VA Office of Research and Development

Traitements32programmes

Essais18liés

Publications15liées

SourceDBlocale

Traitements

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
CarvedilolThe investigators aim to determine, using a point-of-care randomized controlled trial design, if hemodialysis patients, who are randomized to metoprolol succinate (a dialyzable, beta-1 selective beta blocker), have an improved cardiovascular outcome compared to those randomized to carvedilol (a non-dialyzable, non-selective beta blocker with alpha-1 antagonist properties). The investigators will also examine intervention practices to identify components that best support engagement and sustainability.	Maladie rénale chronique	Phase 3	À vérifier	United States	À vérifier
DarbepoetinThe investigators hypothesize that compared to untreated controls, erythropoietin (EPO) therapy in anemic patients with chronic kidney disease will raise diastolic blood pressure (BP). The magnitude of increase in diastolic BP at 12 weeks after treatment will be related to two factors. First, endothelial dysfunction and worsening of endothelial function from baseline to 4 weeks and second, the change of forearm blood flow in response to breathing oxygen and the change in this measure from baseline to 4 weeks. Study procedures include fasting blood draws, ambulatory blood pressure, urine collection, and forearm blood flow tests. The study hopes to accrue 160 subjects.	Hypertension	Phase 2	À vérifier	United States	À vérifier
EMPOWER — Enhancing Mental and Physical Health of Women VeteransWomen Veterans are the fastest growing segment of VA users. This dramatic growth has created challenges for VA to ensure that appropriate services are available to meet women Veterans' needs, and that they will want and be able to use those services. The EMPOWER QUERI 2.0 Program is a cluster randomized type 3 hybrid implementation-effectiveness trial testing two strategies designed to support implementation and sustainment of evidence-based practices for women Veterans in at least 20 VA facilities from 4 regions.	Hypertension	Non applicable	À vérifier	United States	À vérifier
EMSTRespiratory difficulty is one of the primary factors leading to death in patients with Parkinson's Disease (PD) and Multiple Sclerosis. Both diseases are progressive degenerating diseases that cause difficulties in breathing, airway protection and swallowing. Patients with PD and MS typically become sedentary and lose endurance, maximal fitness levels and overall pulmonary function. Much of the research focus has been on the motor symptoms of PD and MS yet the pulmonary and swallowing complications are perhaps ultimately the most important disability as the diseases progress. The inability to generate adequate respiratory pressure is responsible for reduced cough magnitudes and cough response times. Cough is critical for the clearance of foreign materials in the airway helping to reduce infiltration of bacteria and subsequent respiratory infection. With reduced cough function an increased risk for pulmonary disease occurs due to a reduced ability to protect the airways. There are a number of promising outcomes from an expiratory strength-training program. By increasing expiratory muscle strength and expiratory pressure generation, effective breathing, clearance of the airway, and improved swallowing can occur. These explicit outcomes are predicted based on our experience with the use of an innovative device-driven, home-based expiratory strength training program focused on the expiratory muscles of respiration. This project focuses on following patients with PD and MS for an initial 5 weeks of strength training and them testing the outcome of a caregiver program for maintaining treatment effects.	SEP	Phase 2	Traitement symptomatique	United States	À vérifier
Gamification and Physical Activity in PDDespite overwhelming evidence that exercise can improve motor and non-motor symptoms of Parkinson's Disease (PD), less than 25% of Veterans with PD meet recommended activity goals. Interventions to increase PA that are scalable and can be deployed in the community represent a major opportunity. The investigators' preliminary work has demonstrated that gamification, a method commonly used for health promotion, can lead to increases in physical activity in PD. In this study, the investigators will test the effectiveness of gamification in a randomized trial to increase activity. Importantly, the investigators will also examine the effect of step count and exercise intensity on clinical outcomes and explore factors important to widespread implementation of the program VA.	Parkinson	Non applicable	Traitement symptomatique	United States	À vérifier
LabVax 3(22)-23 and GM-CSF (adjuvant) in combination with pembrolizumabThis phase 2 trial tests the safety and effectiveness of a cancer vaccine called LabVax 3(22)-23 and GM-CSF in combination with pembrolizumab in treating adenocarcinoma that has spread to other places in the body (advanced stage). LabVax 3(22)-23 is designed to target a specific antigen (labyrinthin), which is a protein found on the surface of adenocarcinoma tumor cells. Labyrinthin is a protein that is not expressed on normal cells in the skin, lungs, salivary glands, pancreas, nor other tissues. In adenocarcinoma, the tumor cells produce too much labyrinthin causing them to express this protein on the surface of the tumor cells. One way to control the growth of these tumor cells is to teach the immune system to generate an immune response against the labyrinthin protein by vaccination against labyrinthin. GM-CSF, or sargramostim, is a protein that acts as a white blood cell growth factor. It has also been shown to stimulate immune system. Thus, administration of GM-CSF may help to boost the immune system response when given together with the vaccine. This study may improve the general knowledge about LabVax 3(22)-23 and how the body may generate an immune response to kill adenocarcinoma tumor cells. In the second phase of the study, participants will also receive pembrolizumab, which may improve anti-cancer activity when given with LabVax 3(22)-23 and GM-CSF.	Myopathies	Phase 2		United States	À vérifier
Metoprolol SuccinateThe purpose of this trial is to better understand how the beta-blocker metoprolol works in people with Heart Failure with Reduced Ejection Fraction (HFrEF) according to participants genetics. Participants will have the beta-blocker (BB) polygenic score calculated from genotype data. The score will be used to stratify the patients in the low and high polygenic score groups in the study. The hypotheses for this trial are: * HFrEF patients with high polygenic score will have weaker cardiovascular responses to metoprolol succinate than HFrEF patients with low polygenic score. * HFrEF patients with high polygenic score have lower steady-state plasma concentrations of metoprolol succinate than HFrEF patients with low polygenic score. * HFrEF patients with high polygenic score require higher metoprolol succinate plasma concentrations to achieve similar cardiovascular effects as those with low polygenic score.	Insuffisance cardiaque, Maladie rénale chronique	Phase 3	À vérifier	United States	À vérifier
Mobile neural decoding platform (mobile iBCI)Description non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé.	Myopathies, Sclérose latérale amyotrophique	Non applicable	À vérifier	United States	À vérifier
MOTIVATE_IIR — MOTIVATE to Improve Outcomes for Older Veterans With Musculoskeletal Pain and DepressionThe proposed study seeks to evaluate effectiveness, implementation processes, and cost of MOTIVATE among older Veterans with chronic musculoskeletal (MSK) pain and comorbid depressive symptoms.	Myopathies	Non applicable	Traitement symptomatique	United States	À vérifier
nVNSMild traumatic brain injury (mTBI) and posttraumatic stress disorder (PTSD) are important conditions for the Veterans Administration (VA) that frequently occur together in combat Veterans from the conflicts in Afghanistan and Iraq. In many Veterans these become chronic, raising the risk the burden of neurotrauma can worsen over time. This study will examine a new intervention called non-invasive Vagal Nerve Stimulation (nVNS) and its effects on memory and symptoms of PTSD and mTBI as well as brain and physiology in Veterans with mTBI and PTSD.	SEP	Non applicable	Traitement symptomatique	United States	À vérifier
Oxygen + positive airway pressure (PAP) therapyCentral sleep apnea (CSA) is common in patients with heart failure and those using opioid analgesics. Unfortunately, effective treatment of central apnea remains elusive, pressure therapy given the modest efficiency of positive airway pressure therapy. The focus of this proposal is to identify mechanistic pathways to guide future therapeutic interventions for central sleep apnea based on the strong premise that multi-modality therapy will normalize respiration and hence mitigate adverse long-term consequences of CSA. The investigators' proposed studies will test combination therapies, including positive airway pressure (PAP) plus a pharmacological agent who have heart failure or are using opioid analgesics. The investigators anticipate that findings will inform future clinical trials to improve care and quality of life among Veterans suffering from central sleep apnea, which remains difficult to treat using existing approaches.	Insuffisance cardiaque	Phase 4	À vérifier	United States	À vérifier
Piloting a Novel Peer Support Pain Self-Management Intervention (Project CONNECT)The proposed study will test the feasibility and acceptability of an 8-week home-based reciprocal peer support pain self-management intervention (CONNECT) for women Veterans with chronic musculoskeletal pain. The use of this format will improve the accessibility of treatment to women Veterans who experience logistical, healthcare delivery and psychosocial barriers to care. To address these barriers women Veterans who enroll in CONNECT will be paired and work together to learn/practice pain coping skills, set meaningful activity goals, and participate in a graduated walking program; they will exchange nightly text messages and engage in a weekly 20 minute phone call to reinforce each other and provide support for pain self-management efforts. This is a single-arm pilot project; all eligible and interested women with chronic musculoskeletal pain will receive CONNECT. The primary outcome will be post-treatment and long-term follow-up retention rates.	Myopathies	Non applicable	Traitement symptomatique	United States	À vérifier
prazosin hydrochlorideThe purpose of this study is to determine if prazosin is more effective than placebo in decreasing frequency, severity, disability, and other negative effects of headaches related to mild traumatic brain injury in Service Members and Veterans.	Migraine	Phase 1/2	À vérifier	United States	À vérifier
STEP 4 Vets — A Randomized Trial of Behaviorally Designed Gamification and Social Incentives to Increase Physical Activity Among Overweight and Obese VeteransDespite the many associated health benefits, more than half of Veterans do not achieve enough regular physical activity. The investigators' prior work has demonstrated that gamification, a method commonly used for health promotion, can lead to sustained increases in physical activity if it is designed using insights from behavioral economics to enhance social incentives. In this study, the investigators will compare the effectiveness of behaviorally designed gamification that encourages Veterans to collaborate or compete on physical activity levels and examine clinical outcomes as well as costs, barriers and facilitators to implementation of the program within Veterans Affairs.	Hypertension	Non applicable	À vérifier	United States	À vérifier
Trazodone + positive airway pressure (PAP) therapyCentral sleep apnea (CSA) is common in patients with heart failure and those using opioid analgesics. Unfortunately, effective treatment of central apnea remains elusive, pressure therapy given the modest efficiency of positive airway pressure therapy. The focus of this proposal is to identify mechanistic pathways to guide future therapeutic interventions for central sleep apnea based on the strong premise that multi-modality therapy will normalize respiration and hence mitigate adverse long-term consequences of CSA. The investigators' proposed studies will test combination therapies, including positive airway pressure (PAP) plus a pharmacological agent who have heart failure or are using opioid analgesics. The investigators anticipate that findings will inform future clinical trials to improve care and quality of life among Veterans suffering from central sleep apnea, which remains difficult to treat using existing approaches.	Insuffisance cardiaque	Phase 4	À vérifier	United States	À vérifier
WATER-VET — Water-based Activity to Enhance Recall in Veterans: A Randomized Clinical TrialThis four-year study will evaluate the efficacy of an exercise training augmentation for cognitive training intervention to improve memory performance in Veterans with a diagnosis of amnestic Mild Cognitive Impairment (aMCI). This is a two-phased trial: 1) an exercise phase and 2) a cognitive training program. The exercise phase will be an aquatic based exercise program. A combination of exercise and cognitive training programs designed for persons without cognitive impairment have significantly improved memory more than other single intervention groups (exercise only, cognitive training only) and given the success of combination training programs with healthy older adults, it is important to adapt these programs for persons beginning to exhibit clinically significant memory problems, such as those with aMCI.	Alzheimer	Phase 4	À vérifier	United States	À vérifier
Wearable Robotic ExoskeletonThe purpose of this research study is to develop a protocol using a fully wearable, portable lower-limb exoskeleton for improving leg and walking function in people with movement disorders. The study investigates the effects of wearing the device during a set of experiments including leg stretching, treadmill walking and overground walking in muscle activity, joint motion, and gait performance. The goal is to develop an effective lower-limb strategy to restore lost leg function (e.g., range of motion) and gait ability, and improve quality of life in people with movement deficits following a neurological disorder.	Myopathies	Non applicable	À vérifier	United States	À vérifier
EMSTRespiratory difficulty is one of the primary factors leading to death in patients with Parkinson's Disease (PD) and Multiple Sclerosis. Both diseases are progressive degenerating diseases that cause difficulties in breathing, airway protection and swallowing. Patients with PD and MS typically become sedentary and lose endurance, maximal fitness levels and overall pulmonary function. Much of the research focus has been on the motor symptoms of PD and MS yet the pulmonary and swallowing complications are perhaps ultimately the most important disability as the diseases progress. The inability to generate adequate respiratory pressure is responsible for reduced cough magnitudes and cough response times. Cough is critical for the clearance of foreign materials in the airway helping to reduce infiltration of bacteria and subsequent respiratory infection. With reduced cough function an increased risk for pulmonary disease occurs due to a reduced ability to protect the airways. There are a number of promising outcomes from an expiratory strength-training program. By increasing expiratory muscle strength and expiratory pressure generation, effective breathing, clearance of the airway, and improved swallowing can occur. These explicit outcomes are predicted based on our experience with the use of an innovative device-driven, home-based expiratory strength training program focused on the expiratory muscles of respiration. This project focuses on following patients with PD and MS for an initial 5 weeks of strength training and them testing the outcome of a caregiver program for maintaining treatment effects.	SEP	Phase 2	Traitement symptomatique	United States	À vérifier
DarbepoetinThe investigators hypothesize that compared to untreated controls, erythropoietin (EPO) therapy in anemic patients with chronic kidney disease will raise diastolic blood pressure (BP). The magnitude of increase in diastolic BP at 12 weeks after treatment will be related to two factors. First, endothelial dysfunction and worsening of endothelial function from baseline to 4 weeks and second, the change of forearm blood flow in response to breathing oxygen and the change in this measure from baseline to 4 weeks. Study procedures include fasting blood draws, ambulatory blood pressure, urine collection, and forearm blood flow tests. The study hopes to accrue 160 subjects.	Hypertension	Phase 2	À vérifier	United States	À vérifier
STEP 4 Vets — A Randomized Trial of Behaviorally Designed Gamification and Social Incentives to Increase Physical Activity Among Overweight and Obese VeteransDespite the many associated health benefits, more than half of Veterans do not achieve enough regular physical activity. The investigators' prior work has demonstrated that gamification, a method commonly used for health promotion, can lead to sustained increases in physical activity if it is designed using insights from behavioral economics to enhance social incentives. In this study, the investigators will compare the effectiveness of behaviorally designed gamification that encourages Veterans to collaborate or compete on physical activity levels and examine clinical outcomes as well as costs, barriers and facilitators to implementation of the program within Veterans Affairs.	Hypertension	Non applicable	À vérifier	United States	À vérifier
Mobile neural decoding platform (mobile iBCI)Description non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé.	Sclérose latérale amyotrophique	Non applicable	À vérifier	United States	À vérifier
prazosin hydrochlorideThe purpose of this study is to determine if prazosin is more effective than placebo in decreasing frequency, severity, disability, and other negative effects of headaches related to mild traumatic brain injury in Service Members and Veterans.	Migraine	Phase 1/2	À vérifier	United States	À vérifier
MOTIVATE_IIR — MOTIVATE to Improve Outcomes for Older Veterans With Musculoskeletal Pain and DepressionThe proposed study seeks to evaluate effectiveness, implementation processes, and cost of MOTIVATE among older Veterans with chronic musculoskeletal (MSK) pain and comorbid depressive symptoms.	Myopathies	Non applicable	Traitement symptomatique	United States	À vérifier
Piloting a Novel Peer Support Pain Self-Management Intervention (Project CONNECT)The proposed study will test the feasibility and acceptability of an 8-week home-based reciprocal peer support pain self-management intervention (CONNECT) for women Veterans with chronic musculoskeletal pain. The use of this format will improve the accessibility of treatment to women Veterans who experience logistical, healthcare delivery and psychosocial barriers to care. To address these barriers women Veterans who enroll in CONNECT will be paired and work together to learn/practice pain coping skills, set meaningful activity goals, and participate in a graduated walking program; they will exchange nightly text messages and engage in a weekly 20 minute phone call to reinforce each other and provide support for pain self-management efforts. This is a single-arm pilot project; all eligible and interested women with chronic musculoskeletal pain will receive CONNECT. The primary outcome will be post-treatment and long-term follow-up retention rates.	Myopathies	Non applicable	Traitement symptomatique	United States	À vérifier
Gamification and Physical Activity in PDDespite overwhelming evidence that exercise can improve motor and non-motor symptoms of Parkinson's Disease (PD), less than 25% of Veterans with PD meet recommended activity goals. Interventions to increase PA that are scalable and can be deployed in the community represent a major opportunity. The investigators' preliminary work has demonstrated that gamification, a method commonly used for health promotion, can lead to increases in physical activity in PD. In this study, the investigators will test the effectiveness of gamification in a randomized trial to increase activity. Importantly, the investigators will also examine the effect of step count and exercise intensity on clinical outcomes and explore factors important to widespread implementation of the program VA.	Parkinson	Non applicable	Traitement symptomatique	United States	À vérifier
WATER-VET — Water-based Activity to Enhance Recall in Veterans: A Randomized Clinical TrialThis four-year study will evaluate the efficacy of an exercise training augmentation for cognitive training intervention to improve memory performance in Veterans with a diagnosis of amnestic Mild Cognitive Impairment (aMCI). This is a two-phased trial: 1) an exercise phase and 2) a cognitive training program. The exercise phase will be an aquatic based exercise program. A combination of exercise and cognitive training programs designed for persons without cognitive impairment have significantly improved memory more than other single intervention groups (exercise only, cognitive training only) and given the success of combination training programs with healthy older adults, it is important to adapt these programs for persons beginning to exhibit clinically significant memory problems, such as those with aMCI.	Alzheimer	Phase 4	À vérifier	United States	À vérifier
EMPOWER — Enhancing Mental and Physical Health of Women VeteransWomen Veterans are the fastest growing segment of VA users. This dramatic growth has created challenges for VA to ensure that appropriate services are available to meet women Veterans' needs, and that they will want and be able to use those services. The EMPOWER QUERI 2.0 Program is a cluster randomized type 3 hybrid implementation-effectiveness trial testing two strategies designed to support implementation and sustainment of evidence-based practices for women Veterans in at least 20 VA facilities from 4 regions.	Hypertension	Non applicable	À vérifier	United States	À vérifier
Wearable Robotic ExoskeletonThe purpose of this research study is to develop a protocol using a fully wearable, portable lower-limb exoskeleton for improving leg and walking function in people with movement disorders. The study investigates the effects of wearing the device during a set of experiments including leg stretching, treadmill walking and overground walking in muscle activity, joint motion, and gait performance. The goal is to develop an effective lower-limb strategy to restore lost leg function (e.g., range of motion) and gait ability, and improve quality of life in people with movement deficits following a neurological disorder.	Myopathies	Non applicable	Traitement symptomatique	United States	À vérifier
LabVax 3(22)-23 and GM-CSF (adjuvant) in combination with pembrolizumabThis phase 2 trial tests the safety and effectiveness of a cancer vaccine called LabVax 3(22)-23 and GM-CSF in combination with pembrolizumab in treating adenocarcinoma that has spread to other places in the body (advanced stage). LabVax 3(22)-23 is designed to target a specific antigen (labyrinthin), which is a protein found on the surface of adenocarcinoma tumor cells. Labyrinthin is a protein that is not expressed on normal cells in the skin, lungs, salivary glands, pancreas, nor other tissues. In adenocarcinoma, the tumor cells produce too much labyrinthin causing them to express this protein on the surface of the tumor cells. One way to control the growth of these tumor cells is to teach the immune system to generate an immune response against the labyrinthin protein by vaccination against labyrinthin. GM-CSF, or sargramostim, is a protein that acts as a white blood cell growth factor. It has also been shown to stimulate immune system. Thus, administration of GM-CSF may help to boost the immune system response when given together with the vaccine. This study may improve the general knowledge about LabVax 3(22)-23 and how the body may generate an immune response to kill adenocarcinoma tumor cells. In the second phase of the study, participants will also receive pembrolizumab, which may improve anti-cancer activity when given with LabVax 3(22)-23 and GM-CSF.	Myopathies	Phase 2		United States	À vérifier
Metoprolol SuccinateThe purpose of this trial is to better understand how the beta-blocker metoprolol works in people with Heart Failure with Reduced Ejection Fraction (HFrEF) according to participants genetics. Participants will have the beta-blocker (BB) polygenic score calculated from genotype data. The score will be used to stratify the patients in the low and high polygenic score groups in the study. The hypotheses for this trial are: * HFrEF patients with high polygenic score will have weaker cardiovascular responses to metoprolol succinate than HFrEF patients with low polygenic score. * HFrEF patients with high polygenic score have lower steady-state plasma concentrations of metoprolol succinate than HFrEF patients with low polygenic score. * HFrEF patients with high polygenic score require higher metoprolol succinate plasma concentrations to achieve similar cardiovascular effects as those with low polygenic score.	Insuffisance cardiaque	Phase 4	À vérifier	United States	À vérifier
Trazodone + positive airway pressure (PAP) therapyCentral sleep apnea (CSA) is common in patients with heart failure and those using opioid analgesics. Unfortunately, effective treatment of central apnea remains elusive, pressure therapy given the modest efficiency of positive airway pressure therapy. The focus of this proposal is to identify mechanistic pathways to guide future therapeutic interventions for central sleep apnea based on the strong premise that multi-modality therapy will normalize respiration and hence mitigate adverse long-term consequences of CSA. The investigators' proposed studies will test combination therapies, including positive airway pressure (PAP) plus a pharmacological agent who have heart failure or are using opioid analgesics. The investigators anticipate that findings will inform future clinical trials to improve care and quality of life among Veterans suffering from central sleep apnea, which remains difficult to treat using existing approaches.	Insuffisance cardiaque	Phase 4	À vérifier	United States	À vérifier
Metoprolol SuccinateThe purpose of this trial is to better understand how the beta-blocker metoprolol works in people with Heart Failure with Reduced Ejection Fraction (HFrEF) according to participants genetics. Participants will have the beta-blocker (BB) polygenic score calculated from genotype data. The score will be used to stratify the patients in the low and high polygenic score groups in the study. The hypotheses for this trial are: * HFrEF patients with high polygenic score will have weaker cardiovascular responses to metoprolol succinate than HFrEF patients with low polygenic score. * HFrEF patients with high polygenic score have lower steady-state plasma concentrations of metoprolol succinate than HFrEF patients with low polygenic score. * HFrEF patients with high polygenic score require higher metoprolol succinate plasma concentrations to achieve similar cardiovascular effects as those with low polygenic score.	Maladie rénale chronique	Phase 3	À vérifier	United States	À vérifier

Essais cliniques

Molécule	Indication / population	Phase	NCT	Titre	Statut
Metoprolol Succinate	Maladie rénale chronique	Phase 3	NCT05931276	BRAVO — CSP #2026 - Beta Blocker Dialyzability on Cardiovascular Outcomes	RECRUITING
Trazodone + positive airway pressure (PAP) therapy	Insuffisance cardiaque	Phase 4	NCT07210606	CSA-HF — Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment	RECRUITING
Metoprolol Succinate	Insuffisance cardiaque	Phase 4	NCT07490067	Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score	RECRUITING
LabVax 3(22)-23 and GM-CSF (adjuvant) in combination with pembrolizumab	Myopathies	Phase 2	NCT07859592	Labyrinthin Vaccination in Veterans With Lung Adenocarcinoma	NOT_YET_RECRUITING
Wearable Robotic Exoskeleton	Myopathies	Non applicable	NCT05926596	Leg Stretching Using an Exoskeleton on Demand for People With Spasticity	RECRUITING
EMPOWER — Enhancing Mental and Physical Health of Women Veterans	Hypertension	Non applicable	NCT05050266	EMPOWER — Enhancing Mental and Physical Health of Women Veterans	ACTIVE_NOT_RECRUITING
WATER-VET — Water-based Activity to Enhance Recall in Veterans: A Randomized Clinical Trial	Alzheimer	Phase 4	NCT04296565	WATER-VET — Water-based Activity to Enhance Recall in Veterans: A Randomized Clinical Trial	COMPLETED
Intermittent theta burst stimulation	Myopathies	Phase 3	NCT07158567	Veterans' Intervention Blending NeuRomodulation and YogA for Chronic Low BackPaiN Treatment: VIBRANT	NOT_YET_RECRUITING
Gamification and Physical Activity in PD	Parkinson	Non applicable	NCT07286994	Gamification and Physical Activity in PD	NOT_YET_RECRUITING
Piloting a Novel Peer Support Pain Self-Management Intervention (Project CONNECT)	Myopathies	Non applicable	NCT04229134	Piloting a Novel Peer Support Pain Self-Management Intervention (Project CONNECT)	COMPLETED
MOTIVATE_IIR — MOTIVATE to Improve Outcomes for Older Veterans With Musculoskeletal Pain and Depression	Myopathies	Non applicable	NCT05220202	MOTIVATE_IIR — MOTIVATE to Improve Outcomes for Older Veterans With Musculoskeletal Pain and Depression	COMPLETED
sham stimulation	SEP	Non applicable	NCT04437498	VNS mTBI — Vagal Nerve Stimulation in mTBI	RECRUITING
prazosin hydrochloride	Migraine	Phase 1/2	NCT02266329	Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin	COMPLETED
Mobile neural decoding platform (mobile iBCI)	Sclérose latérale amyotrophique	Non applicable	NCT05470478	iBCI Optimization for Veterans With Paralysis	NOT_YET_RECRUITING
STEP 4 Vets — A Randomized Trial of Behaviorally Designed Gamification and Social Incentives to Increase Physical Activity Among Overweight and Obese Veterans	Hypertension	Non applicable	NCT05554601	STEP 4 Vets — A Randomized Trial of Behaviorally Designed Gamification and Social Incentives to Increase Physical Activity Among Overweight and Obese Veterans	ACTIVE_NOT_RECRUITING
Darbepoetin	Hypertension	Phase 2	NCT03810911	EPIC — Mechanisms of EPO-induced Hypertension	TERMINATED
EMST	SEP	Phase 2	NCT00856518	EMST — Expiratory Muscle Training for Persons With Neurodegenerative Disease	COMPLETED
Vitamin D3	Parkinson	Phase 2	NCT01119131	Effects of Vitamin D in Parkinson's Disease (PD)	COMPLETED

Publications

Molécule	Titre	Journal
Trazodone + positive airway pressure (PAP) therapy	Baseline Sleep Efficiency and Arousal Index Do Not Predict Who Will Benefit From Sedatives in Improving Positive Airway Pressure Adherence in Sleep Apnea to 90.	Clinical EEG and neuroscience
Trazodone + positive airway pressure (PAP) therapy	Successful treatment of auto-trilevel positive airway pressure plus trazodone for obstructive sleep apnea complicated by anxiety disorder: a case report.	The Journal of international medical research
Oxygen + positive airway pressure (PAP) therapy	A 10-year nationwide analysis of nocturnal device prescriptions for sleep apnea in France.	Sleep & breathing = Schlaf & Atmung
Oxygen + positive airway pressure (PAP) therapy	Subjective sleep quality reflects sleep continuity rather than respiratory severity or sleep stage composition.	Sleep medicine
Oxygen + positive airway pressure (PAP) therapy	Feasibility, acceptability, and usability of a novel self-monitoring program utilizing a consumer-grade wearable device paired with sleep-related patient-reported outcomes for veterans with obstructive sleep apnea.	Human factors in healthcare
EMPOWER — Enhancing Mental and Physical Health of Women Veterans	Real-world impacts from a decade of Quality Enhancement Research Initiative-partnered projects to translate the Diabetes Prevention Program in the Veterans Health Administration.	Health services research
EMPOWER — Enhancing Mental and Physical Health of Women Veterans	Enhancing mental and physical health of women through engagement and retention (EMPOWER) 3.0 QUERI: study protocol for a cluster-randomized hybrid type 3 implementation-effectiveness trial.	Implementation science : IS
Piloting a Novel Peer Support Pain Self-Management Intervention (Project CONNECT)	How Do Patients with Chronic Pain Benefit from a Peer-Supported Pain Self-Management Intervention? A Qualitative Investigation.	Pain medicine (Malden, Mass.)
Darbepoetin	Association of anemia and necrotizing enterocolitis in neonates: Systematic review and meta-analysis of transfusion thresholds, erythropoietin trials, and observational studies.	Journal of neonatal-perinatal medicine
Darbepoetin	Site-specific enrichment of highly sialylated N-glycans in an erythropoietin-hybrid Fc fusion protein.	European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
EMST	Evaluating mucosal and systemic immunity in an observational cohort of South African children hospitalized with acute respiratory tract infections.	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Darbepoetin	Adsorption characteristics of erythropoietin in two β2-microglobulin absorption systems: a preliminary in vitro study using FILTOR and Lixelle.	Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs
Darbepoetin	Drugs and Cell-Based Therapies for the Prevention and Treatment of Neonatal Brain Injury.	Clinics in perinatology
EMST	Physiologic Adaptations to Modifying Resistive Load and Time Under Tension During Expiratory Muscle Strength Training.	Journal of speech, language, and hearing research : JSLHR
EMST	Mind the dog: real dogs elicit emotional and mental state language in parent-child conversations.	Journal of experimental child psychology