Istanbul Medipol University Hospital

Traitements9programmes

Essais4liés

Publications24liées

SourceDBlocale

Traitements

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
Metabolic Cofactor SupplementationThis double-blind, randomized, placebo-controlled, investigator-initiated, multi-centre trial aims to establish metabolic improvements in AD and PD subjects by dietary supplementation with cofactors N-acetylcysteine, L-carnitine tartrate, nicotinamide riboside and serine. Concomitant use of pivotal metabolic cofactors via simultaneous dietary supplementation will stimulate to enhance hepatic β-oxidation and this study's hypothesis is that this will result in increased mitochondrial activity in human brain cell-types.	Alzheimer, Parkinson	Phase 2	Remyélinisation indirecte / réparation	Turkey (Türkiye)	À vérifier
Repetetive Transcranial Magnetic StimulationSince pharmacological methods are insufficient in the treatment processes of Alzheimer's disease, non-pharmacological methods such as Transcranial Magnetic Stimulation (TMS) have started to be tried as a treatment option as in other neurological and psychiatric diseases. Repeated (rTMS) offers a potential treatment pathway for neurological and psychiatric illnesses. rTMS benefit rate may vary depending on many factors such as the region where it is applied, the progression and the disease degree. The possible effects of TMS on Alzheimer's pathophysiology and modification of disease process (neuroprotective, anti-inflammatory and antioxidant) will also be revealed through blood samples taken from patients before and after treatment. These approaches also constitute the original value of our study.	Alzheimer	Non applicable	Neuroprotection + Ralentissement de la progression + Immunomodulation	Turkey (Türkiye)	À vérifier
Sham treatmentThe aim of the study was to investigate the effectiveness of Manual Therapy Based on the Fascial Distortion Model in individuals with temporomandibular disorders compared to sham control. Individuals diagnosed with temporomandibular disorder will be randomly assigned to groups as Group 1 (Manual Therapy Based on Fascial Distortion Model) and Group 2 (Sham Control). Head posture, cervical and temporomandibular joint range of motion, cervical muscle performance, pain intensity, pressure pain thresholds, temporomandibular disorder severity, disability, dysfunction, health-related quality of life, kinesiophobia, and central sensitization will be assessed.	Maladie rénale chronique, Migraine, Myopathies	Non applicable	Traitement symptomatique	Turkey (Türkiye)	À vérifier
SorbitolThis double-blind, randomized, placebo-controlled, investigator-initiated, multi-centre trial aims to establish metabolic improvements in AD and PD subjects by dietary supplementation with cofactors N-acetylcysteine, L-carnitine tartrate, nicotinamide riboside and serine. Concomitant use of pivotal metabolic cofactors via simultaneous dietary supplementation will stimulate to enhance hepatic β-oxidation and this study's hypothesis is that this will result in increased mitochondrial activity in human brain cell-types.	Alzheimer, Parkinson	Phase 2	Remyélinisation indirecte / réparation	Turkey (Türkiye)	À vérifier
transcranial direct stimulationtDCS can be offered as an alternative to migraine patients who have frequent and severe attacks and who are resistant to or unresponsive to preventive drug therapy. Additionally, this technique may also be an option for patients who refuse or have contraindications to taking anti-migraine medications. A decrease in headache severity and frequency is expected with this neuromodulation applied to migraine patients with frequent attacks. Based on this hypothesis; This tested whether simultaneous modulation of motor (M1, left) and visual cortex (O1 or O2, ipsilateral) with tDCS applied for 3 consecutive days is an effective treatment for migraine patients for the following specific purposes . No significant undesirable effects are expected, except for possible side effects that are simple and do not require medical intervention, such as tingling or itching in the area where the electrodes are attached, moderate fatigue, mild headache, nausea at a rate of less than 3%, and insomnia at a rate of less than 1%. . The research will be conducted within the framework of ethical principles and in accordance with the good clinical practice protocol. A) The primary purpose of this study is to determine whether transcranial direct current stimulation applied simultaneously to the motor and visual cortex in migraine patients provides a significant reduction in pain due to migraine attacks compared to sham tDCS. Additionally, to evaluate the effects of this treatment, They will be measured changes in the number of migraine attacks, abortive medication intake (e.g., opioids, triptans), as well as overall improvement in cognitive status and quality of life. In addition, electrophysiological EEG evaluations, before and after treatment, and the results of these measurements, as a potential biomarker in migraine, will be compared in the active and sham groups. B) It is aimed to determine whether the clinical effects of tDCS are long-lasting. Therefore, It will compared whether there is a difference in improvement of migraine-related pain between active and sham tDCS at pre-treatment (baseline) assessments as well as at 1, 2, and 3 months after treatment. C) Finally, it will be examined whether tDCS treatment applied for 3 consecutive days in migraine patients is safe. Safety will be evaluated through neuropsychological testing and adverse event reporting.	Migraine	Non applicable	Traitement symptomatique	Turkey (Türkiye)	À vérifier
Metabolic Cofactor SupplementationThis double-blind, randomized, placebo-controlled, investigator-initiated, multi-centre trial aims to establish metabolic improvements in AD and PD subjects by dietary supplementation with cofactors N-acetylcysteine, L-carnitine tartrate, nicotinamide riboside and serine. Concomitant use of pivotal metabolic cofactors via simultaneous dietary supplementation will stimulate to enhance hepatic β-oxidation and this study's hypothesis is that this will result in increased mitochondrial activity in human brain cell-types.	Parkinson	Phase 2	Remyélinisation indirecte / réparation	Turkey (Türkiye)	À vérifier
Sham treatmentThe aim of the study was to investigate the effectiveness of Manual Therapy Based on the Fascial Distortion Model in individuals with temporomandibular disorders compared to sham control. Individuals diagnosed with temporomandibular disorder will be randomly assigned to groups as Group 1 (Manual Therapy Based on Fascial Distortion Model) and Group 2 (Sham Control). Head posture, cervical and temporomandibular joint range of motion, cervical muscle performance, pain intensity, pressure pain thresholds, temporomandibular disorder severity, disability, dysfunction, health-related quality of life, kinesiophobia, and central sensitization will be assessed.	Maladie rénale chronique	Phase 1/2	Traitement symptomatique	Russia	À vérifier
Repetetive Transcranial Magnetic StimulationSince pharmacological methods are insufficient in the treatment processes of Alzheimer's disease, non-pharmacological methods such as Transcranial Magnetic Stimulation (TMS) have started to be tried as a treatment option as in other neurological and psychiatric diseases. Repeated (rTMS) offers a potential treatment pathway for neurological and psychiatric illnesses. rTMS benefit rate may vary depending on many factors such as the region where it is applied, the progression and the disease degree. The possible effects of TMS on Alzheimer's pathophysiology and modification of disease process (neuroprotective, anti-inflammatory and antioxidant) will also be revealed through blood samples taken from patients before and after treatment. These approaches also constitute the original value of our study.	Alzheimer	Non applicable	Neuroprotection + Ralentissement de la progression + Immunomodulation	Turkey (Türkiye)	À vérifier
transcranial direct stimulationtDCS can be offered as an alternative to migraine patients who have frequent and severe attacks and who are resistant to or unresponsive to preventive drug therapy. Additionally, this technique may also be an option for patients who refuse or have contraindications to taking anti-migraine medications. A decrease in headache severity and frequency is expected with this neuromodulation applied to migraine patients with frequent attacks. Based on this hypothesis; This tested whether simultaneous modulation of motor (M1, left) and visual cortex (O1 or O2, ipsilateral) with tDCS applied for 3 consecutive days is an effective treatment for migraine patients for the following specific purposes . No significant undesirable effects are expected, except for possible side effects that are simple and do not require medical intervention, such as tingling or itching in the area where the electrodes are attached, moderate fatigue, mild headache, nausea at a rate of less than 3%, and insomnia at a rate of less than 1%. . The research will be conducted within the framework of ethical principles and in accordance with the good clinical practice protocol. A) The primary purpose of this study is to determine whether transcranial direct current stimulation applied simultaneously to the motor and visual cortex in migraine patients provides a significant reduction in pain due to migraine attacks compared to sham tDCS. Additionally, to evaluate the effects of this treatment, They will be measured changes in the number of migraine attacks, abortive medication intake (e.g., opioids, triptans), as well as overall improvement in cognitive status and quality of life. In addition, electrophysiological EEG evaluations, before and after treatment, and the results of these measurements, as a potential biomarker in migraine, will be compared in the active and sham groups. B) It is aimed to determine whether the clinical effects of tDCS are long-lasting. Therefore, It will compared whether there is a difference in improvement of migraine-related pain between active and sham tDCS at pre-treatment (baseline) assessments as well as at 1, 2, and 3 months after treatment. C) Finally, it will be examined whether tDCS treatment applied for 3 consecutive days in migraine patients is safe. Safety will be evaluated through neuropsychological testing and adverse event reporting.	Migraine	Non applicable	Traitement symptomatique	Turkey (Türkiye)	À vérifier

Essais cliniques

Molécule	Indication / population	Phase	NCT	Titre	Statut
transcranial direct stimulation	Migraine	Non applicable	NCT06468189	MIRAGE — Clinical and Neurophysiological Effects of tDCS to Visual and Motor Cortex in Migraine	ACTIVE_NOT_RECRUITING
Repetetive Transcranial Magnetic Stimulation	Alzheimer	Non applicable	NCT05977088	PRIM-A — Prediction of Effectiveness of rTMS Application in Alzheimer's Patients	COMPLETED
Sham treatment	Maladie rénale chronique	Phase 1/2	NCT05757557	DEFENDER — Perioperative Nitric Oxide Prevents Acute Kidney Injury in Cardiac Surgery Patients With Chronic Kidney Disease	COMPLETED
Metabolic Cofactor Supplementation	Parkinson	Phase 2	NCT04044131	Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients	COMPLETED

Publications

Molécule	Titre	Journal
Sorbitol	A wax-printed Janus paper-based microfluidic wearable sensor for metabolic analysis in sweat.	Biosensors & bioelectronics
Sorbitol	Glycohypoxia: a hypothesis linking chronic hyperglycemia to functional hypoxia and diabetic complications in type 2 diabetes.	Medical gas research
Sorbitol	Pharmaceutical development of composition of effervescent tablets with acetylsalicylic acid, paracetamol, and ascorbic acid.	Pharmaceutical science advances
Metabolic Cofactor Supplementation	Multi-walled carbon nanotube buckypaper with covalently bound NAD and immobilized glucose dehydrogenase for reagentless glucose biosensing.	Talanta
Metabolic Cofactor Supplementation	Hydrogen supplementation improves glucose-based n-caproate production in Caproiciproducens galactitolivorans with reverse β-oxidation-associated redox remodeling.	Bioresource technology
Metabolic Cofactor Supplementation	UHPLC-Q-Exactive Orbitrap MS-based brain-gut metabolomics implicates multi-pathway modulation by Ginseng stem-leaf saponins in chronic fatigue syndrome mice.	Journal of pharmaceutical and biomedical analysis
Sorbitol	A Comparative Evaluation of Xylitol, Sorbitol, and Isomalt-containing Candies and Their Effects on Salivary pH and Salivary Flow Rate in Children Aged 6-12 Years: An Study.	International journal of clinical pediatric dentistry
Sorbitol	Lactate dehydrogenase A exhibits sorbitol/fructose-related catalytic activity and contributes to polyol pathway metabolism in tumor cells.	Frontiers in endocrinology
Sorbitol	Epidemiology, Diversity, Physiology, and Chemical Management of Rhizoctonia solani Causing Web Blight in Country Bean.	Journal of basic microbiology
Metabolic Cofactor Supplementation	Vitamin B deficiency and sarcopenia: an integrated narrative review of metabolic, inflammatory, endoplasmic reticulum stress, and myokine signaling pathways.	Journal of Yeungnam medical science
Metabolic Cofactor Supplementation	Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2-KLF4.	Cell proliferation
Sorbitol	Genotoxic and Cytotoxic Potential of Food Sweeteners D-Sorbitol and the Mixtures of D-Sorbitol and Xylitol in Human Lymphocytes.	Journal of applied toxicology : JAT
Sorbitol	Molecular Dynamics Simulation of Sorbitol-Based Surfactants with Different Chiral Configurations at the Gas/Liquid Interface.	Langmuir : the ACS journal of surfaces and colloids
Metabolic Cofactor Supplementation	Pyridoxine/pyridoxal-5'-phosphate repletion to improve outcomes of alcohol withdrawal syndrome and promote long-term abstinence: a hypothesis.	Clinical toxicology (Philadelphia, Pa.)
Sorbitol	A role for the syntaxin protein in post-wound cell survival.	Molecular biology of the cell
Sorbitol	Belgian endive-derived biostimulant activity in , lettuce, and sweet pepper at different developmental stages, environmental conditions, and application methods.	Frontiers in plant science
Sorbitol	A Multifunctional Electrocatalyst for Formate Production with Concurrent Hydrogen Evolution and Electrochemical Hydrogenation of Glucose to Sorbitol.	ACS applied materials & interfaces
Sorbitol	Strain-Sensitive Double-Network Organogel With Strong Adhesion for Movement Monitoring.	Macromolecular rapid communications
Metabolic Cofactor Supplementation	CIA5 and its interacting metal-binding GTPase ZNG3 are degraded by the proteasome in Zn deficiency.	The Plant journal : for cell and molecular biology
Sorbitol	Radial Branch Hydraulics and Cellular Injury Thresholds in Poplar: Insights from Controlled Dehydration and High-resolution Dendrometry.	Tree physiology
Sorbitol	Detection and Zoonotic Implications of Shiga Toxin-Producing Escherichia coli in Black Bengal Goats in Bangladesh.	Veterinary medicine and science
Sorbitol	Luseogliflozin restores GIP responsiveness in diabetic male mice with preserved β-cell function.	Physiological reports
Metabolic Cofactor Supplementation	Effects of Bifidobacterium animalis ssp. lactis IU100 and resistant starch type III on texture and flavor of fermented milk during storage.	Journal of dairy science
Metabolic Cofactor Supplementation	mZVI-Enhanced Mixed Nitrogen Removal in Klebsiella oxytoca via Coordinated Electron Transfer and Metabolic Reprogramming.	Biotechnology and bioengineering