Acibadem University — Biomedical Watch V2

Traitements8programmes

Essais4liés

Publications0liées

SourceDBlocale

Traitements

8

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
Car-T Cell TherapyIt is a treatment that activates and strengthens the immune system against cancer. Recently, T cell receptors have been genetically rearranged by adaptive T cell therapies, which are promising in the fight against cancer, and are now able to recognize antigens on tumor cells. These modified T cell receptors are called chimeric antigen receptors. Many previous clinical studies have shown that different CAR-T cells are effective in relapse / refractory B cell cancers and NHL.	SEP	Phase 1/2	Thérapie cellulaire + Immunomodulation	Turkey (Türkiye)	À vérifier
EDA-Based Adaptive Support in VR ALS TrainingDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé.	Sclérose latérale amyotrophique	Non applicable	À vérifier		À vérifier
Textile-based wearable electrocardiographyThe goal of this observational study is to understand heart rhythm changes in adults with epilepsy. It will also explore whether computer programs can use heart recordings to detect or predict seizures. The study will include 20 adults with temporal lobe epilepsy and 20 healthy volunteers. Participants with epilepsy will have ongoing seizures despite treatment with at least two suitable medicines. All participants will be 18 years or older. In temporal lobe epilepsy, seizures start in a specific region of the brain. These seizures may spread to both sides of the brain, causing muscle stiffening and rhythmic jerking. Researchers will focus on these spreading seizures when developing seizure detection and prediction methods. The main questions are: * How do heart rate and heartbeat timing differ between people with and without epilepsy? * How do these measures change before, during, and after seizures? * Can computer programs learn patterns in heart recordings to detect seizures or predict them before they start? Researchers will compare heart rate and heart rate variability between the two groups. Heart rate variability describes changes in the time between one heartbeat and the next. They will compare recordings during rest, wakefulness, and sleep. Participants will: * Wear a fabric chest band that records the heart's electrical activity. * Have brain activity recorded through sensors on the scalp, alongside video recording. * Rest quietly while awake for one hour during the recording period. Participants with epilepsy will have recordings during their usual hospital monitoring. Healthy volunteers will have 24 hours of recording at the same hospital. Researchers will use the brain recordings and video to identify when seizures happen. They will develop and test computer programs that learn patterns in the heart recordings.	Épilepsie	À vérifier	À vérifier	Turkey (Türkiye)	À vérifier
Turkish Validity and Reliability of the Parkinson's Disease Neuropsychometric Dementia Assessment Questionnaire in Individuals With Parkinson's DiseaseThe aim of this study is to examine the validity and reliability of the Turkish version of the Parkinson's Neuropsychometric Dementia Assessment (PANDA) in individuals with Parkinson's disease. This cross-sectional methodological study will evaluate the psychometric properties of the Turkish PANDA, including internal consistency, test-retest reliability, and construct validity, in order to provide a valid and reliable instrument for the assessment of cognitive impairment and dementia-related cognitive changes in Turkish-speaking individuals with Parkinson's disease.	Parkinson	À vérifier	À vérifier	Turkey (Türkiye)	À vérifier
EDA-Based Adaptive Support in VR ALS TrainingDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé.	Sclérose latérale amyotrophique	Non applicable	À vérifier		À vérifier
Turkish Validity and Reliability of the Parkinson's Disease Neuropsychometric Dementia Assessment Questionnaire in Individuals With Parkinson's DiseaseThe aim of this study is to examine the validity and reliability of the Turkish version of the Parkinson's Neuropsychometric Dementia Assessment (PANDA) in individuals with Parkinson's disease. This cross-sectional methodological study will evaluate the psychometric properties of the Turkish PANDA, including internal consistency, test-retest reliability, and construct validity, in order to provide a valid and reliable instrument for the assessment of cognitive impairment and dementia-related cognitive changes in Turkish-speaking individuals with Parkinson's disease.	Parkinson	À vérifier	À vérifier	Turkey (Türkiye)	À vérifier
Textile-based wearable electrocardiographyThe goal of this observational study is to understand heart rhythm changes in adults with epilepsy. It will also explore whether computer programs can use heart recordings to detect or predict seizures. The study will include 20 adults with temporal lobe epilepsy and 20 healthy volunteers. Participants with epilepsy will have ongoing seizures despite treatment with at least two suitable medicines. All participants will be 18 years or older. In temporal lobe epilepsy, seizures start in a specific region of the brain. These seizures may spread to both sides of the brain, causing muscle stiffening and rhythmic jerking. Researchers will focus on these spreading seizures when developing seizure detection and prediction methods. The main questions are: * How do heart rate and heartbeat timing differ between people with and without epilepsy? * How do these measures change before, during, and after seizures? * Can computer programs learn patterns in heart recordings to detect seizures or predict them before they start? Researchers will compare heart rate and heart rate variability between the two groups. Heart rate variability describes changes in the time between one heartbeat and the next. They will compare recordings during rest, wakefulness, and sleep. Participants will: * Wear a fabric chest band that records the heart's electrical activity. * Have brain activity recorded through sensors on the scalp, alongside video recording. * Rest quietly while awake for one hour during the recording period. Participants with epilepsy will have recordings during their usual hospital monitoring. Healthy volunteers will have 24 hours of recording at the same hospital. Researchers will use the brain recordings and video to identify when seizures happen. They will develop and test computer programs that learn patterns in the heart recordings.	Épilepsie	À vérifier	À vérifier	Turkey (Türkiye)	À vérifier
Car-T Cell TherapyIt is a treatment that activates and strengthens the immune system against cancer. Recently, T cell receptors have been genetically rearranged by adaptive T cell therapies, which are promising in the fight against cancer, and are now able to recognize antigens on tumor cells. These modified T cell receptors are called chimeric antigen receptors. Many previous clinical studies have shown that different CAR-T cells are effective in relapse / refractory B cell cancers and NHL.	SEP	Phase 1/2	Thérapie cellulaire + Immunomodulation	Turkey (Türkiye)	À vérifier

Essais cliniques

4

Molécule	Indication / population	Phase	NCT	Titre	Statut
Car-T Cell Therapy	SEP	Phase 1/2	NCT04206943	ISIKOK-19 — Study of CD19 Specific Chimeric Antigen Receptor Positive T Cells (CAR-T) in ALL and NHL	UNKNOWN
Textile-based wearable electrocardiography	Épilepsie	À vérifier	NCT07835594	EpHR-DP — Studying Heart Rhythms With a Wearable Sensor to Detect and Predict Seizures in People With Epilepsy	NOT_YET_RECRUITING
Turkish Validity and Reliability of the Parkinson's Disease Neuropsychometric Dementia Assessment Questionnaire in Individuals With Parkinson's Disease	Parkinson	À vérifier	NCT07815964	Turkish Validity and Reliability of the Parkinson's Disease Neuropsychometric Dementia Assessment Questionnaire in Individuals With Parkinson's Disease	NOT_YET_RECRUITING
EDA-Based Adaptive Support in VR ALS Training	Sclérose latérale amyotrophique	Non applicable	NCT07650019	EDA-Based Adaptive Support in VR ALS Training	NOT_YET_RECRUITING

Publications

0

Molécule	Indication / population	Titre	Journal	Date
Aucune publication.