University of Utah — Biomedical Watch V2

Traitements23programmes

Essais10liés

Publications15liées

SourceDBlocale

Traitements

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
Effects of Xoçai Antioxidant Supplements on Atherosclerosis Risk FactorsAn antioxidant dietary supplement made from cocoa powder, and extracts of acai, grape and blueberry will be tested for effects on blood sugar, blood pressure, cholesterol and related parameters in human subjects.	Hypertension	NA	À vérifier	United States	À vérifier
Ferumoxytol infusionThis pilot study takes the innovative approach of using ultrasmall superparamagnetic iron oxide (USPIO) nanoparticle enhanced MRI to measure activity of the innate immune system within MS lesions. Activity of innate immunity has been hypothesized as one of the critical pathologic processes underpinning neurologic worsening in progressive MS. As such, in the short term this project proposes to investigate USPIO uptake in SPMS lesions as a promising in vivo imaging biomarker for chronic-active lesions, as distinguished from chronic-inactive lesions.	SEP	Phase 1		United States	À vérifier
FES (Functional Electrical Stimulation)-assisted task-specific practiceUpper extremity (UE) paresis or weakness is one of the most frequent impairments after stroke. Despite intense rehabilitation, motor and functional recovery of patients with severe hand impairments is poor. Hence, there is a need for more effective treatments to enhance motor function in patients with severe hand impairments after stroke. Adaptive functional electrical stimulation (FES) appears to be a promising treatment and has the potential to facilitate active movement in individuals with severe impairments post-stroke. In addition, transcranial random noise stimulation (trns) is a widely studied, non-invasive and safe method to enhance the corticomotor excitability in individuals with chronic stroke. However, the effect of combining trns and adaptive FES in patients with severe hand impairments has not been investigated. Therefore, the purpose of this study is to investigate whether combining trns with FES will enhance hand function in individuals with chronic stroke than FES alone. The investigators predict that combining trns with FES will significantly enhance hand function than FES alone.	Accident vasculaire cérébral	Non applicable	À vérifier	United States	À vérifier
GadoteridolThis pilot study takes the innovative approach of using ultrasmall superparamagnetic iron oxide (USPIO) nanoparticle enhanced MRI to measure activity of the innate immune system within MS lesions. Activity of innate immunity has been hypothesized as one of the critical pathologic processes underpinning neurologic worsening in progressive MS. As such, in the short term this project proposes to investigate USPIO uptake in SPMS lesions as a promising in vivo imaging biomarker for chronic-active lesions, as distinguished from chronic-inactive lesions.	SEP	Phase 1		United States	À vérifier
Genicular Artery EmbolizationGenicular Artery Embolization for Reducing Pain in Symptomatic Knee Osteoarthritis: A Pilot Randomized Sham-Controlled Study (SHAM-PAIN) is a NIH-NIAMS funded project designed to assess enrollment feasibility and detect any differences between GAE and a similar sham intervention in reducing KOA-related pain at 3 months as measured by the Knee injury and Osteoarthritis Outcome Score (KOOS) pain subscore. Additionally, this study aims to determine the magnitude of difference in pain response between GAE and sham to adequately power a larger, more definitive randomized sham-controlled trial (RCT). The influence of psychosocial and psychocognitive factors, changes in analgesic use, and conditions of knee joint cartilage and effusion will similarly be explored to determine their impacts on perceived pain response to GAE.	Myopathies	Phase 2	Traitement symptomatique	United States	À vérifier
IUFU — Transforming Maternal Mental Health CareThe overall objective of this pilot study is to assess the feasibility of a RCT comparing Lōvu-augmented with usual prenatal care at UU. This would be a critical next step toward our long-term goal to identify technology-based interventions to improve maternal mental health in the Intermountain West. Our central hypothesis is that Lōvu will be both feasible and have high patient and clinician satisfaction, and that Lōvu-generated data will be a promising substrate for AI-based mental health risk stratification.	Alzheimer	Non applicable	À vérifier	United States	À vérifier
LipiodolGenicular Artery Embolization for Reducing Pain in Symptomatic Knee Osteoarthritis: A Pilot Randomized Sham-Controlled Study (SHAM-PAIN) is a NIH-NIAMS funded project designed to assess enrollment feasibility and detect any differences between GAE and a similar sham intervention in reducing KOA-related pain at 3 months as measured by the Knee injury and Osteoarthritis Outcome Score (KOOS) pain subscore. Additionally, this study aims to determine the magnitude of difference in pain response between GAE and sham to adequately power a larger, more definitive randomized sham-controlled trial (RCT). The influence of psychosocial and psychocognitive factors, changes in analgesic use, and conditions of knee joint cartilage and effusion will similarly be explored to determine their impacts on perceived pain response to GAE.	Myopathies	Phase 2	Traitement symptomatique	United States	À vérifier
neck exoskeleton controllerDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé.	Sclérose latérale amyotrophique	Non applicable	Traitement symptomatique	United States	À vérifier
Nuestro Sueno: Cultural Adaptation of a Couples Intervention to Improve PAP Adherence and Sleep Health Among Latino Couples With Implications for Alzheimer's Disease RiskThe goal of this clinical trial is to learn if the culturally adapted couples sleep health intervention (Nuestro Sueno) improves positive airway pressure use and sleep among Hispanic couples in which one partner was diagnosed with sleep apnea and starting positive airway pressure treatment. The main questions are: 1. Does Nuestro sueno improve the patient's positive airway pressure use over the first 3 months of using it compared to an information control? 2. Does Nuestro sueno improve sleep quality for both the patient and partner, compared to an information control? 3. Does Nuestro sueno improve other aspects of life including quality of life and memory, compared to an information control?	Alzheimer	Phase 2	À vérifier	United States	À vérifier
ObservationalPeople with fibromyalgia report generalized body pain ("pain all over"), increased sensitivity to painful stimulation, chronic tiredness or low energy, sleep problems, and other physical and functional problems. The exact cause of the disorder is poorly understood, and treatment can be difficult. The degree to which duloxetine is helpful for people with fibromyalgia varies greatly. For some people, it is very helpful for managing fibromyalgia symptoms. For others, people may not notice any benefit. Yet for some, it is a little helpful and the effect is noticeable only when people forget to take the medicine. The purpose of this study is to collect data to better understand the relationship among gene types that control those enzymes, blood concentrations of duloxetine, and how it helps the symptoms.	Myopathies	À vérifier	Traitement symptomatique	United States	À vérifier
powered neck exoskeletonDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé.	Sclérose latérale amyotrophique	Non applicable	Traitement symptomatique	United States	À vérifier
Sham-tRNS (Transcranial Random Noise Stimulation)Upper extremity (UE) paresis or weakness is one of the most frequent impairments after stroke. Despite intense rehabilitation, motor and functional recovery of patients with severe hand impairments is poor. Hence, there is a need for more effective treatments to enhance motor function in patients with severe hand impairments after stroke. Adaptive functional electrical stimulation (FES) appears to be a promising treatment and has the potential to facilitate active movement in individuals with severe impairments post-stroke. In addition, transcranial random noise stimulation (trns) is a widely studied, non-invasive and safe method to enhance the corticomotor excitability in individuals with chronic stroke. However, the effect of combining trns and adaptive FES in patients with severe hand impairments has not been investigated. Therefore, the purpose of this study is to investigate whether combining trns with FES will enhance hand function in individuals with chronic stroke than FES alone. The investigators predict that combining trns with FES will significantly enhance hand function than FES alone.	Accident vasculaire cérébral	Non applicable	À vérifier	United States	À vérifier
Simple angiogramGenicular Artery Embolization for Reducing Pain in Symptomatic Knee Osteoarthritis: A Pilot Randomized Sham-Controlled Study (SHAM-PAIN) is a NIH-NIAMS funded project designed to assess enrollment feasibility and detect any differences between GAE and a similar sham intervention in reducing KOA-related pain at 3 months as measured by the Knee injury and Osteoarthritis Outcome Score (KOOS) pain subscore. Additionally, this study aims to determine the magnitude of difference in pain response between GAE and sham to adequately power a larger, more definitive randomized sham-controlled trial (RCT). The influence of psychosocial and psychocognitive factors, changes in analgesic use, and conditions of knee joint cartilage and effusion will similarly be explored to determine their impacts on perceived pain response to GAE.	Myopathies	Phase 2	Traitement symptomatique	United States	À vérifier
tRNS (Transcranial Random Noise Stimulation)Upper extremity (UE) paresis or weakness is one of the most frequent impairments after stroke. Despite intense rehabilitation, motor and functional recovery of patients with severe hand impairments is poor. Hence, there is a need for more effective treatments to enhance motor function in patients with severe hand impairments after stroke. Adaptive functional electrical stimulation (FES) appears to be a promising treatment and has the potential to facilitate active movement in individuals with severe impairments post-stroke. In addition, transcranial random noise stimulation (trns) is a widely studied, non-invasive and safe method to enhance the corticomotor excitability in individuals with chronic stroke. However, the effect of combining trns and adaptive FES in patients with severe hand impairments has not been investigated. Therefore, the purpose of this study is to investigate whether combining trns with FES will enhance hand function in individuals with chronic stroke than FES alone. The investigators predict that combining trns with FES will significantly enhance hand function than FES alone.	Accident vasculaire cérébral	Non applicable	À vérifier	United States	À vérifier
Effects of Xoçai Antioxidant Supplements on Atherosclerosis Risk FactorsAn antioxidant dietary supplement made from cocoa powder, and extracts of acai, grape and blueberry will be tested for effects on blood sugar, blood pressure, cholesterol and related parameters in human subjects.	Hypertension	NA	À vérifier	United States	À vérifier
Ferumoxytol infusionThis pilot study takes the innovative approach of using ultrasmall superparamagnetic iron oxide (USPIO) nanoparticle enhanced MRI to measure activity of the innate immune system within MS lesions. Activity of innate immunity has been hypothesized as one of the critical pathologic processes underpinning neurologic worsening in progressive MS. As such, in the short term this project proposes to investigate USPIO uptake in SPMS lesions as a promising in vivo imaging biomarker for chronic-active lesions, as distinguished from chronic-inactive lesions.	SEP	Phase 1		United States	À vérifier
Nuestro Sueno: Cultural Adaptation of a Couples Intervention to Improve PAP Adherence and Sleep Health Among Latino Couples With Implications for Alzheimer's Disease RiskThe goal of this clinical trial is to learn if the culturally adapted couples sleep health intervention (Nuestro Sueno) improves positive airway pressure use and sleep among Hispanic couples in which one partner was diagnosed with sleep apnea and starting positive airway pressure treatment. The main questions are: 1. Does Nuestro sueno improve the patient's positive airway pressure use over the first 3 months of using it compared to an information control? 2. Does Nuestro sueno improve sleep quality for both the patient and partner, compared to an information control? 3. Does Nuestro sueno improve other aspects of life including quality of life and memory, compared to an information control?	Alzheimer	Phase 2	À vérifier	United States	À vérifier
IUFU — Transforming Maternal Mental Health CareThe overall objective of this pilot study is to assess the feasibility of a RCT comparing Lōvu-augmented with usual prenatal care at UU. This would be a critical next step toward our long-term goal to identify technology-based interventions to improve maternal mental health in the Intermountain West. Our central hypothesis is that Lōvu will be both feasible and have high patient and clinician satisfaction, and that Lōvu-generated data will be a promising substrate for AI-based mental health risk stratification.	Alzheimer	Non applicable	À vérifier	United States	À vérifier
ObservationalPeople with fibromyalgia report generalized body pain ("pain all over"), increased sensitivity to painful stimulation, chronic tiredness or low energy, sleep problems, and other physical and functional problems. The exact cause of the disorder is poorly understood, and treatment can be difficult. The degree to which duloxetine is helpful for people with fibromyalgia varies greatly. For some people, it is very helpful for managing fibromyalgia symptoms. For others, people may not notice any benefit. Yet for some, it is a little helpful and the effect is noticeable only when people forget to take the medicine. The purpose of this study is to collect data to better understand the relationship among gene types that control those enzymes, blood concentrations of duloxetine, and how it helps the symptoms.	Myopathies	À vérifier	Traitement symptomatique	United States	À vérifier
neck exoskeleton controllerDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé.	Sclérose latérale amyotrophique	Non applicable	Traitement symptomatique	United States	À vérifier
tRNS (Transcranial Random Noise Stimulation)Upper extremity (UE) paresis or weakness is one of the most frequent impairments after stroke. Despite intense rehabilitation, motor and functional recovery of patients with severe hand impairments is poor. Hence, there is a need for more effective treatments to enhance motor function in patients with severe hand impairments after stroke. Adaptive functional electrical stimulation (FES) appears to be a promising treatment and has the potential to facilitate active movement in individuals with severe impairments post-stroke. In addition, transcranial random noise stimulation (trns) is a widely studied, non-invasive and safe method to enhance the corticomotor excitability in individuals with chronic stroke. However, the effect of combining trns and adaptive FES in patients with severe hand impairments has not been investigated. Therefore, the purpose of this study is to investigate whether combining trns with FES will enhance hand function in individuals with chronic stroke than FES alone. The investigators predict that combining trns with FES will significantly enhance hand function than FES alone.	Accident vasculaire cérébral	Non applicable	À vérifier	United States	À vérifier
Genicular Artery EmbolizationGenicular Artery Embolization for Reducing Pain in Symptomatic Knee Osteoarthritis: A Pilot Randomized Sham-Controlled Study (SHAM-PAIN) is a NIH-NIAMS funded project designed to assess enrollment feasibility and detect any differences between GAE and a similar sham intervention in reducing KOA-related pain at 3 months as measured by the Knee injury and Osteoarthritis Outcome Score (KOOS) pain subscore. Additionally, this study aims to determine the magnitude of difference in pain response between GAE and sham to adequately power a larger, more definitive randomized sham-controlled trial (RCT). The influence of psychosocial and psychocognitive factors, changes in analgesic use, and conditions of knee joint cartilage and effusion will similarly be explored to determine their impacts on perceived pain response to GAE.	Myopathies	Phase 2	Traitement symptomatique	United States	À vérifier
powered neck exoskeletonDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé.	Sclérose latérale amyotrophique	Non applicable	Traitement symptomatique	United States	À vérifier

Essais cliniques

Molécule	Indication / population	Phase	NCT	Titre	Statut
powered neck exoskeleton	Sclérose latérale amyotrophique	Non applicable	NCT07491562	Evaluation of a Structurally Suitable Neck Exoskeleton in Patients With Amyotrophic Lateral Sclerosis	COMPLETED
Empagliflozin	Maladie rénale chronique	Phase 1	NCT05614115	Safety, Tolerability, and Feasibility of Empagliflozin Therapy in Dialysis-dependent ESKD	COMPLETED
Genicular Artery Embolization	Myopathies	Phase 2	NCT06859164	SHAM-PAIN — Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis	RECRUITING
tRNS (Transcranial Random Noise Stimulation)	Accident vasculaire cérébral	Non applicable	NCT07887880	A Novel Multimodal Approach to Promote Motor Recovery and Plasticity After Stroke	NOT_YET_RECRUITING
neck exoskeleton controller	Sclérose latérale amyotrophique	Non applicable	NCT07836751	Using Gaze to Enable Head-neck Movements in Patients With Head Drop	RECRUITING
Observational	Myopathies	À vérifier	NCT06866444	DILIGENT — Duloxetine Metabolism and Fibromyalgia	RECRUITING
IUFU — Transforming Maternal Mental Health Care	Alzheimer	Non applicable	NCT07766174	IUFU — Transforming Maternal Mental Health Care	RECRUITING
Nuestro Sueno: Cultural Adaptation of a Couples Intervention to Improve PAP Adherence and Sleep Health Among Latino Couples With Implications for Alzheimer's Disease Risk	Alzheimer	Phase 2	NCT06649929	Nuestro Sueno: Cultural Adaptation of a Couples Intervention to Improve PAP Adherence and Sleep Health Among Latino Couples With Implications for Alzheimer's Disease Risk	ENROLLING_BY_INVITATION
Ferumoxytol infusion	SEP	Phase 1	NCT05357833	Novel Imaging Markers in SPMS	COMPLETED
Effects of Xoçai Antioxidant Supplements on Atherosclerosis Risk Factors	Hypertension	NA	NCT00666250	Effects of Xoçai Antioxidant Supplements on Atherosclerosis Risk Factors	COMPLETED

Publications

Molécule	Titre	Journal
neck exoskeleton controller	Preliminary Investigation of Myoelectric Control of an Assistive Neck Exoskeleton by Individuals With Amyotrophic Lateral Sclerosis.	IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
neck exoskeleton controller	Use of an Intraoperative Head, Neck, and Back Support Exoskeleton on Surgeons' Pain and Posture.	Annals of surgery
neck exoskeleton controller	Physical demands of hernia repair segments and the effect of exoskeleton support.	Surgical endoscopy
Effects of Xoçai Antioxidant Supplements on Atherosclerosis Risk Factors	Cardioprotective effect of the quercetin on cardiovascular remodeling and atherosclerosis in rodents fed a high-fat diet: A systematic review.	Chemico-biological interactions
Effects of Xoçai Antioxidant Supplements on Atherosclerosis Risk Factors	Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes.	Cannabis and cannabinoid research
Effects of Xoçai Antioxidant Supplements on Atherosclerosis Risk Factors	Prophylactic and therapeutic effects of EsV3 on atherosclerotic lesions in ApoE mice.	BMC cardiovascular disorders
Gadoteridol	Gadolinium-Enhanced Portable Ultra-Low-Field MRI for Evaluating Various Intracranial Pathologies.	AJNR. American journal of neuroradiology
Gadoteridol	Dynamic Susceptibility Contrast MRI Using Gadopiclenol for Evaluation of Relative Cerebral Blood Volume at 3T: A Comparison with Gadobutrol.	AJNR. American journal of neuroradiology
Gadoteridol	An Evaluation of the Long-term Impact of Gadolinium-based Contrast Agents on Sensory Nerves in Cynomolgus Monkeys.	Investigative radiology
Gadoteridol	Brain Tumor Imaging with Iopamidol CEST MRI: In Vivo Detection and Validation.	Chemical & biomedical imaging
Gadoteridol	Mn(II)-Tagged DOTA-Modified Sugar-Based Biopolymers as Gadolinium-Free Contrast Agents for Magnetic Resonance Imaging.	Pharmaceutics
Ferumoxytol infusion	Optimizing the ferumoxytol dose for vascular suppression in brachial plexus magnetic resonance neurography.	Physics in medicine and biology
Ferumoxytol infusion	USPIO enhanced MR imaging in CNS tumors (UMIC): a study protocol.	Nanomedicine (London, England)
Effects of Xoçai Antioxidant Supplements on Atherosclerosis Risk Factors	Watermelon Nutritional Composition with a Focus on L-Citrulline and Its Cardioprotective Health Effects-A Narrative Review.	Nutrients
Effects of Xoçai Antioxidant Supplements on Atherosclerosis Risk Factors	Selection and potential of cholesterol-lowering indigenous probiotic: insights from in vitro and in vivo study.	Scientific reports