodeprenyl-D2 NCT07805473 · F-DED PET MS — [18F]F-DED PET Imaging of Reactive Astrocytes in Multiple Scleros… | Sclérose en plaques | Ralentissement de la progression · Immunomodulation | Non applicable | NOT_YET_RECRUITING | Despite significant advancements in multiple sclerosis (MS) treatment over… À vérifier | ClinicalTrials.gov 2026-09-14 12:36:04 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Effects of continuous vs. intermittent transcutaneous electrical stim… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 41866984 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source To compare the effects of two transcutaneous electrical stimulation (TES) patterns applied to the auricular branches of… | Cranio : the journal of craniomandibular practice 2026-11-08 04:38:07 | Source |
| Optimizing Percutaneous Tibial Nerve Stimulation Intensity for Overac… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42554545 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source Overactive bladder (OAB) is a significant global health issue. The standard percutaneous tibial nerve stimulation (PTNS… | Neuromodulation : journal of the International Neuromo… 2026-11-08 04:38:07 | Source |
| Transcutaneous auricular vagus nerve stimulation improves dysautonomi… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42802247 | Maladie rénale chronique | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Autonomic nervous system dysfunction is highly prevalent in hypermobile Ehlers-Danlos syndrome (hEDS) and contributes s… | Neurological sciences : official journal of the Italia… 2026-11-08 04:38:07 | Source |
| Factors associated with high-flow therapy failure in COVID-19-related… Non-Invasive Positive Pressure Ventilation · PMID 42888091 | Maladie rénale chronique | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source The optimal selection of non-invasive respiratory support for patients with COVID-19-related acute hypoxemic respirator… | Enfermedades infecciosas y microbiologia clinica (Engl… 2026-11-08 04:38:06 | Source |
| High-Flow Nasal Cannula in Adult Acute Care: Physiological Mechanisms… Non-Invasive Positive Pressure Ventilation · PMID 42942512 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source High-flow nasal cannula (HFNC) oxygen therapy is widely used in emergency, intensive care, perioperative, and procedura… | Medicina (Kaunas, Lithuania) 2026-11-08 04:38:06 | Source |
| Impact of respiratory support on time to achieve full oral feeding in… Non-Invasive Positive Pressure Ventilation · PMID 42871336 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source Very low birth weight infants often require respiratory support, which may delay full oral feeding. The independent rol… | Frontiers in pediatrics 2026-11-08 04:38:06 | Source |
| A comparative analysis of 3MAX aspiration versus 3 mm Trevo Retriever… Thromboaspiration catheter · PMID 31243066 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Although aspiration and stent retriever thrombectomy perform similarly in proximal occlusions, no comparative series ar… | Journal of neurointerventional surgery 2026-11-08 04:38:02 | Source |
| Percutaneous Pulmonary Thrombectomy Beyond Acute Pulmonary Embolism:… Thromboaspiration catheter · PMID 38385241 | Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Subacute massive pulmonary embolism is an uncommon manifestation of severe pulmonary embolism associated with poor prog… | Journal of endovascular therapy : an official journal… 2026-11-08 04:38:02 | Source |
| Simplified classification of cavernous internal carotid artery tortuo… Thromboaspiration catheter · PMID 35475775 | Hypertension artérielle · Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Thromboaspiration catheters are increasingly used for the endovascular treatment of large vessel stroke (LVS), while to… | Neurological research 2026-11-08 04:38:02 | Source |
| Multifocal continuous theta burst stimulation in idiopathic generaliz… Continuous Theta Burst Stimulation (cTBS) · PMID 42731195 | Accident vasculaire cérébral | Traitement symptomatique | Publication | PubMed | Voir la publication source Idiopathic generalized epilepsy (IGE) is a disorder of the cortico-subcortical networks. Continuous theta burst stimula… | Clinical neurophysiology : official journal of the Int… 2026-11-08 04:38:00 | Source |
| Optimizing brain functional-structural architecture with cTBS to redu… Continuous Theta Burst Stimulation (cTBS) · PMID 42457860 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Alcohol use disorder (AUD) is characterized by high relapse rates, necessitating novel interventions. Continuous theta-… | Molecular psychiatry 2026-11-08 04:38:00 | Source |
| Digital Outreach to Improve Statin Refills in Patients With Low Stati… Cordio System · PMID 42667613 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Statin nonadherence is a leading, addressable driver of preventable cardiovascular events. Although health systems rout… | JAMA 2026-11-08 04:37:54 | Source |
| Endovascular ablation of the right greater splanchnic nerve for the m… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42257781 | Insuffisance cardiaque | Traitement symptomatique | Publication | PubMed | Voir la publication source Heart failure with preserved ejection fraction (HFpEF) remains difficult to manage because conventional therapies often… | The Egyptian heart journal : (EHJ) : official bulletin… 2026-11-08 04:37:54 | Source |
| Incidence, medical therapy, and outcomes in heart failure with improv… Cordio System · PMID 42702264 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source To assess the incidence of heart failure with improved ejection fraction (HFimpEF) across guideline definitions (ACC/AH… | American heart journal 2026-11-08 04:37:54 | Source |
| Relationship Between the Azygos Vein and the Greater Splanchnic Nerve… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42249803 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Although ablation of the greater splanchnic nerve is now being used to treat some patients with heart failure, the anat… | Clinical anatomy (New York, N.Y.) 2026-11-08 04:37:54 | Source |
| Validation of the PREVENT-HF Risk Prediction Equation in US Veterans. Cordio System · PMID 42969140 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Circulation 2026-11-08 04:37:54 | Source |
| Changes in right ventricular-pulmonary artery coupling after transcat… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42822601 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Right ventricular-pulmonary artery (RV-PA) coupling is an established marker of prognosis in mitral regurgitation (MR),… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Intraprocedural evaluation of residual mitral and tricuspid regurgita… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42982241 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Transcatheter edge-to-edge repair (TEER) has emerged as an established therapeutic option for selected patients with se… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Tricuspid transcatheter edge-to-edge repair versus transcatheter tric… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42989943 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Recent clinical studies of tricuspid transcatheter edge-to-edge repair (T-TEER) and transcatheter tricuspid valve repla… | Current opinion in cardiology 2026-11-08 04:37:47 | Source |
| Automated Production of Gene-Edited CAR-T Cells for People Living wit… RAPA-501 Autologous T stem cells · PMID 42847201 | Cancer | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source Adoptive transfer of gene-modified autologous T cells, for example, expressing chimeric antigen receptors (CARs), is a… | Human gene therapy 2026-11-08 04:37:39 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||