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Emory University
Traitements, essais et publications liés.
Traitements40programmes
Essais19liés
Publications8liées
SourceDBlocale
Traitements
40| Molécule | Indication / population | Phase | Objectif | Pays | Résultat |
|---|---|---|---|---|---|
| [F-18]FallyprideThis study is being done to answer the question: what is the effect of Vagal Nerve Stimulation (VNS) dosing on opioid withdrawal responses in individuals with a history of Opioid Use Disorders (OUDs)? Eligible participants will be in the study for one week in an inpatient research hospital stay, have an MRI scan, and have a follow-up call 1-3 months after their inpatient stay. Participants will complete several psychiatric questionnaires/interviews, physiological monitoring with several devices, brain imaging, and VNS testing. | SEP | Phase 3 | À vérifier | United States | À vérifier |
| Clinical DBS SettingPatients with Parkinson's Disease will be studied before, during, and after a deep brain stimulation implantation procedure to see if the stimulation location and the size of the electrical field produced by subthalamic nucleus (STN) DBS determine the degree to which DBS engages circuits that involve prefrontal cortex executive functions, and therefore have a direct impact on the patient's ability to inhibit actions. | Parkinson | Phase 4 | À vérifier | United States | À vérifier |
| David Delight Plus DeviceThis study aims to answer the question: to assess the safety, and tolerability of gamma light in Parkinson's disease (PD) patients with freezing of gait (FOG). Parkinson's disease (PD) patients often experience a complex gait disorder known as Freezing of Gait (FOG). FOG is characterized by brief arrests of stepping when initiating gait, turning, and walking straight and patients describe it as their feet being "glued" to the floor. FOG in Parkinson's disease (PD) is a considerable public health burden worldwide. It is a poorly understood gait symptom that has potentially grave consequences as FOG is intermittent and unpredictable, a leading cause of falls with injury, and results in loss of independence. FOG is generally found to be associated with cognitive decline, particularly executive dysfunction which, in turn, has been associated with higher spinal fluid amyloid (Aβ42) levels in PD. There is data linking amyloid to FOG. A previous study showed that the gamma light helped reduce some amyloid. The research team is studying if gamma light exposure for 1 hour daily is well tolerated. Also, does it have any effect on freezing of gait severity? | Alzheimer, Parkinson | Non applicable | Traitement symptomatique | United States | À vérifier |
| DBS Setting Maximizing Prefrontal ActivationPatients with Parkinson's Disease will be studied before, during, and after a deep brain stimulation implantation procedure to see if the stimulation location and the size of the electrical field produced by subthalamic nucleus (STN) DBS determine the degree to which DBS engages circuits that involve prefrontal cortex executive functions, and therefore have a direct impact on the patient's ability to inhibit actions. | Parkinson | Phase 4 | À vérifier | United States | À vérifier |
| DBS Setting Minimizing Prefrontal ActivationPatients with Parkinson's Disease will be studied before, during, and after a deep brain stimulation implantation procedure to see if the stimulation location and the size of the electrical field produced by subthalamic nucleus (STN) DBS determine the degree to which DBS engages circuits that involve prefrontal cortex executive functions, and therefore have a direct impact on the patient's ability to inhibit actions. | Parkinson | Phase 4 | À vérifier | United States | À vérifier |
| GammaCore/electroCore non-invasive VNS deviceThe tasks of the project are to map the potency and kinetics of the neurologic, autonomic peripheral, inflammatory, and behavioral responses to vagal nerve stimulation (VNS) vs. sham treatment, at baseline and in response to stressful traumatic scripts related to personal traumatic events, as well as a series of other stressors. | SEP | Phase 3 | Immunomodulation | United States | À vérifier |
| Implementation and Cost Evaluation of Project UPLIFTThis study tests Project Using Practice and Learning to Increase Favorable Thoughts (UPLIFT) which is a Mindfulness-based Cognitive Behavioral Therapy program teaching participants with epilepsy methods that include challenging thoughts, behavioral activation, coping, problem-solving, and mindfulness, for well-being and costs. Project UPLIFT is delivered as weekly sessions over 8 weeks. | Épilepsie | Non applicable | À vérifier | United States | À vérifier |
| KetamineChronic daily headaches (CDH) poses a significant burden on patients, healthcare systems and the society. Intravenous (IV) ketamine infusion, an intervention that is widely available and scalable, can treat CDH by reversing receptor-mediated sensitization. This study is a multicenter, placebo-controlled, parallel group randomized trial with blinding of participants and observers with the goal of comprehensively assessing the effect of high-dose IV ketamine infusion (1 mg.kg-1.h-1 for six hours) on the frequency and intensity of headaches, mood, activity, sleep, quality of life and safety of ketamine for three months after the interventions. Use of validated questionnaires, wearable technology, a research team that includes investigators with expertise in studying ketamine and in evaluating treatments for CDH and pain syndromes are some of the unique features of this project. Our study aims to prospectively assess the efficacy and safety of high-dose intravenous ketamine infusions compared to saline infusions in participants with CDH syndrome. | Épilepsie, Migraine | Phase 2 | Traitement symptomatique | United States | À vérifier |
| Ketorolac injection to the shoulder, elbow, wrist, or handOsteoarthritis (OA) and inflammatory conditions of the tendons and joints of the shoulder, elbow, hand, and wrist are common yet disabling diseases. Standard management utilizes conservative measures to minimize pain and improve function. Conservative pharmacological management commonly includes corticosteroid and ketorolac injections which have been well investigated as a modality of pain control and improved function in large joint OA. However, fewer studies yielding mixed results on the duration of symptomatic relief exist for arthropathy and tendinopathy of these joints. The goal of this study is to evaluate the efficacy of ketorolac and triamcinolone injections for common shoulder, elbow, wrist, and hand tendinopathy or arthropathy. Participants will be blinded to the treatment received. The duration of an individual participant's participation in this study is 24 weeks. During this time period, patients will be asked to return to the clinic for an in-person follow-up 6 weeks after the injection with either ketorolac or triamcinolone) in order to assess participants' outcomes. All work related to this project will take place at the Emory Sports Medicine Complex, Emory Executive Park, Emory Musculoskeletal Institute, the Emory University Orthopaedic and Spine Hospital, and the Emory Saint Joseph's Hospital. This study will add to existing knowledge by providing further insight into how wrist arthropathy should be most optimally and conservatively managed. | Myopathies | Phase 4 | Traitement symptomatique | United States | À vérifier |
| LevodopaPatients with Parkinson's Disease will be studied before, during, and after a deep brain stimulation implantation procedure to see if the stimulation location and the size of the electrical field produced by subthalamic nucleus (STN) DBS determine the degree to which DBS engages circuits that involve prefrontal cortex executive functions, and therefore have a direct impact on the patient's ability to inhibit actions. | Parkinson | Phase 4 | À vérifier | United States | À vérifier |
| MRI Guided Focal Laser Interstitial Thermal AblationThe study is a prospective, single-arm, non-randomized, unblinded trial to determine the safety and efficacy of MRI guided focal laser ablation of localized low and intermediate risk prostate cancer. All subjects meeting the inclusion exclusion criteria and are enrolled will undergo a MRI guided focal laser ablation procedure. The primary aim of the study is to study the safety and efficacy of the procedure. | Cancer | Non applicable | À vérifier | United States | À vérifier |
| Sham DBSPatients with Parkinson's Disease will be studied before, during, and after a deep brain stimulation implantation procedure to see if the stimulation location and the size of the electrical field produced by subthalamic nucleus (STN) DBS determine the degree to which DBS engages circuits that involve prefrontal cortex executive functions, and therefore have a direct impact on the patient's ability to inhibit actions. | Parkinson | Phase 4 | À vérifier | United States | À vérifier |
| Sham gammaCore/electroCoreThe tasks of the project are to map the potency and kinetics of the neurologic, autonomic peripheral, inflammatory, and behavioral responses to vagal nerve stimulation (VNS) vs. sham treatment, at baseline and in response to stressful traumatic scripts related to personal traumatic events, as well as a series of other stressors. | SEP | Phase 3 | Immunomodulation | United States | À vérifier |
| Sham-transcutaneous Vagus Nerve Stimulation (tVNS)This study will test whether mindfulness meditation (MM) improves sympathetic function in chronic kidney disease (CKD) and whether transcutaneous vagus nerve stimulation (tVNS) optimizes the sympatho-inhibitory effects of mindfulness meditation (MM) and restores autonomic balance in CKD patients. | Maladie rénale chronique | Non applicable | À vérifier | United States | À vérifier |
| Shear Wave ElastographyThe purpose of this study is to utilize Shear Wave Elastography (SWE) to study the viscoelastic properties of tendons to understand the functional differences between normal/asymptomatic and symptomatic tendon states. The study will also assess the degree of tendon healing following standard of care treatment. | Myopathies | À vérifier | Traitement symptomatique | United States | À vérifier |
| Sodium bicarbonateMetabolic acidosis is a common problem that occurs with worsening chronic kidney disease. Dietary acid can build up when the kidneys are not working well. This can be associated with a higher risk of worsening kidney function and death. The usual treatment is a medication called sodium bicarbonate which works to balance the acids in the body. The medication however often does not work and causes side effects. Consumption of alkalizing fruit and vegetables may work as a treatment for metabolic acidosis. This trial is being done to see if fruit and vegetables, provided via home delivery, can become a viable management for metabolic acidosis in patients with chronic kidney disease. | Maladie rénale chronique | Phase 2 | À vérifier | United States | À vérifier |
| SpironolactoneMany patients on hemodialysis have high blood pressure that does not respond to three or more drugs (resistant hypertension). This pilot study gave a low dose of spironolactone (12.5 mg once daily) for 6 weeks to adults on hemodialysis with resistant hypertension. The study measured changes in blood pressure, heart rate variability, markers of inflammation (interleukin-6 and high-sensitivity C-reactive protein), a marker of cardiac stress (NT-proBNP), and serum potassium. | Alzheimer, Maladie rénale chronique | Phase 4 | Immunomodulation | United States | À vérifier |
| StableEyesThe study aims to study the effects of a novel treatment for vestibular symptoms in people with multiple sclerosis. The main objective is to determine whether daily personalized gaze stabilization training is more beneficial than intermittent gaze stability training in people with multiple sclerosis. | SEP | Non applicable | Traitement symptomatique | United States | À vérifier |
| Surgical managementThe main purpose of this study is to compare patients with a deep bleed in the brain undergoing surgery to patients receiving routine medical care. The standard treatment involves admission to the Intensive Care Unit (ICU) with close monitoring and blood pressure control. It also includes other medical (non-surgical) treatments to prevent more bleeding or another stroke. Sometimes, doctors will recommend surgery to remove the blood if medical treatment alone is not successful. There is evidence that doing minimally invasive surgery early-using a small opening in the skull to remove blood-may help some patients. Researchers aim to understand whether this surgery is better than current medical treatment, which may include surgeries to relieve pressure on the brain in some cases. This study, called REACH, is comparing usual medical care to early minimally invasive surgery so doctors can know which is better for patients. | Accident vasculaire cérébral | Non applicable | À vérifier | United States | À vérifier |
| Transcutaneous Cervical Vagal Nerve StimulationThis study is being done to answer the question: what is the effect of Vagal Nerve Stimulation (VNS) dosing on opioid withdrawal responses in individuals with a history of Opioid Use Disorders (OUDs)? Eligible participants will be in the study for one week in an inpatient research hospital stay, have an MRI scan, and have a follow-up call 1-3 months after their inpatient stay. Participants will complete several psychiatric questionnaires/interviews, physiological monitoring with several devices, brain imaging, and VNS testing. | SEP | Phase 3 | À vérifier | United States | À vérifier |
| Transcutaneous vagus nerve stimulation (tVNS)The goal of this clinical trial is to test the efficacy of transcutaneous vagus nerve stimulation (tVNS) in borderline personality disorder. The main question it aims to answer is: • Is tVNS effective in acutely reducing emotional reactivity in borderline personality disorder? Participants will be randomized to a single session of tVNS or sham-tVNS while going through an affect-inducing procedure. It will consist of the presentation of one neutral and three negative affect-inducing videos in sequence, each of which is followed by a post-induction period during which participants will rate the quality and intensity of their current self-reported emotions. Researchers will compare the tVNS and sham tVNS groups to see if there is a difference in the intensity of the self-reported emotions between the groups. | Maladie rénale chronique, SEP | Non applicable | À vérifier | United States | À vérifier |
| Triamcinolone injection to the shoulder, elbow, wrist, or handOsteoarthritis (OA) and inflammatory conditions of the tendons and joints of the shoulder, elbow, hand, and wrist are common yet disabling diseases. Standard management utilizes conservative measures to minimize pain and improve function. Conservative pharmacological management commonly includes corticosteroid and ketorolac injections which have been well investigated as a modality of pain control and improved function in large joint OA. However, fewer studies yielding mixed results on the duration of symptomatic relief exist for arthropathy and tendinopathy of these joints. The goal of this study is to evaluate the efficacy of ketorolac and triamcinolone injections for common shoulder, elbow, wrist, and hand tendinopathy or arthropathy. Participants will be blinded to the treatment received. The duration of an individual participant's participation in this study is 24 weeks. During this time period, patients will be asked to return to the clinic for an in-person follow-up 6 weeks after the injection with either ketorolac or triamcinolone) in order to assess participants' outcomes. All work related to this project will take place at the Emory Sports Medicine Complex, Emory Executive Park, Emory Musculoskeletal Institute, the Emory University Orthopaedic and Spine Hospital, and the Emory Saint Joseph's Hospital. This study will add to existing knowledge by providing further insight into how wrist arthropathy should be most optimally and conservatively managed. | Myopathies | Phase 4 | Traitement symptomatique | United States | À vérifier |
| Transcutaneous Cervical Vagal Nerve StimulationThis study is being done to answer the question: what is the effect of Vagal Nerve Stimulation (VNS) dosing on opioid withdrawal responses in individuals with a history of Opioid Use Disorders (OUDs)? Eligible participants will be in the study for one week in an inpatient research hospital stay, have an MRI scan, and have a follow-up call 1-3 months after their inpatient stay. Participants will complete several psychiatric questionnaires/interviews, physiological monitoring with several devices, brain imaging, and VNS testing. | SEP | Phase 3 | À vérifier | United States | À vérifier |
| Implementation and Cost Evaluation of Project UPLIFTThis study tests Project Using Practice and Learning to Increase Favorable Thoughts (UPLIFT) which is a Mindfulness-based Cognitive Behavioral Therapy program teaching participants with epilepsy methods that include challenging thoughts, behavioral activation, coping, problem-solving, and mindfulness, for well-being and costs. Project UPLIFT is delivered as weekly sessions over 8 weeks. | Épilepsie | Non applicable | À vérifier | United States | À vérifier |
| KetamineChronic daily headaches (CDH) poses a significant burden on patients, healthcare systems and the society. Intravenous (IV) ketamine infusion, an intervention that is widely available and scalable, can treat CDH by reversing receptor-mediated sensitization. This study is a multicenter, placebo-controlled, parallel group randomized trial with blinding of participants and observers with the goal of comprehensively assessing the effect of high-dose IV ketamine infusion (1 mg.kg-1.h-1 for six hours) on the frequency and intensity of headaches, mood, activity, sleep, quality of life and safety of ketamine for three months after the interventions. Use of validated questionnaires, wearable technology, a research team that includes investigators with expertise in studying ketamine and in evaluating treatments for CDH and pain syndromes are some of the unique features of this project. Our study aims to prospectively assess the efficacy and safety of high-dose intravenous ketamine infusions compared to saline infusions in participants with CDH syndrome. | Migraine | Phase 3 | Traitement symptomatique | Canada | À vérifier |
| David Delight Plus DeviceThis study aims to answer the question: to assess the safety, and tolerability of gamma light in Parkinson's disease (PD) patients with freezing of gait (FOG). Parkinson's disease (PD) patients often experience a complex gait disorder known as Freezing of Gait (FOG). FOG is characterized by brief arrests of stepping when initiating gait, turning, and walking straight and patients describe it as their feet being "glued" to the floor. FOG in Parkinson's disease (PD) is a considerable public health burden worldwide. It is a poorly understood gait symptom that has potentially grave consequences as FOG is intermittent and unpredictable, a leading cause of falls with injury, and results in loss of independence. FOG is generally found to be associated with cognitive decline, particularly executive dysfunction which, in turn, has been associated with higher spinal fluid amyloid (Aβ42) levels in PD. There is data linking amyloid to FOG. A previous study showed that the gamma light helped reduce some amyloid. The research team is studying if gamma light exposure for 1 hour daily is well tolerated. Also, does it have any effect on freezing of gait severity? | Alzheimer | Non applicable | Traitement symptomatique | United States | À vérifier |
| KetamineChronic daily headaches (CDH) poses a significant burden on patients, healthcare systems and the society. Intravenous (IV) ketamine infusion, an intervention that is widely available and scalable, can treat CDH by reversing receptor-mediated sensitization. This study is a multicenter, placebo-controlled, parallel group randomized trial with blinding of participants and observers with the goal of comprehensively assessing the effect of high-dose IV ketamine infusion (1 mg.kg-1.h-1 for six hours) on the frequency and intensity of headaches, mood, activity, sleep, quality of life and safety of ketamine for three months after the interventions. Use of validated questionnaires, wearable technology, a research team that includes investigators with expertise in studying ketamine and in evaluating treatments for CDH and pain syndromes are some of the unique features of this project. Our study aims to prospectively assess the efficacy and safety of high-dose intravenous ketamine infusions compared to saline infusions in participants with CDH syndrome. | Épilepsie | Phase 2 | Traitement symptomatique | United States | À vérifier |
| LevodopaPatients with Parkinson's Disease will be studied before, during, and after a deep brain stimulation implantation procedure to see if the stimulation location and the size of the electrical field produced by subthalamic nucleus (STN) DBS determine the degree to which DBS engages circuits that involve prefrontal cortex executive functions, and therefore have a direct impact on the patient's ability to inhibit actions. | Parkinson | Phase 4 | À vérifier | United States | À vérifier |
| Triamcinolone injection to the shoulder, elbow, wrist, or handOsteoarthritis (OA) and inflammatory conditions of the tendons and joints of the shoulder, elbow, hand, and wrist are common yet disabling diseases. Standard management utilizes conservative measures to minimize pain and improve function. Conservative pharmacological management commonly includes corticosteroid and ketorolac injections which have been well investigated as a modality of pain control and improved function in large joint OA. However, fewer studies yielding mixed results on the duration of symptomatic relief exist for arthropathy and tendinopathy of these joints. The goal of this study is to evaluate the efficacy of ketorolac and triamcinolone injections for common shoulder, elbow, wrist, and hand tendinopathy or arthropathy. Participants will be blinded to the treatment received. The duration of an individual participant's participation in this study is 24 weeks. During this time period, patients will be asked to return to the clinic for an in-person follow-up 6 weeks after the injection with either ketorolac or triamcinolone) in order to assess participants' outcomes. All work related to this project will take place at the Emory Sports Medicine Complex, Emory Executive Park, Emory Musculoskeletal Institute, the Emory University Orthopaedic and Spine Hospital, and the Emory Saint Joseph's Hospital. This study will add to existing knowledge by providing further insight into how wrist arthropathy should be most optimally and conservatively managed. | Myopathies | Phase 4 | Traitement symptomatique | United States | À vérifier |
| Shear Wave ElastographyThe purpose of this study is to utilize Shear Wave Elastography (SWE) to study the viscoelastic properties of tendons to understand the functional differences between normal/asymptomatic and symptomatic tendon states. The study will also assess the degree of tendon healing following standard of care treatment. | Myopathies | À vérifier | Traitement symptomatique | United States | À vérifier |
| GammaCore/electroCore non-invasive VNS deviceThe tasks of the project are to map the potency and kinetics of the neurologic, autonomic peripheral, inflammatory, and behavioral responses to vagal nerve stimulation (VNS) vs. sham treatment, at baseline and in response to stressful traumatic scripts related to personal traumatic events, as well as a series of other stressors. | SEP | Phase 3 | Immunomodulation | United States | À vérifier |
| Surgical managementThe main purpose of this study is to compare patients with a deep bleed in the brain undergoing surgery to patients receiving routine medical care. The standard treatment involves admission to the Intensive Care Unit (ICU) with close monitoring and blood pressure control. It also includes other medical (non-surgical) treatments to prevent more bleeding or another stroke. Sometimes, doctors will recommend surgery to remove the blood if medical treatment alone is not successful. There is evidence that doing minimally invasive surgery early-using a small opening in the skull to remove blood-may help some patients. Researchers aim to understand whether this surgery is better than current medical treatment, which may include surgeries to relieve pressure on the brain in some cases. This study, called REACH, is comparing usual medical care to early minimally invasive surgery so doctors can know which is better for patients. | Accident vasculaire cérébral | Non applicable | À vérifier | United States | À vérifier |
| StableEyesThe study aims to study the effects of a novel treatment for vestibular symptoms in people with multiple sclerosis. The main objective is to determine whether daily personalized gaze stabilization training is more beneficial than intermittent gaze stability training in people with multiple sclerosis. | SEP | Non applicable | Traitement symptomatique | United States | À vérifier |
| Sodium bicarbonateMetabolic acidosis is a common problem that occurs with worsening chronic kidney disease. Dietary acid can build up when the kidneys are not working well. This can be associated with a higher risk of worsening kidney function and death. The usual treatment is a medication called sodium bicarbonate which works to balance the acids in the body. The medication however often does not work and causes side effects. Consumption of alkalizing fruit and vegetables may work as a treatment for metabolic acidosis. This trial is being done to see if fruit and vegetables, provided via home delivery, can become a viable management for metabolic acidosis in patients with chronic kidney disease. | Maladie rénale chronique | Non applicable | À vérifier | Canada | À vérifier |
| SpironolactoneMany patients on hemodialysis have high blood pressure that does not respond to three or more drugs (resistant hypertension). This pilot study gave a low dose of spironolactone (12.5 mg once daily) for 6 weeks to adults on hemodialysis with resistant hypertension. The study measured changes in blood pressure, heart rate variability, markers of inflammation (interleukin-6 and high-sensitivity C-reactive protein), a marker of cardiac stress (NT-proBNP), and serum potassium. | Maladie rénale chronique | Phase 4 | Immunomodulation | Indonesia | À vérifier |
| Transcutaneous vagus nerve stimulation (tVNS)The goal of this clinical trial is to test the efficacy of transcutaneous vagus nerve stimulation (tVNS) in borderline personality disorder. The main question it aims to answer is: • Is tVNS effective in acutely reducing emotional reactivity in borderline personality disorder? Participants will be randomized to a single session of tVNS or sham-tVNS while going through an affect-inducing procedure. It will consist of the presentation of one neutral and three negative affect-inducing videos in sequence, each of which is followed by a post-induction period during which participants will rate the quality and intensity of their current self-reported emotions. Researchers will compare the tVNS and sham tVNS groups to see if there is a difference in the intensity of the self-reported emotions between the groups. | SEP | Non applicable | À vérifier | Sweden | À vérifier |
| SpironolactoneMany patients on hemodialysis have high blood pressure that does not respond to three or more drugs (resistant hypertension). This pilot study gave a low dose of spironolactone (12.5 mg once daily) for 6 weeks to adults on hemodialysis with resistant hypertension. The study measured changes in blood pressure, heart rate variability, markers of inflammation (interleukin-6 and high-sensitivity C-reactive protein), a marker of cardiac stress (NT-proBNP), and serum potassium. | Alzheimer | Phase 4 | Immunomodulation | United States | À vérifier |
| MRI Guided Focal Laser Interstitial Thermal AblationThe study is a prospective, single-arm, non-randomized, unblinded trial to determine the safety and efficacy of MRI guided focal laser ablation of localized low and intermediate risk prostate cancer. All subjects meeting the inclusion exclusion criteria and are enrolled will undergo a MRI guided focal laser ablation procedure. The primary aim of the study is to study the safety and efficacy of the procedure. | Cancer | Non applicable | À vérifier | United States | À vérifier |
| Sodium bicarbonateMetabolic acidosis is a common problem that occurs with worsening chronic kidney disease. Dietary acid can build up when the kidneys are not working well. This can be associated with a higher risk of worsening kidney function and death. The usual treatment is a medication called sodium bicarbonate which works to balance the acids in the body. The medication however often does not work and causes side effects. Consumption of alkalizing fruit and vegetables may work as a treatment for metabolic acidosis. This trial is being done to see if fruit and vegetables, provided via home delivery, can become a viable management for metabolic acidosis in patients with chronic kidney disease. | Maladie rénale chronique | Phase 2 | À vérifier | United States | À vérifier |
| Transcutaneous vagus nerve stimulation (tVNS)The goal of this clinical trial is to test the efficacy of transcutaneous vagus nerve stimulation (tVNS) in borderline personality disorder. The main question it aims to answer is: • Is tVNS effective in acutely reducing emotional reactivity in borderline personality disorder? Participants will be randomized to a single session of tVNS or sham-tVNS while going through an affect-inducing procedure. It will consist of the presentation of one neutral and three negative affect-inducing videos in sequence, each of which is followed by a post-induction period during which participants will rate the quality and intensity of their current self-reported emotions. Researchers will compare the tVNS and sham tVNS groups to see if there is a difference in the intensity of the self-reported emotions between the groups. | Maladie rénale chronique | Non applicable | À vérifier | United States | À vérifier |
Essais cliniques
19| Molécule | Indication / population | Phase | NCT | Titre | Statut |
|---|---|---|---|---|---|
| Transcutaneous vagus nerve stimulation (tVNS) | Maladie rénale chronique | Non applicable | NCT04099992 | MIND-CKD — Mindfulness in Chronic Kidney Disease | COMPLETED |
| Sodium bicarbonate | Maladie rénale chronique | Phase 2 | NCT05928936 | Neurovascular Regulation During Exercise in Humans With Chronic Kidney Disease: Sympatholysis in CKD | RECRUITING |
| MRI Guided Focal Laser Interstitial Thermal Ablation | Cancer | Non applicable | NCT03634579 | MRI Guided Prostate Cancer Focal Laser Ablation | TERMINATED |
| Spironolactone | Alzheimer | Phase 4 | NCT04522739 | STAND — Spironolactone Safety in African Americans With Mild Cognitive Impairment and Early Dementia | COMPLETED |
| Transcutaneous vagus nerve stimulation (tVNS) | SEP | Non applicable | NCT05892900 | Transcutaneous Vagus Nerve Stimulation (tVNS) for Borderline Personality Disorder (tVNS-BPD) | UNKNOWN |
| Spironolactone | Maladie rénale chronique | Phase 4 | NCT07888504 | Low-Dose Spironolactone in Hemodialysis Patients With Resistant Hypertension | COMPLETED |
| Sodium bicarbonate | Maladie rénale chronique | Non applicable | NCT05113641 | Reducing Dietary Acid With Food Versus Oral Alkali in People With Chronic Kidney Disease (ReDACKD) | COMPLETED |
| StableEyes | SEP | Non applicable | NCT06495138 | DIIVA-MS — Incremental Vestibulo-ocular Reflex Adaptation as a Novel Treatment for Dizziness in People With Multiple Sclerosis | RECRUITING |
| Surgical management | Accident vasculaire cérébral | Non applicable | NCT06870812 | REACH — Rapid Evacuation and Access of Cerebral Hemorrhage Trial | RECRUITING |
| Magnetic Resonance Imaging | Cancer | Non applicable | NCT07859722 | CT- Versus MRI-Based Planning for High-Dose-Rate Prostate Brachytherapy for Prostate Cancer | NOT_YET_RECRUITING |
| GammaCore/electroCore non-invasive VNS device | SEP | Phase 3 | NCT02992899 | Closed Loop Vagal Nerve Stimulation for Patients With Posttraumatic Stress Disorder | COMPLETED |
| Shear Wave Elastography | Myopathies | À vérifier | NCT03456778 | Assessing the Tendons With Shear Wave Elastography | COMPLETED |
| Triamcinolone injection to the shoulder, elbow, wrist, or hand | Myopathies | Phase 4 | NCT05292339 | Ketorolac in Upper Extremity Tendinopathy and Arthropathy | RECRUITING |
| Levodopa | Parkinson | Phase 4 | NCT06234995 | Cortical Electrophysiology of Response Inhibition in Parkinson's Disease | RECRUITING |
| Ketamine | Épilepsie | Phase 2 | NCT07768618 | Ketamine-sEEG — Electrophysiologic Mechanisms of Ketamine Antidepressant Response | NOT_YET_RECRUITING |
| David Delight Plus Device | Alzheimer | Non applicable | NCT06295458 | Flicker w FOG — Gamma Sensory Flicker for Parkinson's Disease Patients With Freezing of Gait | COMPLETED |
| Ketamine | Migraine | Phase 3 | NCT05306899 | KetHead — Multi-center RCT of IV Ketamine Efficacy and Safety in Chronic Daily Headaches | RECRUITING |
| Implementation and Cost Evaluation of Project UPLIFT | Épilepsie | Non applicable | NCT06865820 | Implementation and Cost Evaluation of Project UPLIFT | RECRUITING |
| Transcutaneous Cervical Vagal Nerve Stimulation | SEP | Phase 3 | NCT05834478 | VNS in OUD UH3 — Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3 | RECRUITING |
Publications
8| Molécule | Indication / population | Titre | Journal | Date |
|---|---|---|---|---|
| Ketamine | Substance use and mental health outcomes among gay and bisexual men in South Korea: a cross-sectional study. | Addictive behaviors reports | ||
| Ketamine | Investigating the effects of chlorogenic acid on novel object recognition memory impairment, hyperlocomotion, and prefrontal BDNF expression in a sub-chronic ketamine-induced schizophrenia-like rat model. | IBRO neuroscience reports | ||
| Ketamine | Ketamine preserves perineuronal nets in chronic stressed mice brain through the inhibition of microglia activation. | IBRO neuroscience reports | ||
| Implementation and Cost Evaluation of Project UPLIFT | 6S management project to improve workplace productivity in Primary Health Centre in India. | BMC health services research | ||
| [F-18]Fallypride | Imaging of human stem cell-derived dopamine grafts correlates with behavioural recovery and reveals microstructural brain changes. | Neurobiology of disease | ||
| Transcutaneous Cervical Vagal Nerve Stimulation | Cognitive function and brain activation before and after transcutaneous cervical vagus nerve stimulation in healthy adults: A concurrent tcVNS-fMRI study. | Frontiers in psychology | ||
| Transcutaneous Cervical Vagal Nerve Stimulation | Noninvasive electrical neuromodulation for gastrointestinal motility disorders. | Expert review of gastroenterology & hepatology | ||
| Transcutaneous Cervical Vagal Nerve Stimulation | Efficacy and acceptability of noninvasive brain stimulation for treating posttraumatic stress disorder symptoms: A network meta-analysis of randomized controlled trials. | Acta psychiatrica Scandinavica |