Baylor Research Institute — Biomedical Watch V2

Traitements16programmes

Essais7liés

Publications4liées

SourceDBlocale

Traitements

16

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
Active vagus nerve stimulationThis study seeks to evaluate the efficacy of transcranial direct current stimulation (tDCS) and Afferent Vagus nerve simulation (VNS) in treating acute postoperative pain of patients in the post-anesthesia care unit after general surgery. Study outcomes will include changes in pain levels and vital signs. For patients who are admitted after surgery, opioid consumption in the 24 hours after surgery and time from surgery to discharge are recorded as secondary outcomes. Patients will be divided in the following comparison groups: * Group +/+ will receive ten minutes of active tDCS followed by ten minutes of active VNS. * Group +/- will receive ten minutes of active tDCS followed by ten minutes of sham VNS. * Group -/+ will receive ten minutes of sham tDCS followed by ten minutes of active VNS. * Group -/- will receive ten minutes of sham tDCS followed by ten minutes of sham VNS.	Accident vasculaire cérébral, Lupus, SEP	Non applicable	Traitement symptomatique	United States	À vérifier
CapotenThe goal of this clinical trial is to learn if starting four kidney disease medicines quickly and together (a rapid treatment approach) is safe and works well in people with type 2 diabetes and chronic kidney disease. The main questions it aims to answer are: * Is it safe to start these medicines over a short period of time? * How often do kidney function changes or high potassium levels occur? * Does this approach lower protein in the urine (a sign of kidney damage)? * How many participants are able to stay on all four medicines over 6 months? Researchers will compare this approach to usual care, where medicines are started one at a time over several months. Participants will: Be assigned by chance to either this approach or usual care Start up to four approved kidney medicines over about 8 weeks (rapid treatment approach) or follow standard care Have regular clinic visits and lab tests to check kidney function and potassium levels Be followed for about 6 months	Maladie rénale chronique	Phase 4	À vérifier	United States	À vérifier
CFA EndarterectomyThe investigators hypothesize that Shockwave with DCB is non-inferior to surgical endarterectomy for common femoral artery (CFA) stenosis with regard to primary efficacy and safety endpoints. The study will challenge the current guideline that recommends common femoral endarterectomy (CFE) as the primary treatment for symptomatic CFA stenosis.	Maladie coronarienne	Non applicable	Traitement symptomatique	United States	À vérifier
Coronary CTAAI-Guided Coronary CT Angiography Screening in Former High-Intensity Athletes	Maladie coronarienne	Non applicable	À vérifier	United States	À vérifier
Discovery of Novel Biomarkers That Will Lead to the Early Detection of Alzheimer's DiseaseThis study will perform a targeted metabolic analysis in blood and urine samples from subjects attending the Baylor AT\&T Memory Center. The aim is to identify novel biomarkers that can distinguish normal aging subjects with no cognitive impairment from those with mild, moderate or severe cognitive impairment associated with Alzheimer's disease. Subjects will also be screened for B-vitamin deficiencies that may correlate with other metabolic biomarkers and Alzheimer's disease.	Alzheimer	À vérifier	À vérifier	United States	À vérifier
enalaprilTo compare the renal consequences of two different approaches to blocking the renin angiotensin system in subjects with hypertension and concurrent Type II diabetes mellitus and diabetic nephropathy.	Hypertension, Maladie rénale chronique	Phase 4	À vérifier	United States	À vérifier
LotensinThe goal of this clinical trial is to learn if starting four kidney disease medicines quickly and together (a rapid treatment approach) is safe and works well in people with type 2 diabetes and chronic kidney disease. The main questions it aims to answer are: * Is it safe to start these medicines over a short period of time? * How often do kidney function changes or high potassium levels occur? * Does this approach lower protein in the urine (a sign of kidney damage)? * How many participants are able to stay on all four medicines over 6 months? Researchers will compare this approach to usual care, where medicines are started one at a time over several months. Participants will: Be assigned by chance to either this approach or usual care Start up to four approved kidney medicines over about 8 weeks (rapid treatment approach) or follow standard care Have regular clinic visits and lab tests to check kidney function and potassium levels Be followed for about 6 months	Maladie rénale chronique	Phase 4	À vérifier	United States	À vérifier
MonoprilThe goal of this clinical trial is to learn if starting four kidney disease medicines quickly and together (a rapid treatment approach) is safe and works well in people with type 2 diabetes and chronic kidney disease. The main questions it aims to answer are: * Is it safe to start these medicines over a short period of time? * How often do kidney function changes or high potassium levels occur? * Does this approach lower protein in the urine (a sign of kidney damage)? * How many participants are able to stay on all four medicines over 6 months? Researchers will compare this approach to usual care, where medicines are started one at a time over several months. Participants will: Be assigned by chance to either this approach or usual care Start up to four approved kidney medicines over about 8 weeks (rapid treatment approach) or follow standard care Have regular clinic visits and lab tests to check kidney function and potassium levels Be followed for about 6 months	Maladie rénale chronique	Phase 4	À vérifier	United States	À vérifier
Shockwave BalloonTo assess the efficacy and safety of Intravascular Lithotripsy (IVL) in subjects undergoing transfemoral TAVR in patients with severe iliac disease, prohibitive for transfemoral TAVR in patients with severe symptomatic aortic stenosis, otherwise considered for alternative access TAVR. (e.g. trans-carotid)	Maladie coronarienne	À vérifier	Traitement symptomatique	United States	À vérifier
Shockwave CatheterThe investigators hypothesize that Shockwave with DCB is non-inferior to surgical endarterectomy for common femoral artery (CFA) stenosis with regard to primary efficacy and safety endpoints. The study will challenge the current guideline that recommends common femoral endarterectomy (CFE) as the primary treatment for symptomatic CFA stenosis.	Maladie coronarienne	Non applicable	Traitement symptomatique	United States	À vérifier
Discovery of Novel Biomarkers That Will Lead to the Early Detection of Alzheimer's DiseaseThis study will perform a targeted metabolic analysis in blood and urine samples from subjects attending the Baylor AT\&T Memory Center. The aim is to identify novel biomarkers that can distinguish normal aging subjects with no cognitive impairment from those with mild, moderate or severe cognitive impairment associated with Alzheimer's disease. Subjects will also be screened for B-vitamin deficiencies that may correlate with other metabolic biomarkers and Alzheimer's disease.	Alzheimer	À vérifier	À vérifier	United States	À vérifier
Active vagus nerve stimulationThis study seeks to evaluate the efficacy of transcranial direct current stimulation (tDCS) and Afferent Vagus nerve simulation (VNS) in treating acute postoperative pain of patients in the post-anesthesia care unit after general surgery. Study outcomes will include changes in pain levels and vital signs. For patients who are admitted after surgery, opioid consumption in the 24 hours after surgery and time from surgery to discharge are recorded as secondary outcomes. Patients will be divided in the following comparison groups: * Group +/+ will receive ten minutes of active tDCS followed by ten minutes of active VNS. * Group +/- will receive ten minutes of active tDCS followed by ten minutes of sham VNS. * Group -/+ will receive ten minutes of sham tDCS followed by ten minutes of active VNS. * Group -/- will receive ten minutes of sham tDCS followed by ten minutes of sham VNS.	Lupus	Phase 2	Traitement symptomatique	United States	À vérifier
Coronary CTAAI-Guided Coronary CT Angiography Screening in Former High-Intensity Athletes	Maladie coronarienne	Non applicable	À vérifier	United States	À vérifier
Active vagus nerve stimulationThis study seeks to evaluate the efficacy of transcranial direct current stimulation (tDCS) and Afferent Vagus nerve simulation (VNS) in treating acute postoperative pain of patients in the post-anesthesia care unit after general surgery. Study outcomes will include changes in pain levels and vital signs. For patients who are admitted after surgery, opioid consumption in the 24 hours after surgery and time from surgery to discharge are recorded as secondary outcomes. Patients will be divided in the following comparison groups: * Group +/+ will receive ten minutes of active tDCS followed by ten minutes of active VNS. * Group +/- will receive ten minutes of active tDCS followed by ten minutes of sham VNS. * Group -/+ will receive ten minutes of sham tDCS followed by ten minutes of active VNS. * Group -/- will receive ten minutes of sham tDCS followed by ten minutes of sham VNS.	Accident vasculaire cérébral	Non applicable	Traitement symptomatique	United States	À vérifier
Shockwave CatheterThe investigators hypothesize that Shockwave with DCB is non-inferior to surgical endarterectomy for common femoral artery (CFA) stenosis with regard to primary efficacy and safety endpoints. The study will challenge the current guideline that recommends common femoral endarterectomy (CFE) as the primary treatment for symptomatic CFA stenosis.	Maladie coronarienne	Non applicable	Traitement symptomatique	United States	À vérifier
Shockwave BalloonTo assess the efficacy and safety of Intravascular Lithotripsy (IVL) in subjects undergoing transfemoral TAVR in patients with severe iliac disease, prohibitive for transfemoral TAVR in patients with severe symptomatic aortic stenosis, otherwise considered for alternative access TAVR. (e.g. trans-carotid)	Maladie coronarienne	À vérifier	Traitement symptomatique	United States	À vérifier

Essais cliniques

7

Molécule	Indication / population	Phase	NCT	Titre	Statut
Shockwave Balloon	Maladie coronarienne	À vérifier	NCT05862558	ILIT — Intravascular Lithotripsy in High Risk Calcified Iliac Anatomy for Transfemoral TAVR	ACTIVE_NOT_RECRUITING
Shockwave Catheter	Maladie coronarienne	Non applicable	NCT06829914	Shockify — Shockwave™ vs Surgical Endarterectomy for Calcified Severe Common Femoral Artery Stenosis: Comparison of Efficacy, Safety and Long-Term Outcomes	ACTIVE_NOT_RECRUITING
Finerenone	Maladie rénale chronique	Phase 4	NCT07547878	Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD)	ENROLLING_BY_INVITATION
Active vagus nerve stimulation	Accident vasculaire cérébral	Non applicable	NCT04534556	Wireless Nerve Stimulation Device To Enhance Recovery After Stroke	ENROLLING_BY_INVITATION
Coronary CTA	Maladie coronarienne	Non applicable	NCT07460583	ProActive Athlete Heart Program: Proposal for Cardiac Risk Screening in Former High-Intensity Athletes	NOT_YET_RECRUITING
Active vagus nerve stimulation	Lupus	Phase 2	NCT06987565	TvSSLE — Transcutaneous Vagus Nerve Stimulation in SLE	RECRUITING
Discovery of Novel Biomarkers That Will Lead to the Early Detection of Alzheimer's Disease	Alzheimer	À vérifier	NCT03136679	Discovery of Novel Biomarkers That Will Lead to the Early Detection of Alzheimer's Disease	COMPLETED

Publications

4

Molécule	Indication / population	Titre	Journal	Date
enalapril		Sacubitril/Valsartan versus Enalapril or Losartan at Maximum Doses in Heart Failure with Reduced Ejection Fraction: Real-World Data.	Arquivos brasileiros de cardiologia
enalapril		Enalapril, Atenolol, Alendronate and DRESS Syndrome - A Case Report.	Acta dermato-venereologica
enalapril		High-molecular-weight hyaluronic acid promotes the protective axis of the renin-angiotensin-aldosterone system in human dermal fibroblasts.	Biochemical and biophysical research communications
enalapril		Scleroderma Renal Crisis and Posterior Reversible Encephalopathy Syndrome Triggered by Non-steroidal Anti-inflammatory Drugs.	Internal medicine (Tokyo, Japan)