National Taiwan University Hospital — Biomedical Watch V2

Traitements17programmes

Essais13liés

Publications3liées

SourceDBlocale

Traitements

17

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
'Intra-luminal radiofrequency ablation (Habib EndoHPB)Only a small proportion of patients with biliary obstruction caused by hepatopancreatobiliary malignancies are suitable for surgical resection. Therefore, most patients with malignant biliary obstruction will need palliation of their obstructive jaundice to relieve the symptoms and prevent life threatening complications such as biliary sepsis. The endoscopic or percutaneous/transhepatic routes, such as endoscopic retrograde cholangiopancreatography (ERCP) and percutaneous transhepatic cholangiography (PTC), and stents are accepted approaches for the relief of jaundice in malignant biliary obstruction. Improvement in the bilirubin level is also essential before palliative chemotherapy is considered in these patients. However, tumor ingrowth still remains a major cause of obstruction. In this trial, the investigators will use HabibTM EndoHPB (EMcision Ltd., UK) catheter which was used for the endobiliary radiofrequency ablation (RFA) treatment as a form of neoadjuvant therapy in hepatopancreatobiliary adenocarcinoma.	Cancer	Non applicable	Traitement symptomatique		À vérifier
Empagliflozin 25 MGIn patients with ESRD, up to 20% of patients suffer from HFrEF, leading to significant CV morbidity and mortality. Several drug classes that provide survival benefits for patients with HFrEF, including SGLT2i, lack data regarding their efficacy and safety in patients under chronic hemodialysis. As the primary target of SGLT2i is expressed mostly in the kidneys, the efficacy of SGLT2i in patients with ESRD may be limited. On the other hand, patients with ESRD are at higher risks of experiencing cardiovascular events and may still benefit from treatment. Several mechanistic studies have demonstrated direct actions of SGLT2i on the myocardium, thus it is possible that the benefits of SGLT2i on heart failure are independent of their glycosuric actions and may still be present in anuric subjects. Furthermore, pharmacokinetics and pharmacodynamics studies on empagliflozin demonstrated that peak plasma levels of empagliflozin in subjects with renal failure/ESRD were similar to those in subjects with normal renal function. The use of empagliflozin in patients with ESRD seemed safe in terms of pharmacokinetics and pharmacodynamics, yet its efficacy remains to be explored.	Insuffisance cardiaque	Phase 4	À vérifier	Taiwan	À vérifier
Focused Ultrasound for the Treatment of Pancreatic Cancer - an International RegistryThe purpose of the registry is to collect data on the performance of the focused ultrasound (FUS) technology and health outcomes. A wide variety of approaches exist for using FUS on pancreatic cancer patients, and the primary goal is to capture this broad spectrum of approaches and their impact on patients overall health. This information will help provide a better understanding of current care, and may possibly direct further, more specific investigations that will follow this registry.	Cancer	À vérifier	À vérifier		À vérifier
Percutaneous coronary intervention of coronary chronic total occlusionCoronary chronic total occlusions (CTO) present a significant challenge in the field of interventional cardiology. These complex lesions, characterized by complete blockage of a coronary artery for a prolonged duration, often require specialized techniques and strategies to achieve successful revascularization.	Maladie coronarienne	À vérifier	À vérifier	Taiwan	À vérifier
peripheral magnetic stimulationShoulder-hand syndrome is a common complication following stroke, constituting of excessive pain, swelling, heat, limited range of motion, and trophic change of the affected limbs. It not only has an extensive negative impact on both physical and psychological aspects of a stroke patient's well-being, but also impose burden on the health care system and the patient's family. Despite its relatively high incidence, there is neither well-established treatment protocol, nor high quality evidence for a single effective treatment. The objective of the present study is to investigate the efficacy, including pain, spasticity, and subluxation reduction, muscle strengthening, and shoulder range of motion improvement, of high-intensity peripheral magnetic stimulation generated by the super-inductive system to treat patients with post-stroke shoulder-hand syndrome.	Accident vasculaire cérébral	Non applicable	Traitement symptomatique	Taiwan	À vérifier
plasmapheresisDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé.	Sclérose latérale amyotrophique	Non applicable	À vérifier	Taiwan	À vérifier
SMART-2 — Sleep, Music, And Research Trial 2.0The goal of this clinical trial is to learn if a music-based intervention works to improve sleep and health in children with epilepsy and their parents. The main question it aims to answer is: Does the music-based intervention improve sleep and health for both the children and their parents?	Épilepsie	Non applicable	À vérifier	Taiwan	À vérifier
The Efficacy, Safety and Genetic Polymorphism of Hypoca and Adalat OROS in Hypertensive PatientsNifedipine and barnidipine act as calcium channel blockers, and are widely prescribed for pressure control of prehypertension and stage 1 hypertension. CYP3A4 is responsible for the metabolism of nifedipine and nifedipine, while the contribution of CYP3A5 remains ambiguous. This study is aimed to analyze the association between antihypertensive effects of nifedipine as well as barnidipine and single nucleotide polymorphisms of CYP3A4, CYP3A5 and calcium channels.	Hypertension	À vérifier	À vérifier		À vérifier
The Efficacy, Safety and Genetic Polymorphism of Hypoca and Adalat OROS in Hypertensive PatientsNifedipine and barnidipine act as calcium channel blockers, and are widely prescribed for pressure control of prehypertension and stage 1 hypertension. CYP3A4 is responsible for the metabolism of nifedipine and nifedipine, while the contribution of CYP3A5 remains ambiguous. This study is aimed to analyze the association between antihypertensive effects of nifedipine as well as barnidipine and single nucleotide polymorphisms of CYP3A4, CYP3A5 and calcium channels.	Hypertension	À vérifier	À vérifier		À vérifier
plasmapheresisDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé.	Sclérose latérale amyotrophique	Non applicable	À vérifier	Taiwan	À vérifier
plasmapheresisDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé.	Sclérose latérale amyotrophique	Non applicable	À vérifier	Taiwan	À vérifier
Focused Ultrasound for the Treatment of Pancreatic Cancer - an International RegistryThe purpose of the registry is to collect data on the performance of the focused ultrasound (FUS) technology and health outcomes. A wide variety of approaches exist for using FUS on pancreatic cancer patients, and the primary goal is to capture this broad spectrum of approaches and their impact on patients overall health. This information will help provide a better understanding of current care, and may possibly direct further, more specific investigations that will follow this registry.	Cancer	À vérifier	À vérifier		À vérifier
SMART-2 — Sleep, Music, And Research Trial 2.0The goal of this clinical trial is to learn if a music-based intervention works to improve sleep and health in children with epilepsy and their parents. The main question it aims to answer is: Does the music-based intervention improve sleep and health for both the children and their parents?	Épilepsie	Non applicable	À vérifier	Taiwan	À vérifier
Percutaneous coronary intervention of coronary chronic total occlusionCoronary chronic total occlusions (CTO) present a significant challenge in the field of interventional cardiology. These complex lesions, characterized by complete blockage of a coronary artery for a prolonged duration, often require specialized techniques and strategies to achieve successful revascularization.	Maladie coronarienne	À vérifier	À vérifier	Taiwan	À vérifier
peripheral magnetic stimulationShoulder-hand syndrome is a common complication following stroke, constituting of excessive pain, swelling, heat, limited range of motion, and trophic change of the affected limbs. It not only has an extensive negative impact on both physical and psychological aspects of a stroke patient's well-being, but also impose burden on the health care system and the patient's family. Despite its relatively high incidence, there is neither well-established treatment protocol, nor high quality evidence for a single effective treatment. The objective of the present study is to investigate the efficacy, including pain, spasticity, and subluxation reduction, muscle strengthening, and shoulder range of motion improvement, of high-intensity peripheral magnetic stimulation generated by the super-inductive system to treat patients with post-stroke shoulder-hand syndrome.	Accident vasculaire cérébral	Non applicable	Traitement symptomatique	Taiwan	À vérifier
'Intra-luminal radiofrequency ablation (Habib EndoHPB)Only a small proportion of patients with biliary obstruction caused by hepatopancreatobiliary malignancies are suitable for surgical resection. Therefore, most patients with malignant biliary obstruction will need palliation of their obstructive jaundice to relieve the symptoms and prevent life threatening complications such as biliary sepsis. The endoscopic or percutaneous/transhepatic routes, such as endoscopic retrograde cholangiopancreatography (ERCP) and percutaneous transhepatic cholangiography (PTC), and stents are accepted approaches for the relief of jaundice in malignant biliary obstruction. Improvement in the bilirubin level is also essential before palliative chemotherapy is considered in these patients. However, tumor ingrowth still remains a major cause of obstruction. In this trial, the investigators will use HabibTM EndoHPB (EMcision Ltd., UK) catheter which was used for the endobiliary radiofrequency ablation (RFA) treatment as a form of neoadjuvant therapy in hepatopancreatobiliary adenocarcinoma.	Cancer	Non applicable	Traitement symptomatique		À vérifier
Empagliflozin 25 MGIn patients with ESRD, up to 20% of patients suffer from HFrEF, leading to significant CV morbidity and mortality. Several drug classes that provide survival benefits for patients with HFrEF, including SGLT2i, lack data regarding their efficacy and safety in patients under chronic hemodialysis. As the primary target of SGLT2i is expressed mostly in the kidneys, the efficacy of SGLT2i in patients with ESRD may be limited. On the other hand, patients with ESRD are at higher risks of experiencing cardiovascular events and may still benefit from treatment. Several mechanistic studies have demonstrated direct actions of SGLT2i on the myocardium, thus it is possible that the benefits of SGLT2i on heart failure are independent of their glycosuric actions and may still be present in anuric subjects. Furthermore, pharmacokinetics and pharmacodynamics studies on empagliflozin demonstrated that peak plasma levels of empagliflozin in subjects with renal failure/ESRD were similar to those in subjects with normal renal function. The use of empagliflozin in patients with ESRD seemed safe in terms of pharmacokinetics and pharmacodynamics, yet its efficacy remains to be explored.	Insuffisance cardiaque	Phase 4	À vérifier	Taiwan	À vérifier

Essais cliniques

13

Molécule	Indication / population	Phase	NCT	Titre	Statut
Empagliflozin 25 MG	Insuffisance cardiaque	Phase 4	NCT06249932	EMPA-RRED — Empagliflozin in Heart Failure With Reduced Ejection Fraction and End Stage Renal Disease	RECRUITING
'Intra-luminal radiofrequency ablation (Habib EndoHPB)	Cancer	Non applicable	NCT02841800	Intra-luminal Radiofrequency Ablation for Inoperable Malignant Biliary Stenosis	COMPLETED
peripheral magnetic stimulation	Accident vasculaire cérébral	Non applicable	NCT05112094	Peripheral Magnetic Stimulation to Treat Patient With Post-stroke Shoulder-hand Syndrome	COMPLETED
Percutaneous coronary intervention of coronary chronic total occlusion	Maladie coronarienne	À vérifier	NCT06917378	TRIO CTO (Taiwan Research Initiative on Coronary Total Occlusion)	RECRUITING
Melatonin	Épilepsie	Phase 2/3	NCT05439876	Getting SMART for Pediatric Epilepsy	COMPLETED
Histotripsie — HistoSonics Edison System	Cancer	Non applicable	NCT07207343	Symptomatic Abdominal Tumors Are Unsuitable for Surgical Resection, High-intensity Focused Ultrasound (HIFU) Treatment Will be Applied to the Tumors. Postoperatively, Continuous Evaluation and Analysis of the Ablation Effect Will be Performed Using CT or MRI Imaging.	ACTIVE_NOT_RECRUITING
SMART-2 — Sleep, Music, And Research Trial 2.0	Épilepsie	Non applicable	NCT07696442	SMART-2 — Sleep, Music, And Research Trial 2.0	NOT_YET_RECRUITING
Focused Ultrasound for the Treatment of Pancreatic Cancer - an International Registry	Cancer	À vérifier	NCT05010226	Focused Ultrasound for the Treatment of Pancreatic Cancer - an International Registry	NOT_YET_RECRUITING
plasmapheresis	Sclérose latérale amyotrophique	Non applicable	NCT05562960	PALATIN — Plasmapheresis in Amyotrophic Lateral Sclerosis With Autoantibody Against NRIP	COMPLETED
plasmapheresis	Sclérose latérale amyotrophique	Non applicable	NCT07726563	Plasmapheresis in Amyotrophic Lateral Sclerosis With Autoantibody Against NRIP 2 (PALADIN2)	RECRUITING
Histotripsie — HistoSonics Edison System	Cancer	Non applicable	NCT07063771	Safety and Clinical Efficacy of Histotripsy for Liver Cancers Adjacent to Major Intrahepatic Vessels	NOT_YET_RECRUITING
Histotripsie — HistoSonics Edison System	Cancer	Non applicable	NCT07180706	To Evaluate the Safety and Efficacy of Histotripsy for the Symptom Relief of Inoperable Abdominal Tumors	NOT_YET_RECRUITING
The Efficacy, Safety and Genetic Polymorphism of Hypoca and Adalat OROS in Hypertensive Patients	Hypertension	À vérifier	NCT00728858	The Efficacy, Safety and Genetic Polymorphism of Hypoca and Adalat OROS in Hypertensive Patients	COMPLETED

Publications

3

Molécule	Indication / population	Titre	Journal	Date
plasmapheresis		Clinical features, imaging findings, and treatment outcomes of optic neuritis associated with anti-CRMP5 antibodies: a systematic review.	Journal of neuroimmunology
plasmapheresis		Neuro-renal syndrome (NRS) in autoimmune nodopathies and paranodopathies: A warning to consider the diagnosis when anti-node and paranode antibody tests are difficult to perform.	Journal of the neurological sciences
plasmapheresis		Risk factors for hypotension and technical complications during single-session double-filtration plasmapheresis: a 15-year retrospective study of 1,022 procedures.	Renal failure