University Hospital, Geneva — Biomedical Watch V2

Traitements3programmes

Essais1liés

Publications0liées

SourceDBlocale

Traitements

3

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
nCPAP modeThe goal of this clinical trial is to determine whether nasal continuous positive airway pressure (nCPAP) with neurally adjusted ventilatory assist (NAVA) backup ventilation (nCPAP-NAVA-backup mode) reduces the rate of severe apnea in extremely preterm infants ≤28 weeks' gestation compared with standard nasal continuous positive airway pressure (nCPAP mode). Severe apnea episodes is defined as breathing pause with oxygen levels ( SpO2) below 85% lasting at least 5 seconds and/or heart rate (HR) below 100 beats/minute lasting at least 5 seconds. Each participant will receive both interventions in a randomized order, serving as their own control. The total duration of the intervention will be 24h. Each intervention period will last 12 hours. A washout period of 3 hours will be included between intervention periods to minimize potential carryover effects. Randomized sequences to avoid order effects: * Sequence A: nCPAP mode → nCPAP-NAVA-backup mode * Sequence B: nCPAP-NAVA-backup mode →nCPAP mode	Maladie coronarienne	Non applicable	À vérifier	Switzerland	À vérifier
nCPAP-NAVA-backup modeThe goal of this clinical trial is to determine whether nasal continuous positive airway pressure (nCPAP) with neurally adjusted ventilatory assist (NAVA) backup ventilation (nCPAP-NAVA-backup mode) reduces the rate of severe apnea in extremely preterm infants ≤28 weeks' gestation compared with standard nasal continuous positive airway pressure (nCPAP mode). Severe apnea episodes is defined as breathing pause with oxygen levels ( SpO2) below 85% lasting at least 5 seconds and/or heart rate (HR) below 100 beats/minute lasting at least 5 seconds. Each participant will receive both interventions in a randomized order, serving as their own control. The total duration of the intervention will be 24h. Each intervention period will last 12 hours. A washout period of 3 hours will be included between intervention periods to minimize potential carryover effects. Randomized sequences to avoid order effects: * Sequence A: nCPAP mode → nCPAP-NAVA-backup mode * Sequence B: nCPAP-NAVA-backup mode →nCPAP mode	Maladie coronarienne	Non applicable	À vérifier	Switzerland	À vérifier
nCPAP-NAVA-backup modeThe goal of this clinical trial is to determine whether nasal continuous positive airway pressure (nCPAP) with neurally adjusted ventilatory assist (NAVA) backup ventilation (nCPAP-NAVA-backup mode) reduces the rate of severe apnea in extremely preterm infants ≤28 weeks' gestation compared with standard nasal continuous positive airway pressure (nCPAP mode). Severe apnea episodes is defined as breathing pause with oxygen levels ( SpO2) below 85% lasting at least 5 seconds and/or heart rate (HR) below 100 beats/minute lasting at least 5 seconds. Each participant will receive both interventions in a randomized order, serving as their own control. The total duration of the intervention will be 24h. Each intervention period will last 12 hours. A washout period of 3 hours will be included between intervention periods to minimize potential carryover effects. Randomized sequences to avoid order effects: * Sequence A: nCPAP mode → nCPAP-NAVA-backup mode * Sequence B: nCPAP-NAVA-backup mode →nCPAP mode	Maladie coronarienne	Non applicable	À vérifier	Switzerland	À vérifier

Essais cliniques

1

Molécule	Indication / population	Phase	NCT	Titre	Statut
nCPAP-NAVA-backup mode	Maladie coronarienne	Non applicable	NCT07923604	NAVAPNEA — nCPAP-NAVA-Backup Versus Standard nCPAP for Severe Apnea in Preterm Infants ≤28 Weeks	NOT_YET_RECRUITING

Publications

0

Molécule	Indication / population	Titre	Journal	Date
Aucune publication.