Taipei Veterans General Hospital, Taiwan — Biomedical Watch V2

Traitements6programmes

Essais2liés

Publications8liées

SourceDBlocale

Traitements

6

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
CBPPatients with uncontrolled or newly diagnosed hypertension will be randomized to have hypertension management decisions made on the basis of the unattended automated blood pressure (uAOBP) , home BP, and central BP monitoring. This study evaluates the optimal guiding strategy for hypertension will help define which BP monitoring is the most effective strategy to guide the clinical management of hypertension.	Hypertension	NA	À vérifier	Taiwan	À vérifier
Exablate 4000 Transcranial MRgfUS SystemFocused ultrasound (FUS) has been shown to differentially lesion or modulate (excite and inhibit) brain circuit and neural activity across a broad range of acoustic stimulus parameters (intensity, duty cycle, pulse repetition frequency and pulse duration) for decades. From our previous study, FUS sonication may suppress the number of epileptic signal bursts observed in EEG recordings after the induction of acute epilepsy. The presence of the suppressive effect was found in terms of the number of epileptic EEG spikes from the analysis of the unfiltered and theta-band EEG activity, and further discontinue the seizure attacks. EEG activity has also been consistently reported to have a positive correlation with the level of epilepsy, and FUS-mediated reduction of epileptic EEG activity was most notably observed, no matter lesioning or modulating effects. The aims of this study are to demonstrate the safety and efficacy of FUS technology in epilepsy patients and to estimate the optimal parameters of focused ultrasound exposure that will be used in the case of epilepsy.	Épilepsie	Non applicable	À vérifier	Taiwan	À vérifier
Home BPPatients with uncontrolled or newly diagnosed hypertension will be randomized to have hypertension management decisions made on the basis of the unattended automated blood pressure (uAOBP) , home BP, and central BP monitoring. This study evaluates the optimal guiding strategy for hypertension will help define which BP monitoring is the most effective strategy to guide the clinical management of hypertension.	Hypertension	NA	À vérifier	Taiwan	À vérifier
uAOBPPatients with uncontrolled or newly diagnosed hypertension will be randomized to have hypertension management decisions made on the basis of the unattended automated blood pressure (uAOBP) , home BP, and central BP monitoring. This study evaluates the optimal guiding strategy for hypertension will help define which BP monitoring is the most effective strategy to guide the clinical management of hypertension.	Hypertension	NA	À vérifier	Taiwan	À vérifier
uAOBPPatients with uncontrolled or newly diagnosed hypertension will be randomized to have hypertension management decisions made on the basis of the unattended automated blood pressure (uAOBP) , home BP, and central BP monitoring. This study evaluates the optimal guiding strategy for hypertension will help define which BP monitoring is the most effective strategy to guide the clinical management of hypertension.	Hypertension	NA	À vérifier	Taiwan	À vérifier
Exablate 4000 Transcranial MRgfUS SystemFocused ultrasound (FUS) has been shown to differentially lesion or modulate (excite and inhibit) brain circuit and neural activity across a broad range of acoustic stimulus parameters (intensity, duty cycle, pulse repetition frequency and pulse duration) for decades. From our previous study, FUS sonication may suppress the number of epileptic signal bursts observed in EEG recordings after the induction of acute epilepsy. The presence of the suppressive effect was found in terms of the number of epileptic EEG spikes from the analysis of the unfiltered and theta-band EEG activity, and further discontinue the seizure attacks. EEG activity has also been consistently reported to have a positive correlation with the level of epilepsy, and FUS-mediated reduction of epileptic EEG activity was most notably observed, no matter lesioning or modulating effects. The aims of this study are to demonstrate the safety and efficacy of FUS technology in epilepsy patients and to estimate the optimal parameters of focused ultrasound exposure that will be used in the case of epilepsy.	Épilepsie	Non applicable	À vérifier	Taiwan	À vérifier

Essais cliniques

2

Molécule	Indication / population	Phase	NCT	Titre	Statut
Exablate 4000 Transcranial MRgfUS System	Épilepsie	Non applicable	NCT06292494	Focused Ultrasound for Drug-resistant Epilepsy	RECRUITING
uAOBP	Hypertension	NA	NCT03578848	GYMNs — Guiding Hypertension Management Using Different Blood Pressure Monitoring Strategies	UNKNOWN

Publications

8

Molécule	Indication / population	Titre	Journal	Date
CBP		Targeted discovery of anti-skin aging peptides from Camelus bactrianus placenta: Multi-activity screening, network pharmacology, and in vitro validation focusing on MMP-1 inhibition.	Journal of ethnopharmacology
CBP		Bu-Sui-Dan promotes angiogenesis to mitigate age-related osteoporosis via the ZEB1/Notch1 axis.	Journal of ethnopharmacology
CBP		Unlocking raw-corncob consolidated bioprocessing for malic acid production by DyP-enabled lignin deconstruction in .	Synthetic and systems biotechnology
Home BP		Association between orthostatic blood pressure change and masked and white coat hypertension: the Nagahama study.	Journal of hypertension
Home BP		Measurement of blood pressure in European Society of Hypertension Excellence Centres: a survey by the Young Investigators Group of the European Society of Hypertension.	Blood pressure
Home BP		Reassessing blood pressure control: the role of long-term blood pressure variability and time in target range.	Blood pressure
uAOBP		Association of Anxiety with Discrepancies Between Unattended and Attended Office Blood Pressure Measurement.	American journal of hypertension
uAOBP		Comparison of unattended, attended and routine clinic systolic blood pressure measurements and determinants of blood pressure difference between attended and unattended BP.	Journal of human hypertension