University of California, Los Angeles — Biomedical Watch V2

Traitements11programmes

Essais6liés

Publications3liées

SourceDBlocale

Traitements

11

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
Deep Brain Stimulation (DBS)The purpose of this registry is to compile characteristics of world-wide outcomes for the use of Boston Scientific's commercially available Vercise DBS System in the treatment of Parkinson's disease. The utilization of Image Guided Programming (IGP), and other commercially available programming features, used as planning tools for the programming of patients with Boston Scientific's Vercise DBS System are also evaluated. Additionally, the utilization of the DBS Illumina 3D feature that may be used for the programming of patients with Boston Scientific's Vercise DBS Systems is also evaluated.	Parkinson	Non applicable	À vérifier	United States	À vérifier
Optimization of VNS in Epileptic Patients to Induce CardioprotectionThis study is a non-randomized, prospective study in patients with a diagnosis of epilepsy and previously implanted FDA approved Vagus Nerve Stimulation (VNS) devices. The goal of this clinical investigation is to evaluate the effects of adjusting vagus nerve stimulation parameters to engage cardioprotective effects.	Épilepsie	NA	À vérifier	United States	À vérifier
Sonablate HIFU deviceThe Sonablate HIFU device was approved by the U.S.FDA for prostate tissue ablation in October, 2015. The purpose of this observational research study is to investigate the localized treatment of prostate cancer using HIFU through clinical data and health-related quality of life (HRQOL) questionnaires.	Cancer	À vérifier	À vérifier	United States	À vérifier
ThiamineThe purpose of this study is to gain a better understanding of the association between brain changes and cognitive deficits in coronary heart disease (CHD) patients undergoing coronary artery bypass grafting (CABG) and whether a low-cost thiamine intervention can be used to reduce post-CABG cognitive issues in CHD subjects.	Maladie coronarienne	Phase 1	À vérifier	United States	À vérifier
Truvaga PlusIrritable bowel syndrome (IBS) is a chronic disorder of gut-brain interaction that causes abdominal pain and altered bowel habits. Many people with IBS also experience symptoms outside the bowel, such as headaches, widespread pain, poor sleep, anxiety, and depression; these symptoms are especially common in females. This study focuses on stress reactivity (SR), a persistent pattern of stress-system activity that may be linked to autonomic nervous system function, immune activity, the gut microbiome, and brain processing. The investigators will enroll adults with at least moderate IBS symptoms and randomly assign them to 8 weeks of non-invasive vagal nerve stimulation (nVNS) or Usual Care. Participants assigned to nVNS will use a handheld device on the left side of the neck at home twice daily. The investigators will compare changes in IBS severity and other physical symptoms and examine whether baseline or treatment-related changes in blood, stool, heart-rate variability, sex hormones, and brain imaging measures are associated with response. The study will also explore whether treatment effects and predictors differ by sex.	Maladie coronarienne	Non applicable	Traitement symptomatique	United States	À vérifier
Optimization of VNS in Epileptic Patients to Induce CardioprotectionThis study is a non-randomized, prospective study in patients with a diagnosis of epilepsy and previously implanted FDA approved Vagus Nerve Stimulation (VNS) devices. The goal of this clinical investigation is to evaluate the effects of adjusting vagus nerve stimulation parameters to engage cardioprotective effects.	Épilepsie	NA	À vérifier	United States	À vérifier
Deep Brain Stimulation (DBS)The purpose of this registry is to compile characteristics of world-wide outcomes for the use of Boston Scientific's commercially available Vercise DBS System in the treatment of Parkinson's disease. The utilization of Image Guided Programming (IGP), and other commercially available programming features, used as planning tools for the programming of patients with Boston Scientific's Vercise DBS System are also evaluated. Additionally, the utilization of the DBS Illumina 3D feature that may be used for the programming of patients with Boston Scientific's Vercise DBS Systems is also evaluated.	Parkinson	À vérifier	À vérifier	United States, Argentina, Austria, Belgium, Canada, France, Germany, Hungary, Israel, Italy, Poland, South Korea, Spain, Turkey (Türkiye), United Kingdom	À vérifier
Deep Brain Stimulation (DBS)The purpose of this registry is to compile characteristics of world-wide outcomes for the use of Boston Scientific's commercially available Vercise DBS System in the treatment of Parkinson's disease. The utilization of Image Guided Programming (IGP), and other commercially available programming features, used as planning tools for the programming of patients with Boston Scientific's Vercise DBS System are also evaluated. Additionally, the utilization of the DBS Illumina 3D feature that may be used for the programming of patients with Boston Scientific's Vercise DBS Systems is also evaluated.	Parkinson	Non applicable	À vérifier	United States	À vérifier
Sonablate HIFU deviceThe Sonablate HIFU device was approved by the U.S.FDA for prostate tissue ablation in October, 2015. The purpose of this observational research study is to investigate the localized treatment of prostate cancer using HIFU through clinical data and health-related quality of life (HRQOL) questionnaires.	Cancer	À vérifier	À vérifier	United States	À vérifier
ThiamineThe purpose of this study is to gain a better understanding of the association between brain changes and cognitive deficits in coronary heart disease (CHD) patients undergoing coronary artery bypass grafting (CABG) and whether a low-cost thiamine intervention can be used to reduce post-CABG cognitive issues in CHD subjects.	Maladie coronarienne	Phase 1	À vérifier	United States	À vérifier
Truvaga PlusIrritable bowel syndrome (IBS) is a chronic disorder of gut-brain interaction that causes abdominal pain and altered bowel habits. Many people with IBS also experience symptoms outside the bowel, such as headaches, widespread pain, poor sleep, anxiety, and depression; these symptoms are especially common in females. This study focuses on stress reactivity (SR), a persistent pattern of stress-system activity that may be linked to autonomic nervous system function, immune activity, the gut microbiome, and brain processing. The investigators will enroll adults with at least moderate IBS symptoms and randomly assign them to 8 weeks of non-invasive vagal nerve stimulation (nVNS) or Usual Care. Participants assigned to nVNS will use a handheld device on the left side of the neck at home twice daily. The investigators will compare changes in IBS severity and other physical symptoms and examine whether baseline or treatment-related changes in blood, stool, heart-rate variability, sex hormones, and brain imaging measures are associated with response. The study will also explore whether treatment effects and predictors differ by sex.	Maladie coronarienne	Non applicable	Traitement symptomatique	United States	À vérifier

Essais cliniques

6

Molécule	Indication / population	Phase	NCT	Titre	Statut
Truvaga Plus	Maladie coronarienne	Non applicable	NCT07926945	U54: nVNS RCT — Effects of nVNS on Stress Reactivity in IBS	NOT_YET_RECRUITING
Thiamine	Maladie coronarienne	Phase 1	NCT06326996	B1&CABG — Thiamine Intervention and Coronary Artery Bypass Grafting	RECRUITING
Sonablate HIFU device	Cancer	À vérifier	NCT03620786	HIFU for Focal Ablation of Prostate Tissue: An Observational Study	RECRUITING
Deep Brain Stimulation (DBS)	Parkinson	Non applicable	NCT01845883	Perceptual Decision Making Under Conditions of Visual Uncertainty	WITHDRAWN
Deep Brain Stimulation (DBS)	Parkinson	À vérifier	NCT02071134	Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry	RECRUITING
Optimization of VNS in Epileptic Patients to Induce Cardioprotection	Épilepsie	NA	NCT04387435	Optimization of VNS in Epileptic Patients to Induce Cardioprotection	COMPLETED

Publications

3

Molécule	Indication / population	Titre	Journal	Date
Deep Brain Stimulation (DBS)		Motor evoked potentials as markers of internal capsule current spread during deep brain stimulation for Parkinson's disease.	Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Deep Brain Stimulation (DBS)		Established and emerging neuromodulation for drug-resistant epilepsy.	Clinical neurology and neurosurgery
Deep Brain Stimulation (DBS)		Implantation of Deep Brain Stimulator Through Polyetheretherketone (PEEK) Cranioplasty.	The Journal of craniofacial surgery