The University of Hong Kong — Biomedical Watch V2

Traitements19programmes

Essais12liés

Publications5liées

SourceDBlocale

Traitements

19

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
A Self-management Based Survivorship Intervention for Chinese Cancer SurvivorsThis study, using a sequential multiple assessment randomized controlled trial (SMART) approach, will evaluate a cancer survivorship care intervention on physical symptom distress, weight management, self-efficacy in managing cancer and health-related quality of life among Chinese patients recently completed curative cancer treatment.	Cancer	Non applicable	Traitement symptomatique	Hong Kong	À vérifier
Bifidobacterium probiotics supplementationThe primary objective of this study is to investigate if a Bifidobacterium-based probiotic intervention would reduce clinic systolic BP in untreated middle-aged Chinese men and women with hypertension according to ACC/AHA guidelines (SBP ≥130 mm Hg) after 12 weeks of treatment. The investigators anticipate that this feasibility study will provide rationale to conduct a larger randomized clinical trial and preliminary data to estimate the power/ sample size of a larger RCT.	Hypertension	Phase 1	À vérifier	Hong Kong	À vérifier
Comfy Acupressure for the ElderlyThis is an assessor-blinded, randomized controlled trial. A total of 188 older adults aged 60-85 years with early/mild Alzheimer's disease (AD) will be recruited from care and attention homes for the elderly and elderly activity centres. They will be randomly assigned to receive least acupressure control (LAC, n = 94) and Comfy Acupressure for the Elderly (CAE, n = 94), administered by caregivers (i.e., trained research assistants), for 3 sessions a week for 12 months. The primary outcome is the change in the Montreal Cognitive Assessment, Hong Kong version (HK-MoCA) score from baseline. The secondary outcomes include functional independence, psychological well-being, sleep quality, and health-related quality of life. The outcomes will be assessed at baseline and once bimonthly thereafter, totalling 7 sessions. A linear mixed-effect model will be applied to compare the primary and secondary outcomes. Three blood samples will be collected at baseline, 6 months, and 12 months, respectively, and the baseline blood sample will be immediately measured for the measurement of plasma Aβ42, Aβ40, p-tau181, and p-tau217, blood glial fibrillary acidic protein (GFAP) and neurofilament light chain protein (NfL). Two-way repeated measures analysis of variance (ANOVA) will be used to detect significant differences in blood biomarkers between the two groups. Linear regression will be conducted to examine inter-correlations between clinical outcomes and biomarker levels. Health and social care resource use will additionally be recorded at baseline, 6 months, and 12 months for the economic evaluation to examine the cost-effectiveness of the CAE intervention compared with LAC.	Alzheimer	Non applicable	À vérifier	Hong Kong	À vérifier
EchopulseAfter obtaining informed consent, eligible subjects will be assigned randomly into either High intensity focused ultrasound group (HIFU) or Radioactive iodine (131I) therapy group (RAIT). After treatment, they will be followed up for 4 visits (1-month, 3-month, 6- month, 12-month of post treatment). At each visit, they will have physical examination, regular blood test and questionnaire to evaluate their quality of life. The collected data will be used to compare the effectiveness between HIFU and RAIT for non-toxic multi-nodular goiter (NMNG). The primary purepose is to find out the best non-invasive way in treating NMNG. For HIFU, you may experience: 1. Mild bruising and redness at the site of treatment 2. Edema of the skin tissue 3. Pain/discomfort during the procedure 4. Skin burns but rare (\<1%) 5. Vocal cord paresis on the side of the treated lobe but rare (\<1%) 6. Unintentional damage to the surrounding tissue (outside the planned treatment area). For RAIT, you may experience neck tenderness or sore throat in the following few days as developing moderate inflammation in the thyroid and producing discomfort in the neck or throat area. Your symptoms may turn worse for first few week, but will improve over weeks.	Cancer	Non applicable	Traitement symptomatique	Hong Kong	À vérifier
Effectiveness of Strength-based Intervention for Elderly With Dementia Living in the CommunityIn the realm of dementia care, the imperative to intervene at the earliest stages of cognitive decline is paramount. Recognizing this pivotal moment, the development of innovative and effective interventions becomes imperative in delaying dementia progression. Rooted in the Roy Adaptation Model and Zimmer's Theory of Psychological Empowerment, the investigator team has developed the empowerment-based dyadic strength-based intervention, which integrates strength-based and empowerment methodologies. Emphasizing a shift from deficits to capabilities, the strength-based approach fosters awareness of collective strengths within care dyads, facilitating coping mechanisms and resilience in the face of cognitive afflictions.	Alzheimer	Non applicable	Ralentissement de la progression	Hong Kong	À vérifier
Extracorporeal Shock Wave TherapyThis randomized single-blind controlled trial aims to compare the effectiveness of ultrasound-guided dry needling and extracorporeal shock wave therapy in patients with lateral epicondylitis. Sixty participants aged 18-65 years will be randomized into two groups. The dry needling group will receive ultrasound-guided tendon fenestration once weekly for five sessions, while the ESWT group will receive radial extracorporeal shock wave therapy once weekly for five sessions. All participants will be given a standardized home exercise program. Pain, function, grip strength, pressure pain threshold, quality of life, and ultrasonographic findings will be evaluated at baseline, post-treatment, and at 3- and 6-month follow-up. The primary outcome is change in pain severity measured by Visual Analog Scale.	Maladie coronarienne, Myopathies	Non applicable	Traitement symptomatique	Hong Kong	À vérifier
Implementation and Evaluation of a Fear of Cancer Recurrence Screening, Referral and Management ProgramThe purpose of this study is to evaluate the process and outcomes of an implementation program designed to implement fear of cancer screening, referral and management into routine cancer care clinics, using a stepped-wedge cluster randomized controlled trial.	Cancer	Non applicable	À vérifier	Hong Kong	À vérifier
Least acupressure controlThis is an assessor-blinded, randomized controlled trial. A total of 188 older adults aged 60-85 years with early/mild Alzheimer's disease (AD) will be recruited from care and attention homes for the elderly and elderly activity centres. They will be randomly assigned to receive least acupressure control (LAC, n = 94) and Comfy Acupressure for the Elderly (CAE, n = 94), administered by caregivers (i.e., trained research assistants), for 3 sessions a week for 12 months. The primary outcome is the change in the Montreal Cognitive Assessment, Hong Kong version (HK-MoCA) score from baseline. The secondary outcomes include functional independence, psychological well-being, sleep quality, and health-related quality of life. The outcomes will be assessed at baseline and once bimonthly thereafter, totalling 7 sessions. A linear mixed-effect model will be applied to compare the primary and secondary outcomes. Three blood samples will be collected at baseline, 6 months, and 12 months, respectively, and the baseline blood sample will be immediately measured for the measurement of plasma Aβ42, Aβ40, p-tau181, and p-tau217, blood glial fibrillary acidic protein (GFAP) and neurofilament light chain protein (NfL). Two-way repeated measures analysis of variance (ANOVA) will be used to detect significant differences in blood biomarkers between the two groups. Linear regression will be conducted to examine inter-correlations between clinical outcomes and biomarker levels. Health and social care resource use will additionally be recorded at baseline, 6 months, and 12 months for the economic evaluation to examine the cost-effectiveness of the CAE intervention compared with LAC.	Alzheimer	Non applicable	À vérifier	Hong Kong	À vérifier
Managing Fear of Cancer Progression Metacognition-based Vs Supportive-expressive Based ApproachesThe present study aims to conduct a randomized controlled trial to assess the effect of CALM intervention and ConquerFear intervention on fear of cancer progression among Chinese patients diagnosed with advanced cancer.	Cancer	Non applicable	Ralentissement de la progression	Hong Kong	À vérifier
Radioactive iodine (Radioidine i131)After obtaining informed consent, eligible subjects will be assigned randomly into either High intensity focused ultrasound group (HIFU) or Radioactive iodine (131I) therapy group (RAIT). After treatment, they will be followed up for 4 visits (1-month, 3-month, 6- month, 12-month of post treatment). At each visit, they will have physical examination, regular blood test and questionnaire to evaluate their quality of life. The collected data will be used to compare the effectiveness between HIFU and RAIT for non-toxic multi-nodular goiter (NMNG). The primary purepose is to find out the best non-invasive way in treating NMNG. For HIFU, you may experience: 1. Mild bruising and redness at the site of treatment 2. Edema of the skin tissue 3. Pain/discomfort during the procedure 4. Skin burns but rare (\<1%) 5. Vocal cord paresis on the side of the treated lobe but rare (\<1%) 6. Unintentional damage to the surrounding tissue (outside the planned treatment area). For RAIT, you may experience neck tenderness or sore throat in the following few days as developing moderate inflammation in the thyroid and producing discomfort in the neck or throat area. Your symptoms may turn worse for first few week, but will improve over weeks.	Cancer	Non applicable	Traitement symptomatique	Hong Kong	À vérifier
Managing Fear of Cancer Progression Metacognition-based Vs Supportive-expressive Based ApproachesThe present study aims to conduct a randomized controlled trial to assess the effect of CALM intervention and ConquerFear intervention on fear of cancer progression among Chinese patients diagnosed with advanced cancer.	Cancer	Non applicable	Ralentissement de la progression	Hong Kong	À vérifier
A Self-management Based Survivorship Intervention for Chinese Cancer SurvivorsThis study, using a sequential multiple assessment randomized controlled trial (SMART) approach, will evaluate a cancer survivorship care intervention on physical symptom distress, weight management, self-efficacy in managing cancer and health-related quality of life among Chinese patients recently completed curative cancer treatment.	Cancer	Non applicable	Traitement symptomatique	Hong Kong	À vérifier
Effectiveness of Strength-based Intervention for Elderly With Dementia Living in the CommunityIn the realm of dementia care, the imperative to intervene at the earliest stages of cognitive decline is paramount. Recognizing this pivotal moment, the development of innovative and effective interventions becomes imperative in delaying dementia progression. Rooted in the Roy Adaptation Model and Zimmer's Theory of Psychological Empowerment, the investigator team has developed the empowerment-based dyadic strength-based intervention, which integrates strength-based and empowerment methodologies. Emphasizing a shift from deficits to capabilities, the strength-based approach fosters awareness of collective strengths within care dyads, facilitating coping mechanisms and resilience in the face of cognitive afflictions.	Alzheimer	Non applicable	Ralentissement de la progression	Hong Kong	À vérifier
Bifidobacterium probiotics supplementationThe primary objective of this study is to investigate if a Bifidobacterium-based probiotic intervention would reduce clinic systolic BP in untreated middle-aged Chinese men and women with hypertension according to ACC/AHA guidelines (SBP ≥130 mm Hg) after 12 weeks of treatment. The investigators anticipate that this feasibility study will provide rationale to conduct a larger randomized clinical trial and preliminary data to estimate the power/ sample size of a larger RCT.	Hypertension	Phase 1	À vérifier	Hong Kong	À vérifier
Implementation and Evaluation of a Fear of Cancer Recurrence Screening, Referral and Management ProgramThe purpose of this study is to evaluate the process and outcomes of an implementation program designed to implement fear of cancer screening, referral and management into routine cancer care clinics, using a stepped-wedge cluster randomized controlled trial.	Cancer	Non applicable	À vérifier	Hong Kong	À vérifier
EchopulseAfter obtaining informed consent, eligible subjects will be assigned randomly into either High intensity focused ultrasound group (HIFU) or Radioactive iodine (131I) therapy group (RAIT). After treatment, they will be followed up for 4 visits (1-month, 3-month, 6- month, 12-month of post treatment). At each visit, they will have physical examination, regular blood test and questionnaire to evaluate their quality of life. The collected data will be used to compare the effectiveness between HIFU and RAIT for non-toxic multi-nodular goiter (NMNG). The primary purepose is to find out the best non-invasive way in treating NMNG. For HIFU, you may experience: 1. Mild bruising and redness at the site of treatment 2. Edema of the skin tissue 3. Pain/discomfort during the procedure 4. Skin burns but rare (\<1%) 5. Vocal cord paresis on the side of the treated lobe but rare (\<1%) 6. Unintentional damage to the surrounding tissue (outside the planned treatment area). For RAIT, you may experience neck tenderness or sore throat in the following few days as developing moderate inflammation in the thyroid and producing discomfort in the neck or throat area. Your symptoms may turn worse for first few week, but will improve over weeks.	Cancer	Non applicable	Traitement symptomatique	Hong Kong	À vérifier
EchopulseAfter obtaining informed consent, eligible subjects will be assigned randomly into either High intensity focused ultrasound group (HIFU) or Radioactive iodine (131I) therapy group (RAIT). After treatment, they will be followed up for 4 visits (1-month, 3-month, 6- month, 12-month of post treatment). At each visit, they will have physical examination, regular blood test and questionnaire to evaluate their quality of life. The collected data will be used to compare the effectiveness between HIFU and RAIT for non-toxic multi-nodular goiter (NMNG). The primary purepose is to find out the best non-invasive way in treating NMNG. For HIFU, you may experience: 1. Mild bruising and redness at the site of treatment 2. Edema of the skin tissue 3. Pain/discomfort during the procedure 4. Skin burns but rare (\<1%) 5. Vocal cord paresis on the side of the treated lobe but rare (\<1%) 6. Unintentional damage to the surrounding tissue (outside the planned treatment area). For RAIT, you may experience neck tenderness or sore throat in the following few days as developing moderate inflammation in the thyroid and producing discomfort in the neck or throat area. Your symptoms may turn worse for first few week, but will improve over weeks.	Cancer	Phase 1	Traitement symptomatique	United States	À vérifier
Comfy Acupressure for the ElderlyThis is an assessor-blinded, randomized controlled trial. A total of 188 older adults aged 60-85 years with early/mild Alzheimer's disease (AD) will be recruited from care and attention homes for the elderly and elderly activity centres. They will be randomly assigned to receive least acupressure control (LAC, n = 94) and Comfy Acupressure for the Elderly (CAE, n = 94), administered by caregivers (i.e., trained research assistants), for 3 sessions a week for 12 months. The primary outcome is the change in the Montreal Cognitive Assessment, Hong Kong version (HK-MoCA) score from baseline. The secondary outcomes include functional independence, psychological well-being, sleep quality, and health-related quality of life. The outcomes will be assessed at baseline and once bimonthly thereafter, totalling 7 sessions. A linear mixed-effect model will be applied to compare the primary and secondary outcomes. Three blood samples will be collected at baseline, 6 months, and 12 months, respectively, and the baseline blood sample will be immediately measured for the measurement of plasma Aβ42, Aβ40, p-tau181, and p-tau217, blood glial fibrillary acidic protein (GFAP) and neurofilament light chain protein (NfL). Two-way repeated measures analysis of variance (ANOVA) will be used to detect significant differences in blood biomarkers between the two groups. Linear regression will be conducted to examine inter-correlations between clinical outcomes and biomarker levels. Health and social care resource use will additionally be recorded at baseline, 6 months, and 12 months for the economic evaluation to examine the cost-effectiveness of the CAE intervention compared with LAC.	Alzheimer	Non applicable	Ralentissement de la progression	Hong Kong	À vérifier
Extracorporeal Shock Wave TherapyThis randomized single-blind controlled trial aims to compare the effectiveness of ultrasound-guided dry needling and extracorporeal shock wave therapy in patients with lateral epicondylitis. Sixty participants aged 18-65 years will be randomized into two groups. The dry needling group will receive ultrasound-guided tendon fenestration once weekly for five sessions, while the ESWT group will receive radial extracorporeal shock wave therapy once weekly for five sessions. All participants will be given a standardized home exercise program. Pain, function, grip strength, pressure pain threshold, quality of life, and ultrasonographic findings will be evaluated at baseline, post-treatment, and at 3- and 6-month follow-up. The primary outcome is change in pain severity measured by Visual Analog Scale.	Maladie coronarienne	Non applicable	Traitement symptomatique	Hong Kong	À vérifier

Essais cliniques

12

Molécule	Indication / population	Phase	NCT	Titre	Statut
Extracorporeal Shock Wave Therapy	Maladie coronarienne	Non applicable	NCT07068399	CSWT — Use of Shock Wave Therapy for Neo-Vascularisation in Non-critical Coronary Artery Disease: Validation by Quantitative Cardiac MRI Perfusion	RECRUITING
Histotripsie — HistoSonics Edison System	Cancer	Non applicable	NCT07873619	Histotripsy for Peritoneal Tumour and Lymph Node: a Pilot Study	NOT_YET_RECRUITING
Comfy Acupressure for the Elderly	Alzheimer	Non applicable	NCT07779863	Acupressure as Long-term Intervention to Slow the Progression of Early/Mild Alzheimer's Disease	NOT_YET_RECRUITING
Echopulse	Cancer	Phase 1	NCT04116320	AM-003 — Focused Ultrasound Ablation and PD-1 Antibody Blockade in Advanced Solid Tumors	TERMINATED
Histotripsie — HistoSonics Edison System	Cancer	Non applicable	NCT07873606	histo-pancreas — Histotripsy x Pancreatic Cancer	RECRUITING
Focal Therapy for Prostate Cancer	Cancer	À vérifier	NCT07792590	Registry for Prostate Cancer Focal Therapy	RECRUITING
Echopulse	Cancer	Non applicable	NCT04009863	HIFU Ablation vs Fixed-dose RAI-131 Therapy in Moderate-sized Non-toxic MNG	COMPLETED
Implementation and Evaluation of a Fear of Cancer Recurrence Screening, Referral and Management Program	Cancer	Non applicable	NCT06181344	Implementation and Evaluation of a Fear of Cancer Recurrence Screening, Referral and Management Program	RECRUITING
Bifidobacterium probiotics supplementation	Hypertension	Phase 1	NCT07206303	The Effects of Bifidobacterium-based Probiotics in Reducing Blood Pressure in Middle-aged Chinese With Hypertension	NOT_YET_RECRUITING
Effectiveness of Strength-based Intervention for Elderly With Dementia Living in the Community	Alzheimer	Non applicable	NCT07037550	Effectiveness of Strength-based Intervention for Elderly With Dementia Living in the Community	ACTIVE_NOT_RECRUITING
A Self-management Based Survivorship Intervention for Chinese Cancer Survivors	Cancer	Non applicable	NCT05534386	A Self-management Based Survivorship Intervention for Chinese Cancer Survivors	RECRUITING
Managing Fear of Cancer Progression Metacognition-based Vs Supportive-expressive Based Approaches	Cancer	Non applicable	NCT05679518	Managing Fear of Cancer Progression Metacognition-based Vs Supportive-expressive Based Approaches	RECRUITING

Publications

5

Molécule	Indication / population	Titre	Journal	Date
A Self-management Based Survivorship Intervention for Chinese Cancer Survivors		Use and Influencing Factors of mHealth Services Among Adult Survivors of Cancer: Cross-Sectional Survey Study.	Journal of medical Internet research
A Self-management Based Survivorship Intervention for Chinese Cancer Survivors		Culturally Adapting a Video-Based Self-acupressure Intervention to Manage Symptoms for Black and Latina Breast Cancer Survivors.	Journal of cancer education : the official journal of the American Association for Cancer Education
A Self-management Based Survivorship Intervention for Chinese Cancer Survivors		Balancing cancer and comorbidity: a multicenter qualitative study on how comorbidity shapes survivorship care preferences in China.	Journal of cancer survivorship : research and practice
Extracorporeal Shock Wave Therapy		Extracorporeal Shock Wave Therapy Combined with Subtalar Arthroereisis and Medial Column Stabilisation in the Treatment of PCFD: A Retrospective Study.	Indian journal of orthopaedics
Extracorporeal Shock Wave Therapy		Narrative review: Extracorporeal shock wave therapy for pain management in musculoskeletal rehabilitation: Mechanisms, clinical applications, and safety.	The Journal of international medical research