Kutahya Health Sciences University — Biomedical Watch V2

Traitements6programmes

Essais3liés

Publications4liées

SourceDBlocale

Traitements

6

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
Neuroforma virtual reality trainingThe goal of this clinical trial is to learn whether adding virtual reality (VR) training to conventional rehabilitation improves arm movement in adults who had a stroke 6 to 24 months earlier, and whether VR training 5 days a week gives more benefit than VR training 2 days a week. The study will also measure three blood markers that may reflect brain and muscle adaptation (BDNF, irisin and S100B). The main questions it aims to answer are: * Does arm motor function, measured with the Fugl-Meyer Assessment for Upper Extremity 12 weeks after the start of treatment, improve more when VR training is added to conventional rehabilitation, and does it improve more with 5 than with 2 VR sessions a week? * As an exploratory question, do blood levels of BDNF, irisin and S100B change differently between the groups, and are these changes related to the improvement in arm function? Researchers will compare three groups: conventional rehabilitation alone, conventional rehabilitation plus VR training 2 days a week, and conventional rehabilitation plus VR training 5 days a week. Participants will: * Be assigned by chance to one of the three groups * Receive conventional rehabilitation for 45 minutes, 5 days a week, for 4 weeks; depending on their group, they will also receive 30-minute VR sessions with the Neuroforma system 2 or 5 days a week * Follow a home exercise program from week 4 to week 12 * Have arm function tests and a fasting morning blood sample at the start of the study, at week 4 and at week 12	Accident vasculaire cérébral	Non applicable	À vérifier		À vérifier
Nurse-Led Motivational Interviewing for Blood Pressure ControlHypertension is one of the most important risk factors for cardiovascular morbidity and mortality. Effective hypertension management requires medication adherence, lifestyle modification, regular blood pressure monitoring, and self-management behaviors. Motivational interviewing is a counseling approach that may support behavior change and improve hypertension management. This study aims to evaluate the effects of nurse-led individual motivational interviewing and family-involved motivational interviewing on blood pressure control in patients with hypertension. The study will be conducted as a single-center, three-arm, parallel-group, randomized controlled trial. A total of 180 patients with hypertension will be randomly assigned to one of three groups: usual care, individual motivational interviewing, or family-involved motivational interviewing. Participants in the intervention groups will receive a 6-week nurse-led motivational interviewing program. In the family-involved motivational interviewing group, a family member who supports hypertension management will also participate in the sessions. Data will be collected at baseline, 6 weeks, and 18 weeks. The primary outcome is systolic blood pressure. Secondary outcomes include diastolic blood pressure, hypertension knowledge level, treatment adherence, and hypertension self-efficacy.	Hypertension	Non applicable	À vérifier	Turkey (Türkiye)	À vérifier
Pain Phenotypes in Individuals With Multiple SclerosisThis observational cross-sectional study aims to determine chronic pain phenotypes in individuals with multiple sclerosis (MS) and to investigate the clinical characteristics associated with different pain phenotypes. Participants with MS and chronic pain will undergo a comprehensive clinical assessment to identify nociceptive, neuropathic, nociplastic, and mixed pain phenotypes. The assessment will include clinical history, pain characteristics and distribution, quantitative sensory testing, pain intensity, disease severity, fatigue, health-related quality of life, and pain catastrophizing. The clinical characteristics of participants with different pain phenotypes will subsequently be compared.	SEP	À vérifier	Traitement symptomatique	Turkey (Türkiye)	À vérifier
Nurse-Led Motivational Interviewing for Blood Pressure ControlHypertension is one of the most important risk factors for cardiovascular morbidity and mortality. Effective hypertension management requires medication adherence, lifestyle modification, regular blood pressure monitoring, and self-management behaviors. Motivational interviewing is a counseling approach that may support behavior change and improve hypertension management. This study aims to evaluate the effects of nurse-led individual motivational interviewing and family-involved motivational interviewing on blood pressure control in patients with hypertension. The study will be conducted as a single-center, three-arm, parallel-group, randomized controlled trial. A total of 180 patients with hypertension will be randomly assigned to one of three groups: usual care, individual motivational interviewing, or family-involved motivational interviewing. Participants in the intervention groups will receive a 6-week nurse-led motivational interviewing program. In the family-involved motivational interviewing group, a family member who supports hypertension management will also participate in the sessions. Data will be collected at baseline, 6 weeks, and 18 weeks. The primary outcome is systolic blood pressure. Secondary outcomes include diastolic blood pressure, hypertension knowledge level, treatment adherence, and hypertension self-efficacy.	Hypertension	Non applicable	À vérifier	Turkey (Türkiye)	À vérifier
Pain Phenotypes in Individuals With Multiple SclerosisThis observational cross-sectional study aims to determine chronic pain phenotypes in individuals with multiple sclerosis (MS) and to investigate the clinical characteristics associated with different pain phenotypes. Participants with MS and chronic pain will undergo a comprehensive clinical assessment to identify nociceptive, neuropathic, nociplastic, and mixed pain phenotypes. The assessment will include clinical history, pain characteristics and distribution, quantitative sensory testing, pain intensity, disease severity, fatigue, health-related quality of life, and pain catastrophizing. The clinical characteristics of participants with different pain phenotypes will subsequently be compared.	SEP	À vérifier	Traitement symptomatique	Turkey (Türkiye)	À vérifier
Neuroforma virtual reality trainingThe goal of this clinical trial is to learn whether adding virtual reality (VR) training to conventional rehabilitation improves arm movement in adults who had a stroke 6 to 24 months earlier, and whether VR training 5 days a week gives more benefit than VR training 2 days a week. The study will also measure three blood markers that may reflect brain and muscle adaptation (BDNF, irisin and S100B). The main questions it aims to answer are: * Does arm motor function, measured with the Fugl-Meyer Assessment for Upper Extremity 12 weeks after the start of treatment, improve more when VR training is added to conventional rehabilitation, and does it improve more with 5 than with 2 VR sessions a week? * As an exploratory question, do blood levels of BDNF, irisin and S100B change differently between the groups, and are these changes related to the improvement in arm function? Researchers will compare three groups: conventional rehabilitation alone, conventional rehabilitation plus VR training 2 days a week, and conventional rehabilitation plus VR training 5 days a week. Participants will: * Be assigned by chance to one of the three groups * Receive conventional rehabilitation for 45 minutes, 5 days a week, for 4 weeks; depending on their group, they will also receive 30-minute VR sessions with the Neuroforma system 2 or 5 days a week * Follow a home exercise program from week 4 to week 12 * Have arm function tests and a fasting morning blood sample at the start of the study, at week 4 and at week 12	Accident vasculaire cérébral	Non applicable	À vérifier		À vérifier

Essais cliniques

3

Molécule	Indication / population	Phase	NCT	Titre	Statut
Neuroforma virtual reality training	Accident vasculaire cérébral	Non applicable	NCT07919301	Virtual Reality Training Dose for Arm Recovery After Stroke: Clinical and Blood Biomarker Responses	NOT_YET_RECRUITING
Pain Phenotypes in Individuals With Multiple Sclerosis	SEP	À vérifier	NCT07766213	Pain Phenotypes in Individuals With Multiple Sclerosis	NOT_YET_RECRUITING
Nurse-Led Motivational Interviewing for Blood Pressure Control	Hypertension	Non applicable	NCT07747025	Nurse-Led Motivational Interviewing for Blood Pressure Control	RECRUITING

Publications

4

Molécule	Indication / population	Titre	Journal	Date
Nurse-Led Motivational Interviewing for Blood Pressure Control		Evaluation of Polygenic Scores and CT Imaging in Risk Factor Modification in Patients With Diabetes: Rationale and Design of the VOLTAIRE Study.	Clinical cardiology
Pain Phenotypes in Individuals With Multiple Sclerosis		Evidence of skull bone translocator protein overexpression linked to multiple sclerosis progression.	Brain : a journal of neurology
Pain Phenotypes in Individuals With Multiple Sclerosis		Neurogenic Pelvic Floor Dysfunctions Across Neurological Disorders: Mechanisms, Phenotypes, and Precision Rehabilitation Pathways-A Narrative Review.	Journal of clinical medicine
Pain Phenotypes in Individuals With Multiple Sclerosis		Neuropathic pain in multiple sclerosis: discrepancies between DN4 screening and neurophysiological measures.	Multiple sclerosis and related disorders