Royal Brompton & Harefield NHS Foundation Trust — Biomedical Watch V2

Traitements2programmes

Essais2liés

Publications3liées

SourceDBlocale

Traitements

2

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
HydrocortisoneThe purpose of this study is to assess the efficacy and safety of opevesostat plus daily corticosteroids compared to alternative abiraterone acetate or enzalutamide in participants with Metastatic Castration-resistant Prostate Cancer (mCRPC) previously treated with one next-generation hormonal agent (NHA). The primary study hypothesis is that opevesostat is superior to alternative abiraterone acetate or enzalutamide with respect to radiographic progression free survival (rPFS) per Prostate Cancer Working Group (PCWG) Modified Response Evaluation Criteria in Solid Tumors (RECIST 1.1), as assessed by Blinded Independent Central Review (BICR), in androgen receptor ligand binding domain (AR LBD) mutation positive and negative participants.	Cancer, SEP	À vérifier	Ralentissement de la progression	United Kingdom	À vérifier
HydrocortisoneThe purpose of this study is to assess the efficacy and safety of opevesostat plus daily corticosteroids compared to alternative abiraterone acetate or enzalutamide in participants with Metastatic Castration-resistant Prostate Cancer (mCRPC) previously treated with one next-generation hormonal agent (NHA). The primary study hypothesis is that opevesostat is superior to alternative abiraterone acetate or enzalutamide with respect to radiographic progression free survival (rPFS) per Prostate Cancer Working Group (PCWG) Modified Response Evaluation Criteria in Solid Tumors (RECIST 1.1), as assessed by Blinded Independent Central Review (BICR), in androgen receptor ligand binding domain (AR LBD) mutation positive and negative participants.	Cancer	Phase 2	Ralentissement de la progression	United States	À vérifier

Essais cliniques

2

Molécule	Indication / population	Phase	NCT	Titre	Statut
Aminophylline	SEP	À vérifier	NCT02270827	SARAH — A Pilot Study Into Health Pre and Post Treatment With Intravenous Aminophylline and Hydrocortisone in Severe Asthmatics	TERMINATED
Hydrocortisone	Cancer	Phase 2	NCT07763210	Lazarus: IT Therapy for ICANS	NOT_YET_RECRUITING

Publications

3

Molécule	Indication / population	Titre	Journal	Date
Hydrocortisone		Two-week essential oil inhalation treatment modulates the cortisol awakening response and improves self-reported symptoms in stressed adults.	Stress (Amsterdam, Netherlands)
Hydrocortisone		The impact of (poly)phenol-rich sugarcane extract intervention on markers of gastrointestinal integrity and systemic inflammation in response to exertional-heat stress.	Journal of the International Society of Sports Nutrition
Hydrocortisone		The association between pubertal timing and diurnal cortisol activity in middle adolescence.	Stress (Amsterdam, Netherlands)