Capital Medical University — Biomedical Watch V2

Traitements13programmes

Essais7liés

Publications4liées

SourceDBlocale

Traitements

13

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
AlbuminThis study is a prospective, multicenter, open-label, randomized controlled clinical trial. The investigators will apply albumin to the reperfusion treatment of patients with acute ischemic stroke in the anterior circulation. This study aims to verify the efficacy and safety of albumin combined with endovascular treatment in patients with anterior circulation acute ischemic stroke.	Accident vasculaire cérébral	Phase 3	À vérifier	China	À vérifier
Anisodine HydrobromideIn this study,288 adult migraine patients aged 18-65 years (diagnosed with migraine without aura and/or migraine with aura, with at least a 1-year history)will be collected to evaluate the efficacy, safety and tolerability of Anisodine Hydrobromide in preventing migraine attacks in episodic migraine in adults.	Accident vasculaire cérébral, Migraine	Phase 2	À vérifier	China	À vérifier
Cerebrospinal Fluid Mitochondrial Biomarkers in Ischemic Stroke and Alzheimer DiseaseThis prospective observational study aims to investigate cerebrospinal fluid mitochondrial biomarkers in patients with ischemic stroke and Alzheimer disease controls who undergo diagnostic lumbar puncture for clinical indications at Xuanwu Hospital, Capital Medical University. Residual cerebrospinal fluid samples will be analyzed by flow cytometry to quantify mitochondrial content, mitochondrial membrane potential, and cellular or vesicular source-related markers. The flow cytometry panel will include MitoTracker, JC-1, and membrane-associated markers including CD45, CD41, CD24, vWF, and EAAT1. In patients with ischemic stroke, the study will further examine whether cerebrospinal fluid mitochondrial measurements are associated with neurological severity and functional outcomes, including admission and discharge NIHSS scores and the 90-day modified Rankin Scale score. Alzheimer disease patients undergoing diagnostic lumbar puncture will serve as disease controls for biomarker comparison.	Alzheimer	À vérifier	Remyélinisation indirecte / réparation	China	À vérifier
Delayed anticoagulationThis study evaluates the safety and efficacy of early versus delayed initiation of direct oral anticoagulants (DOACs) in patients with acute ischemic stroke related to atrial fibrillation who develop hemorrhagic transformation after endovascular treatment.	Accident vasculaire cérébral	Non applicable	À vérifier	China	À vérifier
Early anticoagulationThis study evaluates the safety and efficacy of early versus delayed initiation of direct oral anticoagulants (DOACs) in patients with acute ischemic stroke related to atrial fibrillation who develop hemorrhagic transformation after endovascular treatment.	Accident vasculaire cérébral	Non applicable	À vérifier	China	À vérifier
Mechanical thrombectomy aloneIschemic post-conditioning is a neuroprotective strategy that has been proven to attenuate reperfusion injury in animal models of stroke. The investigators have conducted a 3 + 3 dose-escalation trial to demonstrate the safety and tolerability of ischemic post-conditioning incrementally for a longer duration of up to 5 min × 4 cycles in stroke patients undergoing mechanical thrombectomy. The purpose of this study is to further determine the efficacy and safety of ischemic post-conditioning in patients with acute ischemic stroke who are treated with mechanical thrombectomy.	Accident vasculaire cérébral	Phase 2	Neuroprotection	China	À vérifier
Mechanical thrombectomy combined with ischemic post-conditioningIschemic post-conditioning is a neuroprotective strategy that has been proven to attenuate reperfusion injury in animal models of stroke. The investigators have conducted a 3 + 3 dose-escalation trial to demonstrate the safety and tolerability of ischemic post-conditioning incrementally for a longer duration of up to 5 min × 4 cycles in stroke patients undergoing mechanical thrombectomy. The purpose of this study is to further determine the efficacy and safety of ischemic post-conditioning in patients with acute ischemic stroke who are treated with mechanical thrombectomy.	Accident vasculaire cérébral	Phase 2	Neuroprotection	China	À vérifier
Anisodine HydrobromideIn this study,288 adult migraine patients aged 18-65 years (diagnosed with migraine without aura and/or migraine with aura, with at least a 1-year history)will be collected to evaluate the efficacy, safety and tolerability of Anisodine Hydrobromide in preventing migraine attacks in episodic migraine in adults.	Migraine	Phase 3	À vérifier	China	À vérifier
Cerebrospinal Fluid Mitochondrial Biomarkers in Ischemic Stroke and Alzheimer DiseaseThis prospective observational study aims to investigate cerebrospinal fluid mitochondrial biomarkers in patients with ischemic stroke and Alzheimer disease controls who undergo diagnostic lumbar puncture for clinical indications at Xuanwu Hospital, Capital Medical University. Residual cerebrospinal fluid samples will be analyzed by flow cytometry to quantify mitochondrial content, mitochondrial membrane potential, and cellular or vesicular source-related markers. The flow cytometry panel will include MitoTracker, JC-1, and membrane-associated markers including CD45, CD41, CD24, vWF, and EAAT1. In patients with ischemic stroke, the study will further examine whether cerebrospinal fluid mitochondrial measurements are associated with neurological severity and functional outcomes, including admission and discharge NIHSS scores and the 90-day modified Rankin Scale score. Alzheimer disease patients undergoing diagnostic lumbar puncture will serve as disease controls for biomarker comparison.	Alzheimer	À vérifier	Remyélinisation indirecte / réparation	China	À vérifier
Anisodine HydrobromideIn this study,288 adult migraine patients aged 18-65 years (diagnosed with migraine without aura and/or migraine with aura, with at least a 1-year history)will be collected to evaluate the efficacy, safety and tolerability of Anisodine Hydrobromide in preventing migraine attacks in episodic migraine in adults.	Accident vasculaire cérébral	Phase 2	À vérifier	China	À vérifier
Early anticoagulationThis study evaluates the safety and efficacy of early versus delayed initiation of direct oral anticoagulants (DOACs) in patients with acute ischemic stroke related to atrial fibrillation who develop hemorrhagic transformation after endovascular treatment.	Accident vasculaire cérébral	Non applicable	À vérifier	China	À vérifier
Mechanical thrombectomy combined with ischemic post-conditioningIschemic post-conditioning is a neuroprotective strategy that has been proven to attenuate reperfusion injury in animal models of stroke. The investigators have conducted a 3 + 3 dose-escalation trial to demonstrate the safety and tolerability of ischemic post-conditioning incrementally for a longer duration of up to 5 min × 4 cycles in stroke patients undergoing mechanical thrombectomy. The purpose of this study is to further determine the efficacy and safety of ischemic post-conditioning in patients with acute ischemic stroke who are treated with mechanical thrombectomy.	Accident vasculaire cérébral	Phase 2	Neuroprotection	China	À vérifier
AlbuminThis study is a prospective, multicenter, open-label, randomized controlled clinical trial. The investigators will apply albumin to the reperfusion treatment of patients with acute ischemic stroke in the anterior circulation. This study aims to verify the efficacy and safety of albumin combined with endovascular treatment in patients with anterior circulation acute ischemic stroke.	Accident vasculaire cérébral	Phase 3	À vérifier	China	À vérifier

Essais cliniques

7

Molécule	Indication / population	Phase	NCT	Titre	Statut
Albumin	Accident vasculaire cérébral	Phase 3	NCT07263308	ARISE-2 — Albumin for Patients With Acute Large Vessel Occlusive Stroke Undergoing Endovascular Therapy -2	RECRUITING
Mechanical thrombectomy combined with ischemic post-conditioning	Accident vasculaire cérébral	Phase 2	NCT05789823	Ischemic Post-conditioning in Acute Ischemic Stroke Thrombectomy (PROTECT-2)	COMPLETED
Early anticoagulation	Accident vasculaire cérébral	Non applicable	NCT07139314	TIMERS-2 — Timing of Anticoagulation After Emergency Endovascular Therapy for Acute Ischemic Stroke With Atrial Fibrillation 2	RECRUITING
Anisodine Hydrobromide	Accident vasculaire cérébral	Phase 2	NCT07800572	Anisodine Hydrobromide for Patients With Acute Ischemic Stroke Undergoing Endovascular Therapy (HEAL-2)	RECRUITING
Tocilizumab	Accident vasculaire cérébral	Phase 3	NCT07509645	IRIS-3 — Efficacy and Safety of Interleukin-6 Receptor Inhibitor Combined With Endovascular Treatment in Patients With Acute Posterior Circulation Large Vessel Occlusion Stroke	RECRUITING
Cerebrospinal Fluid Mitochondrial Biomarkers in Ischemic Stroke and Alzheimer Disease	Alzheimer	À vérifier	NCT07600996	Cerebrospinal Fluid Mitochondrial Biomarkers in Ischemic Stroke and Alzheimer Disease	COMPLETED
Anisodine Hydrobromide	Migraine	Phase 3	NCT05416476	ATEM — Anisodine Hydrobromide For The Preventive Treatment Of Episodic Migraine	UNKNOWN

Publications

4

Molécule	Indication / population	Titre	Journal	Date
Mechanical thrombectomy combined with ischemic post-conditioning		A clinically relevant model of focal embolic cerebral ischemia by thrombus and thrombolysis in rhesus monkeys.	Nature protocols
Mechanical thrombectomy alone		Bridging therapy versus mechanical thrombectomy alone in patients with basilar artery occlusion and mild symptoms: a retrospective observational study.	Journal of neurology
Mechanical thrombectomy alone		Role of ECMO and percutaneous mechanical thrombectomy in the management of acute pulmonary embolism.	Frontiers in cardiovascular medicine
Mechanical thrombectomy alone		Preoperative Magnetic Resonance Imaging Findings Associated with Preexisting Basilar Artery Stenosis in Endovascular Revascularization for Basilar Artery Occlusion.	Neurologia medico-chirurgica