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Incyte Corporation
Traitements, essais et publications liés.
Traitements4programmes
Essais2liés
Publications10liées
SourceDBlocale
Traitements
4| Molécule | Indication / population | Phase | Objectif | Pays | Résultat |
|---|---|---|---|---|---|
| 5-FluorouracilThe purpose of this study was to evaluate the efficacy and safety of pembrolizumab plus epacadostat, pembrolizumab monotherapy, and the EXTREME regimen (cetuximab + cisplatin or carboplatin + 5-fluorouracil) as first-line treatment for recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). | Parkinson | Phase 3 | À vérifier | United States, Australia, Austria, Canada, Hungary, Italy, Japan, Poland, … | À vérifier |
| EpacadostatThe purpose of this study was to evaluate the efficacy and safety of pembrolizumab plus epacadostat, pembrolizumab monotherapy, and the EXTREME regimen (cetuximab + cisplatin or carboplatin + 5-fluorouracil) as first-line treatment for recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). | Parkinson | Phase 3 | À vérifier | United States, Australia, Austria, Canada, Hungary, Italy, Japan, Poland, … | À vérifier |
| INCB000928This Phase 2, Randomized, Double-Blind, Placebo-Controlled Study is intended to evaluate the Efficacy, Safety, and Tolerability and PK of INCB000928 administered to participants with a clinical diagnosis of fibrodysplasia ossificans progressiva (FOP). | Myopathies | Phase 2 | À vérifier | United States, Argentina, Australia, Brazil, Canada, Chile, China, France, … | À vérifier |
| INCB000928This Phase 2, Randomized, Double-Blind, Placebo-Controlled Study is intended to evaluate the Efficacy, Safety, and Tolerability and PK of INCB000928 administered to participants with a clinical diagnosis of fibrodysplasia ossificans progressiva (FOP). | Myopathies | Phase 2 | À vérifier | United States, Argentina, Australia, Brazil, Canada, Chile, China, France, Germany, Italy, Mexico, Netherlands, New Zealand, South Africa, South Korea, Spain, United Kingdom | À vérifier |
Essais cliniques
2| Molécule | Indication / population | Phase | NCT | Titre | Statut |
|---|---|---|---|---|---|
| INCB000928 | Myopathies | Phase 2 | NCT05090891 | To Assess the Efficacy, Safety, and Tolerability of INCB000928 in Participants With Fibrodysplasia Ossificans Progressiva | RECRUITING |
| Pembrolizumab | Parkinson | Phase 3 | NCT03358472 | Pembrolizumab Plus Epacadostat, Pembrolizumab Monotherapy, and the EXTREME Regimen in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (KEYNOTE-669/ECHO-304) | COMPLETED |
Publications
10| Molécule | Indication / population | Titre | Journal | Date |
|---|---|---|---|---|
| 5-Fluorouracil | Exploring the gut microbiome and metabolomic interactions of antimetabolite drugs to optimize therapy. | Gut microbes | ||
| 5-Fluorouracil | Phytochemical basis and mechanistic insight of Swertia macrosperma in treating 5-fluorouracil-induced diarrhea. | Journal of ethnopharmacology | ||
| Epacadostat | A Novel IDO1/NE Dual Inhibitor, IMM-H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression. | Advanced science (Weinheim, Baden-Wurttemberg, Germany) | ||
| Epacadostat | Current applications and development of dual-target inhibitors of Ido1/TDO: From tumor immunology to neuropsychiatric disorders. | European journal of medicinal chemistry | ||
| 5-Fluorouracil | Stem Cell-Delivered Cytosine Deaminase/5-Fluorocytosine and TRAIL Gene Therapy for Castration-Resistant Prostate Cancer: Translational Synthesis and First-in-Human Trial Concept. | International journal of molecular sciences | ||
| 5-Fluorouracil | Inhibition of the AT-Hook DNA-Binding Domain Attenuates HMGA2-Mediated Epithelial Mesenchyme Transition in Esophageal Cancer Cells. | International journal of molecular sciences | ||
| 5-Fluorouracil | Effect of salt-induced structural changes in hydroxypropyl methylcellulose gels on 5-fluorouracil release. | International journal of biological macromolecules | ||
| 5-Fluorouracil | Protection of Fulvic Acid Against 5-Fluorouracil-induced Intestinal Injury in Mice. | Current pharmaceutical biotechnology | ||
| Epacadostat | Integrated pan-cancer systems biology and structure-based simulation identifies Annona muricata-derived natural scaffolds as putative IDO1 modulators for cancer immunotherapy. | Computational biology and chemistry | ||
| Epacadostat | Durable responses to triplet immunotherapy targeting TGF-β, PD-L1, and tumor antigen, with an IL-15 receptor superagonist in mismatch repair proficient castration-resistant prostate cancer. | Journal for immunotherapy of cancer |