University of Aberdeen — Biomedical Watch V2

Traitements6programmes

Essais3liés

Publications0liées

SourceDBlocale

Traitements

6

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
Antiepileptic DrugPeople with epilepsy are predisposed to having seizures ("fits"), where abnormal electrical activity in the brain disrupts normal brain functioning. It is a common condition with around 1% of the population of Scotland having this condition. They are treated with anti-seizure medications, drugs which reduce the chance of having seizures. Unfortunately, people with epilepsy are more likely to have severe infections than those without epilepsy and this is known to increase risk of seizures. The reasons for more severe infections in people with epilepsy are unclear, but one factor may be that anti-seizure medications impair the function of the body's immune system, which fights infection. Our previous work looking at residents in the North-East of Scotland showed a link between these medications and risk of infection. We plan to study people being started on antiseizure medications (ASMs) with a new diagnosis of epilepsy and those already on ASMs with an established diagnosis of epilepsy in NHS Grampian. We will compare with people not taking ASMs in a group of people with a single seizure and in a group of people with migraine. We will investigate immune function and infection risk with more-detailed information about individual's background, their seizures/epilepsy, other health conditions, and blood tests. We will then do laboratory experiments to determine how ASMs may impair the immune system by looking at the function of types of white blood cells that play an important part in immune functioning. We also wish to develop statistical tools which can identify an individual's risk of infection when starting ASMs, based on their demographic, medical and social characteristics, to target closer monitoring/changes in treatment to those with higher risk. This research will allow us to provide better individualised care in terms of which medication to use for treatment, what doses to use and whether blood tests to screen for impaired immune function would be helpful. We hope that this will lead to reduced risk of infections in people with epilepsy, resulting in better outcomes in this condition.	Épilepsie	À vérifier			À vérifier
GUT-PD — Constipation and Changes in the Gut Flora in Parkinson's DiseaseThe aim of this study is to investigate the link between gut health and Parkinson's disease	Parkinson	À vérifier	À vérifier	United Kingdom	À vérifier
MAESTRO — Music as an Adjunctive Epileptic Seizure Treatment OptionMozart's Sonata for two pianos in D major (K448) has been found to reduce the presence of abnormalities in the electroencephalograms of patients with epilepsy. We will examine the long term effects of listening to the K448 sonata on seizure frequency and cognitive functioning in children with drug resistant epilepsy allocated to either a study group or a control group. Patients' parents will complete a seizure diary for the whole study period, during which antiepileptic drug therapy of the child will remain unchanged. Baseline neuropsychological testing will be performed and a seizure diary will be kept for 3 months. The study group will listen to K448 for 8 continuous minutes every day for 2 months, while those in the control group will listen to control music for the same amount of time. Neuropsychological testing will be repeated at the end of the study period and any change from baseline examined. Seizure frequency during periods of exposure to music will be compared to baseline in both groups. Feedback questionnaires and parent focus groups will be used to gather information around the practicalities of exposure to music, potential problems and suggestions for how future studies might be improved.	Épilepsie	Non applicable	À vérifier	United Kingdom	À vérifier
GUT-PD — Constipation and Changes in the Gut Flora in Parkinson's DiseaseThe aim of this study is to investigate the link between gut health and Parkinson's disease	Parkinson	À vérifier	À vérifier	United Kingdom	À vérifier
MAESTRO — Music as an Adjunctive Epileptic Seizure Treatment OptionMozart's Sonata for two pianos in D major (K448) has been found to reduce the presence of abnormalities in the electroencephalograms of patients with epilepsy. We will examine the long term effects of listening to the K448 sonata on seizure frequency and cognitive functioning in children with drug resistant epilepsy allocated to either a study group or a control group. Patients' parents will complete a seizure diary for the whole study period, during which antiepileptic drug therapy of the child will remain unchanged. Baseline neuropsychological testing will be performed and a seizure diary will be kept for 3 months. The study group will listen to K448 for 8 continuous minutes every day for 2 months, while those in the control group will listen to control music for the same amount of time. Neuropsychological testing will be repeated at the end of the study period and any change from baseline examined. Seizure frequency during periods of exposure to music will be compared to baseline in both groups. Feedback questionnaires and parent focus groups will be used to gather information around the practicalities of exposure to music, potential problems and suggestions for how future studies might be improved.	Épilepsie	Non applicable	À vérifier	United Kingdom	À vérifier
Antiepileptic DrugPeople with epilepsy are predisposed to having seizures ("fits"), where abnormal electrical activity in the brain disrupts normal brain functioning. It is a common condition with around 1% of the population of Scotland having this condition. They are treated with anti-seizure medications, drugs which reduce the chance of having seizures. Unfortunately, people with epilepsy are more likely to have severe infections than those without epilepsy and this is known to increase risk of seizures. The reasons for more severe infections in people with epilepsy are unclear, but one factor may be that anti-seizure medications impair the function of the body's immune system, which fights infection. Our previous work looking at residents in the North-East of Scotland showed a link between these medications and risk of infection. We plan to study people being started on antiseizure medications (ASMs) with a new diagnosis of epilepsy and those already on ASMs with an established diagnosis of epilepsy in NHS Grampian. We will compare with people not taking ASMs in a group of people with a single seizure and in a group of people with migraine. We will investigate immune function and infection risk with more-detailed information about individual's background, their seizures/epilepsy, other health conditions, and blood tests. We will then do laboratory experiments to determine how ASMs may impair the immune system by looking at the function of types of white blood cells that play an important part in immune functioning. We also wish to develop statistical tools which can identify an individual's risk of infection when starting ASMs, based on their demographic, medical and social characteristics, to target closer monitoring/changes in treatment to those with higher risk. This research will allow us to provide better individualised care in terms of which medication to use for treatment, what doses to use and whether blood tests to screen for impaired immune function would be helpful. We hope that this will lead to reduced risk of infections in people with epilepsy, resulting in better outcomes in this condition.	Épilepsie	À vérifier			À vérifier

Essais cliniques

3

Molécule	Indication / population	Phase	NCT	Titre	Statut
Antiepileptic Drug	Épilepsie	À vérifier	NCT07903168	Epi-IRIS — Why Do People With Epilepsy Get More Infections?	NOT_YET_RECRUITING
MAESTRO — Music as an Adjunctive Epileptic Seizure Treatment Option	Épilepsie	Non applicable	NCT05545540	MAESTRO — Music as an Adjunctive Epileptic Seizure Treatment Option	ACTIVE_NOT_RECRUITING
GUT-PD — Constipation and Changes in the Gut Flora in Parkinson's Disease	Parkinson	À vérifier	NCT05787756	GUT-PD — Constipation and Changes in the Gut Flora in Parkinson's Disease	COMPLETED

Publications

0

Molécule	Indication / population	Titre	Journal	Date
Aucune publication.