Thomas Jefferson University — Biomedical Watch V2

Traitements11programmes

Essais5liés

Publications7liées

SourceDBlocale

Traitements

11

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
Biopsy of ProstateThis phase III trial compares the use of contrast-enhanced multiparametric ultrasound (mp-US) to multiparametric magnetic resonance imaging (mp-MRI) for the diagnosis of clinically significant prostate cancer (PCa). A mp-US is a procedure in which a probe that sends out high-energy sound waves is inserted into the rectum. The sound waves are bounced off internal tissues or organs and make echoes. The echoes form a picture of body tissue called a sonogram. Perflutren lipid michrosphere (Definity) is a contrast agent that uses microbubbles to enhance ultrasound images of the prostate. Doctors hope to learn if the Definity-enhanced mp-US imaging technique can accurately direct targeted biopsy for the detection of clinically significant prostate cancer when compared to standard of care mp-MRI.	Cancer	Phase 3	À vérifier	United States, Netherlands	À vérifier
ketamine infusionKetamine is a drug used for anesthesia but at low doses it is a very effective pain reliever in several chronic conditions. Preliminary studies have shown that ketamine might be effective for patients with refractory chronic migraine, which is a severe type of headache for which patients usually have tried and failed many medications and can cause severe disability to their lives. This study will evaluate ketamine prospectively when given to patients who have "failed" an initial inpatient treatment.	Migraine	Phase 1	Traitement symptomatique	United States	À vérifier
Perflutren lipid microsphereThis phase III trial compares the use of contrast-enhanced multiparametric ultrasound (mp-US) to multiparametric magnetic resonance imaging (mp-MRI) for the diagnosis of clinically significant prostate cancer (PCa). A mp-US is a procedure in which a probe that sends out high-energy sound waves is inserted into the rectum. The sound waves are bounced off internal tissues or organs and make echoes. The echoes form a picture of body tissue called a sonogram. Perflutren lipid michrosphere (Definity) is a contrast agent that uses microbubbles to enhance ultrasound images of the prostate. Doctors hope to learn if the Definity-enhanced mp-US imaging technique can accurately direct targeted biopsy for the detection of clinically significant prostate cancer when compared to standard of care mp-MRI.	Cancer	Phase 3	À vérifier	United States, Netherlands	À vérifier
Research Study to Determine Sensitivity to Gentle Touch and Pressure During an Active Migraine Attack.Cutaneous allodynia (pronounced q-tane-ee-us all-o-din-ee-a) is common in migraine. It is a heightened skin sensitivity during an active migraine attack. Migraine attacks in patients who experience allodynia are more difficult to treat. This study intends to collect and evaluate data on the phenomenon of allodynia in patients with episodic migraine during an actual attack. The results of this study may help clinicians better understand allodynia, thereby helping them diagnose and more effectively manage patients with migraine and allodynia.	Migraine	À vérifier	À vérifier	United States	À vérifier
Tai Chi for Reducing Aromatase Inhibitor-Induced ArthralgiaThe objective of the pilot RCT is to evaluate the feasibility and acceptability of a Tai Chi intervention "TaiChi4Joint" vs. an HE AC group for relieving AIIA in women with hormone receptor positive stage I-III BCa. The investigators will pilot test our data collection for mechanism measures via three innovatively integrated biobehavioral pathways.	Cancer	Non applicable	À vérifier	United States	À vérifier
ultiparametric Magnetic Resonance ImagingThis phase III trial compares the use of contrast-enhanced multiparametric ultrasound (mp-US) to multiparametric magnetic resonance imaging (mp-MRI) for the diagnosis of clinically significant prostate cancer (PCa). A mp-US is a procedure in which a probe that sends out high-energy sound waves is inserted into the rectum. The sound waves are bounced off internal tissues or organs and make echoes. The echoes form a picture of body tissue called a sonogram. Perflutren lipid michrosphere (Definity) is a contrast agent that uses microbubbles to enhance ultrasound images of the prostate. Doctors hope to learn if the Definity-enhanced mp-US imaging technique can accurately direct targeted biopsy for the detection of clinically significant prostate cancer when compared to standard of care mp-MRI.	Cancer	Phase 3	À vérifier	United States, Netherlands	À vérifier
ketamine infusionKetamine is a drug used for anesthesia but at low doses it is a very effective pain reliever in several chronic conditions. Preliminary studies have shown that ketamine might be effective for patients with refractory chronic migraine, which is a severe type of headache for which patients usually have tried and failed many medications and can cause severe disability to their lives. This study will evaluate ketamine prospectively when given to patients who have "failed" an initial inpatient treatment.	Migraine	Phase 1	Traitement symptomatique	United States	À vérifier
ketamine infusionKetamine is a drug used for anesthesia but at low doses it is a very effective pain reliever in several chronic conditions. Preliminary studies have shown that ketamine might be effective for patients with refractory chronic migraine, which is a severe type of headache for which patients usually have tried and failed many medications and can cause severe disability to their lives. This study will evaluate ketamine prospectively when given to patients who have "failed" an initial inpatient treatment.	Migraine	Phase 1	Traitement symptomatique		À vérifier
Tai Chi for Reducing Aromatase Inhibitor-Induced ArthralgiaThe objective of the pilot RCT is to evaluate the feasibility and acceptability of a Tai Chi intervention "TaiChi4Joint" vs. an HE AC group for relieving AIIA in women with hormone receptor positive stage I-III BCa. The investigators will pilot test our data collection for mechanism measures via three innovatively integrated biobehavioral pathways.	Cancer	Non applicable	À vérifier	United States	À vérifier
Research Study to Determine Sensitivity to Gentle Touch and Pressure During an Active Migraine Attack.Cutaneous allodynia (pronounced q-tane-ee-us all-o-din-ee-a) is common in migraine. It is a heightened skin sensitivity during an active migraine attack. Migraine attacks in patients who experience allodynia are more difficult to treat. This study intends to collect and evaluate data on the phenomenon of allodynia in patients with episodic migraine during an actual attack. The results of this study may help clinicians better understand allodynia, thereby helping them diagnose and more effectively manage patients with migraine and allodynia.	Migraine	À vérifier	À vérifier	United States	À vérifier
ultiparametric Magnetic Resonance ImagingThis phase III trial compares the use of contrast-enhanced multiparametric ultrasound (mp-US) to multiparametric magnetic resonance imaging (mp-MRI) for the diagnosis of clinically significant prostate cancer (PCa). A mp-US is a procedure in which a probe that sends out high-energy sound waves is inserted into the rectum. The sound waves are bounced off internal tissues or organs and make echoes. The echoes form a picture of body tissue called a sonogram. Perflutren lipid michrosphere (Definity) is a contrast agent that uses microbubbles to enhance ultrasound images of the prostate. Doctors hope to learn if the Definity-enhanced mp-US imaging technique can accurately direct targeted biopsy for the detection of clinically significant prostate cancer when compared to standard of care mp-MRI.	Cancer	Phase 3	À vérifier	United States, Netherlands	À vérifier

Essais cliniques

5

Molécule	Indication / population	Phase	NCT	Titre	Statut
ultiparametric Magnetic Resonance Imaging	Cancer	Phase 3	NCT06024772	Multiparametric Ultrasound for the Diagnosis of Clinically Significant Prostate Cancer	NOT_YET_RECRUITING
Research Study to Determine Sensitivity to Gentle Touch and Pressure During an Active Migraine Attack.	Migraine	À vérifier	NCT00329771	Research Study to Determine Sensitivity to Gentle Touch and Pressure During an Active Migraine Attack.	COMPLETED
Tai Chi for Reducing Aromatase Inhibitor-Induced Arthralgia	Cancer	Non applicable	NCT07737951	Tai Chi for Reducing Aromatase Inhibitor-Induced Arthralgia	RECRUITING
ketamine infusion	Migraine	Phase 1	NCT06935552	Ketamine and Lidocaine Infusion in Refractory Chronic Migraine	NOT_YET_RECRUITING
ketamine infusion	Migraine	Phase 1	NCT03896256	Ketamine for Refractory Chronic Migraine: a Pilot Study	COMPLETED

Publications

7

Molécule	Indication / population	Titre	Journal	Date
ketamine infusion		Peri-operative opioid analgesic requirements in dogs undergoing hemilaminectomy with ketamine infusion with or without the use of an erector spinae plane block (ESPB).	Research in veterinary science
ketamine infusion		Safety and Efficacy of the Prescribing Practices of Ketamine for Pain and Agitation in the Medical Intensive Care Unit.	The Annals of pharmacotherapy
ketamine infusion		Increased morning cortisol after ketamine treatment for suicidal depression: Exploratory report from a randomized trial.	Journal of affective disorders
ketamine infusion		A scoping review for published guidelines for use of ketamine in chronic non-cancer pain.	Anaesthesia and intensive care
ketamine infusion		Long-Term Effectiveness of Repeated, Single-Day Intravenous Ketamine Infusions for Severe Arthritis: A Retrospective Cohort Study.	Pain physician
ketamine infusion		Innovative integration of high dose ketamine infusion, psychological services, and specialized multidisciplinary pain care for refractory pain syndromes.	Pain management
ketamine infusion		Comparison of Balanced General Anesthesia Protocols in Sleeve Gastrectomy Surgery with Respect to Postoperative Opioid Consumption.	Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses