Institute of Liver and Biliary Sciences, India — Biomedical Watch V2

Traitements4programmes

Essais2liés

Publications2liées

SourceDBlocale

Traitements

4

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
Organ Dysfunction Associated With Intra Abdominal Pressures in Liver TransplantationPatients with end stage liver disease have varying degrees of intra-abdominal hypertension (IAH) due to the presence of ascites. The perioperative events may either relieve or aggravate the intra-abdominal pressures. Intra-abdominal hypertension has damaging effect on various organ systems. There is an increase in intracranial pressures and a decrease in cerebral perfusion pressures associated with IAH . In the heart, there is an increase of right atrial pressures, increase in systemic vascular resistance and decrease in cardiac output . Pulmonary complications include increase in the peak, mean and plateau airway pressures, with decreased compliance . Renal dysfunction is an early effect of raised intra-abdominal pressure, resulting from decreased renal blood flow, shunting of blood to the medulla, mechanical compression of the kidneys and increased pressures in the renal veins . We would study the intra-abdominal pressures in liver transplant recipients and record hemodynamic, respiratory, cardiac and renal function prospectively. Follow up data for 6 days for neurological, respiratory, cardiac and renal complications will be collected, along with hospital stay, ICU stay and mortality. The association between intra-abdominal pressures and these outcomes will be analysed.	Myopathies	À vérifier	À vérifier	India	À vérifier
Vitamin CThis study is testing whether Vitamin C can help improve kidney function and survival in very sick patients with liver disease. Patients with acute-on-chronic liver failure (ACLF) often develop serious infections that can lead to septic shock and kidney injury, which are major causes of death. In this randomized controlled trial, patients with ACLF and septic shock will be assigned to receive either: 1. Standard medical treatment alone, or 2. Standard medical treatment plus intravenous Vitamin C. Vitamin C is a safe, inexpensive antioxidant that may reduce inflammation, improve circulation, and protect the kidneys. The study will compare how well patients recover from septic shock and kidney injury in the two groups. Blood and urine samples will also be collected to look for biological markers that can predict outcomes.	Maladie rénale chronique	Non applicable	Immunomodulation		À vérifier
Organ Dysfunction Associated With Intra Abdominal Pressures in Liver TransplantationPatients with end stage liver disease have varying degrees of intra-abdominal hypertension (IAH) due to the presence of ascites. The perioperative events may either relieve or aggravate the intra-abdominal pressures. Intra-abdominal hypertension has damaging effect on various organ systems. There is an increase in intracranial pressures and a decrease in cerebral perfusion pressures associated with IAH . In the heart, there is an increase of right atrial pressures, increase in systemic vascular resistance and decrease in cardiac output . Pulmonary complications include increase in the peak, mean and plateau airway pressures, with decreased compliance . Renal dysfunction is an early effect of raised intra-abdominal pressure, resulting from decreased renal blood flow, shunting of blood to the medulla, mechanical compression of the kidneys and increased pressures in the renal veins . We would study the intra-abdominal pressures in liver transplant recipients and record hemodynamic, respiratory, cardiac and renal function prospectively. Follow up data for 6 days for neurological, respiratory, cardiac and renal complications will be collected, along with hospital stay, ICU stay and mortality. The association between intra-abdominal pressures and these outcomes will be analysed.	Myopathies	À vérifier	À vérifier	India	À vérifier
Vitamin CThis study is testing whether Vitamin C can help improve kidney function and survival in very sick patients with liver disease. Patients with acute-on-chronic liver failure (ACLF) often develop serious infections that can lead to septic shock and kidney injury, which are major causes of death. In this randomized controlled trial, patients with ACLF and septic shock will be assigned to receive either: 1. Standard medical treatment alone, or 2. Standard medical treatment plus intravenous Vitamin C. Vitamin C is a safe, inexpensive antioxidant that may reduce inflammation, improve circulation, and protect the kidneys. The study will compare how well patients recover from septic shock and kidney injury in the two groups. Blood and urine samples will also be collected to look for biological markers that can predict outcomes.	Maladie rénale chronique	Non applicable	Immunomodulation		À vérifier

Essais cliniques

2

Molécule	Indication / population	Phase	NCT	Titre	Statut
Vitamin C	Maladie rénale chronique	Non applicable	NCT07184866	VITAKI-ACLF — Vitamin C for Acute Kidney Injury in ACLF With Septic Shock: A Randomized Controlled Trial	NOT_YET_RECRUITING
Organ Dysfunction Associated With Intra Abdominal Pressures in Liver Transplantation	Myopathies	À vérifier	NCT04463745	Organ Dysfunction Associated With Intra Abdominal Pressures in Liver Transplantation	UNKNOWN

Publications

2

Molécule	Indication / population	Titre	Journal	Date
Organ Dysfunction Associated With Intra Abdominal Pressures in Liver Transplantation		Intra-abdominal hypertension, fluid balance, and adverse outcomes after orthotopic liver transplantation.	Journal of critical care
Organ Dysfunction Associated With Intra Abdominal Pressures in Liver Transplantation		Increased intra-abdominal pressure linked to worse long-term prognosis among patients with orthotopic liver transplantation: a retrospective, observational study.	BMC gastroenterology