Children's Hospital Medical Center, Cincinnati — Biomedical Watch V2

Traitements12programmes

Essais7liés

Publications1liées

SourceDBlocale

Traitements

12

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
AmitriptylineThis comparative effectiveness study will clarify current first-line preventive treatment approaches for use by neurologists, psychologists, and primary care providers in the context of real world care, and will demonstrate the feasibility of Cognitive Behavioral Therapy (CBT) via telehealth for youth with migraine. The focus is on applying evidence-based care and enhancing access to it. CBT via telehealth while taking a clinically-prescribed, pill-based prevention therapy (amitriptyline) will be compared to CBT via telehealth alone.	Migraine	Non applicable	À vérifier	United States	À vérifier
Autologous Thymus TransplantThis pilot study will look at whether putting back a child's own thymus tissue during heart surgery is safe and may help support the immune system in children with congenital heart disease (CHD). During some heart surgeries, the thymus gland is removed to allow surgeons access to the heart. The thymus is important for helping the body develop infection-fighting immune cells. Researchers will compare children who have their thymus tissue reimplanted with children who have the thymus removed but not reimplanted. The study will evaluate the safety of the procedure, whether the transplanted tissue survives and functions, and whether it helps maintain or improve immune system health. Researchers will also monitor infections, recovery after surgery, hospital stays, quality of life, and overall health outcomes. Blood samples will be collected over time to better understand how the immune system changes after surgery and whether thymus reimplantation provides long-term benefits. Participants will be followed for up to 24 months after surgery.	Maladie coronarienne	Non applicable			À vérifier
HFOs — Clinical Applications of High-Frequency OscillationsThe objective of this study is to utilize high-frequency brain signals (HFBS) to localize functional brain areas and characterize HFBS in epilepsy, migraine, and other brain disorders. Our goal is to create the world's first high-frequency MEG/EEG/ECoG/SEEG database for the developing brain. HFBS include high-gamma activation/oscillations, high-frequency oscillations (HFOs), ripples, fast ripples, spikelets, fast spikelets, and very high-frequency oscillations (VHFOs). While terminologies and frequency bands may vary among reports, both HFOs and high-gamma waves are crucial for understanding brain function and developing potential treatments for neurological disorders. We have been developing an intelligent software platform to analyze signals from low to very high-frequency ranges across multiple frequency bands. To achieve these goals, we have developed several innovative techniques and software packages: * Accumulated spectrogram * Accumulated source imaging * Frequency-encoded source imaging * Multi-frequency analysis at source levels * Artificial intelligence detection of HFOs * Neural network analysis (Graph Theory) * Other techniques (e.g., Independent Component Analysis, virtual sensors) These methods enable researchers to better understand the characteristics and significance of HFOs and high-gamma brain waves, contributing to advancements in the diagnosis and treatment of neurological disorders.	Migraine	À vérifier	À vérifier	United States	À vérifier
Mind Body Balance for Pediatric MigraineThis study uses a factorial research design to evaluate a nurse delivered mind body intervention using different doses of 3 treatment components to determine the optimized treatment for headache day reduction.	Migraine	Non applicable	À vérifier	United States	À vérifier
Pediatric Radio Frequency Coils GenericThe purpose of this study is to evaluate and optimize advances in radio frequency (RF) coil magnetic resonance imaging (MRI) technology at Cincinnati Children's Hospital Medical Center (CCHMC).	Myopathies	À vérifier	À vérifier	United States	À vérifier
SCP — Supraspinal Processing of Sensory Aspects of PainThe goal of this basic science study is to learn about the brain mechanisms of chronic pain across different chronic pain syndromes in pediatric patients. The main questions it aims to answer are: * Are there shared and distinct brain systems engaged by different forms of pediatric chronic pain? * What are predictors of recovery from chronic pain? * What brain systems are associated with the spread of pain? For this study participants will undergo: * Functional Magnetic Resonance Imaging (fMRI) * Quantitative Sensory Testing * Psychological Assessments	Migraine	Non applicable	Traitement symptomatique	United States	À vérifier
SCP — Supraspinal Processing of Sensory Aspects of PainThe goal of this basic science study is to learn about the brain mechanisms of chronic pain across different chronic pain syndromes in pediatric patients. The main questions it aims to answer are: * Are there shared and distinct brain systems engaged by different forms of pediatric chronic pain? * What are predictors of recovery from chronic pain? * What brain systems are associated with the spread of pain? For this study participants will undergo: * Functional Magnetic Resonance Imaging (fMRI) * Quantitative Sensory Testing * Psychological Assessments	Migraine	Non applicable	Traitement symptomatique	United States	À vérifier
AmitriptylineThis comparative effectiveness study will clarify current first-line preventive treatment approaches for use by neurologists, psychologists, and primary care providers in the context of real world care, and will demonstrate the feasibility of Cognitive Behavioral Therapy (CBT) via telehealth for youth with migraine. The focus is on applying evidence-based care and enhancing access to it. CBT via telehealth while taking a clinically-prescribed, pill-based prevention therapy (amitriptyline) will be compared to CBT via telehealth alone.	Migraine	Non applicable	À vérifier	United States	À vérifier
Mind Body Balance for Pediatric MigraineThis study uses a factorial research design to evaluate a nurse delivered mind body intervention using different doses of 3 treatment components to determine the optimized treatment for headache day reduction.	Migraine	Non applicable	À vérifier	United States	À vérifier
HFOs — Clinical Applications of High-Frequency OscillationsThe objective of this study is to utilize high-frequency brain signals (HFBS) to localize functional brain areas and characterize HFBS in epilepsy, migraine, and other brain disorders. Our goal is to create the world's first high-frequency MEG/EEG/ECoG/SEEG database for the developing brain. HFBS include high-gamma activation/oscillations, high-frequency oscillations (HFOs), ripples, fast ripples, spikelets, fast spikelets, and very high-frequency oscillations (VHFOs). While terminologies and frequency bands may vary among reports, both HFOs and high-gamma waves are crucial for understanding brain function and developing potential treatments for neurological disorders. We have been developing an intelligent software platform to analyze signals from low to very high-frequency ranges across multiple frequency bands. To achieve these goals, we have developed several innovative techniques and software packages: * Accumulated spectrogram * Accumulated source imaging * Frequency-encoded source imaging * Multi-frequency analysis at source levels * Artificial intelligence detection of HFOs * Neural network analysis (Graph Theory) * Other techniques (e.g., Independent Component Analysis, virtual sensors) These methods enable researchers to better understand the characteristics and significance of HFOs and high-gamma brain waves, contributing to advancements in the diagnosis and treatment of neurological disorders.	Migraine	À vérifier	À vérifier	United States	À vérifier
Pediatric Radio Frequency Coils GenericThe purpose of this study is to evaluate and optimize advances in radio frequency (RF) coil magnetic resonance imaging (MRI) technology at Cincinnati Children's Hospital Medical Center (CCHMC).	Myopathies	À vérifier	À vérifier	United States	À vérifier
Autologous Thymus TransplantThis pilot study will look at whether putting back a child's own thymus tissue during heart surgery is safe and may help support the immune system in children with congenital heart disease (CHD). During some heart surgeries, the thymus gland is removed to allow surgeons access to the heart. The thymus is important for helping the body develop infection-fighting immune cells. Researchers will compare children who have their thymus tissue reimplanted with children who have the thymus removed but not reimplanted. The study will evaluate the safety of the procedure, whether the transplanted tissue survives and functions, and whether it helps maintain or improve immune system health. Researchers will also monitor infections, recovery after surgery, hospital stays, quality of life, and overall health outcomes. Blood samples will be collected over time to better understand how the immune system changes after surgery and whether thymus reimplantation provides long-term benefits. Participants will be followed for up to 24 months after surgery.	Maladie coronarienne	Non applicable			À vérifier

Essais cliniques

7

Molécule	Indication / population	Phase	NCT	Titre	Statut
Autologous Thymus Transplant	Maladie coronarienne	Non applicable	NCT07799259	ATTT — Autologous Thymus Transplant in Children With Congenital Heart Disease: A Pilot Study	NOT_YET_RECRUITING
Mycophenolate Mofetil	Lupus	Phase 2	NCT05538208	The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) Study	RECRUITING
Pediatric Radio Frequency Coils Generic	Myopathies	À vérifier	NCT01633866	Pediatric Radio Frequency Coils Generic	ACTIVE_NOT_RECRUITING
HFOs — Clinical Applications of High-Frequency Oscillations	Migraine	À vérifier	NCT00600717	HFOs — Clinical Applications of High-Frequency Oscillations	WITHDRAWN
Mind Body Balance for Pediatric Migraine	Migraine	Non applicable	NCT04715685	Mind Body Balance for Pediatric Migraine	RECRUITING
Amitriptyline	Migraine	Non applicable	NCT05889624	Responding With Evidence and Access for Childhood Headaches	RECRUITING
SCP — Supraspinal Processing of Sensory Aspects of Pain	Migraine	Non applicable	NCT05814497	SCP — Supraspinal Processing of Sensory Aspects of Pain	RECRUITING

Publications

1

Molécule	Indication / population	Titre	Journal	Date
Amitriptyline		Investigating the effects of antidepressants on measures of insulin resistance in major depressive disorder: A systematic review.	Journal of affective disorders