Fiche société
Sabine Mueller, MD, PhD
Traitements, essais et publications liés.
Traitements3programmes
Essais1liés
Publications2liées
SourceDBlocale
Traitements
3| Molécule | Indication / population | Phase | Objectif | Pays | Résultat |
|---|---|---|---|---|---|
| ADI-PEG 20 (Arginine deiminase pegylated)This is an open label, intra-patient dose escalation, to evaluate ADI-PEG 20, in combination with Temozolomide (TMZ) and radiation therapy (RT) in children, adolescents and young adult patients with newly diagnosed high grade glioma (HGG). | Cancer | Phase 1/2 | À vérifier | United States | À vérifier |
| temozolomide (TMZ)The purpose of this study is to see if combining silevertinib with temozolomide after surgery and radiotherapy helps treat newly diagnosed glioblastoma (GBM) better than using temozolomide alone in the maintenance setting. Specifically, this study is being done to find answers to the following questions: * How much of the study drugs (silevertinib combined with temozolomide) should be given to participants with GBM? * What are the side effects participants have when taking the study drug (silevertinib combined with temozolomide)? * Can the study drug (silevertinib combined with temozolomide) help participants with GBM live longer without disease progression compared to treatment with temozolomide alone? | Cancer | Phase 1/2 | Ralentissement de la progression | United States | À vérifier |
| ADI-PEG 20 (Arginine deiminase pegylated)This is an open label, intra-patient dose escalation, to evaluate ADI-PEG 20, in combination with Temozolomide (TMZ) and radiation therapy (RT) in children, adolescents and young adult patients with newly diagnosed high grade glioma (HGG). | Cancer | Phase 1/2 | À vérifier | United States | À vérifier |
Essais cliniques
1| Molécule | Indication / population | Phase | NCT | Titre | Statut |
|---|---|---|---|---|---|
| ADI-PEG 20 (Arginine deiminase pegylated) | Cancer | Phase 1/2 | NCT07389278 | Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG) | NOT_YET_RECRUITING |
Publications
2| Molécule | Indication / population | Titre | Journal | Date |
|---|---|---|---|---|
| temozolomide (TMZ) | Rewiring cell death and evading repair: Evolution of temozolomide and emerging strategies against resistant glioblastoma. | European journal of medicinal chemistry | ||
| temozolomide (TMZ) | A dual-channel electron expressway triggers piezocatalytic ferroptosis-mitochondrial catastrophe cascade for anti-glioblastoma therapy. | Biomaterials |