Institut National de la Santé Et de la Recherche Médicale, France — Biomedical Watch V2

Traitements12programmes

Essais7liés

Publications8liées

SourceDBlocale

Traitements

12

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
@HOME — ECOCAPTURE for the Assessment of Apathy Under Real-life ConditionsECOCAPTURE@HOME is a study which is currently being developed with the objective to capture the behavioral signature of apathy in everyday life context through remote monitoring of participants' behavior for about one month. Participants will not only be patients with apathy but also their spouse caregiver. Behavioral markers of apathy will be extracted from a combination of: 1/ objective physiological data from sensors on a bracelet worn by participants; 2/ subjective data filled by the caregiver through an application. Thus investigators will collect a pool of metrics and show they can measure three assumed behavioral markers of apathy (daytime activity, quality of sleep and emotional arousal), which in turn allow to predict caregiver's perception of the dyad's psychological state. The final goal is to lay the foundations for the development of a clinical tool for the remote follow-up of patient-caregiver couples.	Alzheimer	À vérifier	À vérifier	France	À vérifier
Collection of samplesThe main objective of this study is to generate diagnosis and therapeutic-decision tools through the identification of molecular causes of PIDs with autoimmunity/inflammation and the variability in disease outcome at the transcriptional level using a combination of omics signatures (transcriptomics, epigenomics, proteomics, metagenomics, metabolomics and lipidomics).	Lupus	À vérifier	Immunomodulation	France	À vérifier
HEMI deviceThis prospective, single-center clinical investigation conducted in France will evaluate two non-invasive investigational devices (HEMI and SPG-NINOX) designed to assess microcirculation in adults. The study will include 165 participants divided into five groups (33 per group): healthy volunteers, patients with hypertension without chronic kidney disease (CKD), patients with type 2 diabetes without CKD, patients with moderate CKD, and patients with severe CKD. The primary objective is to compare baseline small vessel pressure measured with the HEMI (Multi-spectral optical system for microcirculation hemodynamics) device across groups in order to identify microvascular alterations associated with cardiometabolic and renal disease. Secondary objectives include assessment of microvascular responses after post-ischemic hyperemia, evaluation of SPG-derived (Speckle plethysmography) small vessel flow and volume parameters, comparison with reference vascular measurements (including SphygmoCor and ultra-high frequency ultrasound), and evaluation of feasibility, acceptability, and measurement reproducibility. Participation is non-randomized, based on participants' pre-existing clinical condition, and study procedures are non-invasive with an expected visit duration of approximately 60 minutes.	Hypertension, Maladie rénale chronique	Non applicable	À vérifier	France	À vérifier
Intracranial macro-microelectrode recordingThe main goal of this project is to study the mechanisms of epileptic activities using intracranial macro and micro electrodes in epileptic patients undergoing pre-surgical investigation. The recordings will also be used to study physiological mechanisms like sleep and different cognitive functions.	Épilepsie	Non applicable	À vérifier	France	À vérifier
Mac2ALS — Expression Profile Study of Macrophages From Patients Affected by ALS or Other Related Motor ImpairmentsDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé.	Sclérose latérale amyotrophique	À vérifier	Traitement symptomatique	France	À vérifier
SPG-NINOX deviceThis prospective, single-center clinical investigation conducted in France will evaluate two non-invasive investigational devices (HEMI and SPG-NINOX) designed to assess microcirculation in adults. The study will include 165 participants divided into five groups (33 per group): healthy volunteers, patients with hypertension without chronic kidney disease (CKD), patients with type 2 diabetes without CKD, patients with moderate CKD, and patients with severe CKD. The primary objective is to compare baseline small vessel pressure measured with the HEMI (Multi-spectral optical system for microcirculation hemodynamics) device across groups in order to identify microvascular alterations associated with cardiometabolic and renal disease. Secondary objectives include assessment of microvascular responses after post-ischemic hyperemia, evaluation of SPG-derived (Speckle plethysmography) small vessel flow and volume parameters, comparison with reference vascular measurements (including SphygmoCor and ultra-high frequency ultrasound), and evaluation of feasibility, acceptability, and measurement reproducibility. Participation is non-randomized, based on participants' pre-existing clinical condition, and study procedures are non-invasive with an expected visit duration of approximately 60 minutes.	Hypertension, Maladie rénale chronique	Non applicable	À vérifier	France	À vérifier
tACS (real or sham)Parkinson's disease is the second most common neurodegenerative disease after Alzheimer's disease. It is mostly characterized by the presence of motor difficulties. However, it can also be accompanied by cognitive disorders which have an equally significant impact on the quality of life of patients and which are not relieved by any treatment. Among the functions affected by Parkinson's disease, inhibition is an essential process for adapting our behaviors in daily life. Inhibition allows us to stop an action that is no longer required or appropriate to the situation in which we find ourselves in. For example, it comes into play when we have to stop at a "stop" sign while driving. Recent studies suggest that it could be possible to improve the functioning of these processes by using non-invasive brain stimulation tools. Transcranial alternating current electrical stimulation has thus showed promising results in improving functions such as working memory. This technique is completely painless and non-invasive and consists in applying an electric current of very low intensity (barely perceptible) at the level of the scalp, using electrodes. The investigators are conducting a study to test whether transcranial alternating current electrical stimulation could improve the functioning of the inhibition process which is altered in patients. For this, the investigators will measure this process using a task performed on a computer (the Stop Signal Reaction Time Task), as well as brain activity using a method called "electroencephalography", before and after stimulation. For this study, the investigators will include 50 patients and 40 healthy participants to investigate the effect of the stimulation on inhibition.	Parkinson	Non applicable	Traitement symptomatique	France	À vérifier
Mac2ALS — Expression Profile Study of Macrophages From Patients Affected by ALS or Other Related Motor ImpairmentsDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé.	Sclérose latérale amyotrophique	À vérifier	Traitement symptomatique	France	À vérifier
@HOME — ECOCAPTURE for the Assessment of Apathy Under Real-life ConditionsECOCAPTURE@HOME is a study which is currently being developed with the objective to capture the behavioral signature of apathy in everyday life context through remote monitoring of participants' behavior for about one month. Participants will not only be patients with apathy but also their spouse caregiver. Behavioral markers of apathy will be extracted from a combination of: 1/ objective physiological data from sensors on a bracelet worn by participants; 2/ subjective data filled by the caregiver through an application. Thus investigators will collect a pool of metrics and show they can measure three assumed behavioral markers of apathy (daytime activity, quality of sleep and emotional arousal), which in turn allow to predict caregiver's perception of the dyad's psychological state. The final goal is to lay the foundations for the development of a clinical tool for the remote follow-up of patient-caregiver couples.	Alzheimer	À vérifier	À vérifier	France	À vérifier
Collection of samplesThe main objective of this study is to generate diagnosis and therapeutic-decision tools through the identification of molecular causes of PIDs with autoimmunity/inflammation and the variability in disease outcome at the transcriptional level using a combination of omics signatures (transcriptomics, epigenomics, proteomics, metagenomics, metabolomics and lipidomics).	Lupus	À vérifier	Immunomodulation	France	À vérifier
Intracranial macro-microelectrode recordingThe main goal of this project is to study the mechanisms of epileptic activities using intracranial macro and micro electrodes in epileptic patients undergoing pre-surgical investigation. The recordings will also be used to study physiological mechanisms like sleep and different cognitive functions.	Épilepsie	Non applicable	À vérifier	France	À vérifier
HEMI deviceThis prospective, single-center clinical investigation conducted in France will evaluate two non-invasive investigational devices (HEMI and SPG-NINOX) designed to assess microcirculation in adults. The study will include 165 participants divided into five groups (33 per group): healthy volunteers, patients with hypertension without chronic kidney disease (CKD), patients with type 2 diabetes without CKD, patients with moderate CKD, and patients with severe CKD. The primary objective is to compare baseline small vessel pressure measured with the HEMI (Multi-spectral optical system for microcirculation hemodynamics) device across groups in order to identify microvascular alterations associated with cardiometabolic and renal disease. Secondary objectives include assessment of microvascular responses after post-ischemic hyperemia, evaluation of SPG-derived (Speckle plethysmography) small vessel flow and volume parameters, comparison with reference vascular measurements (including SphygmoCor and ultra-high frequency ultrasound), and evaluation of feasibility, acceptability, and measurement reproducibility. Participation is non-randomized, based on participants' pre-existing clinical condition, and study procedures are non-invasive with an expected visit duration of approximately 60 minutes.	Hypertension	Non applicable	À vérifier	France	À vérifier

Essais cliniques

7

Molécule	Indication / population	Phase	NCT	Titre	Statut
HEMI device	Hypertension	Non applicable	NCT07604922	STIMULUS-CKD — Investigating Vascular Properties of HEMI and SPG Signals in Individuals With or at Risk for Chronic Kidney Disease	RECRUITING
EEG	Parkinson	Non applicable	NCT05808504	STIMPARK — Investigation of the Benefits of Electrical Non-invasive Stimulation on Cognitive Symptoms in Parkinson's Disease	ACTIVE_NOT_RECRUITING
Intracranial macro-microelectrode recording	Épilepsie	Non applicable	NCT04653012	EpiMicro — Multi-level Approach of Brain Activity Using Intracranial Electrodes in Epileptic Patients	RECRUITING
Collection of samples	Lupus	À vérifier	NCT04902807	ATRACTion — Conception of a Diagnosis, Prognosis and Therapeutic Decision Tool for Patients With Autoimmunity and Inflammation	COMPLETED
@HOME — ECOCAPTURE for the Assessment of Apathy Under Real-life Conditions	Alzheimer	À vérifier	NCT04865172	@HOME — ECOCAPTURE for the Assessment of Apathy Under Real-life Conditions	COMPLETED
Lumbar Puncture	Sclérose latérale amyotrophique	Non applicable	NCT07213440	PremodiALS — Identification of Early Markers for ALS	RECRUITING
Mac2ALS — Expression Profile Study of Macrophages From Patients Affected by ALS or Other Related Motor Impairments	Sclérose latérale amyotrophique	À vérifier	NCT04816227	Mac2ALS — Expression Profile Study of Macrophages From Patients Affected by ALS or Other Related Motor Impairments	RECRUITING

Publications

8

Molécule	Indication / population	Titre	Journal	Date
Mac2ALS — Expression Profile Study of Macrophages From Patients Affected by ALS or Other Related Motor Impairments		Pseudotumoral multiple sclerosis: unveiling its clinical and imaging characteristics.	Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Mac2ALS — Expression Profile Study of Macrophages From Patients Affected by ALS or Other Related Motor Impairments		Neuromuscular, cardiovascular, and cognitive fatigue in motor learning: A systematic review.	Neuroscience and biobehavioral reviews
Mac2ALS — Expression Profile Study of Macrophages From Patients Affected by ALS or Other Related Motor Impairments		In vivo mapping of striatal neurodegeneration in Huntington's disease with Soma and Neurite Density Imaging.	eLife
Mac2ALS — Expression Profile Study of Macrophages From Patients Affected by ALS or Other Related Motor Impairments		RFC1 Repeat Expansions in Chronic Idiopathic Axonal Polyneuropathy: Prevalence, Phenotype, and Diagnostic Implications.	Journal of the peripheral nervous system : JPNS
Mac2ALS — Expression Profile Study of Macrophages From Patients Affected by ALS or Other Related Motor Impairments		Loss of Neocortical Oligodendrocytes in Parkinson's Disease Patients-A Stereological Study.	Journal of neuroscience research
Mac2ALS — Expression Profile Study of Macrophages From Patients Affected by ALS or Other Related Motor Impairments		Brain structure abnormalities in neurodevelopmental synaptopathies.	NeuroImage. Clinical
Mac2ALS — Expression Profile Study of Macrophages From Patients Affected by ALS or Other Related Motor Impairments		Key principles for rehabilitation of critically ill patients with obesity.	Intensive care medicine
Mac2ALS — Expression Profile Study of Macrophages From Patients Affected by ALS or Other Related Motor Impairments		Impact of Sexuality in Patients With Motor Neuron Disease.	Muscle & nerve